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Identification of fangchinoline as a broad-spectrum enterovirus inhibitor through reporter virus based high-content screening

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Virologica Sinica 2024年第2期39卷 301-308页

作者： Qiu-Yan zhang Jia-Qi Li Qi Li yang zhang Zhe-Rui zhang Xiao-Dan Li Hong-Qing zhang Cheng-Lin Deng Feng-Xia yang Yi xu Bo zhang The Joint Center of Translational Precision Medicine Department of Infections and DiseasesGuangzhou Institute of PediatricsGuangzhou Women and Children's Medical CenterGuangzhou510623China key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Science and Technology of china Department of Life Sciences and MedicineHefei230026China Hunan Normal University School of MedicineChangsha410081China

Hand,foot,and mouth disease(HFMD)is a common pediatric illness mainly caused by enteroviruses,which are important human ***,there are no available antiviral agents for the therapy of enterovirus *** this study,an excellent high-content antiviral screening system utilizing the EV-A71-eGFP reporter virus was *** this screening system,we screened a drug library containing 1042.natural compounds to identify potential EV-A71 ***(FAN),a bis-benzylisoquinoline alkaloid,exhibits potential inhibitory effects against various enteroviruses that cause HFMD,such as EV-A71,CV-A10,CV-B3 and *** investigations revealed that FAN targets the early stage of the enterovirus life *** the selection of FAN-resistant EV-A71 viruses,we demonstrated that the VP1 protein could be a potential target of FAN,as two mutations in VP1(E145G and V2.8I)resulted in viral resistance to *** research suggests that FAN is an efficient inhibitor of EV-A71 and has the potential to be a broad-spectrum antiviral drug against human enteroviruses.

关键词： Hand,foot,and mouth disease(HFMD) Enterovirus EV-A71 High-content screening Fangchinoline(FAN)

Experimental Analysis of Shear Strength of Undisturbed Soil in Leucaena Forest in Jiangjia Ravine,Yunnan,china

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Journal of Mountain Science 2010年第4期7卷 386-395页

作者： JIAO Zhen key Laboratory of Mountain Hazards and earth surfaceprocesses ChineseAcademy of Sciences Chengdu 610041 China Graduate University of chineseacademy of {2. Beijing I ooo49 China institute of Mountain Hazards and Environment Chinese Academy of Science Chengdu 61oo41 China

Five leucaena trees of similar age were chosen in Jiangjia Ravine of Dongchuan,Yunnan Province,china,near which the soil samples were collected by digging profiles 2. in depth and 1m in *** each section,soil samples at different depths were taken for direct shear experiments to determine the root amount and mechanical *** is found that the cohesion and internal friction angle of the undisturbed soil are related to the root amount,depth,clay content and breccias *** correlates negatively with root content,a finding that differs from that of other *** addition,internal friction angle correlates positively with all these factors.

关键词： Jiangjia Ravine Leucaena Undisturbedsoil Shear strength Impact factors

Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-yang Wu Hui-Hui Fang Yan-Wu xu Yan-Ling {2. Shao-Chong {2. Wei-Hua yang Shenzhen Eye institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2.13 to December 31,2.2. from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 412. *** 2.13 and 2.2.,{2. had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=2.9)and the highest H-index(33).Ophthalmology is the main category in related *** from 2.2. to 2.2. highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and chinese institutions have the strongest academic influence in the field from 2.13 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

Intelligent Recognition Using Ultralight Multifunctional Nano‑Layered Carbon Aerogel Sensors with Human‑Like Tactile Perception

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Nano-Micro Letters 2024年第1期16卷 172-186页

作者： Huiqi Zhao Yizheng zhang lei Han Weiqi Qian Jiabin Wang Heting Wu Jingchen Li Yuan Dai Zhengyou zhang Chris RBowen Ya {2. CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro‑Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400People’s Republic of China Tencent Robotics X Shenzhen 518054People’s Republic of China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Mechanical engineering University of BathBath BA27AKUK Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004People’s Republic of China

Humans can perceive our complex world through multi-sensory *** limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and ***,replicating this unique capability in robots remains a significant ***,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object *** sensor exhibits human-like pressure(0.04–100 kPa)and temperature(2..5–66.2.)detection,millisecond response times(11 ms),a pressure sensitivity of 92.2. kPa^(−1)and triboelectric durability of over 6000 *** devised algorithm has universality and can accommodate a range of application *** tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%*** sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.

