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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science China(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li Kenneth C.P.Cheung xiaojiao Zheng School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune *** the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing *** allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

Food poisoning due to money tree seeds:a case report of toxic encephalopathy

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Emergency and Critical Care Medicine 2024年第3期4卷 126-129页

作者： Yue Zhao xiaojiao Quan Tao Wang Department of Emergency Medicine Hainan Hospital of Chinese PLA General HospitalSanyaHainanChina The Center of Heat Stroke Prevention and Treatment of Peoples’Liberation Army SanyaHainanChina

Background:The money tree is a favored indoor potted plant in *** seeds resemble chestnuts in both shape and flavor when cooked,which are generally considered non-toxic and safe for *** presentation:This report presents the first published case of food poisoning due to the ingestion of large amounts of money tree seeds.A 67-year-old man exhibited toxic encephalopathy symptoms and dyspnea after consuming the seeds for approximately 6 *** empirical mechanical ventilation,therapeutic plasma exchange,and other medical interventions,the patient’s clinical status improved *** was subsequently discharged from the ***:Consuming a substantial quantity of money tree seeds within a limited timeframe can lead to poisoning,resulting in adverse outcomes,particularly toxic ***,plasma exchange may have some therapeutic effect.

关键词： Case report Money tree Pachira macrocarpa Respiratory failure Toxic encephalopathy

Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao xiaojiao Ge Yuanyuan Wei Lulu He Aiguo Wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

Effect of Y and Ce Micro-alloying on Microstructure and Hot Tearing of As-Cast Al-Cu-Mg Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 939-952页

作者： Chunyu Yue Bowen Zheng Ming Su Yuxiang Wang xiaojiao Zuo Yinxiao Wang Xiaoguang Yuan School of Materials Science and Engineering Shenyang University of TechnologyShenyang110870China Institute of Metal Research Chinese Academy of SciencesShenyang110016China

In this work,the Al-Cu-Mg alloy with different Y(0-0.2 wt%)and Ce(0.5-1.5 wt%)are *** effect of mixed addition of Y and Ce on the grain structure and hot tearing for Al-4.4Cu-1.5Mg-0.15Zr alloy was investigated using"cross"hot tearing *** results indicate that as rare earth Y and Ce increases,the grain size becomes finer,the grain morphology changes from dendrite to equiaxed grain,and effectively reduce the hot tearing sensitivity coefficient(HTS1)and crack susceptibility coefficient(CSC)of the *** the increase of Ce element(0.5-1.5 wt%),the hot tearing susceptibility of the alloy decreases first and then *** the increase of Y element(0-0.2 wt%),the hot tearing sensitivity of the alloy *** the content of rare earth is 0.2 wt%Y+1.0 wt%Ce,the minimum HTS1 value and CSC value of the alloy are 68 and 0.53,*** earth Ce refines the alloy microstructure,shortens the feeding channel,and reduces the hot tearing ***,the rare earth Y can form Al6Cu6Y phase at the grain boundary,improve the feeding capacity of the ***,appropriate addition of rare earth Y and Ce can effectively reduce the hot tearing tendency of the alloy.

关键词： Al-Cu-Mg alloy Y and Ce Microstructure Thermal analysis Hot tearing sensitivity

Bipartite consensus problems of Lurie multi-agent systems over signed graphs: A contraction approach

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Chinese Physics B 2024年第7期33卷 137-145页

作者：张晓娇吴祥 School of Mathematics and Information Science Nanchang Normal UniversityNanchang 330032China School of Mathematical Sciences Guizhou Normal UniversityGuiyang 550001China

This paper examines the bipartite consensus problems for the nonlinear multi-agent systems in Lurie dynamics form with cooperative and competitive communication between different agents. Based on the contraction theory, some new conditions for the nonlinear Lurie multi-agent systems reaching bipartite leaderless consensus and bipartite tracking consensus are presented. Compared with the traditional methods, this approach degrades the dimensions of the conditions, eliminates some restrictions of the system matrix, and extends the range of the nonlinear function. Finally, two numerical examples are provided to illustrate the efficiency of our results.

关键词： contraction theory virtual system bipartite consensus Lurie multi-agent systems

5G发展关键性战略资源管理与技术治理制度研究

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中共中央党校（国家行政学院）学报 2019年第6期23卷 31-36页

作者：杨晓娇易继明国家无线电监测中心政策研究处北京海淀100037 北京大学法学院北京海淀100871

无线电频谱资源是稀缺的国家战略资源,在5G发展中发挥着最关键的基础作用。而频谱资源市场化配置是资源有效利用和保护的重要手段,建立频谱资源的市场准入、信息公开、市场交易、惩罚制度进行基本分析,构建我国频谱资源市场化配置基本制... 详细信息

无线电频谱资源是稀缺的国家战略资源,在5G发展中发挥着最关键的基础作用。而频谱资源市场化配置是资源有效利用和保护的重要手段,建立频谱资源的市场准入、信息公开、市场交易、惩罚制度进行基本分析,构建我国频谱资源市场化配置基本制度,更好地发挥频谱资源在5G发展中的核心基础作用。同时,重构频谱使用评估收回、频谱重耕、频谱共享技术手段等,构建5G发展关键性战略资源技术治理制度,更好地解决5G发展中的突出问题。

关键词：频谱资源 5G发展市场化配置技术治理

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高分辨星载海洋微波辐射测量技术发展综述

空间电子技术 2024年第2期21卷 1-16,F0002页

作者：李一楠周武窦昊锋刘淑波宋广南杨小娇王丛丛李浩吕容川陈文新中国空间技术研究院西安分院西安710000 国家卫星海洋应用中心北京100000

星载微波辐射计作为海洋观测的一种重要技术手段,能够全天时、全天候对海洋环境参数进行长期连续的观测,具有宽幅、高精度等特点,能够为数值预报、台风监测、防灾减灾等应用提供重要保障。随着海洋应用需求不断提升,星载海洋微波辐射探... 详细信息

