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World Journal of Clinical Cases 2024年第23期12卷 5404-5409页

作者： shi-Ping Zhan Department of Dermatology General Hospital of the Yangtze River ShippingWuhan Brain HospitalWuhan 430000Hubei ProvinceChina

BACKGROUNDWith the incidence of pancreatic diseases increasing year by year,pancreatichyperglycemia,as one of the common complications,is gradually gaining attentionfor its impact on the skin health of *** SUMMARYThis was the case of an elderly female with clinical manifestations of necrolyticmigratory erythema,“three more and one less,”diabetes mellitus,hypertension,anemia,hypoproteinemia,and other syndromes,which had been misdiagnosedas *** computed tomography showed a pancreatic caudal spaceoccupyinglesion,and the magnetic resonance scanning of the epigastric regionwith dynamic enhancement and diffusion-weighted imaging suggested a tumorof the pancreatic tail,which was considered to be a neuroendocrine tumor *** patient was referred to a more equipped hospital for laparoscopicpancreatic tail ***-surgery diagnosis revealed a neuroendocrinetumor in the tail of the *** date,the patient’s general condition is good,and she is still under close *** migratory erythema can be induced by endocrine system tumors orendocrine metabolic abnormalities,with complex clinical manifestations,difficultdiagnosis,and easy misdiagnosis by *** initial treatment principlesin dermatology include symptomatic supportive therapy and effectivedrugs to relieve skin *** clarifying the etiology of glucagonoma,comprehensive treatment in collaboration with endocrinologists,generalsurgeons,and oncologists can help provide individualized treatment for patientsand improve their prognosis.

关键词： Glucagonoma Necrolytic loosening of wandering erythema Treatment Prognosis

挤出成形3D打印仿生骨植入钛合金支架制备工艺及性能研究

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粉末冶金技术 2024年第4期42卷 367-373页

作者：刘浩石永亮党海青河北工业职业技术大学材料工程系石家庄050091 哈尔滨工业大学材料科学与工程学院哈尔滨150006

采用万能试验机和扫描电子显微镜研究了挤出成形3D打印Ti6Al4V钛合金支架的制备工艺、力学性能及微观结构,介绍了采用聚乙烯醇(PVA)水凝胶制备钛合金支架的方法,研究了浆料PVA含量、脱脂温度和烧结温度对制备工艺的影响规律,分析了钛合... 详细信息

采用万能试验机和扫描电子显微镜研究了挤出成形3D打印Ti6Al4V钛合金支架的制备工艺、力学性能及微观结构,介绍了采用聚乙烯醇(PVA)水凝胶制备钛合金支架的方法,研究了浆料PVA含量、脱脂温度和烧结温度对制备工艺的影响规律,分析了钛合金支架孔隙率与力学性能的关系。结果表明:采用PVA水凝胶制备钛合金支架可以获得分布均匀且高度互联的多孔结构,当浆料PVA质量分数为15%,脱脂温度和烧结温度分别设定为360℃和1300℃时,制备工艺最佳。孔隙率为59.8%的钛合金支架表现出与人体骨骼相匹配的力学性能,可避免应力遮蔽效应。

关键词：挤出成形 3D打印 PVA水凝胶钛合金支架孔隙率力学性能

Intermittent sliding-lock-knot suture for limbal conjunctival autograft fixation in pterygium surgery:a technique note

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 838-844页

作者： Ling Zhang Run-Hua Lyu Jing-Ru Wang Wen-Jian shi Feng Zheng Ying-Ying Gao Department of Ophthalmology the Second Affiliated HospitalFujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Neurosurgery the Second Affiliated HospitalFujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

