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基于平板扫描仪的氡测量方法研究

核电子学与探测技术 2024年第4期44卷 603-607页

作者：杨晓宇焦岩卫晓峰刘立业曹勤剑赵原中国辐射防护研究院太原030000 辐射安全与防护山西省重点实验室太原030000 中核集团辐射防护技术重点实验室太原030000

CR-39固体径迹探测器因其材料的稳定性、良好的实用性等特点被广泛应用于氡的测量领域。针对现有的商用固体径迹探测器自动测读系统价格昂贵、维护成本及环境要求高的问题,本研究利用平板扫描仪设备,开展固体径迹形态学研究,通过建立基... 详细信息

CR-39固体径迹探测器因其材料的稳定性、良好的实用性等特点被广泛应用于氡的测量领域。针对现有的商用固体径迹探测器自动测读系统价格昂贵、维护成本及环境要求高的问题,本研究利用平板扫描仪设备,开展固体径迹形态学研究,通过建立基于径迹形态学参数的氡径迹识别法则,实现氡的高效、低成本测量。测量结果表明氡暴露量在500 kBq·h/m^(3)以下时,径迹密度-暴露量曲线呈现良好的线性关系。研究表明,基于平板扫描仪的氡测量方法有望实现氡的高效测量且该测读方法兼顾高效、低成本、环境适应性强的特点。

关键词： CR-39 固体径迹探测器氡测量

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Electrical stimulation of the sacral nerve anterior root following induced bladder detrusor contraction

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Neural Regeneration Research 2010年第24期5卷 1900-1904页

作者： Peng Yan xiaoyu yang Qi Gao Xiaoran Wang Jian Liu Maoguang yang Department of Orthopedics China-Japan Union Hospital of Jilin University Changchun 130000 Jilin Province China Department of Urology China-Japan Union Hospitalof Jilin University Changchun 130000 Jilin Province China

The sacral nerve anterior root consists of parasympathetic nerves（dominating urinary bladder detrusor）and somatic motor nerves（dominating urethral sphincter）,and electrical stimulation to the sacral nerve anterior root induces simultaneous contraction of the bladder detrusor and urethral ***,urethral pressure exceeds intravesical pressure,resulting in little or no urination,kidney damage,and trembling of lower limbs due to high intravesical *** the present study,sacral nerve posterior roots were transected in a spastic bladder rabbit model,followed by three-pole electrode and long-pulse electrical stimulation to the sacral anterior *** and urethral pressures were simultaneously measured to verify the feasibility of anode inhibition to the sacral anterior root following induced detrusor *** stimulus intensity increased,somatic motor nerves were increasingly inhibited; with a stimulus pulse width of 300 μs and stimulus current of 1.05 mA,urethral pressure was zero and average intravesical pressure was 3.84 *** addition,detrusor contraction was displayed,and lower extremity trembling was significantly ***-pole electrode and long-pulse electrical stimulation to the sacral nerve anterior root induced detrusor contraction and inhibited low extremity trembling under electrical stimulation.

关键词： anode block bladder detrusor electrical stimulation sacral anterior root

Kinetic Resolution of 1,2-Diamines via Organocatalyzed Asymmetric Electrophilic Aminations of Anilines

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Chinese Journal of Chemistry 2022年第24期40卷 1674-1680页

作者： Jinglei Xie Zheng Guo Wei Liu Dekun Zhang Yu-Peng He xiaoyu yang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Petrochemical Catalytic Science and Technology Liaoning Shihua UniversityFushunLiaoning 113001China Universityof Chinese Academy of Sciences Bejing 100049China State Key Laboratory of Fine Chemicals Ningbo Institute of Dalian University of TechnologyNingboZhejiang 315016China

An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,*** removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.

关键词： Asymmetric catalysis 1,2-Diamines Kinetic resolution Chiral phosphoric acids Amination

两种腹横肌平面阻滞方法在老年择期腹股沟疝修补术中的应用比较

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中华疝和腹壁外科杂志（电子版） 2024年第3期18卷 320-325页

作者：杨晓宇王佳张维峰陈雨辰南京中医药大学附属南京医院(南京市第二医院)麻醉科 210003

目的比较两种腹横肌平面(TAP)阻滞方法在老年择期腹股沟疝修补术中的应用效果。方法选取2021年1月至2022年12月于南京中医药大学附属南京医院择期行腹股沟疝修补术的老年患者90例,使用随机数字表法将患者分为对照组(45例,超声引导下侧路... 详细信息

