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Postoperative recovery from posterior communicating aneurysm complicated by oculomotor palsy

Chinese Medical Journal 2008年第12期121卷 1065-1067页

作者： yang ming-qi wang shuo zhao yuan-li zhang dong zhao ji-zong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Oculomotor palsy is a common complication in patients with posterior communicating aneurysm. This study was conducted to investigate the postoperative recovery of patients with posterior communicating aneurysm complicated with oculomotor palsy and to analyze the factors influencing length of recovery.Methods From 2000 to 2006, 148 patients with posterior communicating aneurysm were treated at our hospital, with 74 of them having concurrent unilateral oculomotor palsy. All of the patients underwent craniotomy after the diagnosis by means of whole-brain digital subtraction angiography （DSA）. The patients were divided into two groups for observation of postoperative recovery during the follow-up period. Patients in group A were treated with simple pedicle clipping of the aneurysm while patients in group B were treated with pedicle clipping of the aneurysm and decompression of the oculomotor nerve.Results Of the 40 patients in group A, 20 underwent surgery within 14 days and completely recovered from oculomotor palsy in 10-40 days. Fourteen patients underwent surgery within 14-30 days, of whom 12 completely recovered within 30-90 days and 2 cases recovered incompletely. The remaining six patients underwent surgery after more than 30 days; of these, four patients recovered completely and two recovered incompletely. Of the 34 cases in group B, 15 underwent surgery within 14 days and completely recovered from oculomotor palsy in 10-40 days. Sixteen patients underwent surgery in 14-30 days, of whom 14 completely recovered in 30-90 days and 2 recovered incompletely. The remaining three patients underwent surgery after more than 30 days, of whom two patients recovered completely and one recovered incompletely.Conclusions Early diagnosis and surgical treatment of patients with unilateral oculomotor palsy induced by posterior communicating aneurysm are important to full postoperative recovery of the oculomotor nerve. No correlation was found, however, between d

关键词： oculomotor palsy cerebral angiography intracranial aneurysm

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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue liN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG zhao-hui qiU Xiao-tang wang Mei li qing-bo li Shan-shan wang Shi-dong DAI Fang liU Zhen-jie zhao ling WEN jian-xuan WU li-yan ZENG Hui-yan zhang jin-ming LU qi-yun HE liu SONG Wei SUN Lu LUO Lu-lu HE jia-li XIE Wen-wen liANG qing-shun HUANG yuan ZHU Sheng-ling LONG jie-er GAO Zhi-juan WEN Ze-huai li Chun-ji OUyang Wen-wei li Geng WU ming-hui li An-xiang HUANG jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen ji-yuan Chen Kai Chen Mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jiNR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Identification of genetic loci for grain yield-related traits in the wheat population Zhongmai 578/jimai 22

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Journal of Integrative Agriculture 2023年第7期22卷 1985-1999页

作者： liU Dan zhao De-hui ZENG jian-qi Rabiu Sani SHAWAI TONG jing-yang li ming li Fa-ji ZHOU shuo HU Wen-li XIA Xian-chun TIAN Yu-bing ZHU qian wang Chun-ping wang De-sen HE Zhong-hu liU jin-dong zhang Yong Institute of Crop Sciences National Wheat Improvement CenterChinese Academy of Agricultural Sciences(CAAS)Beijing 100081P.R.China College of Agriculture Henan University of Science&TechnologyLuoyang 471000P.R.China Department of Crop Science Faculty of Agriculture and Agricultural TechnologyAliko Dangote University of Science and Technology WudilKano 713281Nigeria Crop Research Institute Shandong Academy of Agricultural SciencesJinan 250100P.R.China Institute of Biotechnology and Food Science Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051P.R.China Gaoyi Stock Seed Station Shijiazhuang 053110P.R.China Shangqiu Academy of Agricultural and Forestry Sciences Shangqiu 476000P.R.China International Maize and Wheat Improvement Center(CIMMYT) China Officec/o CAASBeijing 100081P.R.China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China