AIM:To report a technique used with intermittent slidinglock-knot(ISLK)fixation for limbal conjunctival autografts in pterygium surgery and compared with those of routine intermittent(RI)***:Consecutive patients with primary pterygium who had undergone pterygium excision combined with limbal conjunctival autograft transplantation between March 2021 and March 2022 at our institute were retrospectively *** outcome measures were mean duration of surgery and suture removal,degree of conjunctival hyperemia on postoperative day 1,pain score at suture removal,postoperative symptoms at 6mo,including conjunctival hyperemia,foreign body sensation,and graft ***:Ninety-eight patients underwent monocular surgery and were divided into ISLK(51 eyes)and RI(47 eyes)groups according to the type of conjunctiva autograft fixation method *** was no significant difference in mean duration of surgery between the two groups(18.59±2.39min vs 18.15±2.20min,P=0.417);however,compared to the RI group,shorter suture removal times were observed in the ISLK group[0.58min(0.42-0.87)vs 3.00min(2.21-4.15),P<0.001].The degree of conjunctival hyperemia on postoperative day 1 was milder in the ISLK group(P<0.001).Pain scores at suture removal were lower in the ISLK group than in RI group[1(0-3)vs 2(1-4),P<0.001].Postoperative symptoms at 6mo were comparable between the groups(P=0.487),with no ***:ISLK is an innovative method for limbal conjunctival autograft fixation after pterygium *** to RI fixation,ISLK facilitates suture removal and reduces discomfort,with comparable surgery duration and less conjunctival hyperemia.

关键词： intermittent sliding-lock-knot fixation pterygium suture removal

Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis

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Chinese Journal of Natural Medicines 2024年第9期22卷 769-784页

作者： ZHANG Yinhao JIA Kexin LI Yufei MA Zhi FAN Guifang LUO Ranyi LI Yajing yang yang LI Fanghong LIU Runping LIU Jia LI Xiaojiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Available online 20 Sep.2024

Hepatic ischemia/reperfusion injury(HIRI)is a common pathophysiological condition occurring during or after liver resection and transplantation,leading to hepatic viability impairment and functional ***,ferroptosis,a newly recognized form of programmed cell death,has been implicated in *** Radix Praeparata(RRP),extensively used in Chinese herbal medicine for its hepatoprotective,anti-inflammatory,and antioxidant properties,presents a potential therapeutic ***,the mechanisms by which RRP mitigates HIRI,particularly through the regulation of ferroptosis,remain *** this study,we developed a HIRI mouse model and monocrotaline(MCT)-and erastin-induced in vitro hepatocyte injury *** conducted whole-genome transcriptome analysis to elucidate the protective effects and mechanisms of RRP on *** RRP aqueous extract was characterized by the presence of acteoside,rehmannioside D,and *** results demonstrate that the RRP aqueous extract ameliorated oxidative stress,reduced intracellular iron accumulation,and attenuated HIRI-induced liver ***,RRP significantly inhibited hepatocyte death by restoring intracellular iron homeostasis both in vivo and in ***,the RRP aqueous extract reduced intrahepatocellular iron accumulation by inhibiting ZIP14-mediated iron uptake,promoting hepcidin-and ferroportin-mediated iron efflux,and ameliorating mitochondrial iron aggregation through upregulation of Cisd1 ***,siRNA-mediated inhibition of hamp synergistically enhanced the RRP aqueous extract's inhibitory effect on *** conclusion,our study elucidates the mechanisms by which RRP aqueous extracts alleviate HIRI,highlighting the restoration of iron metabolic *** findings position RRP as a promising candidate for clinical intervention in HIRI treatment.

关键词： Hepatic ischemia/reperfusion injury Rehmanniae Radix Praeparata Ferroptosis Intracellular iron homeostasis

Maneuvering target tracking of UAV based on MN-DDPG and transfer learning

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Defence Technology（防务技术） 2021年第2期17卷 457-466页

作者： Bo Li Zhi-peng yang Da-qing Chen shi-yang Liang hao Ma School of Electronics and Information Northwestern Polytechnical UniversityXi’an710072China School of Engineering London South Bank UniversityLondonSE10AAUK AVIC Xi’an Aeronautics Computing Technique Research Institute Xi’an710068China

