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Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano Research 2025年第1期18卷 642-652页

作者： Wen Luo Shiyu Du Yateng Jiang Bangshun He Jun Tang jingjing yang Yujun Song Jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

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含吡唑啉酮类偶合组分黄色活性染料结构与印花性能的关系

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印染 2025年第2期51卷 40-44页

作者：纵兆胜杨晶晶吴丞江苏德美科化工有限公司江苏宜兴214213 南京晓庄学院环境科学学院江苏南京211171

研究了含不同取代基的吡唑啉酮类偶合组分黄色活性染料(KNY-1、KNY-2和KNY-3)的提升性和印花性能。结果表明:以1-(4′-磺酸苯基)-3-羧基-5-吡唑啉酮和1-(2′,5′-二氯-4′-磺酸苯基)-3-羧基-5-吡唑啉酮为偶合组分的染料KNY-2和KNY-3的... 详细信息

研究了含不同取代基的吡唑啉酮类偶合组分黄色活性染料(KNY-1、KNY-2和KNY-3)的提升性和印花性能。结果表明:以1-(4′-磺酸苯基)-3-羧基-5-吡唑啉酮和1-(2′,5′-二氯-4′-磺酸苯基)-3-羧基-5-吡唑啉酮为偶合组分的染料KNY-2和KNY-3的提升性能较好。尿素用量对染料KNY-1和KNY-2印花纯棉织物的表观色深几乎无影响。纯棉织物用染料KNY-1、KNY-2和KNY-3印花后具有良好的色牢度,水洗变色和沾色牢度都达到4~5级,耐摩擦色牢度为4~5级(干)和4级(湿),耐日晒色牢度为4级。

关键词：活性染料印花吡唑啉酮衍生物尿素

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单宁酸复合海藻酸钠微球富集U(Ⅵ)的性能

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工业水处理 2025年第1期45卷 58-65页

作者：刘清黄健滨李伟凡招国栋杨景景南华大学土木工程学院湖南衡阳421001 南华大学污染控制与资源化技术湖南省高校重点实验室湖南衡阳421001 南华大学资源环境与安全工程学院湖南衡阳421001

随着核能的大力发展,开发环境友好型生物基吸附剂对放射性核素污染控制具有重要意义。采用混合交联法制备一种新型单宁酸复合海藻酸钠(TA/SA)微球,考察了TA和SA质量比、溶液pH、U(Ⅵ)初始浓度、接触时间和温度等因素对TA/SA吸附U(Ⅵ)行... 详细信息

随着核能的大力发展,开发环境友好型生物基吸附剂对放射性核素污染控制具有重要意义。采用混合交联法制备一种新型单宁酸复合海藻酸钠(TA/SA)微球,考察了TA和SA质量比、溶液pH、U(Ⅵ)初始浓度、接触时间和温度等因素对TA/SA吸附U(Ⅵ)行为的影响,并进行了吸附动力学和热力学研究,探讨了TA/SA微球对U(Ⅵ)的吸附机理。结果表明,TA和SA的最佳质量比为1∶2,pH对TA/SA微球吸附U(Ⅵ)效果的影响较小。在U(Ⅵ)质量浓度为50 mg/L,TA/SA微球投加量为0.1 g/L,溶液pH=4,温度为323 K,吸附时间为2 h时,TA/SA微球对U(Ⅵ)的最大吸附量为263.42 mg/g。TA/SA微球对U(Ⅵ)的吸附行为符合准二级反应动力学模型和Freundlich等温吸附模型,TA/SA微球对U(Ⅵ)的吸附是一个自发吸热过程,且反应可分为表面吸附、中孔内扩散和微孔内扩散3个阶段。TA/SA表面呈不规则沟壑状,内部是大量开孔的三维网状结构,还原反应在TA/SA微球对U(Ⅵ)的吸附中起主导作用。

关键词：单宁酸海藻酸钠吸附放射性核素铀

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基于深度学习的水果图像识别

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中国农机化学报 2025年第1期46卷 198-203,235页

作者：李春雨郭肖琴杨晶晶李忠华河北北方学院信息科学与工程学院河北张家口075000

为有效辨别水果种类,提高水果产业商业化的深加工和线下水果销售渠道的效率,针对大多数线下超市在水果售卖过程中主要采用人工识别,其成本高、效率低的问题,提出一种基于语义分割模型(U^(2)-Net)和ResNet-50模型结合的水果图像识别方法... 详细信息

