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The deformation pattern and fault rate in the Tianshan Mountains inferred from GPS observations

science {1. Earth sciences 2008年第8期51卷 1064-1080页

作者： yang shaomin1.2. li jie1.3 & wang qi2.1.1.research center of space science and technology,{1., Wuhan 4.0074. china 2 Institute of Seismology, china Earthquake Administration, Wuhan 430071. china 3 Earthquake Administration of Xinjiang Uygur Autonomous Region, Urumqi 83001., china 1. research {1. of space science and technology China University of Geosciences Wuhan 430074 China 2. Institute of Seismology China Earthquake Administration Wuhan 430071 China 3. Earthquake Administration of Xinjiang Uygur Autonomous Region Urumqi 830011 China

Based on GPS measurements conducted from 1.92 to 2006, we present the current crustal movement velocity field for approximately 400 sites in the Tianshan Mountains and their adjacent areas, and estimate slip rates on the major faults using a 2-D elastic dislocation model. Our studies show slip rates within the range of 1.4 mm/a on the NW-SE trending strike-slip faults (such as Talas-Fergana fault) in the Tianshan Mountains. We also found the slip rates on the approximately WE-SN trending gently-dipping detachment fault vary from 1.―1. mm/a for the southwest Tianshan Mountains to 2―5 mm/a for the eastern Tianshan Mountains, and to 6―1. mm/a for the Kyrgrz Tianshan. The GPS velocity field reveals that the total convergence is not uniformly distributed across the Tianshan Mountains, with 80%―90% of the N-S shortening absorbed along the southern and northern edges, and relatively little deformation accommodated within the interior. This first-order feature of strain pattern is explained best by underthrusting of adjacent blocks beneath the Tianshan Mountains along a basal detachment fault. We found the occurrence of historical M7―8 earthquakes somewhere in the locked ramp that connects the creeping and locking segments of the detachment, thereby resulting in elastic strain concentration and accumulation around it. The elastic strain confined in the upper crustal layer above the detachment ultimately releases through infrequent great earthquakes in the Tianshan Mountains, resulting in considerable folding and faulting at their margins. The Tianshan Mountains propagated outward and rose progressively as a wedge-shaped block.

关键词： Tianshan Mountains GPS slip rates tectonic deformation

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The In-Flight Realtime Trigger and Localization Software of GECAM

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research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong Xiang-{1. Wen Xin-qiao li Ce Cai Shuo Xiao qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-qiu Zhang Yue Huang Lu li Xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-li Shi Peng Zhang qi-Bin Yi Chao-{1. li Yan-Bing Xu Xiao-Hua liang Ya-qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng {1. Xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao {1. Dong-jie Hou Yu-Sa wang Rui qiao Xiang Ma Xiao-Bo li Ping wang Xin-Ying Song li-Ming Song Shi-jie Zheng Bing li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan {1. Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei {1. Xue-Juan {1. Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of {1.s Chinese Academy of SciencesBeijing 100049China School of Information science and {1. Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and space {1. College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of {1. and technology Changchun 130022China Chinese Academy of sciences South America {1. for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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青藏高原典型沙地地表反射率光谱特征与星地验证

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光谱学与光谱分析 2024年第11期44卷 3228-3235页

作者：刘勇许华李莉纪山王博林罗杰李凯涛郑杨伽丽丽江启峰李正强西华大学航空航天学院智能空地融合载具及管控教育部工程研究中心西华大学流体及动力机械教育部重点实验室中国科学院空天信息创新研究院国家环境保护卫星遥感重点实验室遥感科学国家重点实验室 31.02部队航天工程大学航天信息学院

测量地表反射率对研究地物光谱特征以及卫星地表产品检验具有重要意义。利用地物光谱仪获得青藏高原阿里地区的沙地地表反射率，并研究分析其典型光谱特征。针对Terra和Aqua卫星的中分辨率成像光谱仪(MODIS)的地表反射率产品(MOD09/MYD... 详细信息