关键词： Multifunctional sensor Tactile perception Multimodal machine learning algorithms Universal tactile system Intelligent object recognition

Study on Catalytic Behavior of Iron-based Catalyst with IITP as Electron Donor in the Polymerization of Butadiene

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chinese Journal of Polymer Science 2024年第5期42卷 612-619,I0007页

作者： Shi-Liang xu Ying-Nan Zhao Yao Yu Qi yang Li-Hua Na Heng Liu Chun-Yu {2. xue-Quan {2. key Laboratory of Advanced Rubber Material Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China Shandong Provincial College Laboratory of Rubber Material and engineering School of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China key Lab of Rubber-Plastics Ministry of Education/Shandong Provincial Key Lab of Rubber-plasticsSchool of Polymer Science and EngineeringQingdao University of Science&TechnologyQingdao266042China

In this study,a novel iron-based catalyst system,Fe(acac)3/(isocyanoimino)triptenylphosphorane(IITP)/AlR3,was employed for the synthesis of syndiotactic 1,2.polybutadiene in *** catalyst system exhibits remarkably high catalytic activity,achieving a polymerization activity of 762.kgpolymer·molcatalyst^(-1)·h^(-1)at 50℃with a[BD]/[Fe]molar ratio of ***,living polymerization characteristic were observed during the investigation of the polymerization kinetics of 1,3-butadiene *** characteristics were well demonstrated by a narrow molecular weight distribution(PDI≈2.0)of the resulting polybutadiene and a linear relationship between-ln(1-c)and polymerization time as well as number average molecular weight and polymer *** resultant polymer showed a 1,2.selectivity of approximately 76%and stereoregularity ranging from 62.to 73%(rrrr).Additionally,through kinetic studies on polymerization reaction,an apparent activation energy Ea value of this catalytic system was calculated to be 84.98 kJ·mol^(-1),which suggests that high polymerization temperature favors efficient polymerization.

关键词： Iron catalyst Syndiotactic 1,2.polybutadiene Elastomers Donor Selectivity

Enhancing efficiency and stability of organic solar cells through a simplified four-step synthesis of fully non-fused ring electron acceptor

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Journal of Energy Chemistry 2024年第6期93卷 601-608,I0015页

作者： Chenyang Han Huanhuan Gao Yanna Sun Yuanyuan Kan Zhaozhao Bi Wei Ma Yani zhang Juan Antonio Zapien Yingguo yang ke Gao College of New Energy Xi’an Shiyou UniversityXi’an 710065ShaanxiChina Shandong Provincial key Laboratory for Science of Material Creation and Energy Conversion Institute of Frontier ChemistrySchool of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237ShandongChina State key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Department of Materials Science and engineering City University of Hong KongKowloonHong Kong 99907China School of Microelectronics Fudan UniversityShanghai 200433China

Design and synthesis of superior cost-effective non-fullerene acceptors(NFAs)are still big challenges for facilitating the commercialization of organic solar cells(OSCs),yet to be ***,two medium bandgap fully non-fused ring electron acceptors(NFREAs,medium bandgap,i,e.,1,3-1,8 eV),namely PTR-2.l and PTR-4Cl are synthesized with only four steps by using intramolecular noncovalent interaction central core,structured alkyl side chain orientation linking units and flanking with different electron-withdrawing end *** them,PTR-4C1 exhibits increased average electrostatic potential(ESP)difference with polymer donor,enhanced crystallinity and compactπ-πstacking compared with the control molecule *** a result,the PTR-4Cl-based OSC achieved an impressive power conversion efficiency(PCE)of 14.72.,with a much higher open-circuit voltage(V_(OC))of 0.953 V and significantly improved fill factor(FF)of 0.758,demonstrating one of the best acceptor material in the top-performing fully NFREA-based OSCs with both high PCE and V_(OC).Notably,PTR-4Cl-based cells maintain a good T_80lifetime of its initial PCE after over 936 h under a continuous thermal annealing treatment and over1300 h T_(80)lifetime without *** work provides a cost-effective design strategy for NFREAs on obtaining high V_(OC),efficient exciton dissociation,and ordered molecular packing and thus high-efficiency and stable OSCs.

关键词： Organic solar cells Fully non-fused ring acceptors End group engineering Morphology regulation High efficiency

Inkjet-Printing Controlled Phase Evolution Boosts the Efficiency of Hole Transport Material Free and Carbon-Based CsPbBr_(3) Perovskite Solar Cells Exceeding 9%

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Energy & Environmental Materials 2024年第2期7卷 209-220页

作者： Lihua zhang Shi Chen Jie Zeng Zhengyan Jiang Qian Ai Xianfu zhang Bihua Hu Xingzhu Wang Shihe {2. Baomin xu Department of Materials Science and engineering and Shenzhen engineering Research and Development Center for Flexible Solar Cells Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Henan key Laboratory of Photovoltaic Materials Henan UniversityKaifeng 475004China Guangdong key Lab of Nano-Micro Material Research School of Chemical Biology and BiotechnologyShenzhen Graduate SchoolPeking UniversityShenzhen 518055China key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of Guangdong Southern University of Science and TechnologyShenzhen 518055China Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