The identification of stable quantitative trait locus(QTL)for yield-related traits and tightly linked molecular markers is important for improving wheat grain *** the present study,six yield-related traits in a recombinant inbred line(RIL)population derived from the Zhongmai 578/jimai 22 cross were phenotyped in five *** parents and 262 RILs were genotyped using the wheat 50K single nucleotide polymorphism(SNP)array.A high-density genetic map was constructed with 1501 non-redundant bin markers,spanning 2384.95 ***-three QTLs for six yield-related traits were mapped on chromosomes 1D(2),2A(9),2B(6),2D,3A(2),3B(2),4A(5),4D,5B(8),5D(2),7A(7),7B(3)and 7D(5),which explained 2.7-25.5%of the phenotypic *** the 53 QTLs,23 were detected in at least three environments,including seven for thousand-kernel weight(TKW),four for kernel length(KL),four for kernel width(KW),three for average grain filling rate(GFR),one for kernel number per spike(KNS)and four for plant height(PH).The stable QTLs ***-2A.1,***-7D,***-7D,***-2B.1,***-4A,***-7A and ***-2A.1 are likely to be new *** QTL-rich regions on 2A,2B,4A,5B,7A and 7D,showed pleiotropic effects on various yield ***2-2B and WAPO-A1 are potential candidate genes for the pleiotropic regions on 2B and 7A,*** pleiotropic QTL on 7D for TKW,KL,KW and PH was verified in a natural *** results of this study enrich our knowledge of the genetic basis underlying yield-related traits and provide molecular markers for high-yield wheat breeding.

关键词： grain yield KASP marker QTL mapping SNP chip

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The Experts Consensus for Patient Management of Neurosurgical Critical Care Unit in China （2015）

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Chinese Medical Journal 2015年第9期128卷 1252-1267页

作者： zhao, ji-zong Zhou, Ding-Biao Zhou, liang-Fu wang, Ren-Zhi zhang, jian-Ning wang, shuo li, Xin-Gang Hua-Feng liu, jian jiang, jiyao zhang, Sai zhang, Jun-Ting zhang, jian-Min Hou, lijun Hong, Tao yuan, Xian-Rui Gao, Guo-dong Kang, De-Zhi You, Chao Bao, Shengde qi, Song-Tao zhao, Shi-Guang zhao, yuan-li Hu, jin Cui, li-ying Peng, Bin liu, Da-Wei Guo, Shu-Bin lin, yuan-Xiang Sun, Shi-Zhong Gao, liang jiang, Rong-Cai Shi, Guang-Zhi Chai, Wen-zhao wang, Ning zhao, yuan-li Wei, Jun-ji China Neurosurgical Critical Care Specialist Counc

INTRODUCTION Great changes have taken place in modern neurosurgery in the past *** models of management for complex neurosurgical patients have been developed in China as the specialty evolving,thus arise many *** demand calls for an expert consensus on neurosurgical inpatients management,especially for the subspecialty of neurosciences critical care （NCC）.

关键词： Experts Consensus Multidisciplinary Neurosurgical Critical Care Patient Management Standardization

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Application of Keyhole Microneurosurgery in China

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Chinese Medical Journal 2017年第16期130卷 1987-1994页