Tracking maneuvering target in real time autonomously and accurately in an uncertain environment is one of the challenging missions for unmanned aerial vehicles(UAVs).In this paper,aiming to address the control problem of maneuvering target tracking and obstacle avoidance,an online path planning approach for UAV is developed based on deep reinforcement *** end-to-end learning powered by neural networks,the proposed approach can achieve the perception of the environment and continuous motion output *** proposed approach includes:(1)A deep deterministic policy gradient(DDPG)-based control framework to provide learning and autonomous decision-making capability for UAVs;(2)An improved method named MN-DDPG for introducing a type of mixed noises to assist UAV with exploring stochastic strategies for online optimal planning;and(3)An algorithm of taskdecomposition and pre-training for efficient transfer learning to improve the generalization capability of UAV’s control model built based on *** experimental simulation results have verified that the proposed approach can achieve good self-adaptive adjustment of UAV’s flight attitude in the tasks of maneuvering target tracking with a significant improvement in generalization capability and training efficiency of UAV tracking controller in uncertain environments.

关键词： UAVs Maneuvering target tracking Deep reinforcement learning MN-DDPG Mixed noises Transfer learning

Acoustic Purcell effect induced by quasibound state in the continuum

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Fundamental Research 2024年第1期4卷 57-62页

作者： Sibo Huang Shuhuan Xie He Gao Tong hao Shuang Zhang Tuo Liu Yong Li Jie Zhu Institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China College of Surveying and Geo-Informatics Tongji UniversityShanghai 200092China Department of Physics The University of Hong KongHong Kong 999077China Key Laboratory of Noise and Vibration Research Institute of AcousticsChinese Academy of SciencesBeijing 100190China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China

We study theoretically and experimentally the acoustic Purcell effect induced by quasi-bound states in the continuum(quasiBICs).A theoretical framework describing the acoustic Purcell effect of a resonant system is developed based on the system’s radiative and dissipative factors,which reveals the critical emission condition for achieving optimum Purcell *** show that the quasiBICs contribute to highly confined acoustic field and bring about greatly enhanced acoustic emission,leading to strong Purcell *** concept is demonstrated via two coupled resonators supporting a Friedrich-Wintgen quasiBIC,and the theoretical results are validated by the experiments observing emission enhancement of the sound source by nearly two orders of *** work bridges the gap between the acoustic Purcell effect and acoustic BICs essential for enhanced wave-matter interaction and acoustic emission,which may contribute to the research of high-intensity sound sources,high-quality-factor acoustic devices and nonlinear acoustics.

关键词： Acoustic Purcell effect Bound state in the continuum Mode coupling Sound emission enhancement High-quality-factor acoustic device

A chromosome-level genome of electric catfish(Malapterurus electricus)provided new insights into order Siluriformes evolution

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Marine Life Science & Technology 2024年第1期6卷 1-14页

作者： Meiru Liu Yue Song Suyu Zhang Lili Yu Zengbao Yuan Hengjia yang Mengqi Zhang Zhuocheng Zhou Inge Seim Shanshan Liu Guangyi Fan Huanming yang College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI-Qingdao BGI-ShenzhenQingdao 266555China BGI-Shenzhen Shenzhen 518083China Professional Committee of Native Aquatic Organisms and Water Ecosystem of China Fisheries Association Beijing 100125China Integrative Biology Laboratory College of Life SciencesNanjing Normal UniversityNanjing 210023China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhen 518083China

The electric catfish(Malapterurus electricus),belonging to the family Malapteruridae,order Siluriformes(Actinopterygii:Ostariophysi),is one of the six branches that has independently evolved electrical *** assembled a 796.75 Mb *** genome and anchored 88.72%sequences into 28 *** family analysis revealed 295 expanded gene families that were enriched on functions related to glutamate *** evolutionary analyses of electric organs among different lineage of electric fishes further revealed that the coding gene of rho guanine nucleotide exchange factor 4-like(arhgef4),which is associated with G-protein coupled receptor(GPCR)signaling pathway,underwent adaptive parallel *** identification suggests visual degradation in catfishes,and an important role for taste in environmental *** findings fill in the genomic data for a branch of electric fish and provide a relevant genetic basis for the adaptive evolution of Siluriformes.