为有效辨别水果种类,提高水果产业商业化的深加工和线下水果销售渠道的效率,针对大多数线下超市在水果售卖过程中主要采用人工识别,其成本高、效率低的问题,提出一种基于语义分割模型(U^(2)-Net)和ResNet-50模型结合的水果图像识别方法,实现水果图像自动识别。使用U^(2)-Net分割出水果的二值图像,然后结合OpenCV算法将二值图中的白色像素值改为水果真实的颜色值,最后通过ResNet-50进行水果图像识别。结果表明,Alexent、VGG16、GoogLeNet和本模型在训练集上的准确率分别为99.66%、99.65%、99.9%、99.8%,在验证集上的准确率分别为96.5%、99.9%、99.6%、100%。提出的水果图像识别方法能够有效提取水果的颜色、形状、纹理等特征,从而实现对不同种类水果图像的准确识别。

关键词：水果深度学习语义分割图像识别二值图像

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Archetype identification and urban building energy modeling for city-scale buildings based on GIS datasets

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Building Simulation 2022年第9期15卷 1547-1559页

作者： Zhang Deng Yixing Chen jingjing yang Zhihua Chen College of Civil Engineering Hunan UniversityChangsha 410082China Key Laboratory of Building Safety and Energy Efficiency of Ministry of Education Hunan UniversityChangsha 410082China

Urban building energy modeling has become an efficient way to understand urban building energy use and explore energy conservation and emission reduction *** paper introduced a method to identify archetype buildings and generate urban building energy models for city-scale buildings where public building information was unavailable.A case study was conducted for 68,966 buildings in Changsha city,***,clustering and random forest methods were used to determine the building type of each building footprint based on different GIS ***,the convolutional neural network was employed to infer the year built of commercial buildings based on historical satellite images from multiple *** year built of residential buildings was collected from the housing ***,twenty-two building types and three vintages were selected as archetype buildings to represent 59,332 buildings,covering 87.4%of the total floor *** scripts leveraging on OpenStudio-Standards were developed to generate building energy models for the archetype ***,monthly and annual electricity and natural gas energy use were simulated for the blocks and the entire city by *** total electricity and natural gas use for the 59,332 buildings was 13,864 GWh and 23.6×10^(6) *** energy conservation measures were evaluated to demonstrate urban energy saving *** proposed methods can be easily applied to other cities in China.

关键词： urban building energy modeling building type year built-archetype building EnergyPlus

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无人机倾斜摄影测量在大范围带状区域三维重建中的应用

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测绘与空间地理信息 2025年第2期48卷 205-206,210页

作者：杨晶晶张龙丰河北省地质矿产勘查开发局第二地质大队(河北省矿山环境修复治理技术中心) 河北唐山063000 唐山市自然资源和规划局河北唐山063000

随着以无人机为主的各种倾斜摄影系统的涌现,无人机倾斜摄影建模已经常态化。基于三维实景建模可以更加直观、高效、方便地开展人员管控。本文以河北省唐山市某铁路为例,介绍了无人机倾斜摄影测量在大范围带状区域三维重建的关键技术,... 详细信息

随着以无人机为主的各种倾斜摄影系统的涌现,无人机倾斜摄影建模已经常态化。基于三维实景建模可以更加直观、高效、方便地开展人员管控。本文以河北省唐山市某铁路为例,介绍了无人机倾斜摄影测量在大范围带状区域三维重建的关键技术,通过外业采集的检查点对模型进行精度检验,结果表明,利用该技术获得的三维模型具有真实、精度高、效率快、效果好等优势,为大范围带状区域三维重建提供了一种高效的新方法。

关键词：大范围带状区域无人机倾斜摄影三维重建精度分析

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HSV-2-encoded miRNA-H4 Regulates Cell Cycle Progression and Act-Dinduced Apoptosis in HeLa Cells by Targeting CDKL2 and CDKN2A

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Virologica Sinica 2019年第3期34卷 278-286页

作者： yang Zhao jingjing yang Yan Liu Jianyong Fan Huilan yang Guangzhou School of Clinical Medicine Southern Medical UniversityGuangzhou 510010China Department of Dermatology General Hospital of Southern Theatre Command of PLAGuangzhou 510010China

MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)*** this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed in HeLa cells to explore potential cellular targets of viral miRNAs and demonstrate their potential biological *** results showed that miRNA-H4-5p could reverse apoptosis induced by actinomycin D(Act-D)and promote cell cycle progression,but miRNA-H4-3p had no such obvious *** analysis,luciferase report assay,quantitative reverse transcription polymerase chain reaction(qRT-PCR),and Western blotting demonstrated that miRNA-H4-5p could bind to the 3-′untranslated region(UTR)of cyclin-dependent kinase inhibitor 2A(CDKN2A)and cyclin-dependent kinase-like 2(CDKL2)to negatively regulate their *** verified that these two targeted genes were associated with cell apoptosis and cell ***,in HeLa cells infected with HSV-2,we detected significantly reduced expression of CDKN2A and CDKL2 and demonstrated the negative regulation effect of miRNA-H4-5p on these two target *** findings show that viral miRNAs play a vital role in regulating the expression of the host's cellular genes that participate in cell apoptosis and progression to reshape the cellular environment in response to HSV-2 infection,providing further information on the roles of encoded herpesvirus miRNAs in pathogen-host interaction.

关键词： Herpes simplex virus 2(HSV-2) MicroRNAs(miRNAs) Anti-apoptosis-Cell cycle progression Pathogen-host interaction

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儿童声带良性增生性病变特征及疗效分析

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听力学及言语疾病杂志 2025年第1期33卷 8-11页

作者：李雪岩程丽宇杨菁菁胡蓉徐文首都医科大学附属北京同仁医院耳鼻咽喉头颈外科、耳鼻咽喉头颈科学教育部重点实验室(首都医科大学) 北京100730

目的分析儿童声带良性增生性病变临床特征和疗效,为治疗方式的选择提供参考。方法回顾性分析2010至2021年诊断为声带良性增生性病变的686例患儿的临床资料,将有随访记录的100例患儿分为非手术组(66例)和手术组(34例),比较两组疗效。结果... 详细信息

目的分析儿童声带良性增生性病变临床特征和疗效,为治疗方式的选择提供参考。方法回顾性分析2010至2021年诊断为声带良性增生性病变的686例患儿的临床资料,将有随访记录的100例患儿分为非手术组(66例)和手术组(34例),比较两组疗效。结果①686例声带良性增生性病变患儿中男孩多见(455例,66.3%),最多分布于6~10岁时可考虑行手术治疗;声带囊肿患儿建议手术治疗。

关键词：儿童声带良性增生性病变非手术手术治疗

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How time latency in navigation Apps affects traffic

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The Journal of China Universities of Posts and Telecommunications 2022年第6期29卷 53-63页

作者： yang jingjing Guo Yuchun Zhao Yongxiang Chen Yishuai School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

With the recent increase in routing App usage, it is urgent to analyze the impact of inevitable information delay in routing Apps on *** analyze the negative impact of such delayed routing Apps on traffic, this paper investigates the impact of ideal and delayed routing Apps on traffic. Firstly, the effect of ideal routing Apps has been explored with theoretical analysis and derivation based on a macroscopic network model. Then, an extended network model is built to characterize the delayed *** impact of such delayed routing Apps is investigated by simulation experiments while considering routing usage proportion and amount of delay. The results demonstrate that ideal navigation does improve traffic efficiency, but in some cases, delayed navigation is even worse than no navigation.

关键词： traffic network delayed routing system performance

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User friendly preferential private recommendation

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The Journal of China Universities of Posts and Telecommunications 2022年第3期29卷 43-53页

作者： yang jingjing Guo Yuchun Feng Tingting Chen Yishuai School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China China Unicom Network Technology Research Institute Beijing 100044China

To provide preferential protection for users while keeping good service utility, a preferential private recommendation framework(named as PrefER) is proposed. In this framework, a preferential budget allocation scheme is designed and implemented at the system side to provide multilevel *** users’ preference is utilized at the user side to improve recommendation performance without increasing users’ burden. This framework is generic enough to be employed with other schemes. Recommendation accuracy based on the MovieLens dataset by the collaborative filtering schemes and PrefER are compared and *** experimental results show that PrefER can provide preferential privacy protection with the improvement of recommendation accuracy.

关键词： preferential privacy protection differential privacy top-k recommendation personalized service

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