检索结果-南通市图书馆

制备近红外光响应性仿生纳米探针及在乳腺癌光热诊疗中的应用

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2024年第5期28卷 669-675页

作者：李文兰王文渊任文秀张玉佩杨小燕王志刚夏纪筑西南医科大学附属医院超声医学科四川省泸州市646000 西南医科大学附属医院放射科四川省泸州市646000 超声分子影像重庆市重点实验室重庆市400010

背景:光热疗法是一种新兴的肿瘤治疗手段,利用光热剂将光能转化为热能来实现肿瘤的无创消融。光热疗法与纳米技术的兴起为乳腺癌的治疗开辟了新视角。目的:制备一种乳腺癌细胞膜修饰的新型近红外仿生纳米探针,探究其体外近红外荧光/超... 详细信息

背景:光热疗法是一种新兴的肿瘤治疗手段,利用光热剂将光能转化为热能来实现肿瘤的无创消融。光热疗法与纳米技术的兴起为乳腺癌的治疗开辟了新视角。目的:制备一种乳腺癌细胞膜修饰的新型近红外仿生纳米探针,探究其体外近红外荧光/超声显像效果,观察其体外对同源肿瘤细胞的靶向能力和光热治疗效果。方法:以具有A-D-A结构的有机小分子ITIC-4CI作为光热剂、聚乳酸/羟基乙酸共聚物为纳米载体、小鼠乳腺癌细胞4T1细胞膜为纳米颗粒表面修饰剂,并核心负载全氟己烷,采用双步乳化法与超声法制备新型近红外仿生纳米探针(4T1m/ITIC-4CI/PFH),对纳米探针进行基本表征,并验证其对同源肿瘤细胞的靶向性;探究纳米探针的光热性能及光热稳定性,观察激光照射下纳米探针的近红外荧光/超声成像效果;采用CCK-8法和钙黄绿素/碘化丙啶染色法评估纳米探针的光热治疗效果。结果与结论:①制备的纳米探针4T1m/ITIC-4CI/PFH尺寸均一、稳定性好,平均粒径为(92.7±2.3)nm,与乳腺癌4T1细胞膜具有相似的蛋白图谱;体外细胞摄取实验证实,该纳米探针可靶向同源乳腺癌4T1细胞;②纳米探针4T1m/ITIC-4CI/PFH具有红移吸收光谱和延伸到近红外Ⅱ区的尾部发射,在激光辐照下可发出明亮的近红外Ⅱ区荧光信号;③经激光照射,纳米探针4T1m/ITIC-4CI/PFH可相变为微气泡,增强超声显像;CCK-8和钙黄绿色/碘化丙啶染色结果显示,纳米探针4T1m/ITIC-4CI/PFH对乳腺癌4T1细胞具有明显的光热杀伤效果;④结果表明,纳米探针4T1m/ITIC-4CI/PFH具有靶向同源肿瘤的能力,并可增强近红外Ⅱ区波段荧光/超声显像和光热疗法疗效。

关键词：癌细胞膜近红外荧光成像双模态成像光热治疗 A-D-A结构纳米探针纳米技术

团体正念认知疗法在抑郁症伴睡眠障碍患者中的应用效果

在线全文

学校读者我要写书评

暂无评论

中华全科医学 2024年第2期22卷 284-287页

作者：张惠玲钱超陈莹杨晓妍绍兴市第七人民医院焦虑障碍科浙江绍兴312000 绍兴市第七人民医院精神障碍科

目的分析团体正念认知疗法对抑郁症伴睡眠障碍患者临床症状、睡眠质量及正念觉知能力的影响。方法选取2023年1—9月绍兴市第七人民医院收治的193例抑郁症伴睡眠障碍患者,根据随机数字表法将其分为对照组(96例)和观察组(97例)。对照组应... 详细信息

