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Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury

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Bioactive Materials 2023年第8期26卷 194-215页

作者： Qinfeng yang shenghui Su Shencai Liu sheng yang Jing Xu Yixiu Zhong Yusheng yang Liangjie Tian Zilin Tan Jian Wang Zhiqiang Yu Zhanjun Shi Fangguo Liang Division of Orthopaedic Surgery Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China Department of Orthopaedics Ningde Municipal Hospital of Ningde Normal UniversityNingdeFujian352100China Department of Ophthalmology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China Department of Dermatology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong518020China Division of Orthopaedics and Traumatology Department of OrthopaedicsNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China Cancer Center Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhouGuangdong510515China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong510515China Department of Plastic and Cosmetic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong510515China

Over the years,electroconductive hydrogels(ECHs)have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral nerve injury(PNI)with diabetes,given their favorable mechanical and electrical properties identical to endogenous nerve ***,PNI causes the loss of locomotor function and inflammatory pain,especially in diabetic *** has been established that bone marrow stem cells-derived exosomes(BMSCs-Exos)have analgesic,anti-inflammatory and tissue regeneration ***,we designed an ECH loaded with BMSCs-Exos(ECH-Exos)electroconductive nerve dressing to treat diabetic PNI to achieve functional recovery and pain *** its potent adhesive and self-healing properties,this laminar dressing is convenient for the treatment of damaged nerve fibers by automatically wrapping around them to form a size-matched tube-like structure,avoiding the cumbersome implantation *** in vitro studies showed that ECH-Exos could facilitate the attachment and migration of Schwann ***,Exos in this system could modulate M2 macrophage polarization via the NF-κB pathway,thereby attenuating inflammatory pain in diabetic ***,ECH-Exos enhanced myelinated axonal regeneration via the MEK/ERK pathway in vitro and in vivo,consequently ameliorating muscle denervation atrophy and further promoting functional *** findings suggest that the ECH-Exos system has huge prospects for nerve regeneration,functional restoration and pain relief in patients with diabetic PNI.

关键词： Diabetic peripheral nerve injury Exosomes Electroconductive hydrogel Nerve regeneration Pain relief

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Numerical Simulation of Directional Solidification of a Nickel-Based Superalloy With Applied Direct Current

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Journal of Iron and Steel Research International 2012年第S1期19卷 158-161页

作者： FENG Xiao-hui yang Yuan-sheng Institute of Metal Research Chinese Academy of Sciences

A macroscopic thermal field calculation and a microstructure simulation are performed to investigate the directional solidification of a nickel-based superalloy with applied direct current in this *** heat effects of electric current passing through the solidification interface as Joule heat and Peltier heat are investigated in the *** calculated result shows that the Joule heat improves the temperature gradient in the solidification interface,while the effect of Peltier heat is negligible for macroscopic thermal *** directional growth of dendrites under the influence of Joule heat is investigated with *** is found that under the influence of Joule heat,the dendrites are provided with self-adjustment ability of coordinating growth to achieve flat interface in macroscale during directional solidification with the direct electric *** interesting phenomenon is brought by the crowdedly passing through the dendrite of electric current in the solidification interface for the large difference of the electrical resistivity between solid state and melt of the superalloy.

关键词： directional solidification dendrite growth direct current Joule heat

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Gastric body diaphragm-like stricture as a rare complication of nonsteroidal anti-inflammatory drugs

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World Journal of Gastroenterology 2013年第23期19卷 3703-3706页

作者： Li-Li Wu Yun-sheng yang Feng-Chun Cai Shu-Fang Wang Department of Gastroenterology and Hepatology Chinese People's Liberation Army General Hospital

Increased risk due to nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been observed in patients. Although diaphragm-like stricture in the small bowel and colon induced by NSAIDs therapy has been rarely reported, gastric body diaphragm-like stricture has not been reported. We describe the first case of gastric body diaphragm-like stricture due to NSAIDs in a 44-year-old male patient who was successfully treated by an endoscopic approach to avoid complicated surgery. This case highlights new insight into the disadvantages of NSAIDs and provides new data for future clinical studies.

关键词： Gastric Gastroscopy Diaphragm Stricture Nonsteroidal anti-inflammatory drug

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Effect of a Low-Voltage Pulsed Magnetic Field on the Microstructure and Mechanical Properties of AZ80 Alloy

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Journal of Iron and Steel Research International 2012年第S1期19卷 256-259页

作者： FU Jun-wei yang Yuan-sheng Institute of Metal Research Chinese Academy of Sciences

Effect of a low-voltage pulsed magnetic field(LVPMF)on the solidified microstructure and mechanical properties of Mg-Al-Zn alloy was *** the LVPMF is applied during solidification,the as-cast microstructure is significantly refined and a-Mg is modified from developed dendrite to fine *** morphology modification is caused by the accumulation of Joule heat on dendrite *** of Joule heat on dendrite tip melts the dendrite tip and increases the radius of *** increased radius of curvature at the dendrite tip lowers the growth rate and results in the formation of rosette *** the application of the LVPMF,β precipitates,formed in the interdendritic liquid region,are connected to each other due to the smaller dimension of the primary and secondary arms and larger volume fraction of the β precipitates between the *** results indicate that the yield strength and ultimate tensile strength are both increased under with the application of the ***,elongation is slightly decreased with the application of the LVPMF due to the continuous β precipitates.

