检索结果-南通市图书馆

Journal of Iron and Steel Research International 2021年第3期28卷 370-382页

作者： Dong-hui Li Wen-chao He Xu Zhang Mao-guo Xiao Shao-hong Li Kun-yu Zhao Mao-sheng yang School of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093YunnanChina Institute for Special Steels Central Iron and Steel Research InstituteBeijing100081China

The effects of traditional heat treatment(quenching and then tempering)and deep cryogenic treatment on the microstructure and mechanical properties of a low-carbon high-alloy martensitic bearing steel were studied by Rockwell hardness test,X-ray diffractometry,scanning electron microscopy and transmission electron *** results show that the deep cryogenic treatment promotes the transformation of the retained austenite to martensite during cooling,which leads to the hardness of the sample after deep cryogenic treatment higher than that at the quenched ***,the carbon content in the martensite matrix after different treatments was calculated and the results indicated that deep cryogenic treatment can promote the segregation of carbon atoms in martensite to *** segregated carbon atoms act as and grow into nuclei for the formation of fine carbide particles during subsequent *** this resulted in the fact that the hardness of the tempered experimental steel after deep cryogenic treatment is higher than that without deep cryogenic treatment.

关键词： Heat treatment High-alloy martensitic bearing steel Deep cryogenic treatment Carbide Retained austenite

Research on the influence of action between fin and anti-rolling tank on the integrated stabilization effect

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Marine Science and Application 2007年第1期6卷 9-14页

作者： YU Li-jun JIN Hong-zhang WANG Hui yang sheng College of Automation Harbin Engineering University Harbin 150001 China

Through analyzing the roll model of the integrated system of fin and anti-rolling tank, this paper uses binomial equation to simplify the module and check how the approximate parameters simulate the original function. Based on the simplified module, the influence of fin and anti-rolling tank on the coefficient items of the roll module is discussed, and the influencing factors between fin and anti-rolling tank are analysed. And through simulation, the influence of action between fin and anti-rolling tank on the static characteristics, and the integrated stabilization effect, are analyzed.

关键词： fin stabilizer anti-rolling tank integrated stabilization action each other influence

Application of phase-field modeling in solid-state phase transformation of steels

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第6期29卷 867-880页

作者： Shao-jie Lv Shui-ze Wang Gui-lin Wu Jun-heng Gao Xu-sheng yang Hong-hui Wu Xin-ping Mao Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China yangjiang Branch Guangdong Laboratory for Materials Science and Technology(Yangjiang Advanced Alloys Laboratory)Yangjiang 529500GuangdongChina Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina

Solid-state phase transformation is usually associated with excellent mechanical properties in steel materials.A deep understanding of the formation and evolution of phase structure is essential to tailor their service *** a powerful tool for capturing the evolution of complex microstructures,phase-field simulation quantitatively calculates the phase structures evolution without explicit assumptions about transient *** the development of advanced numerical technology and computing ability,phase-field methods have been successfully applied to solid-state phase transformation in steels and greatly support the research and development of advanced steel *** phase-field simulations of solid-phase transformation in steels were summarized,and the future development was proposed.

关键词： Phase-field model Solid-state phase transformation Microstructure evolution Advanced steel material Phase-field simulation

Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2023年第4期2023卷 437-451页

作者： Yu Jiang Xiyuan Li Fenghui Qian Bingbing Sun Xiyuan Wang Yan Zhang Deqiang Zhang Meiyu Geng Zuoquan Xie sheng yang Shanghai Research and Development Center of Industrial Biotechnology ShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina. School of Life Science and Technology ShanghaiTech UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghaiChina Huzhou Research Center of Industrial Biotechnology Shanghai Institutes for Biological SciencesChinese Academy of SciencesHuzhouChina Shanghai Taoyusheng Biotechology Co.Ltd.Shanghai China

The stimulator of interferon genes(STING)protein is an important and promising innate immune target for tumor ***,the instability of the agonists of STING and their tendency to cause systemic immune activation is a *** STING activator,cyclic di-adenosine monophosphate(CDA),produced by the modified Escherichia coli Nissle 1917,shows high antitumor activity and effectively reduces the systemic effects of the“off-target”caused by the activation of the STING *** this study,we used synthetic biological approaches to optimize the translation levels of the diadenylate cyclase that catalyzes CDA synthesis in *** developed 2 engineered strains,CIBT4523 and CIBT4712,for producing high levels of CDA while keeping their concentrations within a range that did not compromise the *** CIBT4712 exhibited stronger induction of the STING pathway corresponding to in vitro CDA levels,it had lower antitumor activity than CIBT4523 in an allograft tumor model,which might be related to the stability of the surviving bacteria in the tumor ***4523 exhibited complete tumor regression,prolonged survival of mice,and rejection of rechallenged tumors,thus,offering new possibilities for more effective tumor *** showed that the appropriate production of CDA in engineered bacterial strains is essential for balancing antitumor efficacy and self-toxicity.