作者： li-Gang Chen Shu-Da Chen Guang-Fu Huang Ying Huang De-Zhi Kang qing Lan Gang li Xin-Gang li Zhi-Xiong liu Song-Tao qi Xin-Hua Tian Guo-liang wang shuo wang Xiang-Yu wang Yong-Fei wang Yun-jie wang Chao You Yan-Bing Yu Shu-yuan Yue dong zhang jian-Min zhang jian-Ning zhang Jun-Ting zhang Shi-Zhong zhang Xian zhang Ya-Zhuo zhang ji-zong zhao Wei-Guo zhao yuan-li zhao Ding-Biao Zhou liang-Fu Zhou Department of Neurosurgery The Affiliated Hospital of Southwest Medical University Luzhou Sichuan 646000 China Department of Neurosurgery Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China Department of Neurosurgery Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Neurosurgery Tianjin Huanhu Hospital Tianjin 300060 China Department of Neurosurgery The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 350005 China Department of Neurosurgery The Second Affiliated Hospital of Soochow University Suzhou Jiangsu 215004 China Department of Neurosurgery Qilu Hospital of Shandong University Jinan Shandong 250012 China Department of Neurosurgery Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Neurosurgery Nanfang Hospital of Southern Medical University Guangzhou Guangdong 510515 China Department of Neurosurgery The Affiliated Zhongshan Hospital of Xiamen University Xiamen Fujian 361004 China Department of Neurosurgery General Hospital of Guangzhou Military Command of PLA Guangzhou Guangdong 510010 China Department of Neurosurgery The Affiliated Beijing Tiantan Hospital of Capital Medical University Beijing 100050 China Department of Neurosurgery The First Affiliated Hospital of Jinan University Guangzhou Guangdong 510630 China Department of Neurosurgery The Affiliated Huashan Hospital of Fudan University Shanghai 200040 China Department of Neurosurgery The First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Neurosurgery West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Neurosurgery Sino-Japanese Friendship Hospital Beijing 100029 China Department of Neurosurgery General Hospital of Tianjin Medical University Tianjin 300052 China Department of Neurosurgery The Second Affiliated Hospital of Zhejiang University Medical College Hangzhou Zhejiang 310009 China Department of

INTRODUCTIONMicroneurosurgery made its debut in the early 1960s. It became popular in the medical field and became a primary operation method in neurosurgery since it improved the efficacy of neurosurgery with a less surgery-related injury. Over the past five decades, the accumulation of experience of microsurgery, improvement of microsurgery techniques, refined micro-instruments, and advanced preoperative diagnostic imaging allowed the evolution of microneurosurgery techniques and further reduced surgery-related trauma.

关键词： China: Keyhole Surgery Microneurosurgery

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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng zhao dong li Shao-lin Xiong Yan-qiu zhang yang Su Wei Chen Yi zhao Xiao-Bo li jia-Cong liu Wen-Xi Peng Rui qiao Xin-qiao li Xiang-yang Wen li-ming Song Shi-jie Zheng Xin-Ying Song Xiao-Yun zhao Yue Huang Shuang-Nan zhang shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen Yan-qi Du Min Gao Ke Gong dong-Ya Guo Zhi-Wei Guo jian-jian He Bin li Chao li Chao-yang li Gang li jian-Hui li Lu li qing-Xin li Yan-Guo li jing liang Xiao-Hua liang jin-yuan liao Xiao-jing liu Ya-qing liu qi Luo Xiang Ma Bin Meng Ge Ou dong-li Shi jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo Chen-Wei wang Hui wang jin wang jin-Zhou wang Ping wang Wen-Shuai wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu wang-Chen Xue Sheng yang Min Yao jian-Ying Ye qi-Bin Yi Chao-Yue zhang Da-li zhang Fan zhang Fei zhang Hong-Mei zhang Kai zhang Peng zhang Xiao-Lu zhang Zhen zhang Guo-Ying zhao Shi-Yi zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

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Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

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Bioactive Materials 2022年第11期7卷 81-108页

作者： Sheng-Long Ding Xin liu Xi-yuan zhao Ke-Tao wang Wei Xiong Zi-li Gao Cheng-Yi Sun Min-Xuan jia Cheng li qi Gu ming-Zhu zhang Center of Foot and Ankle Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing100730China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China Beijing Institute for Stem Cell and Regeneration University of Chinese Academy of SciencesBeijing100101China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijing100083China

Successful regeneration of cartilage tissue at a clinical scale has been a tremendous challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery, have been studied broadly across a wide range of medical fields, especially the cartilage tissue engineering (TE). Notably, microcarrier systems provide an attractive method for regulating cell phenotype and microtissue maturations, they also serve as powerful injectable carriers and are combined with new technologies for cartilage regeneration. In this review, we introduced the typical methods to fabricate various types of microcarriers and discussed the appropriate ma-terials for microcarriers. Furthermore, we highlighted recent progress of applications and general design prin-ciple for microcarriers. Finally, we summarized the current challenges and promising prospects of microcarrier-based systems for medical applications. Overall, this review provides comprehensive and systematic guidelines for the rational design and applications of microcarriers in cartilage TE.

