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Thiol-acrylate Catalyst Enabled Post-Synthesis Fabrication of Liquid Crystal Actuators

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高分子科学:英文版 2023年第10期41卷 1656-1662页

作者： huan liang Ya-Wen Liu Hong-Tu Xu yang yang En-Jian He Zhijun yang Yen Wei Yan Ji K The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084China Department of Chemistry Center for Nanotechnology and Institute of Biomedical TechnologyChung-Yuan Christian UniversityTaiwan32023China

Synthesizing orientated liquid crystal elastomers(LCEs)via the two-stage thiol-acrylate Michael addition and photopolymerization(TAMAP)reaction is extensively used.However,excess acrylates,initiators,and strong stimuli are inevitably involved in the second stage crosslinking.Herein,we simplify the strategy through taking advantage of a volatile alkaline(originally added to catalyze the thiol-acrylate addition in the first crosslinking stage).Without excess functional groups,the residual catalyst after annealing is still enough to trigger reactions of dynamic covalent bonds at a relatively mild temperature(80℃)to program the alignment of LCEs.The reversible reaction switches off by itself after this process since the catalyst gradually but totally evaporates upon heating.The obtained soft actuators exhibit robust actuation during repeated deformation(over 1000 times).Many shape-morphing modes can be achieved by rationally designing orientation patterns.This strategy not only facilitates the practical synthesis of LCE actuators,but also balances the intrinsic conflict between stability and reprogrammability of exchangeable LCEs.Moreover,the method of applying volatile catalysts has the potential to be extended to other dynamic covalent bonds(DCBs)applied to crosslinked polymer systems.

关键词： Liquid crystal elastomer Vitrimer Covalent adaptable network Soft actuator

Hydrogen storage thermodynamics and kinetics of as-cast Ce-Mg-Ni-based alloy

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Journal of Iron and Steel Research(International) 2024年第3期31卷 752-766页

作者： Yan Qi Xin Zhang Jun Li Dong-liang Zhao Shi-hai Guo yang-huan Zhang Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China China Rare Earth New Material(Weishan)Co..Ltd. Jining 277600ShandongChina Collaborative Innovation Center of Integrated Exploitation of Bayan Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina

The reaction kinetics of alloys based on magnesium are known to be greatly improved by the partial substitution of Mg with rare earths and transition metals,particularly Ni.The enhanced superficial hydrogen dissociation rate,the weakened Mg-H bond and the lower activation energy following element replacement are thought to be related to the better performance.The experimental alloys Ce5Mg_(95-x)Ni_(x)(x=5,10,15)were smelted by the vacuum induction melting.The phase transformation and structural evolution of experimental alloys before and after reaction with hydrogen were char-acterized by X-ray diffraction,scanning electron microscopy and transmission electron microscopy.The cast specimens contain CeMg_(12),Mg and Mg_(2)Ni phases,and the increase in Ni content results in an obvious growth of Mg_(2)Ni phase.The isothermal and non-isothermal hydrogenation and dehydrogenation kinetics of the experimental specimens were investi-gated using the Sievert apparatus,differential scanning calorimetry and thermal gravimetric analyzer.The activation energy may be calculated using the Arrhenius and Kissinger equations.The experimental alloys have been shown to have good activation properties,with a reversible hydriding and dehydriding capacities of around 5.0 wt.%in the first cycle.The initial dehydrogenation temperature of MgH_(2) decreases from 557.5 to 537.7 K with changing Ni content from 5 to 15 at.%.The dehydrogenation activation energy also reduces from 77.09 to 62.96 kJ/mol,which explains the improved hydrogen storage performance caused by Ni substitution.It can be shown that the impact of Ni on the decomposition enthalpy of MgH_(2) is quite modest,with the absolute enthalpy(ΔHr)only decreasing from 78.48 to 76.15 kJ/mol.