关键词： interferon tuning offering

Effects of Cerium Nitrate on Expression of CaM Ⅰ and PMCA Ca^( 2+ ) -ATPase mRNA in Rat Liver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2001年第3期19卷 219-222页

作者：杨维东王艇刘洁生雷衡毅杨燕生 Dept. of Biotechnol. Ji'nan Univ. Guangzhou 510632 China

The effect of cerium nitrate on expression of CaM Ⅰ and PMCA1b in rat liver was studied by means of reverse transcription-polymerase chain reaction (RT-PCR). The result shows that neither a high dose (50 mg·kg -1 ) nor a low dose (1 mg·kg -1 ) of cerium nitrate induces any alterations of expression of CaM Ⅰ and PMCA 1b mRNA after recurrent intraperitoneal injection of cerium nitrate, which suggests that effect of cerium nitrate on CaM and Ca 2+ -ATPase might be at posttranscription level.

关键词： rare earths cerium nitrate reverse transcription-polymerase chain reaction CaM, Ca 2+ -ATPase

Seven New Sesquiterpene Lactones from Eupatorium chinense

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2005年第11期23卷 1530-1536页

作者： yang, sheng-Ping CHENG, Jia-Gao HUO, Jun JIANG, Hua-Liang CHEN, Kai-Xian YUE, Jian-Min State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Zhangjiang Hi-Tech Park Shanghai 201203 China

Seven new sesquiterpenoids, namely eupatochinilides Ⅰ-Ⅶ （1-7）, together with eight known compounds, euponin （8）, mollisorin A （9）, niveusin B （10）, 8β-（4＇-acetoxy-tiglyloxy）-3β-hydroxy-6Hβ,7Hα-germacra-1（10）E,4E,11（13）-trien-6,12-olide （11）, eupalinifide B （12）, 8β-（4＇-hydroxytigloyloxy）-5-desoxy-8-desacyleuparotin （13）, 3-deacetyeupalinin A （14）, and 15-hydroxyleptocarpin （15）, were isolated from the ethanolic extract of the whole plant of Eupatorium chinense L. Their structures and stereochemistry were established by spectroscopic methods and GIAO based ^13C NMR chemical shift calculations.

关键词： Eupatorium chinense sesquiterpenoid eupatochinilides Ⅰ-Ⅶ gauge-independent atomic orbital,quantum chemical calculation

SPATIAL-TEMPORAL CHANGES AND TRENDS OF AGEING IN CHINA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical Science 2005年第3期15卷 200-205页

作者： WANG Wu-yi ZHANG Li LI Hai-rong LI Ri-bang yang Lin-sheng LIAO Yong-feng Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Scienees Beijing 100101 P. R. China National Centre of Disaster Reduction Ministry of Civil Affairs of China Beijing 100053 P. R. China

This study focuses on the development stages of ageing and its regional differences in China based on examination of official statistics and documents. The development of ageing in China has experienced three major stages. Firstly, in the 1950s, low coefficient of elderly population (over 65 years) paced up to primary adult type. Secondly, there was a deeply drop of the elderly population because of natural disaster and political factors in the 1960s. Thirdly, from the 1970s to the end of 20th century, the constant increasing of elderly coefficient made China close to elderly society. With statistic data of population, Logistic model is used to simulate the future development of ageing, and two characteristics of development of ageing are presented. Firstly, as for ageing from 2005 to 2050, the elderly coefficient will grow up significantly from 8.48% to 16.30%. Secondly, after 2025, the increasing rate of elderly coefficient will slow down gradually. The regional differences of elderly population in China can be summarized as follows: 1) the eastern China possesses higher elderly coefficient and huger elder population than the western China; 2) about 47.4% of municipalities and provinces in the eastern China become elderly especially Shanghai, Zhejiang Province, Jiangsu Province, Beijing, Tianjin and Shandong Province; 3) ageing intensity is higher in rural area than urban area but getting close each other, and there are more elderly people in rural area than in urban area. Therefore, these will arose aged care problems, and it becomes important issue to establish the social security system in rural areas as soon as possible for elderly people.

