检索结果-南通市图书馆

A novel transposable Mu-like prophage in Bacillus alcalophilus CGMCC 1.3604(ATCC 27647)

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2015年第1期30卷 63-65页

作者： Junjie yang Yimeng Kong Xuan Li sheng yang Key Laboratory of Synthetic Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai Research and Development Center of Industrial Biotechnology Shanghai Collaborative Innovation Center for Biomanufacturing Technology University of the Chinese Academy of Sciences

Dear Editor,Transposable phages,which are reproduced by transposition(Harshey,2012;Taylor,1963),have been widely applied in the field of biotechnology to manipulate operon/gene fusions,in vivo cloning,randomion mutagenesis,and integration of DNA into bacterial genomes(Abalakina et al.,2008;Akhverdyan et al.,2011).One of the best-studied transposable phages is

关键词： cloning biotechnology reproduced mutagenesis phage sequencing DNA http Sanger chromosome

Detection of superficial esophageal squamous cell neoplasia by chromoendoscopy-guided confocal laser endomicroscopy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第22期21卷 6974-6981页

作者： Jin Huang Yun-sheng yang Zhong-sheng Lu Shuang-Fang Wang Jing yang Jing Yuan Department of Gastroenterology and Hepatology Chinese PLA 153 Hospital Department of Gastroenterology and Hepatology Chinese PLA General Hospital Department of Pathology Chinese PLA General Hospital

AIM: To evaluate the diagnostic potential of Lugol'schromoendoscopy-guided confocal laser endomicroscopy(CLE) in detecting superficial esophageal squamous cell neoplasia(ESCN).METHODS: Between December 2008 and September2010, a total of 52 patients were enrolled at the Chinese PLA General Hospital in Beijing, China. First,Lugol's chromoendoscopy-guided CLE was performed in these patients and the CLE in vivo histological diagnosis was recorded. Then, chromoendoscopyguided biopsy was performed in the same patients by another endoscopist who was blinded to the CLE findings. Based on the biopsy and CLE diagnosis, en bloc endoscopic resection was performed. The CLE in vivo diagnosis and the histological diagnosis of biopsy of ESCN were compared, using a histological examination of the endoscopic resection specimens as the standard ***: A total of 152 chromoendoscopy-guided biopsies were obtained from 56 lesions. In the 56 lesions of 52 patients, a total of 679 CLE images were obtained vs 152 corresponding biopsies. The sensitivity, specificity, negative predictive value and positive predictive value of chromoendoscopy-guided CLE compared with biopsy were 95.7% vs 82%(P 0.05), *** was a significant improvement in sensitivity,specificity, negative predictive value, and accuracy when comparing chromoendoscopy-guided CLE with ***: Lugol's chromoendoscopy-guided CLE is a real-time, non-invasive endoscopic diagnostic technology; the accuracy of the detection of superficial ESCN is equivalent to or may be superior to biopsy histology.

关键词： Superficial esophageal neoplasia Squamous cell neoplasm Confocal endomicroscopy Endoscopicsubmucosal dissection Chromoendoscopy

Crystalline Morphology and Crystallization Characteristics of In-situ Blends of Anionic Polyamide 6 with Noncrystallizable Semiaromatic Polyamide Copolymer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2007年第3期23卷 360-365页

作者： WANG Xiao-chun ZHENG Qiang yang Gui-sheng Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P. R. China Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Hangzhou 310027 P. R. China Key Laboratory＇of Engineering Plastics Institute of Chemistry Chinese Academy of Sciences Beijing 100080 P. R. China

A noncrystallizable semiaromatic polyamide copolymer（NSAP） was dissolved in molten caprolactam, and PA6/ NSAP blends were produced in-situ via the anionic ring-opening polymerization of caprolactam. The presence of a single loss tangent（tanS） peak measured by means of dynamic mechanical analysis（DMA） proves the miscibility between PA6 and NSAP in the blends. It was found that there existed drastic changes in the crystallographic form and crystallization kinetics for the in-situ blends, e.g. , when 20% NSAP was added, nearly all crystallites existed in the ,y form and the crystallization could hardly occur upon cooling even at a rate of 2.5 ℃/min. Moreover, cold crystallization appears during the subsequent heating, and its melting point is 40 ℃ lower than that of the virgin system. On the other hand, the size of the spherulites only decreases modestly. It is suggested that the introduction of irregular stiff segments originated from NSAP into PA6 macromolecule chain, which resulted from transamidation during the polymerization play a dominant role in the drastic change of crystallization kinetics and the resultant morphology of the in-situ blends.