目的比较两种腹横肌平面(TAP)阻滞方法在老年择期腹股沟疝修补术中的应用效果。方法选取2021年1月至2022年12月于南京中医药大学附属南京医院择期行腹股沟疝修补术的老年患者90例,使用随机数字表法将患者分为对照组(45例,超声引导下侧路TAP阻滞)和观察组(45例,超声引导下TAP两点阻滞),观察并比较2组围手术期指标、血流动力学参数、镇痛效果及应激指标,并观察恶心、呕吐等麻醉不良反应发生情况。结果2组患者的疝环直径、手术时间及术中出血等手术情况差异无统计学意义(P>0.05),观察组术后下床时间和住院时间较对照组缩短,差异有统计学意义(P0.05),术后1、3 d 2组患者IL-6、皮质醇明显升高,但观察组明显低于对照组(P<0.05);术后1、3 d,观察组胰岛素未见明显改变,而术后1 d对照组胰岛素明显低于术前,且与观察组比较差异有统计学意义(P<0.05)。治疗期间,观察组不良反应发生率明显低于对照组(P<0.05)。结论超声引导下腹横肌平面两点阻滞具有镇痛效果佳,血流动力学稳定,应激反应小及不良反应少的优点,可提高老年腹股沟疝修补术患者的手术舒适度及安全性,利于患者康复。

关键词：疝,腹股沟超声引导腹横肌平面阻滞疝修补术老年人

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磷酸芦可替尼有关杂质的合成

山西化工 2024年第8期44卷 48-50页

作者：杨晓宇姚凯刘艳飞张雷山西振东制药股份有限公司山西长治046000

根据磷酸芦可替尼原料药合成方法,分析了其合成过程中可能产生的潜在工艺杂质,并进行合成。以6-氯-7-氮杂嘌呤为起始原料经取代反应、偶联反应、水解反应分别进行了3个潜在杂质的合成,经高效液相色谱检测纯度均大于97.0%。合成方法具有... 详细信息

根据磷酸芦可替尼原料药合成方法,分析了其合成过程中可能产生的潜在工艺杂质,并进行合成。以6-氯-7-氮杂嘌呤为起始原料经取代反应、偶联反应、水解反应分别进行了3个潜在杂质的合成,经高效液相色谱检测纯度均大于97.0%。合成方法具有制备过程简单、所得杂质纯度高等特点,化合物采用核磁共振氢谱碳谱,以及液质联用仪[2]进行了化学结构确证,结构确证数据与目标化合物相符,可以作为磷酸芦可替尼杂质对照品进行未知杂质的分析和鉴定。

关键词：骨髓纤维磷酸芦可替尼杂质合成

2022年重庆市巴南区成人烟草使用监测结果分析

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黑龙江科学 2024年第17期15卷 32-34页

作者：杨笑语潘冬梅陈鹏苏耀重庆市巴南区健康教育所重庆401320

为了解2022年重庆市巴南区成人烟草使用现状,分析相关影响因素,为控烟策略或政策的有效制定与改进提供科学依据,结合多阶段分层整群随机抽样法、PPS抽样调研法及简单随机抽样法对重庆市巴南区居民进行调查,统计其人口学特征、吸烟率、... 详细信息

为了解2022年重庆市巴南区成人烟草使用现状,分析相关影响因素,为控烟策略或政策的有效制定与改进提供科学依据,结合多阶段分层整群随机抽样法、PPS抽样调研法及简单随机抽样法对重庆市巴南区居民进行调查,统计其人口学特征、吸烟率、戒烟率、电子烟知晓率、非吸烟者二手烟暴露率等信息。调查结果显示,巴南区居民吸烟率为19.35%,不同性别间的差异具有统计学意义,性别是影响巴南区居民吸烟率的主要因素。非吸烟者二手烟暴露率为34.67%,不同年龄、文化程度及城乡间的差异具有统计学意义。吸烟率与非吸烟者二手烟暴露率均显著低于2020年监测指标及国内平均水平。戒烟率及电子烟知晓率分别为24.38%、39.8%,不同年龄、文化程度受访者的电子烟知晓率差异具有统计学意义。基于此,应加强宣传,完善相关法律法规,完善戒烟服务体系,从而使居民有效控烟戒烟。

关键词：烟草监测吸烟率二手烟暴露率戒烟率电子烟知晓率

Genome-wide characterization of MATE family members in Cucumis melo *** their expression profiles in response to abiotic and biotic stress

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Horticultural Plant Journal 2022年第4期8卷 474-488页

作者： Shuoshuo Wang Kun Chen Jiayu Zhang Jianquan Wang Haosen Li xiaoyu yang Qinghua Shi College of Horticulture Science and Engineering Shandong Agricultural UniversityTai’anShandong 271018China State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai’anShandong 271018China Institute of Vegetables Shangqiu Academy of Agriculture and Forestry SciencesShangqiuHenan 476002China

