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Effect of hormone therapy on carotid elasticity in postmenopausalwomen by Echo-tracking technique

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South China Journal of Cardiology 2011年第1期12卷 20-26,39页

作者： yang jin-ru LI Fen JIANG Jue Department of Ultrasonics The First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710061 China Maternal and Child Health Center The First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710061 China Department of Ultrasonics The Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 710003 China

Background Studies showed that arterial elasticity changes appear earlier than any structural changes, therefore, its accurate evaluation could be applied at early stage to prevent disease. Echo-tracking（E-tracking） technique can track the wall motion trajectory in real-time, calculate the change in vascular diameter automatically, and assessment of vascular stiffness and flexibility directly. This article aims to assess the change of elasticity of carotid artery after hormone therapy （HT） using Echo-tracking technology. Methods Echotracking was used to evaluate the carotid elastic moduli, such as the pressure-strain elastic modulus （Ep）, stiffness parameter （β）, arterial compliance （AC）, pulse wave conducting velocity （PWVβ） and augmentation index （AI） by Aloka α10 color Doppler ultrasound diagnosis system. Results Ep,β and PWVβ in HT group were significantly lower than those in the control group （P 〈 0.01）, while AC was obviously higher than the control group （P 〈 0.01）. E2 was negatively related to β, Ep and PWVβ （r = -0.607, r = -0.573, r = -0.574, P 〈 0.001）, while positively related to AC （r = 0.574, P 〈 0.001）; endothelial-dependent dilatation （EDD） was negatively related to β, Ep and PWVβ （r = -0.521, r = -0.411, r = -0.456, P 〈 0.001）, while positively related to AC （r = 0.443, P 〈 0.001）; But IMT was positively related to β, Ep and PWVβ（r = 0.553, r = 0.444, r = 0.529, P 〈 0.001）, while negatively related to AC （r = -0.400, P 〈 0.001）. Conclusions Arterial stiffness increases and compliance decreases in menopausal women. As EDD decreases arterial elasticity recedes, and HT can improve arterial elasticity. E-tracking technology can discover the early changes in arterial stiffness effectively and it is more sensitive in finding out the changes of stiffness in early atherosclerosis than IMT of carotid artery.

关键词： echo-tracking technique hormone therapy menopause arterial elasticity

Role of voltage-gated potassium channel α subunits in cardiovascular system

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生理学报 2024年第5期76卷 761-774页

作者： yang jin-ru HUANG Peng LING Shu-Kuan School of Sport Medicine and Physical Therapy Beijing Sport UniversityBeijing 100084China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325000China

Voltage-gated ion channels(VGICs) are central to cellular excitation, orchestrating skeletal and cardiac muscle contractions and enabling neural signal transduction. Among these, voltage-gated potassium(Kv) channels are particularly significant in cardiac electrophysiology, especially during the repolarization phase of the cardiac action potential. In cardiac myocytes, Kv channels are integral to a multitude of sophisticated functions, including electrical conduction. Despite their importance, research on Kv channels in the context of cardiovascular diseases is limited. This review offers a comprehensive summary of the structural complexities of Kv channels, delineating the regulatory mechanisms involved in channel gating, expression, and membrane localization. Additionally, we examine the role of different Kv α-subunits in modulating Kv channels and their impact on cardiac remodeling, and assess the potential of targeting Kv channels for the development of anti-arrhythmic therapies.

关键词： cardiovascular disease voltage-gated potassium channels arrhythmia cardiac remodeling

Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO jin-Hui yang Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

替勃龙对绝经期妇女颈动脉、眼动脉血流动力学的影响

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西安交通大学学报（医学版） 2009年第5期30卷 613-615,642页

作者：杨锦茹李芬西安交通大学医学院第一附属医院超声科陕西西安710061

目的观察绝经期妇女经替勃龙治疗后颈动脉、眼动脉血流动力学的变化情况。方法有更年期症状的绝经期妇女60例,随机分为两组:治疗组30例,每天口服替勃龙(利维爱)2.5 mg;另30例未进行激素治疗的作为对照组,均为自然绝经。采用无创性高分... 详细信息

