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TabHLH27 orchestrates root growth and drought tolerance to enhance water use efficiency in wheat

Journal of Integrative Plant Biology 2024年第7期66卷 1295-1312页

作者： Dongzhi Wang Xiuxiu zhang Yuan Cao Aamana Batool Yongxin Xu Yunzhou Qiao Yongpeng Li Hao Wang Xuelei Lin Xiaomin Bie Xiansheng zhang Ruilian Jing Baodi Dong Yiping Tong Wan Teng Xigang Liu Jun Xiao Key laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of chinese academy of sciences Beijing 100049China Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China Key laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'an 271018China State Key laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Education Key laboratory of molecular and cellular Biology Hebei Research Center of the Basic Discipline of Cell BiologyHebei Collaboration Innovation Center for Cell Signaling and Environmental AdaptationHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China Centre of Excellence for Plant and Microbial Science(CEPAMS) JIC‐CASBeijing 100101China

Cultivating high-yield wheat under limited water resources is crucial for sustainable agriculture in semiarid *** water scarcity,plants activate drought response signaling,yet the delicate balance between drought tolerance and development remains *** genome-wide association studies and transcriptome profiling,we identified a wheat atypical basic helix-loop-helix(b HLH)transcription factor(TF),Tab HLH27-A1,as a promising quantitative trait locus candidate for both relative root dry weight and spikelet number per spike in *** HLH27-A1/B1/D1 knockout reduced wheat drought tolerance,yield,and water use efficiency(WUE).Tab HLH27-A1 exhibited rapid induction with polyethylene glycol(PEG)treatment,gradually declining over *** activated stress response genes such as Ta CBL8-B1 and Ta CPI2-A1 while inhibiting root growth genes like Ta SH15-B1 and Ta WRKY70-B1 under short-term PEG *** distinct transcriptional regulation of Tab HLH27-A1 involved diverse interacting factors such as Ta ABI3.D1 and Tab *** variations of Tab HLH27-A1influence its transcriptional responses to drought stress,with Tab HLH27-A1^(Hap-II)associated with stronger drought tolerance,larger root system,more spikelets,and higher WUE in ***,the excellent Tab HLH27-A1^(Hap-II)was selected during the breeding process in china,and introgression of Tab HLH27-A1^(Hap-II)allele improved drought tolerance and grain yield,especially under water-limited *** study highlights Tab HLH27-A1's role in balancing root growth and drought tolerance,providing a genetic manipulation locus for enhancing WUE in wheat.

关键词： drought tolerance GWAS root growth wheat WUE

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Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration

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chinese Chemical Letters 2017年第11期28卷 2116-2120页

作者： hui-hui Ren hui-Yu Zhao {3. Cui Xiang Ao Ai-Ling Li Zhong-Min zhang Dong Qiu Beijing National laboratory for molecular sciences State Key Laboratory of Polymer Physics and Chemistry CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of chinese academy of sciences Beijing 100190 China Department of Orthopedics The Third Affiliated Hospital of Southern Medical University Guangzhou 510665 China

Poly（1,8-octanediol-co-citrate）（POC） represents a new promising biocompatible and biodegradable polyester that has been extensively investigated for soft tissue engineering. However, the poor mechanical performance and poor bioactivity limit its application in bone regeneration. In this study, a series of POC/bioactive glasses （BG） composites were developed using 45S5 Bioglass^Θ and a phytic acid- derived bioactive glass （referred as PSC）. The results indicated that calcium in BG could enhance the crosslinking of the POC/BG composites by forming calcium dicarboxylate bridges and thus improve their mechanical performances. When PSC were used, the composites exhibited significantly better mechanical properties compared to composites with 45S5 Bioglass^Θ. For example, by incorporating 70wt% PSC, the compressive strength of POC/PSC composites could be improved to approximately 50 MPa and modulus 1.3.h 0.1 GPa. Furthermore, all these POC/PSC composites showed good in vitro bioactivity and cellular biocompatibility. Histology results in femoral condyle defects of Sprague-Dawley rats indicated that the POC/PSC samples integrated well with surrounding tissues and stimulated bone regeneration. The improved mechanical properties and bioactivity of POC/PSC composites make them promising for potential application in bone regeneration.

