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A metabolic intervention strategy to break evolutionary adaptability of tumor for reinforced immunotherapy

Acta Pharmaceutica Sinica B 2023年第2期13卷 775-786页

作者： Qianhua Feng Yutong Hao shuaiqi yang Xiaomin Yuan Jing Chen Yuying Mei Lanlan Liu Junbiao Chang Zhenzhong Zhang Lei Wang School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Pharmacy The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

The typical hallmark of tumor evolution is metabolic *** addition to secreting immunoregulatory metabolites,tumor cells and various immune cells display different metabolic pathways and *** the metabolic differences to reduce the tumor and immunosuppressive cells while enhancing the activity of positive immunoregulatory cells is a promising *** develop a nanoplatform(CLCeMOF)based on cerium metal-organic framework(CeMOF)by lactate oxidase(LOX)modification and glutaminase inhibitor(CB839)*** cascade catalytic reactions induced by CLCeMOF generate reactive oxygen species“storm”to elicit immune ***,LOX-mediated metabolite lactate exhaustion relieves the immunosuppressive tumor microenvironment,preparing the ground for intracellular *** noticeably,the immunometabolic checkpoint blockade therapy,as a result of glutamine antagonism,is exploited for overall cell *** is found that CLCeMOF inhibited glutamine metabolism-dependent cells(tumor cells,immunosuppressive cells,etc.),increased infiltration of dendritic cells,and especially reprogrammed CD8^(+)T lymphocytes with considerable metabolic flexibility toward a highly activated,long-lived,and memory-like *** an idea intervenes both metabolite(lactate)and cellular metabolic pathway,which essentially alters overall cell fates toward the desired ***,the metabolic intervention strategy is bound to break the evolutionary adaptability of tumors for reinforced immunotherapy.

关键词： Metabolic intervention Immunotherapy Glutamine metabolism Lactate oxidase Reactive oxygen species Cerium metal-organic framework Immunogenic tumor cell death Drug delivery

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Nuclear translocation of OsMADS25 facilitated by OsNAR2.1 in reponse to nitrate signals promotes rice root growth by targeting OsMADS27 and OsARF7

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Plant Communications 2023年第6期4卷 329-341页

作者： Junyu Wu shuaiqi yang Nana Chen Qining Jiang Linli Huang Jiaxuan Qi Guohua Xu Lisha Shen Hao Yu Xiaorong Fan Yinbo Gan Zhejiang Key Laboratory of Crop Germplasm Department of AgronomyCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310000China State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China Temasek Life Sciences Laboratory and Department of Biological Sciences National University of Singapore1 Research LinkSingapore 117604Singapore

Nitrate is an important nitrogen source and signaling molecule that regulates plant growth and *** several components of the nitrate signaling pathway have been identified,the detailed mechanisms are still *** previous results showed that OsMADS25 can regulate root development in response to nitrate signals,but the mechanism is still ***,we try to answer two key questions:how does OsMADS25 move from the cytoplasm to the nucleus,and what are the direct target genes activated by OsMADS25 to regulate root growth after it moves to the nucleus in response to nitrate?Our results demonstrated that OsMADS25 moves from the cytoplasm to the nucleus in the presence of nitrate in an *** immunoprecipitation sequencing,chromatin immunoprecipitation qPCR,yeast one-hybrid,and luciferase experiments showed that OsMADS25 directly activates the expression of OsMADS27 and OsARF7,which are reported to be associated with root ***,OsMADS25-RNAi lines,the Osnar2.1 mutant,and OsMADS25-RNAi Osnar2.1 lines exhibited significantly reduced root growth compared with the wild type in response to nitrate supply,and expression of OsMADS27 and OsARF7 was significantly suppressed in these ***,these results reveal a new mechanismby which OsMADS25 interacts with *** interaction is required for nuclear accumulation of OsMADS25,which promotes OsMADS27 and OsARF7 expression and root growth in a nitratedependent manner.