关键词： ageing ageing in rural area China

Geographic variation in photoperiodic diapause induction and diapause intensity in Sericinus montelus （Lepidoptera Papilionidae）

在线全文

学校读者我要写书评

暂无评论

Insect Science 2012年第3期19卷 295-302页

作者： Xiao-Ping Wang Qiu-sheng yang Peter Dalin Xing-Miao Zhou Zhi-Wen Luo Chao-Liang Lei Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden College of Life Science Jiamusi UniversityJiamusiHelongjiang ProvinceChina

Due to the risk of extinction and ornamental value of the swallowtail butterfly, Sericinus montelus Gray （Lepidoptera： Papilionidae） in China, knowledge about local adaptations is important for the conservation and economical utilization of the species. In the present study, photoperiodie diapause induction and diapause intensity of S. montelus populations from Jiamusi （46°37＇N）, Beijing （40° 15＇N）, Zibo （36°48＇N）, Fangxian （32°36＇N）, Wuhan （30°33＇N） and Huaihua （27°33＇N） were characterized at 25℃. Logistic regression analysis revealed a significant population x hours of light interaction, confirming that photoperiodic responses varied among populations. The critical photoperiod was positively correlated with latitude and increased toward the north at a rate of about 1 h for each 6.67 degrees of latitude. Survival analyses indicated that survival time of diapausing pupae before adult eclosion differed significantly among populations at 25℃ and 16 ： 8 L ＂D h. The mean duration of pupal diapause was also positively correlated with latitude. Our study reveals geographic variation in the critical photoperiod for diapause induction and in diapause intensity of S. montelus. These results provide useful information for our general understanding about seasonal adaptation in insects and may also be used to predict how geographic populations respond to climate warming.

关键词： critical photoperiod duration of diapause geographic population pupal diapause Sericinus montelus

Silence of HIN-1 expression through methylation of its gene promoter in gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第4期17卷 526-533页

作者： Yan Gong Ming-Zhou Guo Zhi-Jia Ye Xiu-Li Zhang Yong-Liang Zhao Yun-sheng yang Department of Gastroenterology and Hepatology Chinese PLAGeneral Hospital Beijing 100853 China Department of Genetics Yale Medical School TACS320 1 Gilbert Street New Haven CT 06520 United States Department of General Surgery Southwest Hospital Third Military Medical University Chongqing 400038China

AIM: To clarify the role of high in normal-1 (HIN-1) gene promoter methylation during gastric cancer development. METHODS: Gastric cancer cell lines and tissue specimens were analyzed for expression of HIN-1 mRNA and protein using the semi-quantitative reverse transcription polymerase chain reaction and immunohistochemistry. The methylation of the HIN-1 gene promoter was detected in gastric carcinoma cells and tissues using methylation-specific polymerase chain reaction. The 3-(4,5-dimethylthiazol-2yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium cell viability assay and flow cytometry were used to assess the changes in behaviors of gastric cancer cells with or without 5-aza-2’-deoxycytidine treatment. RESULTS: HIN-1 was not expressed in 4 of 5 gastric cancer cell lines. The demethylation reagent 5-aza-2’-deoxycytidine was able to induce or upregulate HIN-1 expression in gastric cancer cell lines, which is associated with reduction of tumor cell viability. Furthermore, methylation of the HIN-1 gene promoter was shown in 57.8% (26/45) of the primary gastric cancer and 42.1% (17/38) of adjacent tissue samples, but was not shown in normal gastric mucosa (0/10). From the clinicopathological data of the patients, methylation of the HIN-1 gene promoter was found to be associated with tumor differentiation (P = 0.000). CONCLUSION: High methylation of HIN-1 gene promoter results in silence of HIN-1 expression in gastric cancer. 5-aza-2’-deoxycytidine reverses HIN-1 methylation and reduces viability of gastric cancer cells.

关键词： High in normal-1 Gene methylation 5-aza-2’-deoxycytidine Tumor differentiation Gastric cancer

Chemically Modified Ordered Mesoporous Carbon/Polyaniline Composites for Electrochemical Capacitors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第2期27卷 295-299页

作者： KONG Llng-bin ZHANG Jing CAI Jlan-jun yang Zhen-sheng LUO Yong-chun KANG Long State Key Laboratory of Gansu Advanced Non-ferrous Metal Materials School of Materials Science and Engineering Lanzhou University of Technology Lanzhou 730050 P. R. China

Chemically modified ordered mesoporous carbon CMK-3 materials were prepared by means of an easy wet-oxidative method in 2 mol/L nitric acid aqueous solution. A large amount of oxygen-containing functional groups were introduced onto the CMK-3 surface. Modified CMK-3（m-CMK-3） and aniline monomer were polymerized via an in situ chemical oxidative polymerization method. Morphological characterizations of m-CMK-3/PANI （polyaniline） composites were carried out via field emission scanning electron microscopy（SEM）. Their electrochemical properties were investigated with cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy. The m-CMK-3/PANI composites have excellent properties in capacitance, and the highest specific capacitance（SC） value was up to 489 F/g, suggesting their potential application in the electrode material for electrochemical capacitors.

关键词： Ordered mesoporous carbon Polyaniline Chemical modification In situ chemical polymerization Electrochemical capacitor