关键词： Bioactive glasses Poly(1 8-octanediol-co-citrate) Composites Mechanical properties Bioactivity

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Phylogeny of higher taxa of hexapoda according to 12sRNA sequences

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chinese Science Bulletin 2001年第10期46卷 840-842页

作者： zhang Yazhou zhang yaping LUAN Yunxia CHEN Yongjiu YIN Wenying Shanghai institute of Entomology Chinese Academy of SciencesShanghai 200025China laboratory of cellular and molecular Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China

The phylogenetic relationship of Hexapoda has been debated for a long time, which will be resolved mainly depending on the settlement of monophyly, affinities and interrelationships among Protura, Collembola and Diplura. Mitochondrial 12sRNA gene about 3.5 bp fragments from one proturan species, two collembolan species, two dipluran species and one oribatid species were sequenced. The Ki-mura 2-parameter distances were calculated and a series of molecular phylogenetic trees were reconstructed by using the N-J method, from which the following points were drawn: (i) Protura and Collembola compose a monophyletic group representing absent-cerci; (ii) Diplura is not a monophyletic group, in which Campodeoid with filiform cerci belongs to a clade and Japygoid with pincer cerci and Ectognatha compose another clade, that is, Insecta s. str. stemmed from Japygoid. So it would be suggested that the phylogenetic relationship of Hexapoda is [Parainsecta (Collembola + Protura) +Campodeoid +Insecta (Japygoid +

关键词： Hexapoda 12sRNA phytogeny higher taxa monophyly.

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Association of Polymorphisms in the Pit-1 Intron 5 with Growth Traits in chinese Cattle

Association of Polymorphisms in the Pit-1 Intron 5 with Grow...

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第十次全国畜禽遗传标记研讨会

作者： yang Dong-ying, CHEN Hong, LAN Xian-yong, zhang Zheng-feng, TANG Li-gang, zhang Liang-zhi, WANG Xin-zhuang, WANG Yi-min, NIU Hu (College of Animal Science and Technology, Northwest A&F University, Shaanxi Key {3. of molecular Biology for Agriculture, yangling, Shaanxi 712100, china institute of cellular and molecular Biology, Xuzhou Normal University, Xuzhou, Jiangsu 221116, china The Research Center of Beef Cattle Engineering and Technology in Henan, Zhengzhou, Henan 450003. china)

The Pit-1 gene was studied as a candidate for genetic markers of growth traits in chinese cattle in this study. The single-strand conformation polymorphism method was used to detecte polymorphism in the Pit-1 gene including intron 5. One single nucleotide polymorphism was found in intron 5 of Pit-1. The frequencies of alleles A/B in Nanyang cattle(NY), Qinchuan cattle(QC). Jiaxian Red cattle(JXR), Xizhen cattle(XZ), Luxi cattle(LX) and Holstein cow(H) populations were 0.444/0.556 , 0.477/0.523. 0.53./0.462, 0.421/0.579, 0.523.0.477, 0.475/0.525 respectively. Associations of the polymorphisms with growth traits in Nanyang cattle were analyzed using a general linear model procedure. The following parameters were greater in individuals with genotype AA than with genotype AB: body weight, average daily gain, body height, chest girth at 6, 12, 18 and 24 months(P allele A in other age groups. Therefore, genotype BB maybe a dominant genotype and allele B may be a dominant allele. These results imply that allele B of Pit-1 gene likely positively affects growth traits.

关键词： Beef cattle Growth traits Pit intron 5 Polymorphism

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Differential Expression Analysis of Proteins Regulated by Rare Earth Cerium in Soybean Leaves at Seedling Stage

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Journal of Northeast Agricultural University(English Edition) 2024年第1期31卷 42-52页

作者： Ren Hongyu zhang Tianren Miao Yanli Li Haoyang zhang Shuying zhang Xingwen College of Resources and Environment Northeast Agricultural UniversityHarbin 150030China College of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China