关键词： Mg-based alloy Ni content Hydrogen storage kinetics Thermodynamic property Activation energy

Research progress in Mg-based hydrogen storage alloys

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Rare Metals 2014年第5期33卷 499-510页

作者： Dong-liang Zhao yang-huan Zhang Department of Functional Material Research Central Iron and Steel Research Institute

Magnesium and magnesium-based alloy hydrides remain attractive hydrogen storage materials owing to high hydrogen capacity and rich reserves in the earth＇s crust. A high stability of hydride and sluggish hydriding/dehydriding kinetics at practical temperatures for the materials drove researchers into alloying with other elements, using different preparation techniques, using catalyst and thin film hydride to improve the hydrogen absorption/desorption properties. In this review, the development of these approaches and their effects on the thermodynamic and kinetics properties of magnesium and magnesium-based alloy hydrides were descript in details.

关键词： Magnesium-based storage alloy Thermodynamic and kinetics Preparation technique Alloying and catalyzing

An integrated bioinformatics analysis and experimental study identified key biomarkers CD300A or CXCL1,pathways and immune infiltration in diabetic nephropathy mice

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BIOCELL 2022年第8期46卷 1989-2002页

作者： WEI liang QIANG LUO ZONGWEI ZHANG KEJU yang ANKANG yang QINGJIA CHI huan HU Division of Nephrology Renmin Hospital of Wuhan UniversityWuhanChina Nephrology and Urology Research Institute of Wuhan University WuhanChina The First College of Clinical Medical Science China Three Gorges UniversityYichangChina Department of Engineering Structure and Mechanics Wuhan University of TechnologyWuhanChina School of Life Science and Engineering Southwest Jiaotong UniversityChengdu610000China

Diabetic nephropathy(DN)is a common microvascular complication that easily leads to end-stage renal disease.It is important to explore the key biomarkers andmolecular mechanisms relevant to diabetic nephropathy(DN).We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of mice.Then we used LIMMA to analyze differentially expressed genes(DEGs)between DN and non-diabetic glomerular samples.And we performed KEGG,gene ontology functional(GO)enrichment,and gene set enrichment analysis to reveal the signaling pathway of the disease.The CIBERSORT algorithm based on support vector machine was used to determine the immune infiltration score.Random forest algorithm and Cytoscape obtained hub genes.Finally,we applied co-staining,immunohistochemical staining,RT-qPCR and western blotting to validate the protein and mRNA expression of both hub genes.We obtained 913 DEGs mainly related to inflammatory factors and immunity.GSEA results showed that differential genes were mainly enriched in IL-17 signaling pathway,lipid and atherosclerosis,rheumatoid arthritis,TNF signaling pathway,neutrophil extracellular trap formation,Staphylococcus aureus infection and other pathways.The intersection of the random forest algorithm and Cytoscape revealed both hub genes of CD300A and CXCL1.Experiments have shown that the both key genes of CD300A and CXCL1 shown increased expression in glomerular podocytes,and are related to the inflammation of diabetic nephropathy.And immunohistochemical staining and RT-qPCR further confirmed that the protein and mRNA expression level of CD300A or CXCL1 in glomeruli tissue in DN mice were increased.The expression levels of CD300A and CXCL1 increased significantly under HG(high glucose)stimulation,further confirming that diabetes can lead to increased levels of CD300A and CXCL1 at the cellular level.Through bioinformatics analysis,machine learning algorithms,and experimental research,CD300A and CXCL1 are confirmed as both potential biomarkers in

关键词： Diabetic nephropathy Immune infiltration Machine learning Bioinformatics Biomarkers

Pollinator diversity benefits natural and agricultural ecosystems,environmental health,and human welfare

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Plant Diversity 2022年第5期44卷 429-435页

作者： Daniel Mutavi Katumo huan liang Anne Christine Ochola Min Lv Qing-Feng Wang Chun-Feng yang CAS Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Center of Conservation Biology Core Botanical GardensChinese Academy of SciencesWuhan 430074China

