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准噶尔盆地南缘近地表方位各向异性特征及地震成像

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新疆石油地质 2021年第1期42卷 100-106页

作者：罗勇谭佳杨晓海窦强峰刘宜文中国石油新疆油田分公司勘探开发研究院地球物理研究所乌鲁木齐830013

准噶尔盆地南缘安集海背斜近地表非均质性强,岩性剧变,风化层速度变化大,复杂的表层激发接收条件改变了地震波传播的路径和速度,产生严重的近地表方位各向异性,导致有效地震波无法同相叠加成像,严重影响复杂构造的成像精度,是地震成像... 详细信息

准噶尔盆地南缘安集海背斜近地表非均质性强,岩性剧变,风化层速度变化大,复杂的表层激发接收条件改变了地震波传播的路径和速度,产生严重的近地表方位各向异性,导致有效地震波无法同相叠加成像,严重影响复杂构造的成像精度,是地震成像首先应该解决的问题。通过分析原始单炮初至走时特征,结合野外地质露头和卫星图,分析了动、静校正后的地震道集与炮点、检波点的对应关系,并与近地表各类冲沟、介质岩性进行紧密关联;通过分方位动、静校正及分方位加权叠前时间偏移成像处理,构建了不同方位的加权系数场,叠前时间偏移成像中“画弧”现象得到压制,成像效果明显改善,利用叠前时间偏移成像结果有效落实了安集海背斜中、下组合圈闭特征。

关键词：准噶尔盆地安集海背斜方位各向异性地震成像叠前时间偏移地质露头卫星图加权系数

近似真地表处理基准面的逆向统一构建及应用——以准噶尔南缘安集海背斜三维为例

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地球物理学进展 2021年第6期36卷 2531-2539页

作者：罗勇杨晓海妥军军郑鸿明谭佳中国石油新疆油田分公司勘探开发研究院地球物理研究所乌鲁木齐830011

准噶尔盆地南缘复杂构造近似真地表叠前深度偏移技术研究逐步深化,但成像精度始终难以满足精确落实构造和圈闭特征的要求,究其原因除了信噪比极低、地震波场复杂之外,关键是始终未解决好不同处理基准面的偏前数据与深度速度模型的匹配问... 详细信息

准噶尔盆地南缘复杂构造近似真地表叠前深度偏移技术研究逐步深化,但成像精度始终难以满足精确落实构造和圈闭特征的要求,究其原因除了信噪比极低、地震波场复杂之外,关键是始终未解决好不同处理基准面的偏前数据与深度速度模型的匹配问题.本次研究从近似真地表叠前深度偏移出发,精选地表小平滑面作为偏移基准面,并通过时深转换方法逆向构建成静校正计算底界面和时间域CMP处理参考面,开展时间域高频道间时差校正、近地表速度模型反演以及DSR动静校正处理,规避了时间域到深度域不同处理基准面的地震数据校正问题以及转换产生的误差.另外,将初至层析反演的近地表速度模型和超深微测井相结合,提高叠前深度偏移浅层速度模型精度,通过井控优选速度模型融合面,建立初始的全深度速度模型.南缘安集海背斜三维实际资料应用证实了逆向统一构建处理基准面技术思路的有效性和合理性.

关键词：近似真地表叠前深度偏移高频时差校正层析反演 DSR动静校正全深度速度模型

表面等离子体子共振生物传感器用于乙肝表面抗原的测定

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化学学报 2003年第1期61卷 137-140页

作者：陈泽忠王柯敏羊小海黄杉生黄红梅李杜王青湖南大学化学化工学院湖南大学化学生物传感与计量学国家重点实验室长沙410082

运用自行研制的表面等离子体子共振(SPR)生物传感器,采用自组装成膜技术并以戊二醛作偶联剂,在传感片表面修饰HBsAg单克隆抗体,将其用于乙肝表面抗原(HBsAg)的检测.实验结果表明SPR生物传感器对HBsAg的检出限为 0.0 6ng/mL.与传统的酶... 详细信息

运用自行研制的表面等离子体子共振(SPR)生物传感器,采用自组装成膜技术并以戊二醛作偶联剂,在传感片表面修饰HBsAg单克隆抗体,将其用于乙肝表面抗原(HBsAg)的检测.实验结果表明SPR生物传感器对HBsAg的检出限为 0.0 6ng/mL.与传统的酶联免疫吸附试验(ELISA)相比,SPR生物传感器的检出灵敏度明显高于ELISA法.用该SPR生物传感器对HBsAg质控血清与纯化的HBsAg溶液进行比较检测。

关键词：测定表面等离子体子共振生物传感器表面抗原自组装膜乙型肝炎诊断 HBsAg

Multiphysics simulation and optimization of the in-situ beneficiation process of ilmenite minerals from lunar regolith

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Science China Earth Sciences 2025年第1期68卷 195-207页