目的分析团体正念认知疗法对抑郁症伴睡眠障碍患者临床症状、睡眠质量及正念觉知能力的影响。方法选取2023年1—9月绍兴市第七人民医院收治的193例抑郁症伴睡眠障碍患者,根据随机数字表法将其分为对照组(96例)和观察组(97例)。对照组应用常规心理干预,观察组在对照组的基础上应用团体正念认知疗法。比较2组患者干预前后抑郁症状[抑郁自评量表(SDS)及汉密尔顿抑郁量表(HAMD)]、睡眠质量[阿森斯失眠量表(AIS)和失眠严重程度指数(ISI)]及正念觉知能力[五因素正念度量表(FFMQ)]。结果干预后,观察组患者SDS、HAMD、AIS、ISI得分分别为(51.20±3.64)分、(17.46±2.52)分、(11.05±2.33)分、(12.24±2.80)分,对照组分别为(55.64±4.71)分、(19.72±3.43)分、(14.11±3.14)分、(15.91±3.17)分,观察组均低于对照组(P<0.05)。干预后,观察组患者FFMQ各维度得分及总分均明显高于对照组(P<0.05)。结论团体正念认知疗法能明显缓解抑郁症伴睡眠障碍患者抑郁症状,提高患者睡眠质量及正念水平。

关键词：抑郁症睡眠障碍团体正念认知疗法正念水平

Unsteady aerodynamic modeling based on POD-observer method

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2010年第8期53卷 2032-2037页

作者： yang Chao,LIU xiaoyan &WU ZhiGang Beijing University of Aeronautics and Astronautics,Beijing 100191,China Beijing University of Aeronautics and Astronautics

A new hybrid approach to constructing reduced-order models(ROM)of unsteady aerodynamics applicable to aeroelastic analysis is presented by using proper orthogonal decomposition(POD)in combination with observer *** modes are generated through POD by sampling observations of solutions derived from the full-order *** response in the POD training is projected onto the fluid modes to determine the time history of the modal *** resulting data are used to extract the Markov parameters of the low-dimensional model for modal amplitudes using a related deadbeat *** state-space realization is synthesized from the system's Markov parameters that are processed with the eigensystem realization *** POD-observer method is applied to a two-dimensional airfoil system in subsonic flow *** results predicted by the ROM are in general agreement with those from the full-order *** ROM obtained by the hybrid approach captures the essence of a fluid system and produces vast reduction in both degrees of freedom and computational time relative to the full-order model.

关键词： aeroelasticity aerodynamic modeling proper orthogonal decomposition observer eigensystem realization algorithm

Using pipette tips to readily generate spheroids comprising single or multiple cell types

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第10期24卷 875-885页

作者： Rong PAN xiaoyan yang Shiming WU Yuanyuan XIE Feng CHEN Ke NING Wei SUN Ling YU Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationInstitute for Clean Energy and Advanced MaterialsSchool of Materials and EnergySouthwest UniversityChongqing 400715China College of Chemistry and Chemical Engineering Hainan Normal UniversityHaikou 571158China

Three-dimensional(3D)cell culture methods have been validated that can replicate the tumor environment in vivo to a large extent,providing an effective tool for studying *** this study,we demonstrated the use of standard laboratory pipette tips as micro vessels for generating 3D cell *** microfabrication or wet-chemistry surface modifications were involved in the *** consisting of single or multiple cell types were generated within 24 h just by pipetting and incubating a cell suspension in pipette *** electron microscope and optical microscope proved that the cells grew together tightly,and suggested that while gravity force might have initiated the sedimentation of cells at the bottom of the tip,the active aggregation of cells to form tight cell-cell interactions drove the formation of *** common laboratory micropipettes and pipette tips,the rate of spheroid generation and the generation reproducibility was characterized from five boxes each with 80 *** ease of transferring reagents allowed modeling of the growth of microvascular endothelial cells in tumor ***,the pairing and fusion of tumor spheroids could be manipulated in the pipette tips,suggesting the potential for building and assembling heterogeneous micro-tumor tissues in vitro to mimic solid tumors in *** study demonstrated that spheroids can be readily and cost-effectively generated in standard biological laboratories in a timely manner using pipette tips.