测量地表反射率对研究地物光谱特征以及卫星地表产品检验具有重要意义。利用地物光谱仪获得青藏高原阿里地区的沙地地表反射率，并研究分析其典型光谱特征。针对Terra和Aqua卫星的中分辨率成像光谱仪(MODIS)的地表反射率产品(MOD09/MYD09)和地表反照率产品(MCD43 A4)开展真实性检验和误差影响分析。结果表明，阿里地区戈壁具有典型沙地光谱特征，各波段的地表反射率数值在0.08～0.35之间，在300～700 nm光谱范围的地表反射率随波长增大而增加，而在750～1.750 nm光谱范围的地表反射率变化较小。与我国敦煌辐射校正场的沙地反射率相比，光谱曲线相似度很高，光谱夹角为2.1.°。星地对比的结果受观测几何和大气光照条件的影响，下午星Aqua产品验证效果优于上午星Terra,平均误差约为5%,这与MODIS官方标称的精度相一致。研究表明，阿里地区沙地的光谱特征稳定且有代表性，是我国光学卫星在轨辐射定标和检验的理想场地。

关键词：地表反射率沙地光谱真实性检验 MODIS地表产品

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Impact of backwater on water surface profile in curved channels

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Water science and Engineering 2023年第3期16卷 295-301页

作者： Rui-hua Nie qi-hang Zhou Wen-{1. li Xing-nian liu Gang Xie Lu wang State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu 610065China National Engineering research {1. for Inland Waterway Regulation Chongqing Jiaotong UniversityChongqing 400074China china Institute of Water Resources and Hydropower {1. Beijing 100048China

Owing to extensive construction of dams, the impact of backwater on flow may lead to navigation or flood control issues in curved channels. To date, the impact of backwater on the water surface profile in curved channels remains unknown and requires investigation. In this study, experiments were conducted in a glass-walled recirculating flume with a length of 1..4 m, a width of 0.6 m, and a depth of 0.8 m, and the impact of backwater on the water surface profile in a 90° channel bend was investigated. The experimental results showed that the backwater degree had a significant impact on the transverse and longitudinal flow depth distributions in the bend. The transverse slope of the flow (Jr) increased linearly with an increase in the Froude number of the approach flow upstream of the bend. Jr increased with the longitudinal location parameter ξ when −0.2 1.. Furthermore, the results showed that Jr asymptotically decreased to zero with an increase in the degree of backwater. An equation was formulated to estimate the transverse slope of the flow in a 90° bend in backwater zones.

关键词： Backwater Curved channel Experimental model Transverse slope Water surface profile

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Seamless maps of major elements of the Moon:Results from high-resolution geostationary satellite

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research in Astronomy and Astrophysics 2021年第2期21卷 52-60页

作者： Yu Lu Yun-Zhao Wu Cui li Jin-Song Ma Wen-Wen qi Wei Tan Xiao-Man li Zhi-Cheng Shi Hong-Yan He Shu-Wu Dai Guo li Feng-Jing liu Jing-qiao wang Xiao-Yan wang qi wang ling-jie Meng Key Laboratory of Planetary sciences Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and space {1. University of Science and Technology of ChinaHefei 230026China CAS center for Excellence in Comparative Planetology Hefei 230026China space {1. Institute Macao University of Science and TechnologyMacaoChina School of Geography and Ocean science Nanjing UniversityNanjing 210023China Jiangsu center for Collaborative Innovation in Geographical Information Resource Development and App{1.cation Nanjing 210023China Beijing Institute of space Mechanics and Electricity Beijing 100076China Beijing Institute of spacecraft System Engineering Beijing 100076China china Centre for Resources Satel{1.te Data and App{1.cation Beijing 100094China Earth Observation System and Data center China National Space AdministrationBeijing 100010China