Biodiversity loss during the Anthropocene is a serious ecological challenge.Pollinators are important vectors that provide multiple essential ecosystem services but are declining rapidly in this changing world.However,several studies have argued that a high abundance of managed bee pollinators,such as honeybees(Apis mellifera),may be sufficient to provide pollination services for crop productivity,and sociological studies indicate that the majority of farmers worldwide do not recognize the contribution of wild pollinator diversity to agricultural yield.Here,we review the importance of pollinator diversity in natural and agricultural ecosystems that may be thwarted by the increase in abundance of managed pollinators such as honeybees.We also emphasize the additional roles diverse pollinator communities play in environmental safety,culture,and aesthetics.Research indicates that in natural ecosystems,pollinator diversity enhances pollination during environmental and climatic perturbations,thus alleviating pollen limitation.In agricultural ecosystems,pollinator diversity increases the quality and quantity of crop yield.Furthermore,studies indicate that many pollinator groups are useful in monitoring environmental pollution,aid in pest and disease control,and provide cultural and aesthetic value.During the uncertainties that may accompany rapid environmental changes in the Anthropocene,the conservation of pollinator diversity must expand beyond bee conservation.Similarly,the value of pollinator diversity maintenance extends beyond the provision of pollination services.Accordingly,conservation of pollinator diversity requires an interdisciplinary approach with contributions from environmentalists,taxonomists,and social scientists,including artists,who can shape opinions and behavior.

关键词： Bee Complementarity Ecological indicator Plant community Pollen limitation

Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma

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Journal of Genetics and Genomics 2023年第6期50卷 422-433页

作者： Bo Gong Yi liang Qian Zhang huan Li Jialing Xiao liang Wang Han Chen Wenjie yang Xiaoqing Wang Yi Wang Zongze He Department of Health Management Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China The Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Neurology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Pathology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Critical Care Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan610072China

Gliomas are the most prevalent and aggressive malignancies of the nervous system.Previous bioinformatic studies have revealed the crucial role of the secretory pathway kinase FAM20C in the prediction of glioma invasion and malignancy.However,little is known about the pathogenesis of FAM20C in the regulation of glioma.Here,we construct the full-length transcriptome atlas in paired gliomas and observe that 22 genes are upregulated by full-length transcriptome and differential APA analysis.Analysis of ATAC-seq data reveals that both FAM20C and NPTN are the hub genes with chromatin openness and differential expression.Further,in vitro and in vivo studies suggest that FAM20C stimulates the proliferation and metastasis of glioma cells.Meanwhile,NPTN,a novel cancer suppressor gene,counteracts the function of FAM20C by inhibiting both the proliferation and migration of glioma.The blockade of FAM20C by neutralizing antibodies results in the regression of xenograft tumors.Moreover,MAX,BRD4,MYC,and REST are found to be the potential trans-active factors for the regulation of FAM20C.Taken together,our results uncover the oncogenic role of FAM20C in glioma and shed new light on the treatment of glioma by abolishing FAM20C.

关键词： Glioma Alternativepolyadenylation sites FAM20C Trans-activefactors

Boosting C–C coupling to multicarbon products via high-pressure CO electroreduction

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Journal of Energy Chemistry 2023年第10期85卷 102-107,I0005页

作者： Wenqiang yang huan Liu Yutai Qi Yifan Li Yi Cui liang Yu Xiaoju Cui Dehui Deng State Key Laboratory of Catalysis Collaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Vacuum Interconnected Nanotech Workstation Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina

Electrochemical CO reduction reaction(CORR) provides a promising approach for producing valuable multicarbon products(C_(2+)), while the low solubility of CO in aqueous solution and high energy barrier of C–C coupling as well as the competing hydrogen evolution reaction(HER) largely limit the efficiency for C_(2+)production in CORR. Here we report an overturn on the Faradaic efficiency of CORR from being HER-dominant to C_(2+)formation-dominant over a wide potential window, accompanied by a significant activity enhancement over a Moss-like Cu catalyst via pressuring CO. With the CO pressure rising from 1 to 40 atm, the C_(2+)Faradaic efficiency and partial current density remarkably increase from 22.8%and 18.9 mA cm^(-2)to 89.7% and 116.7 mA cm^(-2), respectively. Experimental and theoretical investigations reveal that high pressure-induced high CO coverage on metallic Cu surface weakens the Cu–C bond via reducing electron transfer from Cu to adsorbed CO and restrains hydrogen adsorption, which significantly facilitates the C–C coupling while suppressing HER on the predominant Cu(111) surface, thereby boosting the CO electroreduction to C_(2+)activity.