关键词： Cartilage tissue engineering Cartilage regeneration Microcarriers Cargo delivery Bioprinting

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儿童期颅内动脉瘤的诊断及治疗

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中华医学杂志 2010年第15期90卷 1032-1034页

作者：杨明琪王硕赵元立张东赵继宗首都医科大学附属北京天坛医院神经外科 100050

目的描述儿童颅内动脉瘤的临床特点，评价不同治疗方法对儿童颅内动脉瘤的疗效和安全性。方法总结北京天坛医院1990年1月至2008年12月诊治的23例儿童颅内动脉瘤病例的临床资料，其中男16例，女7例，年龄3～15例。观察手术组16例和电解... 详细信息

目的描述儿童颅内动脉瘤的临床特点，评价不同治疗方法对儿童颅内动脉瘤的疗效和安全性。方法总结北京天坛医院1990年1月至2008年12月诊治的23例儿童颅内动脉瘤病例的临床资料，其中男16例，女7例，年龄3～15例。观察手术组16例和电解可脱性微弹簧栓塞术（GDC），5例的疗效。全部病例中有2例未做进一步的治疗。结果手术治疗组中15例恢复良好，1例死亡；GDC治疗组中1例栓塞成功，术后恢复良好；2例栓塞治疗后动脉瘤有残留，1例行动脉瘤孤立切除术，术后死亡。1例行瘤颈夹闭动脉瘤切除术，恢复良好；2例介入治疗后动脉瘤再通，其中1例二次行栓塞治疗后再通，经手术切除动脉瘤后恢复良好。结论显微手术治疗儿童颅内动脉瘤是安全有效的，GDC对急性出血的儿童颅内动脉瘤的治疗也是安全的，但需长期随访观察其疗效，如有动脉瘤残留或再通者，建议行显微手术治疗。

关键词：颅内动脉瘤电解可脱性微弹簧栓塞术儿童

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Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)

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Journal of Geriatric Cardiology 2021年第4期18卷 261-270页

作者： Yu-qi liU Dan-Dan li Meng CHAI Hong-liang CONG Xiao-qiang CONG Jun DAI Rong-Pin DU ming GAO jin-Cheng GUO Yan-qing GUO Xiao-jian HONG Rong-Chong HUANG Feng-Shun jiA jia-Yu li qing li jia-Mei liU Xin-Ping liU Yu-Guo liU Hong-Gang NIE Bing SHAO Xiao-Yu SHEN Hai-qing SONG Yi-Jun SONG li-Jun wang shuo wang dong-Mei WU jing XIA Zhi-Yong yang Hong-Ying YU Hui zhang Tie-Mei zhang ji-Yi zhao liang-Chen zhao ming-qi ZHENG Yun-Dai CHEN Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Department of Cardiology Tianjin Chest HospitalTianjinChina Department of Cardiology the First Hospital of Jilin UniversityChangchunChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Hebei People’s HospitalShijiazhuangChina Department of Cardiology Kailuan General HospitalHebei Union UniversityTangshanChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Tangshan Worker’s HospitalTangshanChina Department of Cardiology China-Japan Friendship Hospital Affiliated Jilin UniversityChangchunChina Department of Cardiology Handan Central HospitalHebeiChina Heart Center Beijing Key Laboratory of HypertensionBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Department of Cardiology the First Affiliated Hospital of Dalian Medical UniversityLiaoningChina Department of Cardiology the Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospital of Shenyang Medical CollegeShenyangChina Department of Cardiology the Second Hospital of Shanxi Medical UniversityTaiyuanChina Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurology Tianjin Medical University Gen

BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for *** In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real

关键词： LDL RWE-PCSK study Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high r

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