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Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy

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Journal of Traditional Chinese Medicine 2024年第2期44卷 345-352页

作者： ZHANG Xinchang HUANG Zheng HUANG Peiyan yang Mengning ZHANG Zhihui ni Guangxia College of Acupuncture-Moxibustion and Tuina Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ***:Sprague-Dawley male rats were divided into four groups:the sham group,model group,acupuncture group,and sham acupuncture *** 2 h of middle cerebral artery occlusion(MCAO),reperfusion was performed for 24 h to induce *** rats were treated with acupuncture at the Neiguan(PC6)and Shuigou(GV26)*** neurological function was evaluated by taking their Bederson scores at 2 h after ischaemia and 24 h after *** chloride staining was applied to assess the cerebral infarct volume at 24 h after *** malondialdehyde(MDA)and ferrous iron(Fe^(2+))levels were observed after 24 h of reperfusion using an assay *** blotting was performed to detect the expression of NCOA4 and ferritin heavy chain 1(FTH1)at 24 h after ***,the colocalization of ferritin with neurons,NCOA4 with microtubule-associated protein 1 light chain 3(LC3),and NCOA4 with ferritin was visualized using immunofluorescence ***:Acupuncture significantly improved neurological function and decreased cerebral infarct volume in the acupuncture *** CIRI,the expression of NCOA4,LC3 and FTH1 was increased,which enhanced ferritinophagy and induced an inappropriate accumulation of Fe^(2+)and MDA in the ischaemic ***,acupuncture dramatically downregulated the expression of NCOA4,LC3 and FTH1,inhibited the overactivation of ferritinophagy,and decreased the levels of MDA and Fe^(2+).CONCLUSIONS:Acupuncture can inhibit NCOA4-mediated ferritinophagy and protect neurons against CIRI in a rat model.

关键词： acupuncture ferritinophagy ferroptosis ferritin nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury

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LncRNA HCP5-encoded protein contributes to adriamycin resistance through ERK/mTOR pathway-mediated autophagy in breast cancer cells

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Genes & Diseases 2024年第4期11卷 69-72页

作者： Jia-ni Xing Yi-ni Shang Zheng-Ling Yu Shun-Heng Zhou Wang-yang Chen Li-Hong Wang Department of Pathophysiology Medical College of Southeast UniversityNanjingJiangsu 210009China Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 211106China School of Medicine Taizhou UniversityTaizhouZhejiang 318000China Jiangsu Provincial Key Laboratory of Critical Care Medicine NanjingJiangsu 210009China

Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to ***,improving the curative effect of ADR remains an urgent problem to be *** is a complex catabolic process;normal living cells break down damaged organelles or aggregated molecules and absorb energy to maintain homeostasis through autophagy.

关键词： breast cancer homeostasis

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Emerging strategies for nerve repair and regeneration in ischemic stroke:neural stem cell therapy

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Neural Regeneration Research 2024年第11期19卷 2430-2443页

作者： Siji Wang Qianyan He yang Qu Wenjing Yin Ruoyu Zhao Xuyutian Wang Yi yang Zhen-ni Guo Stroke Center Department of Neurologythe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of Neurologythe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Breast Surgery General Surgery Centerthe First Hospital of Jilin UniversityChangchunJilin ProvinceChina

Ischemic stroke is a major cause of mortality and disability worldwide,with limited treatment options available in clinical *** emergence of stem cell therapy has provided new hope to the field of stroke treatment via the restoration of brain neuron *** neural stem cells are beneficial not only in cell replacement but also through the bystander *** stem cells regulate multiple physiological responses,including nerve repair,endogenous regeneration,immune function,and blood-brain barrier permeability,through the secretion of bioactive substances,including extracellular vesicles/***,due to the complex microenvironment of ischemic cerebrovascular events and the low survival rate of neural stem cells following transplantation,limitations in the treatment effect remain *** this paper,we provide a detailed summary of the potential mechanisms of neural stem cell therapy for the treatment of ischemic stroke,review current neural stem cell therapeutic strategies and clinical trial results,and summarize the latest advancements in neural stem cell engineering to improve the survival rate of neural stem *** hope that this review could help provide insight into the therapeutic potential of neural stem cells and guide future scientific endeavors on neural stem cells.