目的观察绝经期妇女经替勃龙治疗后颈动脉、眼动脉血流动力学的变化情况。方法有更年期症状的绝经期妇女60例,随机分为两组:治疗组30例,每天口服替勃龙(利维爱)2.5 mg;另30例未进行激素治疗的作为对照组,均为自然绝经。采用无创性高分辨超声法分别检测基础状态下及用药后3、6、9、12个月时颈动脉、眼动脉的峰值流速(Vmax)及阻力指数(RI)。结果经替勃龙治疗后不同时间颈内动脉、眼动脉的Vmax、RI有差别,且Vmax逐渐升高(P<0.05),而RI降低(P<0.05)。结论替勃龙能改善颈内动脉、眼动脉的血流动力学状态,有对抗动脉硬化的潜在益处。

关键词：替勃龙绝经颈内动脉眼动脉血流动力学

替勃龙治疗对绝经期妇女颈动脉内中膜厚度和动脉粥样硬化斑块面积的影响

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中国现代医学杂志 2010年第1期20卷 84-86页

作者：杨锦茹李芬西安交通大学医学院第一附属医院超声科陕西西安710061

目的观察替勃龙治疗对绝经期妇女颈动脉内中膜厚度及动脉粥样硬化斑块面积的影响。方法100例绝经后妇女被分为绝经期治疗组50例,每天口服替勃龙(利维爱)2.5mg;50例未进行激素治疗的作为对照组。采用无创性高分辨超声分别检测颈动脉内中... 详细信息

目的观察替勃龙治疗对绝经期妇女颈动脉内中膜厚度及动脉粥样硬化斑块面积的影响。方法100例绝经后妇女被分为绝经期治疗组50例,每天口服替勃龙(利维爱)2.5mg;50例未进行激素治疗的作为对照组。采用无创性高分辨超声分别检测颈动脉内中膜厚度(IMT)及动脉粥样硬化斑块面积。结果治疗组颈总动脉的IMT下降了27.1%,从治疗前的(0.73±0.18)mm(95%CI0.68～0.78mm),下降到治疗后的(0.57±0.21)mm(95%CI0.51～0.63mm)(P<0.01);颈动脉粥样硬化斑块面积明显减少(P<0.05)。结论替勃龙治疗后胆固醇、LDL降低,IMT变薄,动脉粥样硬化斑块面积减少,认为有降低动脉硬化的作用。

关键词：替勃龙绝经内中膜厚度动脉粥样硬化斑块

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超声对高血压患者动脉弹性的检测

中国现代医学杂志 2006年第20期16卷 3156-3157,3161页

作者：杨锦茹魏炜西安交通大学医学院附属第一医院超声室西安710061

目的探讨超声评价动脉弹性的意义。方法选取原发性高血压患者80例,使用美国惠普公司SONOS-5500型GEL5彩色多普勒超声诊断仪,以颈动脉横断面顺应性和容积扩张性作为评价大动脉缓冲功能的指标。结果高血压组无论在收缩期、舒张期其内径均... 详细信息

目的探讨超声评价动脉弹性的意义。方法选取原发性高血压患者80例,使用美国惠普公司SONOS-5500型GEL5彩色多普勒超声诊断仪,以颈动脉横断面顺应性和容积扩张性作为评价大动脉缓冲功能的指标。结果高血压组无论在收缩期、舒张期其内径均大于对照组,而相对及绝对内径均小于对照组。横断面顺应性和容积扩张性均小于对照组。差异有显著性(P<0.01)。结论随着血压的增高,动脉内径增宽其弹性逐渐降低。超声检查为临床提供了一种无创、简便、可动态评估高血压患者动脉弹性的方法。

关键词：高血压颈动脉弹性超声检查

血管回声跟踪技术在评价绝经期女性颈动脉弹性中的应用

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西安交通大学学报（医学版） 2012年第4期33卷 490-493页

作者：杨锦茹李芬姜珏西安交通大学医学院第一附属医院超声科陕西西安710061 西安交通大学医学院第一附属医院妇幼中心陕西西安710061 西安交通大学医学院第二附属医院超声研究室陕西西安710003

