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Association of Dietary Carotenoids Intake with Skeletal Fluorosis in the Coal-burning Fluorosis Area of Guizhou Province

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Biomedical and Environmental Sciences 2018年第6期31卷 438-447页

作者： LIU Jun yang sheng LUO Ming Jiang ZHAO Xun ZHANG Yuan Mei LUO Ya Department of Nutrition and Food Hygiene School of Public HealthZunyi Medical UniversityZunyi 563006GuizhouChina Experimental Teaching Demonstration Center for Preventive medicine of Guizhou Province Zunyi 563006GuizhouChina Department of Cross Infection Control the Fourth People's hospital of ZunyiZunyi 563004 GuizhouChina Department of Chronic Disease Center of Disease Control and Prevention of Zhijin CountyZhijin 552100GuizhouChina

Objective To explore whether the intake of dietary carotenoids could protect against skeletal fluorosis in Guizhou province in which coal-burning fluorosis is endemic. Methods A case-control study of 196 patients with skeletal fluorosis and 196 age and gender-matched controls was conducted in Zhijin, Guizhou Province. Face-to-face interviews were conducted to assess habitual dietary intake using a 75-item food frequency questionnaire and various covariates with structured questionnaires. Urinary fluoride was measured using an ion-selective electrode method. The genotype of superoxide dismutase 2（SOD2） rs11968525 was detected by Taq Man method. Results We observed significant dose-dependent inverse associations of skeletal fluorosis with intake of β-carotene, lutein/zeaxanthin, lycopene, and total carotenoids（P-trend = 0.002 to 0.018）, whereas α-carotene and β-cryptoxanthin intakes were not found to be related to skeletal fluorosis, after adjustment for potential confounders. The adjusted ORs and 95% CI of skeletal fluorosis for the highest versus lowest quartile were 0.30（0.10, 0.86） for β-carotene, 0.23（0.08, 0.66） for lycopene, 0.26（0.10, 0.75） for lutein/zeaxanthin and 0.34（0.14, 0.74） for total carotenoids（all P-trend ＆lt; 0.05）. Stratified analyses showed that the protective effects of lutein/zeaxanthin and total carotenoids on skeletal fluorosis were more evident for individuals with the AG＋AA genotypes of SOD2（rs11968525）. Conclusion Increased intakes of β-carotene, lutein/zeaxanthin, lycopene, and total carotenoids are independently associated with a lower risk of coal-burning skeletal fluorosis. SOD2（rs11968525） polymorphisms might modify the inverse associations between dietary carotenoids and skeletal fluorosis.

关键词： Case-control study Dietary intake Carotenoids Skeletal fluorosis

Application of the WHO Growth Reference (2007) to Assess the Nutritional Status of Children in China

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Biomedical and Environmental Sciences 2009年第2期22卷 130-135页

作者： YAN-PING LI XIAO-QI HU JING-ZHAO XIAO-GUANG yang AND GUAN-sheng MA National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To assess the nutrition status of children and adolescents in China using the WHO growth reference （2007） in comparison with that defined by the International Obesity Task Force （IOTF） and the Working Group on Obesity in China （WGOC）. Methods Overweight and obesity were defined by age-, sex-, specific BMI reference developed by WHO （2007）, IOTF （2000）, and WGOC （2004）, respectively. Stunting and thinness were defined as height and BMI less than two standard deviations （SD） of the WHO growth reference （2007）, respectively. Data of children and adolescents aged 5 to 19 years （n=54 857, 28 273 boys, 26 584 girls） from the 2002 China National Nutrition and Health Survey （CNNHS） were used in the study. Results The prevalence of overweight, obesity, stunting and thinness among Chinese children and adolescents aged 5-19 years was 5.0%, 1.2%, 13.8%, and 7.4%, respectively when the WHO growth reference （2007） was used, whereas the estimated absolute total number affected by these 4 conditions were 14.6, 3.7, 40.6, and 21.8 million, respectively. The prevalence of overweight and obesity was 18.1% in large cities, while the stunting prevalence was 25.1% in rural 4. Obesity prevalence assessed by the WHO growth reference was higher than that as assessed by the IOTF reference, and obesity prevalence assessed by the WGOC reference was lower than that as assessed by the IOTF reference. Conclusion The nutritional status of children and adolescents is not equal in different areas of China. Stunting is still the main health problem of the poor, while overweight and obesity are the main health problems in large cities.

