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Construction of an alternative NADPH regeneration pathway improves ethanol production in Saccharomyces cerevisiae with xylose metabolic pathway

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Synthetic and Systems Biotechnology 2024年第2期9卷 269-276页

作者： Yali Qiu Wei Liu Meiling Wu Haodong Bao Xinhua Sun Qin Dou Hongying Jia weifeng Liu Yu Shen State Key Laboratory of Microbial Technology Institute of Microbial TechnologyShandong UniversityQingdao266237China Advanced Medical Research Institute Shandong UniversityJinan250012China

Full conversion of glucose and xylose from lignocellulosic hydrolysates is required for obtaining a high ethanol ***,glucose and xylose share flux in the pentose phosphate pathway(PPP)and glycolysis pathway(EMP),with glucose having a competitive advantage in the shared metabolic *** this work,we knocked down ZWF1 to preclude glucose from entering the *** reduced the[NADPH]level and disturbed growth on both glucose or xylose,confirming that the oxidative PPP,which begins with Zwf1p and ultimately leads to CO_(2) production,is the primary source of NADPH in both glucose and *** glucose depletion,gluconeogenesis is necessary to generate glucose-6-phosphate,the substrate of *** re-established the NADPH regeneration pathway by replacing the endogenous NAD^(+)-dependent glyceraldehyde-3-phosphate dehydrogenase(GAPDH)gene TDH3 with heterogenous NADP^(+)-GAPDH genes GDH,gapB,and *** the resulting strains,the strain BZP1(zwf1Δ,tdh3::GDP1)exhibited a similar xylose consumption rate before glucose depletion,but a 1.6-fold increased xylose consumption rate following glucose depletion compared to the original strain BSGX001,and the ethanol yield for total consumed sugars of BZP1 was 13.5%higher than *** suggested that using the EMP instead of PPP to generate NADPH reduces the wasteful metabolic cycle and excess CO_(2)^(++) release from oxidative ***,we used a copper-repressing promoter to modulate the expression of ZWF1 and optimize the timing of turning off the ZWF1,therefore,to determine the competitive equilibrium between glucose-xylose *** strategy allowed fast growth in the early stage of fermentation and low waste in the following stages of fermentation.

关键词： Saccharomyces cerevisiae Xylose Ethanol NADPH Glyceraldehyde-3-phosphate dehydrogenase

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青岛李沧区不同风化程度煌斑岩工程性质的研究

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建筑结构 2019年第S2期49卷 888-893页

作者：王焱刘凯杨伟峰中国矿业大学资源与地球科学学院徐州221116 青岛地矿岩土工程有限公司青岛266000

依托青岛李沧区具体工程实例,克服以往相关研究的缺陷,配合系统的原位测试和室内试验,通过数理统计分析,从基本工程性质和软化特性两个方面,开展了对青岛李沧区不同风化程度煌斑岩工程性质的研究。结果表明:与相应风化程度的其他常见基... 详细信息

依托青岛李沧区具体工程实例,克服以往相关研究的缺陷,配合系统的原位测试和室内试验,通过数理统计分析,从基本工程性质和软化特性两个方面,开展了对青岛李沧区不同风化程度煌斑岩工程性质的研究。结果表明:与相应风化程度的其他常见基岩比较,强风化煌斑岩基本工程性质衰减幅度最大,中风化煌斑岩次之,微风化煌斑岩衰减幅度最小;中风化、微风化煌斑岩饱和吸水率Wsat与软化系数K之间分别存在较为明确的指数函数关系、线性函数关系。

关键词：青岛李沧区不同风化程度煌斑岩基本工程性质软化特性

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Threshold voltage modulation in monolayer MoS_(2) field-effect transistors via selective gallium ion beam irradiation

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Science China Materials 2022年第3期65卷 741-747页

作者： Baoshan Tang Yunshan Zhao Changjie Zhou Mingkun Zhang Huili Zhu Yida Li Jin Feng Leong Hao Shuai Hao Gong weifeng yang Department of Microelectronics and Integrated Circuit School of Electronic Science and EngineeringXiamen UniversityXiamen 361005China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore NNU-SULI Thermal Energy Research Center(NSTER)&Center for Quantum Transport and Thermal Energy Science(CQTES) School of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Department of Physics School of ScienceJimei UniversityXiamen 361021China Engineering Research Center of Integrated Circuits for Next-Generation Communications Ministry of EducationSouthern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Electronic regulation of two-dimensional(2 D)transition metal dichalcogenides(TMDCs)is a crucial step towards next-generation optoelectronics and ***,we demonstrate controllable and selective-area defect engineering in 2D molybdenum disulfide(MoS_(2))using a focused ion beam with a low-energy gallium ion(Ga^(+))*** find that the surface defects of MoS_(2)can be tuned by the precise control of ion energy and ***,the fieldeffect transistors based on the monolayer MoS_(2)show a significant threshold voltage modulation over 70 V after Ga+***-principles calculations reveal that the Ga impurities in the monolayer MoS_(2)introduce a defect state near the Fermi level,leading to a shallow acceptor level of 0.25 eV above the valence band *** defect engineering strategy enables direct writing of complex pattern at the atomic length scale in a controlled and facile manner,tailoring the electronic properties of 2D TMDCs for novel devices.