关键词： In-situ blend Noncrystallizable polyamide copelymer Anionic polymerization Morphology Crystallization

The Computation of the Transient Electromagnetic Response for Ramp Turn-off of a Large Fixed Rectangle Transmitting Loop

在线全文

学校读者我要写书评

暂无评论

石油地球物理勘探 2012年第A2期47卷 135-140页

作者： Liu Zheng yang sheng Kunming University of Science and Technology Kunming Yunnan 650093 China China Nonferrous Metals Resource Geological Survey Beijing 100012China

Direct photolysis of N-methoxypyridiniums for the pyridylation of carbon/heteroatom-hydrogen bonds

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2022年第12期65卷 2494-2499页

作者： He sheng Bei-Bei Zhang Qiang Liu Zhu-sheng yang Zhi-Xiang Wang Xiang-Yu Chen School of Materials and Architectural Engineering Guizhou Normal UniversityGuiyang550025China School of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China

Current synthetic methods for the functionalization of pyridinium salts usually rely on transition metals,oxidants and/or *** date,no direct photolysis method exists under photocatalyst-,transition metal-and oxidant-free *** herein demonstrate the first direct photolysis of N-methoxypyridinium salts for the selective assembly of various pyridines by using a series of common feedstocks,including amine-boranes,unactivated alkanes,phosphine oxides,amides,silanes and aldehydes.

关键词： photolysis N-methoxypyridiniums hydrogen atom transfer pyridines

同方期刊数据库

Investigation of the kinetic mechanism of the demanganization reaction between carbon-saturated liquid iron and CaF2–CaO–SiO2-based slags

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2018年第4期25卷 399-404页

作者： sheng-chao Duan Chuang Li Han-jie Guo Jing Guo Shao-wei Han Wen-sheng yang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing 100083 China China Metallurgical Planning and Research Institute Beijing 100711 China

The demanganization reaction kinetics of carbon-saturated liquid iron with an eight-component slag consisting of CaO–SiO2–MgO–FeO–MnO–Al2O3–TiO2–CaF2 was investigated at 1553, 1623, and 1673 K in this study. The rate-controlling step（RCS） for the demanganization reaction with regard to the hot metal pretreatment conditions was studied via kinetics analysis based on the fundamental equation of heterogeneous reaction kinetics. From the temperature dependence of the mass transfer coefficient of a transition-metal oxide（MnO）, the apparent activation energy of the demanganization reaction was estimated to be 189.46 kJ·mol^–1 in the current study, which indicated that the mass transfer of MnO in the molten slag controlled the overall rate of the demanganization reaction. The calculated apparent activation energy was slightly lower than the values reported in the literature for mass transfer in a slag phase. This difference was attributed to an increase in the ＂specific reaction interface＂（SRI） value, either as a result of turbulence at the reaction interface or a decrease of the absolute amount of slag phase during sampling, and to the addition of calcium fluoride to the slag.

关键词： demoaganization reaction kinetics reaction mechanism kinetic model rate-controlling step mass transfer coefficient apparent activation energy

Atomistic simulations of the surface severe plastic deformation-induced grain refinement in polycrystalline magnesium:The effect of processing parameters

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第5期10卷 1242-1255页

作者： Xiaoye Zhou Hui Fu Ji-Hua Zhu Xu-sheng yang Guangdong Province Key Laboratory of Durability for Marine Civil Engineering School of Civil EngineeringShenzhen UniversityShenzhenGuangdong 518060China State Key Laboratory of Ultra-precision Machining Technology Advanced Manufacturing Technology Research CentreDepartment of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina

Magnesium(Mg)based alloys are promising candidates for many applications,but their untreated surfaces usually have low strength and *** this study,a single point diamond turning(SPDT)technique was applied to refine the grain size and improve the mechanical properties of the surface layers of Mg-Li *** refining grains in the topmost layer to the nanometer scale(~60 nm),the surface hardness was found to be enhanced by approximately 60%.The atomic plastic deformation process during the SPDT was then studied by the real-time atomistic molecular dynamics(MD)simulations.A series of MD simulations with different combinations of parameters,including rake angle,cutting speed and cutting depth,were conducted to understand their influences on the microstructural evolution and associated plastic deformation mechanisms on the surface layer of the *** MD simulation results suggest that using increased rake angle,cutting speed and cutting depth can help to achieve better grain *** simulation results,which provide atomic-level details of the deformation mechanism,can assist the parameter design for the SPDT techniques to achieve the high-performance heterogeneous nanostructured materials.