关键词： OsMADS25 OsNAR2.1 OsMADS27 OsARF7 nitrate signaling rice root

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The Mechanism of Rural Tourism Development-Taking yangshuo County as an Example

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Journal of Resources and Ecology 2024年第5期15卷 1240-1250页

作者： LI Heying WANG Jinye WEI Qingqing yang shuaiqi Nanning College of Technology Nanning 541000China School of Tourism and Landscape Architecture Guilin University of TechnologyGuilinGuangxi 541006China Faculty of Geography Yunnan Normal UniversityKunming 650500China

Rural tourism plays a crucial role in promoting the process of urban-rural integration and regionally coordinated *** on theories of tourism system drive and system science,this study constructed a rural tourism system dynamics model with four subsystems:demand,supply,media,and ***,we predicted the optimal mechanism for rural tourism development using scenario simulation *** findings were four-fold.(1)The rural tourism development dynamics system constructed in this study overcame the limitations of previous subsystem divisions.(2)Under the development scenarios of Natural development mechanism(NDM),Demand driven mechanism(DDM),Supply driven mechanism(SDMe),Media driven mechanism(MDM),Support driven mechanism(SDMu),and Synergistic driven mechanism(SDMy),the rural tourism development index values in 2035 were 0.678,0.702,0.755,0.715,0.776,and 0.836,*** these scenarios,SDMy emerged as the ideal mechanism for rural tourism development in yangshuo County.(3)Based on the characteristics of the rural tourism development index,rural tourism in yangshuo County has undergone three stages:fluctuating growth,rapid development,and recession.(4)yangshuo County’s rural tourism supply index grows slowly and is always below 0.8,which is a key link for future structural *** study proposes a direction for rural tourism development in yangshuo and a later impetus,which can accelerate the process of urban-rural integration in yangshuo and similar areas.

关键词： mechanism rural tourism system dynamics yangshuo County

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我国学校竞技体育后备人才多元化培养模式的实践探索

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湖北体育科技 2020年第7期39卷 648-651页

作者：杨帅琦杜放东北师范大学体育学院吉林长春130024

采用文献资料法、案例分析法,对我国学校竞技体育后备人才培养模式进行实践探索,皆在塑造与培育卓越的学校竞技体育后备人才。研究认为:我国学校竞技体育后备人才培养模式的类型主要包括“企业高度参与型”“非营利组织主导型”“体教... 详细信息

采用文献资料法、案例分析法,对我国学校竞技体育后备人才培养模式进行实践探索,皆在塑造与培育卓越的学校竞技体育后备人才。研究认为:我国学校竞技体育后备人才培养模式的类型主要包括“企业高度参与型”“非营利组织主导型”“体教结合型”“高校主导-多元合作型”;学校竞技体育后备人才培养已不再是教育系统内部的独立发展,而是依靠企业、政府、学校、非盈利组织等协同参与、多元合作,形成了1+1大于2、1+1+1多元组合式的协同互融新模式。建议:我国学校竞技体育后备人才培养应加快社会力量补位,建立合作互促机制,推进政府角色转变,完善职业生涯规划,助力体育强国建设。

关键词：学校竞技体育体育后备人才培养模式

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江南园林中的文人精神浅析——以无锡寄畅园为例

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园林 2022年第3期39卷 131-137页

作者：杨帅琦王金叶桂林理工大学旅游与风景园林学院桂林541006

从时代变迁之视镜洞观中国古典园林,最具“精神”的莫过于明清江南园林。寄畅园作为江南园林的典型个案,始终受锡山秦氏家族传承之影响,彰显了不同时期的文人精神和家族风貌。其文源体现隐逸风情和诗画情意;文脉贯穿于寄畅园初建、转折... 详细信息

从时代变迁之视镜洞观中国古典园林,最具“精神”的莫过于明清江南园林。寄畅园作为江南园林的典型个案,始终受锡山秦氏家族传承之影响,彰显了不同时期的文人精神和家族风貌。其文源体现隐逸风情和诗画情意;文脉贯穿于寄畅园初建、转折、改建和兴盛各时期,从最初的山林原野到臻入佳境;文体集中体现在山水、植物和建筑方面,园林山水具有环山而园、山水相依的特点;园林植物具有错落搭配、时序有节等特点;园林建筑以“凤谷行窝”为特色,集诗书文化于一体。探析寄畅园文人精神不仅可观察江南“山水园林”之实,亦可知文学望族孝友传承之礼,以及江南文人乐知天命、隐遁自然之风骨。

关键词：山水园林景面文心文人精神锡山秦氏寄畅园

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机器人辅助下前柱螺钉与前环内置外固定架治疗不稳定骨盆骨折的疗效比较