关键词： WHO Obesity Stunting Children Adolescents China

Interleukin-18 Suppresses Angiogenesis and Lymphangiogenesis in Implanted Lewis Lung Cancer

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Chinese Journal of Cancer Research 2010年第4期22卷 303-309页

作者： sheng yang Xiang-qi Chen Hui-shan Lu Zhi-ying Li Ting-yan Lin Department of Oncology the Union Hospital Fu Jian Medical University Fuzhou 350001 China Department of Respiratory the Union Hospital Fu Jian Medical University Fuzhou 350001 China

Objective： To investigate the effects of interleukin-18 （IL-18） on implanted Lewis lung cancer in suppressing angiogenesis and lymphangiogenesis. Methods： One week after hypodermic inoculation of Lewis cells, sixteen tumor-bearing syngeneic mice were randomly divided into two groups. The mice in the treatment group （group A） were intraperitoneally injected with the IL-18 and in the control group （group B） were intraperitoneally injected with normal saline for 7 days. The mice were killed on day 19. The morphology of the tumors was studied, the growth curve was described and the tumor inhibition rate was calculated. The numbers of metastasized pulmonary colonies were calculated using hematoxylin-eosin （HE） staining. The vascular endothelial growth factor A （VEGF-A）, vascular endothelial growth factor C （VEGF-C）, microvessel density （MVD） and lymphatic microvessel density （LMVD） in tumor mass were measured by immunohistochemistry staining （IHCS）. Results： In the group A, the tumor volume, tumor weigh, lung metastatic nodules, expression of VEGF-A and VEGF-C, MVD were all decreased significantly （P0.01 or P0.05）. The tumor inhibition rate was 75% and the inhibition rate of lung metastatic nodules was 61%. The LMVD in group A was also lower than group B, but without significant difference （P0.05）. Conclusion： IL-18 could suppress the tumor growth and metastasis of implanted Lewis lung cancer by way of down-regulating VEGF-A and VEGF-C expression, suppressing angiogenesis and lymphangiogenesis.

关键词： Interleukin-18 Lung cancer VEGF LMVD

Affine & Scale-Invariant Heterogeneous Pyramid Features for Automatic Matching of High Resolution Pushbroom Imagery from Chang'e 2 Satellite

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Journal of Earth Science 2016年第4期27卷 716-726页

作者： sheng yang Shibing Zhu Zhenju Li Xuejun Li Tao Liu Jue Wang Jianwei Xie Department of Information Equipment the Equipment Academy

The automatic feature extracting and matching for large amount of linear pushbroom imagery with higher and higher resolution is urgent and challenging in three dimensional reconstructions, remote sensing and mapping. Affine ＆ scale-invariant heterogeneous pyramid feature is proposed in this paper, along with the new scale-invariant analysis method, the detecting of the key points, the affine ＆ scale-invariant descriptor, the steering method of the matching, and the quasi-dense matching algorithm based on the extensive epipolar geometry. The automatic matching is devised for the linear pushbroom imagery. The whole process is executed on lunar images of the highest resolution of ~7 m/pixel（or ~1 m/pixel in the lower orbits） from the Chinese Chang＇e 2 satellite, it runs robustly at present, and resulting in large amounts of well-distributed-correspondences with accuracy of 0.3 pixels and excellent reliability, which gives great support for the further exploration both on the Moon and the Earth.

关键词： image matching linear pushbroom imagery epipolar geometry quasi-dense matching.

A COMPLETE BOUNDARY INTEGRAL FORMULATION FOR STEADY COMPRESSIBLE INVISCID FLOWS GOVERNED BY NONLINEAR EQUATIONS

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Chinese Journal of Aeronautics 1991年第4期6卷 333-338页

作者： yang Zuo-sheng Nanjing Aeronautical Institute

A complete boundary integral formulation for steady compressible inviscid flows governed by nonlinear equations is established by using ρV as variable. Thus, the dimensionality of the problem to be solved is reduced ... 详细信息

关键词： A COMPLETE BOUNDARY INTEGRAL FORMULATION FOR STEADY COMPRESSIBLE INVISCID FLOWS GOVERNED BY NONLINEAR EQUATIONS PV

Model-Based Networked Control Systems with Multiple Packet Transmission

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Model-Based Networked Control Systems with Multiple Packet T...

Binding Constants for Terbium(Ⅲ) with Chicken Apoovotransferrin

第二十九届中国控制会议

作者： yang sheng-Hsiung WU Jenq-Lang Department of Electrical Engineering National Taiwan Ocean University

ISBN: (纸本)9781424462636

This paper studies the stabilization problem for discrete-time model-based networked control systems under multiple packet *** dynamics of model-based multiple packet transmission NCSs are modeled as switched control systems.A sufficient condition for stabilization is derived by the multiple Lyapunov function *** is shown that stabilizing networked feedback laws can be obtained by solving matrix inequalities.A numerical example is proposed for verification.

关键词： Networked Control Systems Model-based Control Multiple Packet Transmission Linear Matrix Inequality.