This study was to explore the functional mechanism of rare earth regulating soybean leaves and the characteristics and functions of differentially expressed proteins under the regulation of rare earth. In this study, Dongnong 42 was used as material, and 3. mg·L^(-1) CeCl_(3. solution was sprayed on soybean leaves at the seedling stage. Tandem mass tag(TMT) quantitative proteomics technique and bioinformatics analysis were used to identify soybean leaf proteins. A total of 8 510 proteins were identified, and 127 differentially expressed proteins(DEPs) in response to rare earth cerium regulation were identified, among which 64 were upregulated and 63.were down-regulated. The gene ontology(GO) annotation indicated that DEPs were mainly involved in metabolic process, cellular process, response to stimulus, biological regulation, and response to a stimulus;DEPs in cell module categories were mainly involved in cells, cell part, organelle, membrane, membrane part, organelle par, and protein-containing complex;DEPs in molecular functional categories were mainly involved in catalytic activity, binding and antioxidant activity. Kyoto encyclopedia of genes and genomes(KEGG) pathway significantly enriched starch and sucrose metabolism, glycolysis/gluconeogenesis, galactose metabolism, pentose phosphate pathway, and MAPK signaling pathway-plant. These DEPs were mainly involved in photosynthesis, glucose metabolism and stress response. Forty-six differential protein interaction networks were identified by protein interaction network analysis. This experiment provided a reference for studies of the mechanism of rare earth cerium regulating soybean leaf function from the proteomic perspective.

关键词： rare earth soybean proteomics tandem mass tag(TMT)

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RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3.and FADD-mediated cell death

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cellular & molecular Immunology 2024年第1期21卷 80-90页

作者： Xiaoxue Deng Lingxia Wang Yunze Zhai Qiuyue Liu Fengxue Du Yu zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi Ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing zhang Haikun Wang State Key laboratory of Cardiology Shanghai East HospitalTongji University School of MedicineShanghai200120China CAS Key laboratory of molecular Virology and Immunology Shanghai Institute of Immunity and InfectionChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China CAS Key laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200031China The Research Center for Traditional chinese Medicine Shanghai Institute of Infectious Diseases and BiosecurityShanghai University of Traditional Chinese MedicineShanghai201203China institute of Vascular Disease Shanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200433China

Regulatory T(T_(reg))cells play an essential role in maintaining immune balance across various physiological and pathological ***,the mechanisms underlying T_(reg)homeostasis remain incompletely ***,we report that RIPK1 is crucial for T_(reg) cell survival and *** generated mice with T_(reg) cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell *** conventional T cells,Treg cells with Ripk1 deficiency were only partially rescued from cell death by blocking FADD-dependent ***,simultaneous removal of both Fadd and Ripk3.completely restored the homeostasis of Ripk1-deficient Treg cells by blocking two cell death ***,our study highlights the critical role of RIPK1 in regulating Treg cell homeostasis by controlling both apoptosis and necroptosis,thereby providing novel insights into the mechanisms of Treg cell homeostasis.

关键词： Treg cell Homeostasis Apoptosis Necroptosis

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Association of two novel SNPs in coding region of bovine Fat-inducing transcript gene with growth traits

Association of two novel SNPs in coding region of bovine Fat...

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中国畜牧兽医学会第七届养牛学分会2009年学术研讨会

作者： Jiajie Sun~1,Chunlei zhang~1,Xingtang Fang~1,Qijiang Jin~1,Danxia Chen~1, Xiuying Shi~1,Yu Du~1,Hong Chen~(1 2*) (1.institute of cellular and {3. Biology,Xuzhou Normal University,Xuzhou,Jiangsu 221116,china 2.College of Animal Science and Technology,Northwest A&F University,Shaanxi Key laboratory of {3. Biology for Agriculture, yangling,Shaanxi 712100,china.)

Fat-inducing transcript(FIT) are endoplasmic reticulum resident membrane proteins that induce lipid droplet *** plays a crucial role in the fundamental process of storing *** this study, according to PCR-SSCP and DNA sequencing methods,polymorphism of the FIT gene was detected in 708 individuals from four chinese cattle *** results showed that only P locus had two SNPs,resulting in a synonymous mutation(NM01103.95:m.199G>T resulting in L124L) and a missense mutation (NM01103.95:m.43. G>T resulting in V176L).The associations between polymorphic loci and the growth traits of Nangyang bovine were analysed,and significant statistical association results were found in body weight and average daily *** AA were 3.75%and 4.88%higher than those of individuals with genotype AB in body weight(P=0.007) and average daily gain(P=0.001),respectively.

关键词： association analysis FIT gene cattle growth traits mutation SSCP SNP

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Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress

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International Journal of Oral Science 2024年第3期16卷 553-562页

作者： Zhiyao Yuan Junjie Li Fuyu Xiao Yu Wu Zhiting zhang Jiahong Shi Jun Qian Xudong Wu Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyState Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingChina

Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival *** therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative ***(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant *** study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular *** found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory *** Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in *** molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence *** immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor *** functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant ***,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing HO-1 expression and inhibiting oxidative ***,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.