关键词： two-dimensional transition metal dichalcogenides field-effect transistors defect engineering Ga ion irradiation

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碎软煤层空气泡沫复合定向钻进技术应用研究

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煤田地质与勘探 2021年第5期49卷 278-285页

作者：刘建林方俊褚志伟杨伟锋中煤科工集团西安研究院有限公司陕西西安710077

针对碎软煤层空气定向钻进存在空气螺杆马达降温润滑,煤尘降尘处理和孔内煤层出水处置技术需求,在分析钻渣运移特性的基础上,通过集成稳定高效发泡、"机械+泡沫"复合排渣和"空气+泡沫"复合钻进等关键技术,配套定向钻机、泡沫发生灌注系... 详细信息

针对碎软煤层空气定向钻进存在空气螺杆马达降温润滑,煤尘降尘处理和孔内煤层出水处置技术需求,在分析钻渣运移特性的基础上,通过集成稳定高效发泡、"机械+泡沫"复合排渣和"空气+泡沫"复合钻进等关键技术,配套定向钻机、泡沫发生灌注系统、空气螺杆马达、异形钻杆和随钻测量系统等关键装备,开发了碎软煤层空气泡沫复合定向钻进技术。在安徽省宿州市某矿开展了应用试验,在出水碎软煤层中顺利施工了主孔深度232m顺煤层定向钻孔,与应用空气定向钻进技术施工的2个钻孔相比,成孔深度分别提高了97%和105%,显著提高了顺煤层定向钻孔成孔深度,增强了碎软煤层瓦斯抽采效果,同时达到了降温润滑空气螺杆马达,降低孔口返出煤尘目的,可为碎软煤层定向钻孔施工提供一种新的技术途径。

关键词：碎软煤层泡沫空气排渣复合钻进定向钻进

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Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

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Chinese Medical Journal 2024年第11期137卷 1332-1342页

作者： Shujung Hsu Yencheng Chao Yong Hu yang Zhang weifeng Hong Yixing Chen Rongxin Chen Zhaochong Zeng Shisuo Du Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and June 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(P<0.001).Median overall survival was 20.9 months in the RT-PD1 cohort vs.11.2 months in the PD1 cohort(P=0.018).Compared with patients in the PD1 cohort,patients in the RT-PD1 cohort had significantly higher objective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

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Selective nano-buckling improves the performance of graphene logic transistors

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National Science Review 2024年第2期11卷 95-96页

作者： Tong yang Ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

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基于风-储联合的双层频率响应控制策略

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电力系统自动化 2022年第12期46卷 184-193页

作者：杨伟峰文云峰张武其邓步青湖南大学电气与信息工程学院湖南省长沙市410082

当多个风-储场站参与调频时,由于运行状态不同,导致其提供调频出力时的成本存在一定差异。另外,风电场参与调频时场内风机上的疲劳载荷也会增加,对风机安全性造成影响。为解决上述问题,文中提出一种基于风-储联合的双层频率响应控制策略... 详细信息

当多个风-储场站参与调频时,由于运行状态不同,导致其提供调频出力时的成本存在一定差异。另外,风电场参与调频时场内风机上的疲劳载荷也会增加,对风机安全性造成影响。为解决上述问题,文中提出一种基于风-储联合的双层频率响应控制策略,可通过协调风-储场站间与场内风机间的出力,在满足系统调频需求的同时,降低调频总成本及各风电场内载荷总量。首先,分析并量化风-储场站调频时的内损、老化及风险成本,并在场站协调层上建立场站有功分配控制策略,确定成本最低的各场站出力方案。然后,基于风机出力与尾流波动、疲劳载荷间的线性关系,采用和增积减算法在机组协调层上构建风电场分散式有功控制策略,协调风机间出力,在维持风电场调频性能的同时,降低场内载荷总量。最后,在MATLAB/Simulink中搭建含2个100×5 MW双馈风电场和2个100 MW/100 MW?h锂电池储能电站的IEEE RTS-79系统,仿真验证了所提策略的有效性。

关键词：风电场储能调频双层控制分散式控制疲劳载荷

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Research advances on the consolidated bioprocessing of lignocellulosic biomass

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Engineering Microbiology 2024年第2期4卷 91-103页

作者： Zhongye Li Pankajkumar R.Waghmare Lubbert Dijkhuizen Xiangfeng Meng weifeng Liu State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityNo.72 Binhai RoadQingdao 266237China CarbExplore Research BV Groningenthe Netherlands Microbiology Groningen Biomolecular Sciences and Biotechnology Institute(GBB)University of GroningenGroningenthe Netherlands