关键词： Mg alloy Grain refinement Surface severe plastic deformation MD simulations

Atomic-scale dissecting the formation mechanism of gradient nanostructured layer on Mg alloy processed by a novel high-speed machining technique

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第23期82卷 227-238页

作者： Hui Fu Xiaoye Zhou Bo Wu Lei Qian Xu-sheng yang State Key Laboratory of Ultra-precision Machining Technology Advanced Manufacturing Technology Research CentreDepartment of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina Guangdong Province Key Laboratory of Durability for Marine Civil Engineering School of Civil EngineeringShenzhen UniversityShenzhen 518060China

Severe plastic deformation(SPD)-induced gradient nanostructured(GNS)metallic materials exhibit superior mechanical performance,especially the high strength and good *** this study,a novel high-speed machining SPD technique,namely single point diamond turning(SPDT),was developed to produce effectively the GNS layer on the hexagonal close-packed(HCP)structural Mg *** high-resolution transmission electron microscopy observations and atomistic molecular dynamics simulations were mainly performed to atomic-scale dissect the grain refinement process and corresponding plastic deformation mechanisms of the GNS *** was found that the grain refinement process for the formation of the GNS Mg alloy layer consists of elongated coarse grains,lamellar fine grains with deformation-induced-tension twins and contraction twins,ultrafine grains,and nanograins with the grain size of~70 nm along the direction from the inner matrix to ***,experiment results and atomistic simulations reveal that these deformation twins are formed by gliding twinning partial dislocations that are dissociated from the lattice dislocations piled up at grain *** corresponding deformation mechanisms were evidenced to transit from the deformation twinning to dislocation slip when the grain size was below 2.45μ***,the Hall-Petch relationship plot and the surface equivalent stress along the gradient direction estimated by finite element analysis for the SPDT process were incorporated to quantitatively elucidate the transition of defo rmation mechanisms during the grain refinement *** findings have implications for the development of the facile SPD technique to construct high strength-ductility heterogeneous GNS metals,especially for the HCP metals.

关键词： Gradient nanostructured Mg alloy High-speed machining Deformation twinning High-resolution transition electron microscopy Hall-Petch relationship

PhaseⅠdose-finding study of sorafenib with FOLFOX4 as firstline treatment in patients with unresectable locally advanced or metastatic gastric cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2015年第3期27卷 239-246页

作者： Yihebali Chi Jianliang yang sheng yang Yongkun Sun Bo Jia Yuankai Shi Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences & Peking Union Medical College National Center for Anticancer Drugs Clinical Study Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs

Objective： To determine the maximum tolerated dose（MTD）, dose-limiting toxicity（DLT） and efficacy of sorafenib in combination with FOLFOX4（oxaliplatin/leucovorin（LV）/5-fluorouracil） as first-line treatment for advanced gastric cancer, we performed a phase I dose-finding study in nine evaluable patients with unresectable locally advanced or metastatic gastric cancer or gastroesophageal junction adenocarcinoma. Methods： According to modified Fibonacci method, the design of this study was to guide elevation of the sorafenib dosage to the next level（from 200 mg twice daily to 400 mg twice daily and then, if tolerated, 600 mg twice daily）. If the patient achieved complete response（CR）, partial response（PR） or stable disease（SD） after eight cycles of treatment, combination chemotherapy was scheduled to be discontinued and sorafenib monotherapy continued at the original dose until either disease progression or unacceptable toxicity. Results： In sorafenib 200 mg twice daily group, DLT was observed in 1 of 6 patients, and in 400 mg twice daily group, it was observed in 2 of 3 patients. Seven of 9（77.8%） evaluable patients achieved PR, with a median overall survival（OS） of 11.8 [95% confidence interval（CI）： 8.9-14.7] months. Common adverse effects include hand-foot syndrome, leukopenia, neutropenia, anorexia, and ***： Twice-daily dosing of sorafenib 200 mg in combination with FOLFOX4 was proven effective and safe for the treatment of advanced gastric cancer, and could be an appropriate dosage for subsequent phase II clinical studies.

关键词： Sorafenib gastric cancer FOLFOX4