作者： Peng ZHANG Xin LIU Guanghui LIU Wei DAI Hanzhe yang Haibo ZHENG Zhi WANG Ran NIU Yifan BAI yang ZHANG Chengbao LIU Ge yang Junwei yang Guang ZHANG Technology and Engineering Center for Space Utilization Chinese Academy of Sciences Beijing Hegong Simulation Co. Ltd

The exploration and utilization of lunar resources have become the major objectives of future lunar exploration missions. The classified collection and processing of lunar minerals is the basic prerequisite for the in-situ exploration and utilization of lunar resources. In this study, we propose a scheme for in-situ separation of magnetic minerals from lunar soils using the dry magnetic separation method. The scheme can realize the purpose of separating magnetic minerals from lunar regolith by altering the motion trajectory of lunar regolith particles with different magnetic properties. Detailed modeling of the dry magnetic separation device is conducted, and the three-dimensional distribution of magnetic parameters is calculated and analyzed. Based on the characterization and analysis of the Chang E-5's samples, the morphologies and physical parameters of lunar regolith particles are modeled and simulated. A discrete element simulation of the motion process of lunar regolith particles under multi-physical field conditions is performed, and the influences of key parameters on the beneficiation performance of lunar magnetic minerals are investigated. Our results indicate that optimal separation and beneficiation of lunar regolith particles can be achieved under specific conditions of magnetic field strength and drum speed. Additionally, we analyze the effects of lunar weak gravity conditions and the charged nature of lunar particles on the beneficiation process, showing that these factors can obviously enhance the beneficiation process of lunar ilmenites. This study demonstrates the feasibility of using the dry magnetic separation method for the beneficiation of magnetic minerals from lunar regolith, providing a theoretical basis for the scientific tasks of collecting, processing, and utilizing lunar mineral resources.

关键词： Lunar regolith In-situ resource utilization Magnetic separation Classified sampling

准南双复杂区高精度叠前地震成像关键影响因素研究

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新疆地质 2020年第4期38卷 493-498页

作者：罗勇杨晓海谭佳窦强峰刘宜文中国石油新疆油田分公司勘探开发研究院地球物理研究所新疆乌鲁木齐830013

准噶尔盆地南缘安集海背斜为典型双复杂油气勘探区,近年来多轮次二、三维地震叠前偏移成像均基于CMP浮动面。中、下组合资料偏移画弧严重,无法精准反映安集海背斜中下组合圈闭特征。通过大偏移距初至近地表结构反演和优势偏移距初至层... 详细信息

准噶尔盆地南缘安集海背斜为典型双复杂油气勘探区,近年来多轮次二、三维地震叠前偏移成像均基于CMP浮动面。中、下组合资料偏移画弧严重,无法精准反映安集海背斜中下组合圈闭特征。通过大偏移距初至近地表结构反演和优势偏移距初至层析静校正相结合,解决了时间域高精度静校正问题,为后期深度速度模型提供了精确近地表模型。首次详细分析了浅地表方位各向异性对地震成像的影响,针对性采取基于地表小平滑面的时间域-深度域一体化、分方位处理成像对策,开展处理基准面试验、井控全深度速度建模的速度融合方法等,取得了理想的地震成像效果。地震成像质量明显提升,准确反映安集海背斜中下组合圈闭特征,对准噶尔盆地南缘各复杂探区高精度地震成像具非常重要的参考和推广价值。

关键词： CMP浮动面近地表模型层析反演方位各向异性偏移基准面叠前深度偏移

Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma

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Oncology Research 2025年第1期33卷 199-212页

作者： WEN yang BIN TANG DAN XU WENXIU yang Department of Pathology Guizhou Medical UniversityThe Affiliated Hospital of Guizhou Medical UniversityGuiyang550004China

Background:The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma(DLBCL)has been reported ***,the detailed mechanisms of CCR7 in DLBCL,particularly regarding its interaction with lenalidomide treatment,are not fully ***:Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control *** data and clinical information from 122 patients with DLBCL were analyzed to assess the correlation of CCR7 and p-ERK1/2 expression with the prognosis of ***,in vitro and in vivo experiments were conducted to clarify the role of CCR7 in the response of DLBCL to lenalidomide ***:Our bioinformatics analysis pinpointed CCR7 as a hub gene in the context of lenalidomide treatment in ***,31.14%and 36.0%(44/122)of DLBCL cases showed positive expression for CCR7 and ERK1/2 respectively,establishing them as independent prognostic factors for adverse outcomes in DLBCL via multivariate Cox regression ***,our studies demonstrated that the external application of the protein CCL21 promoted proliferation,migration,invasion,and activation of the ERK1/2 pathway in SU-DHL-2 and OCI-LY3 cell lines with high levels of CCR7 *** effect was mitigated by CCR7 silencing through siRNA,application of ERK inhibitors,or lenalidomide *** vivo experiments reinforced the efficacy of lenalidomide,significantly reducing tumor growth rate,tumor mass,serum total LDH levels,and expression of CCR7 and p-ERK1/2 in a SUDHL-2 xenograft model in nude mice(p<0.05).Conclusion:Our study clarifies the potential role of the CCL21/CCR7/ERK1/2 axis in the therapeutic effects of lenalidomide in DLBCL treatment.