Major elements such as Fe,Ti,Mg,Al,Ca and Si play very important roles in understanding the origin and evolution of the *** maps of these major elements derived from orbital data are based on mosaic images or low-resolution gamma-ray *** hue variations and gaps among orbital boundaries in the mosaic images are not conducive to geological *** paper aims to produce seamless and homogenous distribution maps of major elements using the single-exposure image of the whole lunar disk obtained by china’s high-resolution geostationary satel{1.te,Gaofen-4,with a spatial resolution of500 *** elemental contents of soil samples returned by Apollo and Luna missions are regarded as ground truth,and are correlated with the reflectance of the samp{1.ng sites extracted from Gaofen-4 *** final distribution maps of these major oxides are generated with the statistical regression *** these products,the average contents and proportions of the major elements for maria and highlands were estimated and *** results showed that Si O2 and Ti O2 have the highest and lowest fractions in mare and highland areas,***,the relative concentrations of these elements could serve as indicators of geologic processes,e.g.,the obviously asymmetric distributions of Al2 O3,Ca O and Si O2 around Tycho crater may suggest that Tycho crater was formed by an ob{1.que impact from the southwest direction.

关键词： Moon-Data analysis-Imaging spectroscopy

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The first all-season sample set for mapping global land cover with Landsat-8 data

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science Bulletin 2017年第7期62卷 508-515页

作者： Congcong li Peng Gong jie wang Zhiliang Zhu Gregory S. Biging Cui Yuan Tengyun Hu Haiying Zhang qi wang Xuecao li Xiaoxuan liu Yidi Xu Jing Guo Caixia liu Kwame O. Hackman Meinan Zhang Yuqi Cheng Le Yu Jun yang Huabing Huang Nicholas Clinton Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System Science Tsinghua University Beijing 100084 China Department of Environmental science Policy and Management University of California Berkeley. CA 94720-3J 14 USA Joint center for Global Change Studies Beijing 100875 China State Key Laboratory of Remote Sensing science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100101 China United States Geological Survey Restan VA 20192 USA Ministry of Education Key Laboratory for Geospatial technology for the Middle and Lower Yellow River Regions College of Environment and Planning Henan University Kaifeng 475004 China Googie Inc. 1600 Amphitheatre Pkwy. Mountain View CA 94042 USA

We report the world's first all-season training and validation sample sets for global land cover classification with Landsat-8 *** to this,such samples were only available at a single date primarily from the growing *** is unknown how much limitation such a single-date sample has to mapping global land cover in other seasons of the *** answer this question,we selected available Landsat-8 images from four seasons and collected training and validation samples from *** compared the performances of training samples in different seasons using Random Forest *** found that the use of training samples from any individual season would result in the best overall classification accuracy when validated by samples in the same *** global overall accuracy from combined best seasonal results was 67.2% when classifying the 1. Level-1.classes in the Finer Resolution Observation and Monitoring of Global Land Cover(FROM-GLC) classification *** use of training samples from all seasons(named all-season training sample set hereafter) produced an overall accuracy of 67.0%.We also tested classification within 1.° latitude 60° longitude zones using all-season training subsample within each zone and obtained an overall accuracy of 70.2%.This indicates that properly grouped subsamples in space can help improve classification *** the results in this study seem to suggest that it is possible to use an all-season training sample set to reach global optimality with universal applicability in classifying images acquired at any time of a year for global land cover mapping.

关键词： Training sample Validation Latitudinal zones Anytime Anywhere

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong li Ruo-Yu liu Ruizhi yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of {1.s Beijing 100049China TIANFU Cosmic Ray research {1. ChengduChina Institute of Frontier and Interdisciplinary {1. Shandong UniversityQingdao 266237China School of Astronomy and space {1. Nanjing UniversityNanjing 210023China university of {1. and technology of china Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 1.0deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 1. PeV.A log-parabola form with the photon indexΓ(E)=(2.71.0.02)+(0.1.±0.02)×log1.(E/1. TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1.*** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

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Evidence for particle acceleration approaching PeV energies in the W51.complex