关键词： Pipette tip 3D cell culture Tumor spheroids Co-culture In-situ observation

Solid-solution partitioning of arsenic(As) in the paddy soil profiles in Chengdu Plain,Southwest China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2012年第6期3卷 901-909页

作者： xiaoyan yang Qingye Hou Zhongfang yang Xin Zhang Yijun Hou School of Earth Science and Resources China University of Geosciences(Beijing)Beijing 100083China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China Information Center Ministry of Land and Resources of the People's Republic of ChinaBeijing 100033China

To predict the long-term behavior of arsenic （As） in soil profiles, the solid-solution partitioning of As was studied in four paddy soil profiles obtained from agricultural areas in Chengdu Plain, Southwest China. Paddy soil profile samples were collected and soil solution samples were extracted. Total As contents in soil solution and soil solid were analyzed, along with the soil solid phase properties. The As in soil solu- tion was significantly higher in the upper layer （0--20 cm） and had a definite tendency to decrease towards 40 cm regardless of the sampling locations. When the concentration of arsenic in soil solution decreased, its content in solid phase increased. Field-based partition coefficient （Kd） for As was determined by calculating the ratio of the amount of As in the soil solid phase to the As concentration in the soil solution. Kj values varied widely in vertical samples and correlated well with soil pH, total organic carbon （TOC） and total As. The results of this study would be useful for evaluating the accumulation trends of hrsenic in soil profiles and in improving the management of the agricultural soils.

关键词： Soil profiles Arsenic (As) Soil solution Partition coefficient (Kd)Geochemistry

托法替布用于类固醇难治性免疫相关性心肌炎病例分析

在线全文

学校读者我要写书评

暂无评论

中国临床医学 2024年第4期31卷 565-570页

作者：李金银姜玲陈莉王黎铭杨晓燕上海市徐汇区中心医院药剂科上海200031 上海市徐汇区中心医院肿瘤科上海200031

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)是近年来抗肿瘤治疗的重要药物,能为患者带来显著的生存收益。然而ICIs引起的免疫相关性不良反应不容忽视,特别是ICIs相关性心肌炎,发生率低但致死率高。糖皮质激素是目前治疗ICIs... 详细信息

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)是近年来抗肿瘤治疗的重要药物,能为患者带来显著的生存收益。然而ICIs引起的免疫相关性不良反应不容忽视,特别是ICIs相关性心肌炎,发生率低但致死率高。糖皮质激素是目前治疗ICIs相关性心肌炎的首选及核心方案。在激素治疗过程中,如病情加重,可联合吗替麦考酚酯(mycophenolate mofetil,MMF)、他克莫司、英夫利昔单抗等其中1种药物。阿仑单抗和阿巴西普对于糖皮质激素治疗无效的严重心肌炎患者可能有效,但阿巴西普可能促进肿瘤的生长。本文对1例使用特瑞普利单抗联合西妥昔单抗以及伊立替康抗肿瘤方案出现免疫相关性心肌炎,随即采用糖皮质激素联合人免疫球蛋白治疗失败后,加用口服托法替布,心肌损伤生物标志物显著下降的结肠癌患者进行分析讨论,以期为临床类固醇难治性免疫相关性心肌炎提供新的治疗思路。

关键词：托法替布类固醇免疫相关性心肌炎免疫检查点抑制剂

贺兰山东麓不同子产区土壤对葡萄酒品质的影响研究

在线全文

学校读者我要写书评

暂无评论

酿酒科技 2024年第5期 65-71,76页

作者：杨小燕徐海龙张丽强李茹一宁夏大学食品与葡萄酒学院宁夏银川750021

为了研究贺兰山东麓子产区土壤对赤霞珠葡萄酒品质的影响,分别选取了金山产区、银川产区、石嘴山产区、红寺堡产区、青铜峡产区和永宁产区的6个酒庄中土壤和子产区所酿造赤霞珠葡萄酒为研究对象。通过相关性分析,葡萄酒中的酚类物质花... 详细信息