关键词： pulsed magnetic field microstructure mechanical properties AZ80 alloy

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Soil C and N Pools in Chinese Fir and Evergreen Broadleaf Forests and their Changes with Slash Burning in Mid-Subtropical China

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Pedosphere 2006年第1期16卷 56-63页

作者： GUO Jian-Fen yang Yu-sheng CHEN Guang-Shui XIE Jin-sheng LIN Peng College of Life Science Xiamen University Xiamen 361005 （China） College of Geography Science Fujian Normal University Fuzhou 350007 （China） College of Forestry Fujian Agriculture and Forestry University Fuzhou 350002 （China）

Soil organic carbon （C） and total nitrogen （N） pools of a Chinese fir （Cunninghamia lanceolata （Lamb.） Hook.）（CF） forest, and an evergreen broadleaf （EB） forest located in mid-subtropical, southeastern China, were compared before clearcutting, with the effect of slash burning on organic C and total N in the top 10 cm of soil before and after burning also being evaluated. Prior to clearcutting CF forest had significantly lower （P 〈0.05） organic C and total N in the soil （0-100 cm） compared to EB forest with approximately 60% of the C and N at the two forest sites stored at the 0 to 40 cm soil. In post-burn samples of the 0-10 cm depth at 5 days, 1 year, and 5 years for CF and EB forests, significantly lower levels （P 〈0.05） of organic C and total N than those in the pre-burn samples were observed. Compared to the pre-burn levels, at post-burn year 5, surface soil organic C storage was only 85% in CF forest and 72% in EB forest, while total N storage was 77% for CF forest and 73% for EB forest. Slash burning caused marked long-term changes in surface soil C and N in the two forest types.

关键词： Chinese fir evergreen broadleaf forest slash burning soil carbon soil nitrogen

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Low glucose metabolism in hepatocellular carcinoma with GPC3 expression

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World Journal of Gastroenterology 2018年第4期24卷 494-503页

作者： You-cai Li chuan-sheng yang Wen-Lan Zhou Hong-sheng Li Yan-jiang Han Quan-shi Wang Hu-bing Wu Nanfang PET Center Nanfang Hospital Southern Medical University

AIM To investigate the relationship between glucose metabolism and glypican-3(GPc3)expression in hepatocellular carcinoma(Hcc).METHODSImmunohistochemical staining of pathological samples for GPc3 and glucose transporter 1(GLUT1),and whole-body ^(18)F-FDG PET/c T for measuring tumour glucose uptake were performed in 55 newly diagnosed Hcc *** maximum standard uptake value(s UVmax)and tumour-to-non-tumourous liver uptake(T/NT)ratio were used to quantify ^(18)F-FDG *** vitro ^(18)F-FDG uptake assay of GPc3-expressing Hep G2 and non-GPc3-expressing RH7777 cel ls was used to examine the effect of GPc3 in cellular glucose *** relationships between GPc3 expression and ^(18)F-FDG uptake,GLUT1 expression,tumour differentiation,and other clinical indicators were analysed using spearman rank correlation,univariateand multiple logistic regression *** GPc3 expression was observed in 67.3%of Hcc patients,including 75.0%of those with well or moderately differentiated Hcc and 36.4%of those with poorly differentiated *** was an inverse relationship between GPc3 expression and s UVmax(Spearman correlation coefficient=-0.281,P=0.038)and a positive relationship between GLUT1 expression and sU Vmax(Spearman correlation coefficient=0.681,P0.05).Further multivariate analysis revealed that only the T/N ratio was significantly correlated with GPC3 expression in patients with Hcc(P<0.05).In vitro assay revealed that the uptake of ^(18)F-FDG in GPc3-expressing HepG2 cells was significantly lower than that of non-GPc3-expressing RH7777 cells(t=-20.352,P<0.001).CONCLUSIONThe pres

关键词： Hepatocellular carcinoma glypican-3 18F-FDG Maximum standard uptake value T/NT ratio Glucose metabolism glucose transporter 1

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基于资源约束的企业绩效及利益相关者管理

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同济大学学报（自然科学版） 2009年第12期37卷 1706-1711页

作者：杨晟同济大学交通运输工程学院上海200092

企业对利益相关者管理的战略目标是在企业现有资源约束条件下,达到综合绩效最大化.通过资源约束的线性规划模型,对企业绩效指标的改进进行定量化分析,明确了需优先改进的绩效指标和改进的程度.通过绩效改进指标与利益相关者的相关度分析... 详细信息

企业对利益相关者管理的战略目标是在企业现有资源约束条件下,达到综合绩效最大化.通过资源约束的线性规划模型,对企业绩效指标的改进进行定量化分析,明确了需优先改进的绩效指标和改进的程度.通过绩效改进指标与利益相关者的相关度分析,指出了与改进指标密切相关的利益相关者,为企业针对不同利益相关者实施管理策略提供了依据.