来源： cnki会议评论

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Chemical Research in Chinese Universities 2001年第1期17卷 6-13页

作者： yang Bin sheng LI Ying qi Institute of Molecular Science Shanxi UniversityTaiyuan 030006P.R.China

The binding of Tb 3+ to chicken apoovotransferrin was studied by monitoring the fluorescent intensity of Tb 3+ at 549 nm. The conditional equilibrium constants for the complexation of Tb 3+ by chicken apoovotransferrin in 0 1 mol/L hepes, at pH 7 4 and room temperature were measured. The successive macroscopic binding constants are lg K 1=9 08±0 12 and lg K 2=7 36±0 22. The molar fluorescence enhancement of Tb 3+ apoovotransferrin complex is (2 06±0 14)×10 4 mol -1 ·L. The fluorescence quenching experiment and the titration of N terminal monoferric ovotransferrin showed that Tb 3+ has a preference for being bound to the N terminal binding site of apoovotransferrin.

关键词： Terbium Transferrin Binding constant Fluorescence

Clinical significance of detection of antibodies to fetal and adult acetylcholine receptors in myasthenia gravis

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Neuroscience Bulletin 2012年第5期28卷 469-474页

作者： Qi-Guang Shi Zhi-Hong Wang Xiao-Wei Ma Da-Qi Zhang Chun-sheng yang Fu-Dong Shi Li yang Department of Neurology and Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin 300052 China Department of Neurology Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix Arizona 85013 USA

Objective To evaluate the frequency, distribution and clinical significance of the antibodies to the fetal and/or adult acetylcholine receptor （AChR） in patients with myasthenia gravis （MG）. Methods AChR antibodies were detected by cell-based assay in the serum of ocular MG （OMG）（n = 90） and generalized MG （GMG） patients （n = 110）. The fetal-type （2α： β： γ： δ） and adult-type （2α： β： ε： δ） AChR were used as antigens, and their relevance to disease presentation was assessed. Results The overall frequencies of anti-adult and anti-fetal AChR antibodies were similar in all 200 patients examined, with 14 having serum specific to the AChR-γ subunit, and 22 to the AChR-ε subunit. The overall sensitivity when using the fetal and adult AChR antibodies was higher than that when using the fetal AChR antibody only （P = 0.015）. Compared with OMG patients, the mean age at disease onset and the positive ratio of antibodies to both isoforms of the AChR were significantly higher in patients who subsequently progressed to GMG. Older patients and patients with both anti-fetal and anti-adult AChR antibodies had a greater risk for developing generalized disease [odds ratio （OR）, 1.03; 95% confidence interval （CI）, 1.01–1.06 and OR, 5.09; 95% CI, 2.23–11.62]. Conclusion Using both fetal-and adult-type AChRs as the antigens may be more sensitive than using either subtype. Patients with serum specific to both isoforms are at a greater risk of progressing to GMG. Patients with disease onset at an advanced age appear to have a higher frequency of GMG conversion.

关键词： myasthenia gravis acetylcholine receptor antibodies acetylcholine receptor subunit cell-based assay adult fetal

Eye-movement Patterns of Chinese Children with Developmental Dyslexia during the Stroop Test

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Biomedical and Environmental Sciences 2018年第9期31卷 677-685页

作者： WU Yu Jia yang Wen Han WANG Qing Xiong yang De sheng HU Xiao Yun JING Jin LI Xiu Hong Department of Maternal and Child Health School of Public Health Sun Yat-sen University

Objective To compare the eye-movement patterns of Chinese children with developmental dyslexia（DD children） with those of non-dyslexic children as they perform the Stroop Color and Word Test（SCWT）, and to explore the relationship between their eye-movement patterns and interference effect. Methods An EyeLink II was used to record the eye-movement parameters of 32 DD children and 37 non-dyslexic children as they performed the SCWT. The independent samples t-test and repeated measures were used to analyze behavioral and eye-movement parameters. Results Compared to the control group, Chinese DD children presented lower accuracy（F = 8.488）, slower response time（F = 25.306）, and larger interference effect（t = 2.29）; Chinese DD children also exhibited lower frequency of fixations（F = 6.069）, greater numbers of saccades（F = 7.914） and fixations（F = 5.272）, and shorter mean saccade distance（F = 4.03）. All behavioral and eye-movement parameters differed significantly among the three tasks in the SCWT. There was significant interaction between groups and tasks in accuracy（F = 5.844）, and marginally significant interaction in response time（F = 3.040）. Chinese DD children tended to have lower accuracy and longer response time than the control group in the ＇color-word naming＇ task. Conclusion Compared to non-dyslexic children, Chinese DD children are subject to a stronger interference effect. When performing the SCWT, Chinese DD children exhibit abnormal eye-movement patterns, namely shorter mean saccade distance, lower frequency of fixations, and more fixations and saccades. These abnormal eye movements may be relatively stable oculomotor patterns of DD children performing visual processing, and not influenced by impaired interference effect.

关键词： Developmental dyslexia Chinese children Eye movement Stroop Color and Word Test