星载微波辐射计作为海洋观测的一种重要技术手段,能够全天时、全天候对海洋环境参数进行长期连续的观测,具有宽幅、高精度等特点,能够为数值预报、台风监测、防灾减灾等应用提供重要保障。随着海洋应用需求不断提升,星载海洋微波辐射探测技术也向着更高分辨率、更高精度的方向发展。文章对高分辨率海洋微波辐射测量新技术的概念、系统组成以及发展情况进行了介绍,包括基于密集馈源阵列的多波束推扫辐射计、集中式综合孔径辐射计以及分布式综合孔径辐射计。文章结合三种高分辨率微波辐射测量技术的特点和当前技术水平对未来星载海洋微波辐射测量技术的发展思路进行了讨论,对其中的重要的关键技术进行了梳理,并针对不同应用需求给出了发展建议。

关键词：高分辨率海洋微波辐射测量技术多波束推扫分布式

Radiation Spectral Analysis of 3D Dust Molecular Clusters(PAHs)and Peptoids under Ionization and Electric Field in ISM

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Research in Astronomy and Astrophysics 2024年第1期24卷 70-77页

作者： Ruiqing Wu Chunhua Zhu Guoliang Lü xiaojiao Zhang Xizhen Lu Jinlong Yu Wujin Chen Mengqiu Long School of Physics and Electronics Central South UniversityChangsha 410083China School of Physical Science and Technology Xinjiang UniversityUrumqi 830046China School of Microelectronics and Physics Hunan University of Technology and BusinessChangsha 410205China College of Mechanical and Electronic Engineering Tarim UniversityAlar 843300China School of Medicine Xinjiang Medical UniversityUrumqi 830011China

Polycyclic aromatic hydrocarbons(PAHs),PANHs,and peptoids dust spectral calculations from the interstellar medium(ISM)are important for dust observations and *** goal is to calculate the radiation spectrum of spherical PAHs dust clusters in a vacuum containing ionized and applied in the presence of an electric *** propose a new simple computational model to calculate the size of three-dimensional spherical dust clusters formed by different initial dust *** the Vienna Ab-initio Simulation Package code,the density functional theory with the generalized approximation was used to calculate the electron density gradient and obtain the radiation spectrum of *** the radius of spherical dust clusters is~[0.009-0.042]μm,the dust radiation spectrum agrees well with the Z=0.02 mMMP stellar spectra,and the PAHs radiation spectrum of NGC 4676 at wavelengths of(0-5]μm and(5-10]μm,*** the ionized state,the N-PAH,C_(10)H_(9)N,2(C_(4)H_(4))^(1+),and peptoids 4(CHON),(C_(8)H_(10)N_(2)O_(5))^(1+)dust clusters at 3.3μm,while the 2(C_(22)H_(21)N_(3)O_(2))^(1+),4(CHON)dust clusters at 5.2μm have obvious *** is a characteristic of part of PAHs and peptoids clusters radiation at the nearinfrared wavelength of 2μ***,especially after applying an electric field to the dust,the emission spectrum of the dust increases significantly in the radiation wavelength range[3-10]μ***,the dust clusters of PAHs,PANHs,and peptoids of the radius size~[0.009-0.042]μm are likely to exist in the ISM.

关键词： ISM:structure ISM:molecules radiation mechanisms:general (ISM:)dust extinction

Catalytic effects of V-and O-species derived from PrF_(3)/V_(2)C for efficient hydrogen storage in MgH_(2)

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Nano Research 2024年第8期17卷 7117-7125页

作者： Zhenluo Yuan Yuhang Wang Xiuxiu Zhang Shuyan Guan xiaojiao Wang Liqiang Ji Qiuming Peng Shumin Han Yanping Fan Baozhong Liu College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000China Henan Famous Diamond Co. Ltd.Mengzhou 454763China School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

Magnesium hydride(MgH_(2))is considered as an ideal hydrogen storage material with excellent hydrogen capacity,but the slow kinetics impedes its ***,an efficient additive of V2C MXene-anchored PrF_(3) nanoparticles(PrF_(3)/V_(2)C)was synthesized,which presents excellent catalytic effect in improving the reversibility and stability of hydrogen storage in MgH_(2).The initial dehydrogenation temperature of the 5 wt.% PrF_(3)/V_(2)C-containing MgH_(2)(182℃) is 105℃ lower than that of pure MgH_(2),and 6.5 wt.%hydrogen is rapidly released from 5 wt.%PrF_(3)/V_(2)C-added MgH_(2)sample in 6 min at 240℃.In addition,5 wt.%PrF_(3)/V_(2)C-containing MgH_(2) sample possesses outstanding reversible hydrogen storage capability of 6.5 wt.% after 10 cycles of dehydrogenation and *** analysis shows that the introduction of Pr improves the stability of V-species(V^(0)and V^(2+))and O-species(lattice oxygen(OL)and vacancy oxygen(OV))formed during ball milling,promotes the interaction between V-species and O-species,and enhances their reversibility,which contributes to the significant improvement in re/dehydrogenation reversibility and cycling stability of MgH_(2).This study provides effective ideas and strategies for the purpose of designing and fabricating high-efficient catalysts for solid-state hydrogen storage materials.

关键词： hydrogen storage materials MgH_(2) dehydrogenation reversibility cyclic stability