关键词： Electric fish Karyotype analysis Convergent evolution Environmental adaptation Historical effective population size

3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage–bone interface

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The Innovation 2024年第2期5卷 88-97页

作者： Yijian Zhang Duo Li yang Liu Liuqi Peng Dongdong Lu Pinpin Wang Dongxu Ke Huilin yang Xuesong Zhu Changshun Ruan Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Research Center for Human Tissue and Organ Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Novaprint Therapeutics Suzhou Co. Ltd.Room 605B1 BuildingBioBayNo.218 Xinghu StreetSuzhou Industrial ParkSuzhou 215000China

Reconstruction of osteochondral(OC)defects represents an immense challenge due to the need for synchronous regeneration of special stratified *** revolutionary innovation of bioprinting provides a robust method for precise fabrication of tissue-engineered OCs with hierarchical structure;however,their spatial living cues for simultaneous fulfilment of osteogenesis and chondrogenesis to reconstruct the cartilage-bone interface of OC are ***,inspired by natural OC bilayer features,anisotropic bicellular living hydrogels(ABLHs)simultaneously embedding articular cartilage progenitor cells(ACPCs)and bone mesenchymal stem cells(BMSCs)in stratified layers were precisely fabricated via two-channel extrusion *** optimum formulation of the 7%GelMA/3%AlgMA hydrogel bioink was demonstrated,with excellent printability at room temperature and maintained high cell ***,the chondrogenic ability of ACPCs and the osteogenic ability of BMSCs were demonstrated in vitro,confirming the inherent differential spatial regulation of ABLHs.

关键词： printing stratified boost

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贝雷梁设计中的相关问题探讨

公路 2024年第2期69卷 39-44页

作者：戴世伟危志豪中国路桥工程有限责任公司北京市100011 中交一公局集团有限公司北京市100024

贝雷梁是一种装配式横跨结构,具有自身承载能力大、安拆便捷、结构布置灵活、使用成本低等众多优点,现已被广泛运用于现代工程当中。但实际运用过程中,时常被一些常见问题所困扰。为此,针对实际工程应用中一些常见问题,如跨径布置、非... 详细信息

贝雷梁是一种装配式横跨结构,具有自身承载能力大、安拆便捷、结构布置灵活、使用成本低等众多优点,现已被广泛运用于现代工程当中。但实际运用过程中,时常被一些常见问题所困扰。为此,针对实际工程应用中一些常见问题,如跨径布置、非常规支点设置等,采用有限元软件从理论上探讨并分析原因,提出相应处理方案,同时也为后续类似问题的解决提供参考。

关键词：桥梁工程贝雷梁支点设置设计计算常见问题研究

长三角地区居民城际出行时间异质性及影响机制研究

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热带地理 2024年第5期44卷 850-863页

作者：战武麟席广亮居阳石飞南京大学建筑与城市规划学院南京210093 江苏智慧城市研究基地南京210093 南京大学地理与海洋科学学院南京210023

探究城际出行网络的时间异质性及其影响机制,对推动区域内部不同城市的分工协同和一体化发展具有重要价值。文章基于百度迁徙数据,利用PPML(Poisson Pseudo Maximum Likelihood)重力模型和交互项检验方法,分析长三角地区工作日、周末和... 详细信息

探究城际出行网络的时间异质性及其影响机制,对推动区域内部不同城市的分工协同和一体化发展具有重要价值。文章基于百度迁徙数据,利用PPML(Poisson Pseudo Maximum Likelihood)重力模型和交互项检验方法,分析长三角地区工作日、周末和节假日城际出行网络特征,并挖掘城际出行时间异质性的影响机制。结果表明:1)长三角地区城际出行具有明显的时间异质性特征,表现为工作日城际出行强度最低,周末倾向短途出行,节假日城际出行强度最高的特点;2)城际出行受到推拉力和中间障碍的影响作用。城市发展水平、个体出行诱因等推拉力要素对城际出行具有促进作用,出行成本和行政文化壁垒等中间障碍因素对城际出行具有阻碍作用,推拉要素的作用效果在不同时段具有差异性。

关键词：城际出行出行特征影响机制时间异质性长三角地区