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science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAASO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao J.Chang J.F.Chang A.M.Chen E.S.Chen H.X.Chen liang Chen lin Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan J.H.Fan Y.Z.Fan J.Fang J.H.Fang K.Fang C.F.Feng H.Feng L.Feng S.H.Feng X.T.Feng Y.Feng Y.L.Feng S.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He J.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu S.C.Hu D.H.Huang T.Q.Huang W.J.Huang X.T.Huang X.Y.Huang Y.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang X.W.Jiang Z.J.Jiang M.Jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.li C.M.li Cheng li Cong li D.li F.li H.B.li H.C.li Jian li jie li K.li S.D.li W.L.li W.L.li X.R.li Xin li Y.Z.li Zhe li Zhuo li E.W.liang Y.F.liang S.J.lin B.liu C.liu D.liu D.B.liu H.liu H.D.liu J.liu J.L.liu M.Y.liu R.Y.liu S.M.liu W.liu Y.liu Y.N.liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma J.R.Mao Z.Min W.Mitthumsiri H.J.Mu Y.C.Nan A.Neronov L.J.Ou P.Pattarakijwanich Z.Y.Pei J.C.qi M.Y.qi B.Q.qiao J.J.qin A.Raza D.Ruffolo A.Sáiz M.Saeed D.Semikoz L.Shao O.Shchegolev X.D.Sheng F.W.Shu H.C.Song Yu.V.Stenkin V.Stepanov Y.Su D.X.Sun Q.N.Sun X.N.Sun Z.B.Sun J.Takata P.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian C.wang C.B.wang G.W.wang H.G.wang H.H.wang J.C.wang Kai wang Kai wang L.P.wang L.Y.wang P.H.wang R.wang W.wang X.G.wang X.Y.wang Y.wang Y.D.wang Y.J.wang Z.H.wang Z.X.wang Zhen wang Zheng wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu Q.W.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan J.Z.Yan T.Yan C.W.yang C.Y.yang F.yang F.F.yang L.L.yang M.J.yang R.Z.yang W.X.yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of {1.s Beijing 100049China TIANFU Cosmic Ray research {1. ChengduChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany School of Physical science and {1.&School of Information science and {1. Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and space {1. Nanjing UniversityNanjing 210023China center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear research of Russian Academy of {1.s Moscow 117312Russia Hebei Normal university Shijiazhuang 050024China university of {1. and technology of china Hefei 230026China State Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China research {1. for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet university) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary {1. Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51.complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(SNR)W51. and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51. for CRs remains *** on observations conducted with the Large High Altitude Air Shower Observatory(LHAASO),we report a significant detection ofγrays emanating from the W51.complex,with energies from 2 to 200 *** LHAASO measurements,for the first time,extend theγ-ray emission from the W51.complex beyond 1.0 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51.region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of SNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51. could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51.complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays SNR W51. Star clusters

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GCH1.variants contribute to the risk and earlier age-at-onset of Parkinson's disease:a two-cohort case-control study

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Translational Neurodegeneration 2020年第3期9卷 409-420页

作者： Hong-xu Pan Yu-wen Zhao Jun-pu Mei Zheng-huan Fang Yige wang Xun Zhou {1.-jie Zhou Rui Zhang Kai-lin Zhang li Jiang qian Zeng Yan He Zheng wang Zhen-hua liu qian Xu qi-ying Sun {1. {1. Ya-cen Hu Ya-se Chen Juan Du li-fang Lei Hai-nan Zhang Chun-yu wang Xin-xiang Yan Lu Shen Hong Jiang jie-qiong Tan Jin-chen li Bei-sha Tang Ji-feng Guo Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical {1. center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Centre for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Department of Geriatrics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangsha 410011China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China