关键词：资源约束绩效改进利益相关者管理

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A systematic study of the antiferromagnetic-ferromagnetic conversion and competition in MnNiGe：Fe ribbon systems

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Journal of Materials Science & Technology 2017年第11期33卷 1362-1370页

作者： Lin Zhang shengcan Ma Qing Ge Kai Liu Qingzheng Jiang Xingqi Han sheng yang Kun Yu Zhenchen Zhong School of Material Science and Engineering Nanchang Hangkong University Nanchang 330063 China Institute for Rare Earth Magnetic Materials and Devices (IREMMD) Institute of Engineering & Research Jiangxi University of Science and TechnologyGanzhou 341000 China

MnNiGe：Fe ribbon samples are prepared. Partial Ni-and Mn-substitution of Fe element can both induce the antiferromagnetic-ferromagnetic conversion in the Ti Ni Si-type state of these MnNiGe：Fe ribbon systems. It is found out, however, that some factors such as annealing, temperature variation process field-cycling, substituted site and magnetic field can affect the conversion and competition between the antiferromagnetic and ferromagnetic states in these ribbons. Therefore, in this paper these major influencing factors are studied systematically and further discussed are the related magnetic and magnetocaloric properties in MnNiGe：Fe ribbon systems.

关键词： Influencing factors Conversion and competition TiNiSi-type state MnNiGe:Fe ribbon systems

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THICKENING TECHNIQUE OF CYCLONEFLOCCULATED SEDIMENTATION

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中国有色金属学会会刊：英文版 1995年第2期5卷 13-15页

作者： yang, Xiao sheng chenJin Lu, Guizhi Chen, Tingzhong (Department of Mineral Engineering, Central South University of Technology,Changsha,410083) Central South Univ of Technology Changsha China

ＴＨＩＣＫＥＮＩＮＧＴＥＣＨＮＩＱＵＥＯＦＣＹＣＬＯＮＥＦＬＯＣＣＵＬＡＴＥＤＳＥＤＩＭＥＮＴＡＴＩＯＮ￥Ｙａｎｇ，Ｘｉａｏｓｈｅｎｇ；ｃｈｅｎＪｉｎ；Ｌｕ，Ｇｕｉｚｈｉ；Ｃｈｅｎ，Ｔｉｎｇｚｈｏｎｇ（Ｄｅｐａｒｔｍ... 详细信息

ＴＨＩＣＫＥＮＩＮＧＴＥＣＨＮＩＱＵＥＯＦＣＹＣＬＯＮＥＦＬＯＣＣＵＬＡＴＥＤＳＥＤＩＭＥＮＴＡＴＩＯＮ￥Ｙａｎｇ，Ｘｉａｏｓｈｅｎｇ；ｃｈｅｎＪｉｎ；Ｌｕ，Ｇｕｉｚｈｉ；Ｃｈｅｎ，Ｔｉｎｇｚｈｏｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＭｉｎｅｒａｌＥｎｇｉｎ...

关键词： cyclone-flocculated sedimentation thickening technique flocculant

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Construction of Chiral One-dimensional Chains via Mononuclear Chiral Precursors and Circular Dichroism Properties

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Chinese Journal of Structural Chemistry 2021年第6期40卷 767-774,685页

作者： JU Hai-Yan yang Ming ZHANG Gang LIU De-Zheng yang Yong-sheng ZHANG Yan-Bo School of Chemistry and Engineering Wuhan Textile UniversityWuhan 430073China Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing Wuhan Textile UniversityWuhan 430073China Hubei Key Laboratory of Power System Design and Test for Electrical Vehicle Hubei University of Arts and ScienceXiangyang 441053China

One-dimensional(1D)chiral chain complexes[CuLSCu(Pydc)](2S)and[CuLRCu(Pydc)](2R)(LS=(E)-3-(((1S,2S)-2-(((E)-3-oxo-3-(4-pyridin-4-yl)phenyl)propylidene)amono)-1,2-diphenyl)imino)-1-(4-(py-ridi-4-yl)phenyl)butan-1-one)and LR=(E)-3-(((1R,2R)-2-(((E)-3-oxo-3-(4-pyridin-4-yl)phenyl)propyli-dene)amono)-1,2-diphenyl)imino)-1-(4-(pyridi-4-yl)phenyl)butan-1-one and Pydc=2,6-pyridinedicarboxylic acid)have been synthesized vis mononuclear chiral enantiomer precursors CuLS(1S)and CuLR(1R).Their different chiral configurations of 1S,1R,2S and 2R were determined by single-crystal X-ray diffraction analyses and further characterized by elemental analyses,infrared spectra(IR),powder X-ray diffraction(PXRD),thermal gravimetric analyses(TGA)and circular dichroism spectra(CD).

关键词： mononuclear chiral precursors 1D chiral chain circular dichroism spectra

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