目的应用血管回声跟踪技术评价性激素治疗(HT)后血管弹性的变化情况。方法自然绝经1年以上,年龄50～60岁,诊断为更年期综合征者60例,根据是否进行HT分为:激素组30例,坚持HT 1年以上。对照组30例,未进行激素治疗,进行一般对症治疗。应用E... 详细信息

目的应用血管回声跟踪技术评价性激素治疗(HT)后血管弹性的变化情况。方法自然绝经1年以上,年龄50～60岁,诊断为更年期综合征者60例,根据是否进行HT分为:激素组30例,坚持HT 1年以上。对照组30例,未进行激素治疗,进行一般对症治疗。应用E-Tracking技术检测颈总动脉的弹性参数,包括弹性模量(Eρ)、僵硬度(β)、动脉顺应性(AC)、单点脉搏波速度(PWVβ)和膨大指数(AI),并将雌二醇(E2)、内皮依赖性舒张功能(EDD)和内膜中层厚度(IMT)与这些弹性参数进行相关分析。结果激素组β、Eρ、PWVβ明显降低,AC升高(P<0.01)。E2与β、Eρ、PWVβ呈负相关(r分别为-0.607、-0.573、-0.574、P均<0.01);而与AC呈正相关(r=0.574,P<0.01)。EDD与β、Eρ、PWVβ呈负相关(r分别为-0.521、-0.411、-0.456,P均<0.01);而与AC呈正相关(r=0.443,P<0.01)。IMT与β、Eρ、PWVβ呈正相关(r分别为0.553、0.444、0.529,P均<0.01);而与AC呈负相关(r=-0.400,P<0.01)。结论绝经期女性随着雌激素水平的下降,动脉僵硬度增加,激素治疗可使动脉弹性得到一定程度的改善。

关键词：回声跟踪技术绝经动脉弹性激素治疗

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维摩诘变对唐代士大夫的影响

运城学院学报 2017年第5期35卷 37-40页

作者：杨金茹陕西师范大学历史文化学院西安710119

作为印度早期大乘佛教的重要经典,《维摩诘经》塑造刻画了一个智慧通达、游戏神通、辩才无碍的维摩诘居士形象,其大乘智慧和居家修禅的修行方式令人称道。《维摩诘经》传入中国后,特别是维摩诘变的大量衍生,对唐代士大夫产生了很大的影... 详细信息

作为印度早期大乘佛教的重要经典,《维摩诘经》塑造刻画了一个智慧通达、游戏神通、辩才无碍的维摩诘居士形象,其大乘智慧和居家修禅的修行方式令人称道。《维摩诘经》传入中国后,特别是维摩诘变的大量衍生,对唐代士大夫产生了很大的影响。它不仅使唐代士大夫在家出家这一修行方式获得理论上的支持,也使他们在面对出世入世等矛盾时获得精神上的消解。同时为唐代士大夫的诗歌创作提供了素材,成为他们诗歌创作的一大灵感源泉。

关键词：维摩诘维摩诘变唐代士大夫影响

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山西高平羊头山炎帝农耕文化

晋城职业技术学院学报 2017年第3期10卷 1-4页

作者：杨金茹陕西师范大学历史文化学院西安710119

炎帝是中华民族的先祖,探寻炎帝遗迹、了解和传承炎帝文化是炎黄子孙的责任。山西晋东南地区高平羊头山诸多与炎帝有关的历史遗址遗迹、方志碑刻、民间传说和文献记载,都反映了羊头山地区是当年炎帝活动的重要场所。结合当地"神农尝百... 详细信息

炎帝是中华民族的先祖,探寻炎帝遗迹、了解和传承炎帝文化是炎黄子孙的责任。山西晋东南地区高平羊头山诸多与炎帝有关的历史遗址遗迹、方志碑刻、民间传说和文献记载,都反映了羊头山地区是当年炎帝活动的重要场所。结合当地"神农尝百谷""耒耜发明"等炎帝发明农业的历史资料,考察羊头山地区的生态环境、土壤结构、植物物种等历史自然条件,可大致了解羊头山地区与炎帝农耕文化的关系。探究羊头山地区的炎帝农耕文化,了解其在炎帝农耕文化及整个炎帝文化中的地位,有利于促进区域文化的发展。

关键词：羊头山炎帝农耕文化