The multidrug and toxic compound extrusion(MATE) family plays pivotal roles in the detoxification process in plants, while no information has been provided for this gene family in melon(Cucumis melo L.) thus far, limiting our understanding of its functions in melon acclimation to stressful environments. In this study, a total of 39 MATEs(CmMATE1–CmMATE39) were observed in the melon genome;these were unevenly distributed in all chromosomes, with the most on Chromosome 1. Based on their orthologous relationship with those from Arabidopsis, rice, and sorghum, melon MATEs were clustered into three subfamilies of Clades Ⅰ, Ⅱ, and Ⅲ, wherein 23, 9, and 7 members were included, *** exon number was observed in CmMATEs, and the most were harbored by CmMATE8. Gene ontology(GO) term and cis-regulatory element(CRE) analyses pointed to the potential roles of CmMATEs in both the regulation of melon development and acclimation to various abiotic and biotic stressors. The RNA-seq and qRT-PCR(quantitative real-time PCR) results demonstrated that under normal growth conditions, CmMATEs were expressed in a tissue-and development-specific manner, while their abundance apparently varied in a stress-dependent manner when melon plants were exposed to unfavorable environmental conditions. Altogether, these observations could expand our knowledge about the plant MATE family and benefit functional genomics analysis for CmMATEs in the future.

关键词： Melon MATE Orthologous relationship GO term Expression Stress

Nanomedicine potentiates mild photothermal therapy for tumor ablation

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 738-761页

作者： Zijun Jiang Tianyi Li Hao Cheng Feng Zhang xiaoyu yang Shihao Wang Jianping Zhou yang Ding Key Laboratory of Drug Quality Control and Pharmacovigilance(Ministry of Education) State Key Laboratory of Natural MedicinesNMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and ExcipientsDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

The booming photothermal therapy(PTT)has achieved great progress in non-invasive oncotherapy,and paves a novel way for clinical *** note,mild temperature PTT(mPTT)of 42–45°C could avoid treatment bottleneck of the traditional PTT,including nonspecific injury to normal tissues,vasculature and host antitumor ***,cancer cells can resist mPTT via heat shock response and autophagy,thus leading to insufficient mPTT monotherapy to ablate *** overcome the deficient antitumor efficacy caused by thermo-resistance of cancer cells and mono mPTT,synergistic therapies towards cancer cells have been conducted with *** review summarizes the recent advances in nanomedicine-potentiated mPTT for cancer treatment,including strategies for enhanced single-mode mPTT and mPTT plus synergistic ***,challenges and prospects for clinical translation of nanomedicine-potentiated mPTT are discussed.

关键词： Nanomedicine Mild temperature PTT Thermo-resistance Promote mPTT monotherapy Synergistic therapy

Crustal structure beneath the central and western North China from receiver function analysis

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Earthquake Science 2022年第6期35卷 448-473页

作者： Xin Gao Yonghua Li xiaoyu yang Zhiyuan Ren Institute of Geophysics China Earthquake AdministrationBeijing 100081China Key Laboratory of Earthquake Source Physics China Earthquake AdministrationBeijing 100081China Shandong Earthquake Agency Jinan 250014China

The North China Craton(NCC)is one of the oldest cratons on *** important tectonic transformations of MesozoicCenozoic tectonic regime led to the destruction of the North China *** knowledge of crustal structure can provide important constraints for the formation and evolution of *** maps of sediment thickness,crustal thickness(H)and v_(P)/v_(S)(κ)in the central and western NCC were obtained using sequential H-κstacking.P-wave receiver functions are calculated using teleseismic waveform data recorded by 405 stations from Chin Array *** from the densely distribution of temporary seismic stations,our results reveal details of the crustal structure in the study *** thickness of sedimentary layer in North China ranges from 0–6.4 km,and the thickest sedimentary layer is in Ordos block and its surroundings(about 2.8–6 km);The thickness of sedimentary layer in the Mongolia fold belt and Yinshan orogenic belt is relatively thin(less than 1 km).The crustal thickness of the study area varies between 27–48 km,of which the crust of the North China Plain is about 30–33 km,the central NCC is about 33–40 km,and the Ordos block is 40–48 km *** average v_(P)/v_(S)ratios in the study area is mostly between 1.66 and 1.90,and that in the Yanshan-Taihang mountain fold belt is between 1.70 and 1.85,and that in the Ordos block is between 1.65 and 1.90,with an average value of 1.77,indicating the absence of a thick basaltic lower *** obvious negative correlation between crustal thickness and average v_(P)/v_(S)ratio within Ordos and Central Asia orogenic belt may be related to magmatic underplating during the crustal *** is no significant correlation between the crustal thickness and the v_(P)/v_(S)ratio in the Lüliang-Taihang mountain fold belt,which may be related to the multiple geological processes such as underplating and crustal extension and thinning in this *** lack of correlation between crust thickness and t

关键词： receiver functions H-κstacking crustal thicknesses v_(P)/v_(S)ratios North China