Lignocellulosic biomass is an abundant and renewable bioresource for the production of biofuels and biochem-ical *** classical biorefinery process for lignocellulosic degradation and conversion comprises three stages,i.e.,pretreatment,enzymatic saccharification,and ***,the complicated pretreatment process,high cost of cellulase production,and insufficient production performance of fermentation strains have restricted the industrialization of *** bioprocessing(CBP)technology combines the pro-cess of enzyme production,enzymatic saccharification,and fermentation in a single bioreactor using a specific microorganism or a consortium of microbes and represents another approach worth exploring for the production of chemicals from lignocellulosic *** present review summarizes the progress made in research of CBP technology for lignocellulosic biomass *** this review,different CBP strategies in lignocellulose biore-finery are reviewed,including CBP with natural lignocellulose-degrading microorganisms as the chassis,CBP with biosynthetic microorganisms as the chassis,and CBP with microbial co-culturing *** review provides new perspectives and insights on the utilization of low-cost feedstock lignocellulosic biomass for production of biochemicals.

关键词： Lignocellulosic biomass Biorefinery Consolidated bioprocessing Biochemicals

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Zeolite-confined Fe-site Catalysts for the Hydrogenation of CO_(2) to Produce High-value Chemicals

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Chemical Research in Chinese Universities 2024年第1期40卷 78-95页

作者： HAN Xiaoyang XIA Huicong TU weifeng WEI Yifan XUE Dongping LI Minhan YAN Wenfu ZHANG Jia-Nan HAN Yi-Fan College of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001P.R.China State Key Laboratory of Coking Coal Resources Green Exploitation Zhengzhou UniversityZhengzhou450001P.R.China Engineering Research Center of Advanced Functional Material Manufacturing of Ministry of Education School of Chemical EngineeringZhengzhou UniversityZhengzhou450001P.R.China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry and College of Chemistry Jilin UniversityChangchun130012P.R.China State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai200237P.R.China

Zeolite-confined Fe-site catalysts(ZFCs)have emerged as superior materials for sustainably producing high-value chemicals through CO_(2) hydrogenation,owing to their adaptable framework,customizable composition,and thermal *** excel in activating,adsorbing,and converting CO_(2) with remarkable efficiency and consistency in *** has sparked a surge in research interest in recent *** review delves into the latest advancements in CO_(2) catalytic hydrogenation to olefins,alcohols,aromatics,and other liquid hydrocarbons,examining the synthesis,modification tactics,and the correlation between structure and performance across various ***,it underscores the pivotal factors affecting performance and sheds light on the mechanisms behind selectivity control in the CO_(2) hydrogenation process facilitated by *** conclude,it presents pressing challenges and strategic recommendations to inspire the development of high-performance,durable ZFCs for CO_(2) hydrogenation applications.

关键词： Zeolite-confined Fe-site catalyst CO_(2) hydrogenation Modification strategy High-value chemical

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Design Optimization and Operating Performance of S-CO_(2) Brayton Cycle under Fluctuating Ambient Temperature and Diverse Power Demand Scenarios

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Journal of Thermal Science 2024年第1期33卷 190-206页

作者： yang Jingze yang Zhen DUAN Yuanyuan Key Laboratory for Thermal Science and Power Engineering of MOE Beijing Key Laboratory for CO_(2) Utilization and Reduction TechnologyTsinghua UniversityBeijing 100084China

The supercritical CO_(2)(S-CO_(2)) Brayton cycle is expected to replace steam cycle in the application of solar power tower system due to the attractive potential to improve efficiency and reduce *** the concentrated solar power plant with thermal energy storage is usually located in drought area and used to provide a dispatchable power output,the S-CO_(2) Brayton cycle has to operate under fluctuating ambient temperature and diverse power demand *** addition,the cycle design condition will directly affect the off-design *** this work,the combined effects of design condition,and distributions of ambient temperature and power demand on the cycle operating performance are analyzed,and the off-design performance maps are proposed for the first time.A cycle design method with feedback mechanism of operating performance under varied ambient temperature and power demand is introduced *** show that the low design value of compressor inlet temperature is not conductive to efficient operation under low loads and sufficient output under high ambient *** average yearly efficiency is most affected by the average power demand,while the load cover factor is significantly influenced by the average ambient *** multi-objective optimization,the optimal solution of designed compressor inlet temperature is close to the minimum value of35℃ in Delingha with low ambient temperature,while reaches 44.15℃ in Daggett under the scenario of high ambient temperature,low average power demand,long duration and large value of peak load during the peak temperature *** the cycle designed with compressor inlet temperature of 35℃ instead of 44.15℃ in Daggett under light industry power demand,the reduction of load cover factor will reach 0.027,but the average yearly efficiency can barely be improved.

关键词： supercritical CO_(2)Brayton cycle ambient temperature fluctuating power demand scenarios design optimization off-design performance

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