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中华创伤杂志 2023年第1期39卷 38-46页

作者：佘荣峰张彬蒋昆豆杨帅旗骆朝明孙立张一贵州省人民医院急诊外科贵阳550002 贵州省人民医院骨科贵阳550002

目的比较骨科机器人辅助下微创置入前柱螺钉与前环内置外固定架(INFIX)内固定治疗不稳定骨盆骨折的临床疗效。方法采用回顾性队列研究分析2018年6月至2021年12月贵州省人民医院收治的42例不稳定骨盆骨折患者的临床资料,其中男25例,女17... 详细信息

目的比较骨科机器人辅助下微创置入前柱螺钉与前环内置外固定架(INFIX)内固定治疗不稳定骨盆骨折的临床疗效。方法采用回顾性队列研究分析2018年6月至2021年12月贵州省人民医院收治的42例不稳定骨盆骨折患者的临床资料,其中男25例,女17例;年龄16~68岁[(41.8±3.2)岁]。前柱螺钉组(22例)采用骨科机器人辅助下前柱螺钉固定骨盆前环骨折;INFIX组(20例)采用INFIX固定骨盆前环骨折。骨盆后环损伤均采用闭合复位经皮骶髂螺钉内固定。比较两组骨盆前环手术时间、术中出血量、术中透视次数、患者负重时视觉模拟评分(VAS)0.05)。前柱螺钉组术中出血量为(15.9±3.1)ml,INFIX组为(41.4±6.2)ml(P0.05)。前柱螺钉组负重时VAS<3分的下床活动时间为(3.2±0.4)周,INFIX组为(6.6±1.2)周(P<0.01)。前柱螺钉组骨折愈合时间为(12.7±1.4)周,INFIX组为(16.2±1.9)周(P<0.01)。根据Matta评分标准:两组骨盆后环复位质量优良率均为100%;前柱螺钉组骨盆前环复位质量优16例,良6例,优良率为100%,而INFIX组优11例,良7例,可2例,优良率为90.0%(P<0.05)。末次随访时前柱螺钉组Majeed功能评分优16例,良4例,可2例,优良率为90.9%;INFIX组优10例,良6例,可4例,优良率为80.0%(P<0.05)。两组术中均未出现血管、神经、精索等重要组织损伤。前柱螺钉组术后未出现感染、精索损伤及内固定断裂等并发症。INFIX组术后发生切口脂肪液化2例,股外侧皮神经症状4例,异位骨化1例;未出现内固定断裂情况。结论与前环INFIX内固定比较,骨科机器人辅助下前柱螺钉治疗不稳定骨盆骨折具有出血量少、下地时间早、骨折愈合快、骨折复位质量良好、术后功能恢复满意、并发症少等优点。

关键词：机器人骨盆骨折固定术,内外科手术

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Beyond Performance of Learning Control Subject to Uncertainties and Noise: A Frequency-Domain Approach Applied to Wafer Stages

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 198-214页

作者： Fazhi Song Ning Cui shuaiqi Chen Kai Zhang yang Liu Xinkai Chen Jiubin Tan IEEE the Center of Ultra-precision Optoelectronic Instrument Engineering Harbin Institute of Technology the Key Laboratory of Ultra-Precision Intelligent Instrumentation Ministry of Industry and Information Technology the State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of Technology the Center of Ultraprecision Optoelectronic Instrument Engineering Harbin Institute of Technology the Key Laboratory of UltraPrecision Intelligent Instrumentation Ministry of Industry and Information Technology the Department of Electronic and Information Systems Shibaura Institute of Technology

The increasingly stringent performance requirement in integrated circuit manufacturing, characterized by smaller feature sizes and higher productivity, necessitates the wafer stage executing a extreme motion with the accuracy in terms of nanometers. This demanding requirement witnesses a widespread application of iterative learning control(ILC), given the repetitive nature of wafer scanning. ILC enables substantial performance improvement by using past measurement data in combination with the system model knowledge. However, challenges arise in cases where the data is contaminated by the stochastic noise, or when the system model exhibits significant uncertainties, constraining the achievable performance. In response to this issue, an extended state observer(ESO) based adaptive ILC approach is proposed in the frequency *** being model-based, it utilizes only a rough system model and then compensates for the resulting model uncertainties using an ESO, thereby achieving high robustness against uncertainties with minimal modeling effort. Additionally, an adaptive learning law is developed to mitigate the limited performance in the presence of stochastic noise, yielding high convergence accuracy yet without compromising convergence speed. Simulation and experimental comparisons with existing model-based and data-driven inversion-based ILC validate the effectiveness as well as the superiority of the proposed method.