Background:Common and rare variants of guanosine triphosphate cyclohydrolase 1.GCH1.gene may play important roles in Parkinson's disease(PD).However,there is a lack of comprehensive analysis of GCH1.genotypes,especially in non-coding *** aim of this study was to explore the genetic characteristics of GCH1.including rare and common variants in coding and non-coding regions,in a large population of PD patients in Chinese mainland,as well as the phenotypic characteristics of GCH1.variant ***:In the first cohort of this case-control study,we performed whole-exome sequencing in 1.55 patients with early-onset or familial PD and 2234 healthy controls;then in the second cohort,whole-genome sequencing was performed in sporadic late-onset PD samples(1.62 patients),as well as 1.79 *** at target GCH1.regions were extracted,and then genetic and detailed phenotypic data were analyzed using regression models and the sequence kernel association *** also performed a meta-analysis to correlate deleterious GCH1.variants with age at onset(AAO)in PD ***:For coding variants,we identified a significant burden of GCH1.deleterious variants in early-onset or familial PD cases compared to controls(1.2%VS 0.1.,P1..In the analysis of possible regulatory variants in GCH1.non-coding regions,rs1.323905(P=0.001.odds ratio=1.1.,95%CI 1.07-1.32)was significantly associated with PD,and variant sets in untranslated regions and intron regions,GCH1.brain-specific expression quantitative trait loci,and two possible promoter/enhancer(GH1.J054857 and GH1.J054880)were suggestively associated with *** phenotype correlation analysis revealed that the carriers of GCH1.deleterious variants manifested younger AAO(P1.,and had milder motor symptoms,milder fatigue symptoms and more autonomic nervous ***-analysis of six studies demonstrated 6.4-year earlier onset in GCH1.deleterious variant carriers(P=0.0009).Conclusions:The results

关键词： Parkinson's disease Age at onset GCH1 Deleterious variants Non-coding variants

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Probing star formation and feedback using CCOSMA and archival data in the CFG028.68–0.28 quasi-sinusoidal filament

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research in Astronomy and Astrophysics 2019年第12期19卷 305-317页

作者： Jin-Long Xu Jirgen Stutzki Yuefang Wu Xin Guan Jun-jie {1. M.Miller yang Chen Sheng-li qin Jun-Zhi {1. Chang-Chun Ning Danzengluobu Tian-Lu Chen Nai-Ping Yu Chuan-Peng Zhang Xiao-Lan liu Jian-Bin L Karl Jacobs Urs UGraf Gang Xu Nan li Guo-Yin Zhang and qi Wu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China I.Physikalisches Institut Universitat zu KolnZilpicher Str.7750937 KolnGermany Department of Astronomy Peking UniversityBeijing 100871China School of Astronomy and space {1. Nanjing UniversityNanjing 210023China Department of Astronomy Yunnan Universityand Key Laboratory of Astroparticle Physics of Yunnan ProvinceKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Tibet university LhasaTibet 850000China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China NAOC-TU Joint center for Astrophysics Lhasa 850000China

We have performed a multi-wavelength study toward a quasi-sinusoidal filament(CFG028.68–0.28). A new large-scale ^1.CO J = 3-2 map was obtained from the china-Cologne Observation for Sub Mil{1.meter Astronomy(CCOSMA) 3m radio telescope. Based on the ATLASGAL catalog, we have identified 27 dust clumps in the filament. Through the relationship between the mass and radius of these clumps, 67% of these clumps are dense and massive enough to potentially form massive stars. The obtained CFE is ~1.% in the filament. The filament has a {1.near mass density of ~305 M⊙pc^-1. which is smaller than its critical mass to length ratio. This suggests that the external pressure from the neighboring H Ⅱ regions may help prevent the filament from dispersing under the effects of turbulence. Comparing the energy injection from outflows and H Ⅱ regions in the filament, the ionization feedback from the H Ⅱ regions can help maintain the observed turbulence.

关键词： stars:formation stars:early-type ISM:HⅡregions ISM:individual(CFG028.68-0.28,IRDC G28.53-0.25,and N49)

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