Hole transport material free carbon-based all-inorganic CsPbBr_(3)perovskite solar cells(PSCs)are promising for commercialization due to its low-cost,high open-circuit voltage(V_(oc))and superior *** to the different solubility of PbBr_(2.and CsBr in conventional solvents,CsPbBr_(3)films are mainly obtained by multi-step spin-coating through the phase evolution from PbBr_(2.to CsPb_(2.Br_(5)and then to CsPbBr_(3).The scalable fabrication of high-quality CsPbBr_(3)films has been rarely ***,an inkjet-printing method is developed to prepare high-quality CsPbBr_(3)*** formation of long-range crystalline CsPb_(2.Br_(5)phase can effectively improve phase purity and promote regular crystal stacking of CsPbBr_(3).Consequently,the inkjet-printed CsPbBr_(3)C-PSCs realized PCEs up to 9.09%,8.59%and 7.81%with active areas of 0.09,0.2.,and 1 cm^(2.,respectively,demonstrating the upscaling potential of our fabrication method and *** high performance is mainly ascribed to the high purity,strong crystal orientation,reduced surface roughness and lower trap states density of the as-printed CsPbBr_(3)*** work provides insights into the relationship between the phase evolution mechanisms and crystal growth dynamics of cesium lead bromide halide films.

关键词： all-inorganic perovskite solar cells CsPbBr_(3) inkjet-printing phase evolution

Numerical study on local scour characteristics around submarine pipelines in the Yellow River Delta silty sandy soil under waves and currents

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Deep Underground Science and engineering 2024年第2期3卷 182-196页

作者： Peng Yu Ruigeng Hu Jike zhang Qi {2. Jieru Zhao lei Cao Chenghao Zhu key Laboratory of Geological Safety of Coastal Urban Underground Space Ministry of Natural ResourcesQingdaoChina Qingdao Geo-engineering Surveying institute(Qingdao Geological Exploration Development Bureau) QingdaoChina Sinopec Petroleum engineering Corporation DongyingChina State key Laboratory of Hydroscience and engineering Tsinghua UniversityBeijingChina Department Civil and Environmental engineering Politecnico di MilanoMilanItaly College of Environmental Science and engineering Ocean University of ChinaQingdaoChina

Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource *** to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational *** the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference *** volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is *** rationality of the numerical model is verified using a self-built waveflow *** this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is *** results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable *** maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2.As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of *** study can provide a valuable reference for the protection of submarine pipelines in this area.

关键词： local scour numerical simulation submarine pipelines Yellow River Delta

Tunable quantum anomalous Hall effects in ferromagnetic van der Waals heterostructures

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National Science Review 2024年第3期11卷 100-107页

作者： Feng xue Yusheng Hou Zhe Wang Zhiming xu {2. He Ruqian Wu Yong xu Wenhui Duan Beijing academy of Quantum Information sciences State key Laboratory of Low Dimensional Quantum Physics Department of Physics Tsinghua University Guangdong Provincial key Laboratory of Magnetoelectric Physics and Devices Center for Neutron Science and Technology School of Physics Sun Yat-sen University State key Laboratory of Surface Physics Key Laboratory of Computational Physical Sciences and Department of PhysicsFudan University Frontier Science Center for Quantum Information Department of Physics and Astronomy University of California-Irvine Tencent Quantum Laboratory Tencent Technology(Shenzhen)Co.Ltd RIkeN Center for Emergent Matter Science(CEMS) institute for Advanced Study Tsinghua University

The quantum anomalous Hall effect（QAHE） has unique advantages in topotronic applications, but it is still challenging to realize the QAHE with tunable magnetic and topological properties for building functional devices. Through systematic first-principles calculations, we predict that the in-plane magnetization induced QAHE with Chern numbers C = ±1 and the out-of-plane magnetization induced QAHE with high Chern numbers C = ±3 can be realized in a single material candidate, which is composed of van der Waals（vdW）coupled Bi and MnBi2.e4monolayers. The switching between different phases of QAHE can be controlled in multiple ways, such as applying strain or（weak） magnetic field or twisting the vdW materials. The prediction of an experimentally available material system hosting robust, highly tunable QAHE will stimulate great research interest in the field. Our work opens a new avenue for the realization of tunable QAHE and provides a practical material platform for the development of topological electronics.

关键词： quantum anomalous Hall effect topological quantum phase transition van der Waals heterostructures tunable Chern number high Chern number