关键词： bystander effect cell replacement extracellular vesicles ischemic stroke neural stem cells neural stem cell engineering

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Numerical analysis of coupled sloshing and motion of a cylindrical FPSO in regular waves

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Journal of Hydrodynamics 2024年第3期36卷 457-465页

作者： Wei-wen Zhao xiao-long yang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Offshore Oil Engineering Co.Ltd. Tianjin300461China

In this paper,the coupled sloshing and motion characteristics of a cylindrical floating production storage offloading(CFPSO)are numerically investigated by means of computational fluid dynamics(CFD)*** simulations are performed using an in-house CFD solver naoe-FOAM-SJTU which is developed based on *** active wave generating-absorbing boundary condition(GABC)is utilized for wave generation and *** stabilized k-omega SST turbulence model are used to avoid excessive eddy viscosity near the free *** with and without partially filled liquid tanks in regular waves with different wave periods are simulated and vertical planar motions such as surge,heave and pitch response amplitude operators(RAOs)are *** due to liquid sloshing and wave loads are extracted and *** free surface motions inside liquid tanks in one wave period presented to explain the motion characteristics.

关键词： Coupled analysis liquid sloshing wave motion cylindrical floating production storage offloading(CFPSO)

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Photoredox-Catalyzed Metal-Free Regio-&Stereoselective C(sp^(2))-H Amination of Enamides with N-Aminopyridium Salts

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Chinese Journal of Chemistry 2024年第18期42卷 2235-2242页

作者： Zheng-Bao Qin Kun ni Li Wang xiao-Di Wu Yu Zhang Kai Zhao Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjingJiangsu211816China college of Chemical Engineering Nanjing Forestry UniversityNanjingJiangsu 210037China

A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp')-H amination of enamides with bench-stable and A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp)-H amination of enamides with bench-stable and easily accessible N-aminopyridium salts is developed,affording synthetically and biologically prominent vicinal 1,2-diamine scaffolds with broad substrate scope and excellent functional group *** transformation proceeded through a radical pathway involving the Giese addition of the relatively electrophilic N-centered sulfonamidyl radical species to nucleophilicβ-olefinic position of enamides followed by the ensuing single electron oxidation andβ-H elimination,delivering geometrically-defined Z-configuredβ-sulfonamidylated *** operational simplicity,environmental friendliness and cost efficiency of this methodology allowed it to pave a new avenue to enrich the arsenal of synthetically crucial functionalized enamides and their related derivatives.

关键词： Enamides Amination Photoredox catalysis Regioselective Stereoselective Metal-free

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Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： Shan-Hu Wang yang-yang Wu xiao-Jiao Xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

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An Investigation into the Performances of Cement Mortar Incorporating Superabsorbent Polymer Synthesized with Kaolin

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1393-1406页

作者： xiao Huang Jin yang State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite Structures and School of ResourcesEnvironment and MaterialsGuangxi UniversityNanning530004China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China

Cement-based materials are fundamental in the construction industry,and enhancing their properties is an ongoing *** use of superabsorbent polymers(SAP)has gained significant attention as a possible way to improve the performance of cement-based materials due to their unique water-absorption and retention *** study investigates the multifaceted impact of kaolin intercalation-modified superabsorbent polymers(K-SAP)on the properties of cement *** results show that K-SAP significantly affects the cement mortar’s rheological behavior,with distinct phases of water absorption and release,leading to changes in workability over ***,K-SAP alters the hydration kinetics,delaying the exothermic peak of hydration and subsequently modifying the heat release ***,K-SAP effectively maintains a higher internal relative humidity within the mortar,reducing the autogenous shrinkage ***,K-SAP can have a beneficial effect on pore structure and this can be ascribed to the internal curing effect of released water from K-SAP.

关键词： Superabsorbent polymer kaolin cement mortar rheological behavior autogenous shrinkage

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Improving flangeability of multiphase steel by increasing microstructural homogeneity

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Journal of Iron and Steel Research International 2024年第7期31卷 1736-1745页

作者： xiao-yu yang Yong-gang yang Xing Fang Han-long Zhang Zhen-li Mi Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Engineering TechnologyUniversity of Science and Technology BeijingBeijing 100083China Shanghai Baosteel Group Corp.Technology Center Shanghai 201900China