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Stress-induced potential barriers and charge distributions in a piezoelectric semiconductor nanofiber

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Applied Mathematics and Mechanics(English Edition) 2019年第5期40卷 591-600页

作者： shuaiqi FAN Yuantai HU Jiashi yang Department of Mechanics Hubei Key Laboratory of Engineering Structural Analysis and Safety AssessmentHuazhong University of Science and Technology Department of Mechanical and Materials Engineering University of Nebraska-Lincoln

The performance of a piecewise-stressed ZnO piezoelectric semiconductor nano?ber is studied with the multi-?eld coupling theory. The ?elds produced by equal and opposite forces as well as sinusoidally distributed forces are examined. Speci?c distributions of potential barriers, wells, and regions with effective polarization charges are found. The results are fundamental for the mechanical tuning on piezoelectric semiconductor devices and piezotronics.

关键词： ZnO nanofiber mechanical tuning multi-field coupling theory potential barrier potential well

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Image separation using wavelet-complex shearlet dictionary

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Journal of Systems Engineering and Electronics 2014年第2期25卷 314-321页

作者： shuaiqi Liu Shaohai Hu yang Xiao Institute of Information Science Beijing Jiaotong University Beijing Key Laboratory of Advanced Information Science and Network Technology

This paper presents a new method for image separation through employing a combined dictionary consisting of wavelets and complex shearlets. Because the combined dictionary sparsely represents points and curvilinear singularities respectively, the image can be decomposed into pointlike and curvelike parts as accurate as possible. The proposed method based on the geo- metric separation theory introduced by Donoho in 2005 shows that accurate geometric separation of the morphologically distinct fea- tures of points and curves can be achieved by l1 minimization. The experimental results show that the proposed method can not only be effective but also greatly reduce the computing time.

关键词： geometric separation l1 minimization sparse approx-imation complex shearlet.

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川东北地区开江—梁平海槽东侧长兴组沉积特征及有利区预测

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沉积学报 2024年第6期42卷 2102-2118页

作者：姚鑫阳胡忠贵武赛军谢武仁杨帅奇姚敏毕宇航长江大学地球科学学院武汉430100 长江大学沉积盆地研究中心武汉430100 中国石油勘探开发研究院北京100083

【目的】开江—梁平海槽广泛发育长兴组礁滩储层,油气资源丰富。海槽东侧的取心及地震资料有限,传统地质定性方法无法准确进行层序地层划分与对比,为优质储层预测带来一定困难。深入开展长兴组高频层序地层研究有助于细化层序格架内沉... 详细信息

【目的】开江—梁平海槽广泛发育长兴组礁滩储层,油气资源丰富。海槽东侧的取心及地震资料有限,传统地质定性方法无法准确进行层序地层划分与对比,为优质储层预测带来一定困难。深入开展长兴组高频层序地层研究有助于细化层序格架内沉积相展布规律,厘清海槽东侧沉积演化历程,提高有利储层预测准确率,以期为深化礁滩储层勘探开发提供依据。【方法】基于野外剖面、岩心、测井地震等资料并融入INPEFA测井旋回技术,对川东地区长兴组高频层序地层及沉积体系特征开展研究。【结果】长兴组自下而上划分为2个三级层序和5个四级层序;长兴组早期发育碳酸盐缓坡沉积,中—晚期发育碳酸盐台地沉积,可细分为开阔台地相、台地边缘相及斜坡—盆地相,长兴组有利储集相带主要为台缘礁滩相;长兴组发育晶粒白云岩、(残余)颗粒白云岩、生物礁云岩储层,储层非均质性较强,整体呈“低孔—中、低渗”特征。【结论】有利储集区带呈“Y”形展布,主要集中在普光5井—老君1井—七里北2井—七里北101井—黄龙5井—黄龙8井—黄龙4井区域,沿台地边缘带呈断续条带状或点状分布,七里北地区后排台缘带为次有利区,在区内呈条带状分布。川东北地区长兴组沉积相时空演化规律、有利储层分布预测成果可为下步礁滩储层勘探开发提供地质依据。

关键词：川东北地区开江—梁平海槽东侧长兴组沉积特征有利区预测

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