为了研究贺兰山东麓子产区土壤对赤霞珠葡萄酒品质的影响,分别选取了金山产区、银川产区、石嘴山产区、红寺堡产区、青铜峡产区和永宁产区的6个酒庄中土壤和子产区所酿造赤霞珠葡萄酒为研究对象。通过相关性分析,葡萄酒中的酚类物质花色苷除了与土壤中的EC呈负相关,其余的都呈正相关,而总酚只与土壤中的pH和全钾呈正相关,单宁与土壤pH呈正相关;葡萄酒中的总糖与总酸只与土壤pH呈正相关,其余呈负相关;挥发酸与EC、有机碳、碱解氮、有效磷、速效钾、全氮、全磷均呈正相关;酒精度与土壤pH呈正相关。由此证明,葡萄酒质量相关指标总糖、总酸、酚类物质、挥发酸、酒精度与土壤中的pH、有效磷、速效钾、全氮、全钾、EC含量存在关联。通过感官评价分析,产区所产葡萄酒入口柔顺,口感强劲而丰富,酒体饱满,典型性和结构感强,单宁和酸度均适中,余味适中。综合来看,贺兰山东麓子产区葡萄酒的品质和土壤pH、有效磷、速效钾、全氮、全钾、EC含量有关联性,并且呈正相关。

关键词：贺兰山东麓产区土壤葡萄酒感官评价

在线全文

学校读者我要写书评

暂无评论

土地整治项目实施中存在的问题及对策研究

南方农机 2024年第7期55卷 170-172,190页

作者：潘杰华凌宇吴猛张林波杨小艳江苏省土地开发整理中心江苏南京210024 徐州市土地储备中心江苏徐州221009 徐州市自然资源和规划局江苏徐州221009 江苏师范大学地理测绘与城乡规划学院江苏徐州221116

土地整治项目是实现耕地数量与质量双提升、促进建设用地集约利用、提高农民收入并改善区域生态环境状况的有效手段。基于此,文章以X省省级投资土地整治项目为对象,系统研究了土地整治项目实施管理中在可研论证、规划设计、招投标、项... 详细信息

土地整治项目是实现耕地数量与质量双提升、促进建设用地集约利用、提高农民收入并改善区域生态环境状况的有效手段。基于此,文章以X省省级投资土地整治项目为对象,系统研究了土地整治项目实施管理中在可研论证、规划设计、招投标、项目施工、资金管理及内业资料归档等方面存在的问题与成因,并据此提出了相应的对策与建议,仅供参考。

关键词：土地整治项目实施问题对策

Photochemical Degradation of Triadimefon in Seawater

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2008年第2期7卷 171-176页

作者： SUN Xiaochun yang Guipeng CAO xiaoyan LIN Zhifeng Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Qingdao 266100 P. R. China

The photochemical degradation of triadimefon in seawater was investigated under different reaction conditions in this study. The results showed that triadimefon could be effectively degraded by the irradiation of a high-pressure mercury lamp and the photodegradation rates were influenced by aquatic media, heavy metal ions and photosensitizers. The photochemical degradation of triadimefon followed the first-order reaction kinetic behavior, with the rate constants ranging from 0.0027 to 0.0128 min-1 under the studied conditions. The photolysis of triadimefon was slower in natural seawater than in distilled water or synthetic seawater. All the heavy metal ions studied in this paper had inhibition effects on the photolysis of triadimefon. Acetone, as a common photosensitizer, could accelerate the photolysis of triadimefon. Three photoproducts were identified by GC-MS analysis. Our study confirmed that photochemical degradation is an effective pathway to remove triadimefon in seawater.

关键词： triadimefon photochemical degradation seawater photoproducts kinetics