关键词： CO electroreduction High pressure electrochemistry Cu catalyst C–C coupling Multicarbon products

A cancer cell turn-on protein-CuSMn nanoparticle as the sensor of breast cancer cell and CH_3O-PEG-phosphatide

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Chinese Chemical Letters 2018年第10期29卷 1528-1532页

作者： huan yang Hongjuan liang Yuwen Xie Qiuyun Chen School of Chemistry and Chemical Engineering Jiangsu University

Cancer activated protein-inorganic nanoparticles can be cancer targeting turn-on imaging and therapy agents. Although various techniques were successfully employed for development of hybrid proteininorganic nanoparticles, cancer cell activated protein-inorganic nanoparticles have been challengeable.Herein, a cancer cell responsive nanoparticle（PDAMn-CuS@BSA-FA, NPs） was constructed and characterized. It is found that the quenching interaction of dyes（PDA） and central metal in NPs can be adjusted by CH_3O-PEG-phosphatide or the cancer cells, hence, NPs showed turn-on fluorescence emission with the titration of CH_3O-PEG-phosphatide. In particular, breast cancer cells lysis can switch on the green emission greatly, while normal cells show less effect. Breast cancer cells turn-on fluorescence imaging and mitochondria targeting imaging demonstrate that the NPs can sense breast cancer cells and enter mitochondria. Therefore, NPs can be both breast cancer targeting nanosensor.

关键词： Activable sensor Protein-inorganic nanoparticle Cancer CH3O-PEG-phosphatide Attenuator

Research and application of Ti-Mn-based hydrogen storage alloys

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Journal of Iron and Steel Research(International) 2023年第4期30卷 611-625页

作者： yang-huan Zhang Chen Li Wei Zhang Xin Wei Jun Li Yan Qi Dong-liang Zhao Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China Collaborative Innovation Center of Integrated Exploitation of Bayan Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina China Rare Earth New Material(Weishan)Co. Ltd.Jining 277600ShandongChina

Ti–Mn-based hydrogen storage alloys are considered to be one of the most promising hydrogen storage alloys for proton exchange membrane fuel cell applications,because of their good hydrogen absorption and desorption kinetics,low price,good activation performance,possession of high electrochemical capacity,and good cycling performance.The structure,performance characteristics,crystal structure of hydrides,development and application status of Ti–Mn-based hydrogen storage alloys were reviewed,and the methods to improve Ti–Mn-based hydrogen storage alloys were discussed:optimization of the preparation process,element substitution,and surface treatment.(1)In the study of the alloy preparation process,it was found that the use of the annealing process can significantly improve the high rate discharge performance,and cycling stability performance,increasing the maximum discharge capacity of the alloy electrode.In addition,using vacuum plasma spraying to prepare the electrode has better cycling stability and kinetic performance.(2)In element substitution,the effects of using Zr elements to partially replace Ti and Mn with Cr,V,Mo,and Fe on the hydrogen storage properties of Ti–Mn-based alloys were investigated.(3)In the study of surface treatment,palladium was plated on the surface of TiMn_(1.5) alloy by chemical deposition,and the strong affinity of palladium for hydrogen accelerated the cleavage of hydrogen molecules,which significantly improved the hydrogen absorption kinetics of TiMn_(1.5) alloy.Meanwhile,a new binary alloy system was formed by adding TiMn_(2) to MgH_(2),and it was shown that the addition of TiMn_(2) significantly improved the hydrogen absorption/desorption kinetics of the MgH_(2) alloy.Finally,the prospect of the application of Ti–Mn-based hydrogen storage alloys is presented,and the insight of further development of the alloy is offered.

关键词： Hydrogen storage Ti-Mn-based alloy Property characterization Modification treatment Cycle life