Multiphase microstructure significantly increases the strength,usually at the expense of flangeability because of lacking microstructure *** further improve the strength-flangeability of multiphase steel,the microstructural homogeneity was advanced by adjusting the hard martensite/austenite(M/A)*** strength-flangeability was measured via uniaxial tensile tests and hole expansion *** microstructures were characterized using a scanning electron microscope equipped with an electron backscatter diffraction detector and a transmission electron *** tests were supplementally used to quantitatively reveal the microstructural homogeneity of the *** show that the adjusted multiphase steel achieves an excellent ultimate tensile strength(~800 MPa)and flangeability(~135%hole expansion ratio).A promising homogeneous multiphase microstructure was obtained by controlling undercooled austenite transformed at about 600℃.This microstructure consists of soft polygonal ferrite,blocky bainitic ferrite,and hard M/A *** volume fraction of M/A islands is around 5%,and the average size is less than l *** nanoindentation analysis indicated that the participation of M/A islands impressively influenced the microstructural *** strain partition and better mechanical compatibility were present in the adjusted multiphase steel since the plasticity initiation started late,which resulted in a positive ***,avoiding M/A islands distributed in the chain along the rolling direction on the matrix hindered the possibility of voids coalescing into cracks and stabilized the flanging performance.

关键词： Multiphase steel Flangeability Martensite/austenite island-Microstructural homogeneity-Microstructure Compact strip production process

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Low‑light enhancement method with dual branch feature fusion and learnable regularized attention

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Frontiers of Optoelectronics 2024年第3期17卷 93-111页

作者： Yixiang Sun Mengyao ni Ming Zhao Zhenyu yang Yuanlong Peng Danhua Cao School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China State Grid Information&Telecommunication Branch Beijing 100761China

Restricted by the lighting conditions,the images captured at night tend to sufer from color aberration,noise,and other unfavorable factors,making it difcult for subsequent vision-based *** solve this problem,we propose a two-stage size-controllable low-light enhancement method,named Dual Fusion Enhancement Net(DFEN).The whole algorithm is built on a double U-Net structure,implementing brightness adjustment and detail revision respectively.A dual branch feature fusion module is adopted to enhance its ability of feature extraction and *** also design a learnable regularized attention module to balance the enhancement efect on diferent ***,we introduce a cosine training strategy to smooth the transition of the training target from the brightness adjustment stage to the detail revision stage during the training *** proposed DFEN is tested on several low-light datasets,and the experimental results demonstrate that the algorithm achieves superior enhancement results with the similar *** is worth noting that the lightest DFEN model reaches 11 FPS for image size of 1224×10^(24)in an RTX 3090 GPU.

关键词： Power inspection Low-light enhancement Feature fusion Learnable regularized attention

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3D robust anisotropic diffusion filtering algorithm for sparse view neutron computed tomography 3D image reconstruction

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Nuclear Science and Techniques 2024年第3期35卷 13-29页

作者： yang Liu Teng-Fei Zhu Zhi Luo xiao-Ping Ouyang School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi’an 710024China

The most critical part of a neutron computed tomography(NCT) system is the image processing algorithm,which directly affects the quality and speed of the reconstructed *** types of noise in the system can degrade the quality of the reconstructed ***,to improve the quality of the reconstructed images of NCT systems,efficient image processing algorithms must be *** anisotropic diffusion filtering(ADF) algorithm can not only effectively suppress the noise in the projection data,but also preserve the image edge structure information by reducing the diffusion at the image ***,we propose the application of the ADF algorithm for NCT image *** compare the performance of different algorithms in NCT systems,we reconstructed images using the ordered subset simultaneous algebraic reconstruction technique(OS-SART) algorithm with different regular terms as image processing *** the iterative reconstruction,we selected two image processing algorithms,the Total Variation and split Bregman solved total variation algorithms,for comparison with the performance of the ADF ***,the filtered back-projection algorithm was used for comparison with an iterative *** reconstructing the projection data of the numerical and clock models,we compared and analyzed the effects of each algorithm applied in the NCT *** on the reconstruction results,OS-SART-ADF outperformed the other algorithms in terms of denoising,preserving the edge structure,and suppressing *** example,when the 3D Shepp–Logan was reconstructed at 25 views,the root mean square error of OS-SART-ADF was the smallest among the four iterative algorithms,at only *** universal quality index,mean structural similarity,and correlation coefficient of the reconstructed image were the largest among all algorithms,with values of 0.9877,0.9878,and 0.9887,respectively.

关键词： NCT OS-SART Sparse-view Anisotropic diffusion filtering

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