关键词： Bach1 period prompt

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Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP,TGFβ,and Wnt signaling in articular cartilage formation and osteoarthritis

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Bone Research 2022年第4期10卷 882-892页

作者： Yan zhang Tao Zuo Abigail McVicar hui-Lin yang Yi-Ping Li Wei Chen Department of Pathology University of Alabama at BirminghamBirminghamAL 35294USA Key laboratory of Biomedical Information Engineering of Ministry of Education Biomedical Informatics and Genomics CenterSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049 ShaanxiP.R.China Department of Orthopaedics the First Affiliated Hospital of Soochow UniversityOrthopaedic Institute of Soochow University899 Pinghai RoadSuzhou 215031 JiangsuP.R.China Division in cellular and molecular Medicine Department of Pathology and Laboratory MedicineTulane University School of MedicineTulane UniversityNew OrleansLA 70112USA

Runt-related transcription factor 1(Runx1)plays a key role in cartilage formation,but its function in articular cartilage formation is *** generated non-inducible and inducible Runx1-deficient mice(Runx1^(f/f)Col2α1-Cre and Runx1^(f/f)Col2α1-CreER mice)and found that chondrocyte-specific Runx1-deficient mice developed a spontaneous osteoarthritis(OA)-like phenotype and showed exacerbated articular cartilage destruction under OA,characterized by articular cartilage degradation and cartilage ossification,with decreased Col2α1 expression and increased Mmp13.and Adamts5 ***-sequencing analysis of hip articular cartilage from the Runx1^(f/f)Col2α1-Cre mice compared to that from wild-type mice and subsequent validation analyses demonstrated that Runx1 is a central regulator in multiple signaling pathways,converging signals of the Hippo/Yap,TGFβ/Smad,and Wnt/β-catenin pathways into a complex network to regulate the expression of downstream genes,thereby controlling a series of osteoarthritic pathological ***-sequencing analysis of mutant knee joints showed that Runx1’s role in signaling pathways in articular cartilage is different from that in whole knee joints,indicating that Runx1 regulation is *** analysis confirmed that Runx1 deficiency decreased the levels of YAP and p-Smad2/3.and increased the levels of activeβ-*** of Runx1 dramatically increased YAP expression in ***-associated virus-mediated Runx1 overexpression in the knee joints of osteoarthritic mice showed the protective effect of Runx1 on articular cartilage damaged in *** results notably showed that Runx1 is a central regulator of articular cartilage homeostasis by orchestrating the YAP,TGFβ,and Wnt signaling pathways in the formation of articular cartilage and OA,and targeting Runx1 and its downstream genes may facilitate the design of novel therapeutic approaches for OA.

关键词： cartilage homeostasis protective

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RF-PSSM:A Combination of Rotation Forest Algorithm and Position-Specific Scoring Matrix for Improved Prediction of Protein-Protein Interactions Between Hepatitis C Virus and Human

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Big Data Mining and Analytics 2023年第1期6卷 21-31页

作者： Xin Liu yaping Lu Liang Wang Wei Geng Xinyi Shi Xiao zhang School of Medical Informatics and Engineering Xuzhou Medical UniversityXuzhou 221000China College of Computer Science and Technology China University of Mining and TechnologyXuzhou 221116China laboratory Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Hangzhou institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310005China

The identification of hepatitis C virus(HCV)virus-human protein interactions will not only help us understand the molecular mechanisms of related diseases but also be conductive to discovering new drug *** increasing number of clinically and experimentally validated interactions between HCV and human proteins have been documented in public databases,facilitating studies based on computational *** this study,we proposed a new computational approach,rotation forest position-specific scoring matrix(RF-PSSM),to predict the interactions among HCV and human *** particular,PSSM was used to characterize each protein,two-dimensional principal component analysis(2DPCA)was then adopted for feature extraction of ***,rotation forest(RF)was used to implement *** results of various ablation experiments show that on independent datasets,the accuracy and area under curve(AUC)value of RF-PSSM can reach 93.74% and 94.29%,respectively,outperforming almost all cutting-edge *** addition,we used RF-PSSM to predict 9 human proteins that may interact with HCV protein E1,which can provide theoretical guidance for future experimental studies.

关键词： protein-protein interactions hepatitis C virus position specific scoring matrix two-dimensional principal component analysis rotation forest

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