关键词： CCR7 CCL21 ERK1/2 Lenalidomide Diffuse large B-cell lymphoma(DLBCL)

Reconstructing forest and grassland cover changes in China over the past millennium

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Science China Earth Sciences 2025年第1期68卷 94-110页

作者： Fanneng HE Fan yang Yafei WANG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Research Institute of Yellow River Civilization and Sustainable Development Henan University University of Chinese Academy of Sciences

Historical forest and grassland cover changes not only are critical indicators for quantifying ecological and environmental change processes but also serve as fundamental data for long-term climate change simulations and terrestrial ecosystem carbon emission assessments. However, because of limitations in historical data, quantitative estimations and spatially gridded reconstructions of these changes remain challenging, necessitating further methodological exploration. This study focused on China's present-day land area over the past millennium, objectively capturing the characteristics and drivers of forest and grassland cover changes. On this basis, using the forest transition theory and the space-for-time substitution method, we depicted the historical deforestation process as an inverted “S” curve and developed a model to reconstruct historical forest area changes based on the functional relationship between the forest area and population size dynamics. Subsequently, a gridded forest allocation model was established on the basis of deforestation tendencies. For the grassland cover, we implemented regionspecific methods, such as the cropland area deduction method and the habitat constraint method, to quantitatively reconstruct historical changes. Consequently, we obtained provincial forest and grassland area changes over the past millennium and mapped 10-km-resolution gridded data of forest and grassland cover. The results indicated the following.(1) The methods developed using population data as a proxy objectively reproduced the spatiotemporal evolution of forest and grassland cover in China over the past millennium. These feasible methods offer a novel pathway for the quantitative reconstruction of historical forest and grassland cover changes.(2) The data indicated that China's forest area generally decreased over the past millennium, characterized by a “decrease-then-increase” pattern. The forest area experienced three distinct phases: a slow decline(AD 1000

关键词： Land use and land cover change Forest Grassland Quantitative reconstruction Gridded reconstruction China historical period

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聚合物在荧光检测领域的应用

高等学校化学学报 2016年第2期37卷 201-212页

作者：宋春霞羊小海王柯敏王青刘剑波黄晋李文山黄海花刘卫湖南大学化学生物传感与计量学国家重点实验室化学化工学院生物纳米与分子工程湖南省重点实验室长沙410082

聚合物是由一种或几种重复单体以共价键连接形成的大分子化合物,它不仅能够保持单体的性质,而且由于聚合后单体间的协同作用,使其表现出独特的性能.聚合物作为基础材料在荧光检测领域得到广泛应用.聚合物通过氢键作用、亲疏水作用及范... 详细信息

聚合物是由一种或几种重复单体以共价键连接形成的大分子化合物,它不仅能够保持单体的性质,而且由于聚合后单体间的协同作用,使其表现出独特的性能.聚合物作为基础材料在荧光检测领域得到广泛应用.聚合物通过氢键作用、亲疏水作用及范德华力等分子间相互作用,实现了对特定目标物的选择性识别;通过信号转换和放大功能,可以将分子识别作用转化为荧光信号;可以作为骨架连接多个识别单元,通过多价结合作用等提高识别目标物的能力,或连接不同的功能单元,构建多功能的分子器件.本文对聚合物在荧光检测领域的应用进行了概述.

关键词：聚合物荧光检测分子识别信号转换探针骨架

准噶尔盆地腹部SN13井区井震时深关系“异常”分析

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新疆地质 2020年第4期38卷 504-507页

作者：窦强峰马国财杨晓海刘宜文中国石油新疆油田分公司勘探开发研究院地球物理研究所新疆乌鲁木齐830000 中国石油新疆油田分公司采油一厂新疆克拉玛依834000

准噶尔盆地腹部目的层侏罗系为砂泥互层,各向异性条件成熟,井震标定时发生时深关系“异常”,一定程度上对地质勘探研究产生不利影响。首次在该区开展了各向异性叠前深度偏移,通过时间域基于微测井静校正精度分析评价,结合深度域井震各... 详细信息

准噶尔盆地腹部目的层侏罗系为砂泥互层,各向异性条件成熟,井震标定时发生时深关系“异常”,一定程度上对地质勘探研究产生不利影响。首次在该区开展了各向异性叠前深度偏移,通过时间域基于微测井静校正精度分析评价,结合深度域井震各向异性叠前深度偏移时深关系分析,认为井震结合各向异性叠前深度偏移可有效提高该区成像精度。实际资料证明该区出现井震时深关系“异常”的合理性,为后续地质勘探研究工作提供了资料分析依据。

关键词：准噶尔盆地时深关系微测井静校正各向异性叠前深度偏移