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Intelligent representation method of image flatness for cold rolled strip

Journal of Iron and Steel Research International 2024年第5期31卷 1177-1195页

作者： yang-huan Xu Dong-cheng Wang hong-min Liu Bo-wei Duan National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment China National Heavy Machinery Research Institute Co.Ltd.Xi’an710018ShaanxiChina State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina

Real flatness images are the bases for flatness detection based on machine vision of cold rolled *** characteristics of a real flatness image are analyzed,and a lightweight strip location detection(SLD)model with deep semantic segmentation networks is *** interference areas in the real flatness image can be eliminated by the SLD model,and valid information can be *** this basis,the concept of image flatness is proposed for the first *** image flatness representation(IFAR)model is established on the basis of an autoencoder with a new *** optimal structure of the bottleneck layer is 16×16×4,and the IFAR model exhibits a good representation ***,interpretability analysis of the representation factors is carried out,and the difference and physical meaning of the representation factors for image flatness with different categories are *** flatness with new defect morphologies(bilateral quarter waves and large middle waves)that are not present in the original dataset are generated by modifying the representation factors of the no wave ***,the SLD and IFAR models are used to detect and represent all the real flatness images on the test *** average processing time for a single image is 11.42 ms,which is suitable for industrial *** research results provide effective methods and ideas for intelligent flatness detection technology based on machine vision.

关键词： Cold rolled strip Image flatness Location detection Representation learning Bottleneck layer

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Singularity analysis and avoidance for an SSRMS-type reconfigurable space manipulator with a non-spherical wrist and two lockable passive telescopic links

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Chinese Journal of Aeronautics 2024年第8期37卷 435-459页

作者： Zhiyuan ZHAO Xiaohang yang Yuntao LI Zichun XU Jingdong ZHAO hong LIU State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China

This study focuses on addressing kinematic singularity analysis and avoidance issues for a space station remote manipulator system(SSRMS)-type reconfigurable space *** manipulator is equipped with a non-spherical wrist and two lockable passive telescopic links(LPTLs),which enable it to have both active revolute and passive prismatic joints and operate in two distinct *** begin with the kinematic singularity analysis,the study derives the differential kinematic equations for the manipulator and identifies the dominant Jacobian matrix that causes ***,an in-depth analysis of singularities from multiple perspectives is ***,a kinematic singularity map method is proposed to capture the distribution of singularities within the reachable ***,the influence of the two LPTLs on singularities is thoroughly ***,a new method based on the matrix rank equivalence principle is introduced to determine singularity conditions,enabling the identification of all the singular configurations for the SSRMS-type reconfigurable ***,this method significantly reduces computational complexity,and the singularity conditions obtained have more concise *** the singularity avoidance problem,a novel method is developed,which simultaneously addresses the requirements of real-time performance,high precision,and the avoidance of both kinematic singularities and joint limit *** from these excellent properties,the proposed method can effectively resolve the singularity issues encountered separately by the SSRMS-type reconfigurable manipulator in its two operational *** typical simulations validate the utility of all the proposed methods.

关键词： Reconfigurable space manipulator Redundant manipulator Kinematics Singularity analysis Singularity avoidance

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Generative Models for the Evolution of Transportation Systems

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Yixu He hongyi Lin lan yang yang Liu School of Information Engineering， Chang'an University School of Vehicle and Mobility， Tsinghua University Department of Architecture and Civil Engineering， Chalmers University of Technology

As the development of big data and artificial intelligence accelerates， many studies have begun to incorporate methods of machine learning and deep learning to address multifaceted challenges within the field of transportation. Generative models， garnering increasing attention in recent years， are gradually bolstering the progression of intelligent transportation systems. This paper conducts an extensive investigation into the applications and potential of generative models in the evolution of transportation systems. It specifically delves into three primary areas: trajectory generation， traffic flow prediction， and autonomous driving. While generative models have already made significant contributions， their full capabilities remain underexplored. Consequently， this paper introduces promising avenues for future exploration， such as the potential integration of diffusion models in autonomous driving， harnessing generative models for infrastructure planning， and leveraging generative models to enhance traffic safety. It is anticipated that this paper will serve as a comprehensive and insightful reference for researchers and scholars engaged in generative models and their applications in the transportation domain.

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A Complex Fuzzy LSTM Network for Temporal-Related Forecasting Problems

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Computers, Materials & Continua 2024年第9期80卷 4173-4196页

作者： Nguyen Tho Thong Nguyen Van Quyet Cu Nguyen Giap Nguyen Long Giang Luong Thi hong lan Institute of Information Technology Vietnam Academy of Science and TechnologyHoang Quoc VietCau GiayHanoi100000Vietnam Academic Affairs Department Thai Nguyen University of EducationThai Nguyen250000Vietnam Center of Science and Technology Research and Development Thuongmai UniversityHo Tung MauCau GiayHanoi100000Vietnam Faculty of Information Technology Hanoi University of IndustryBac Tu LiemHanoi100000Vietnam

Time-stamped data is fast and constantly growing and it contains significant information thanks to the quick development ofmanagement platforms and systems based on the Internet and cutting-edge information communication *** the time series data including time series prediction has many practical *** new techniques were developed for use with various types of time series data in the prediction *** those,this work suggests a unique strategy to enhance predicting quality on time-series datasets that the timecycle matters by fusing deep learning methods with fuzzy *** order to increase forecasting accuracy on such type of time-series data,this study proposes integrating deep learning approaches with fuzzy ***,it combines the long short-termmemory network with the complex fuzzy set theory to create an innovative complex fuzzy long short-term memory model(CFLSTM).The proposed model adds a meaningful representation of the time cycle element thanks to a complex fuzzy set to advance the deep learning long short-term memory(LSTM)technique to have greater power for processing time series *** on standard common data sets and real-world data sets published in the UCI Machine Learning Repository demonstrated the proposedmodel’s utility compared to other well-known forecasting *** results of the comparisons supported the applicability of our proposed strategy for forecasting time series data.

关键词： Complex fuzzy set long short-term memory(LSTM) CFLSTM T-CFLSTM

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Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： Yani Xu lan yang Min Li Haozhou Shu Na Jia Yunzhen Gao Rongying Shi Xiaojia yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate from<5%by 5-FU alone to~80.1%.This nanotherapeutic platform achieved higher therapeutic efficacy with a lower agent dose,thereby minimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil Nanocomposite

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Propylene epoxidation coupled with furfural oxidation over Pt(Ⅱ?) TPP porphyrin with molecular oxygen

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Green Chemical Engineering 2024年第4期5卷 519-525页

作者： hong-Qi Li Hai-yang Yu yang Li Xiao-Qi He Xian-Tai Zhou Huizhou Research Institute Sun Yat-sen University School of Chemical Engineering and Technology Sun Yat-sen University

The development of green route for preparing propylene oxide (PO) with molecular oxygen is of significance both in academic and industrial. In this work, propylene epoxidation coupled with furfural oxidation catalyzed by platinum meso-tetraphenylporphyrin (Pt (II)TPP) has been developed. Propylene conversion and PO selectivity reached up to 56%and 83%, respectively. Meanwhile, furfural was almost completely converted to furoic *** on operando characterizations and electron paramagnetic resonance (EPR) tests, a mechanism involved high-valent Pt species was proposed. This work is expected to provide a potential application prospects for producing PO and furoic acid simultaneously in chemical industry.

关键词： Propylene Epoxidation Molecular oxygen Furfural Platinum porphyrins

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Identification and immune analysis of antimicrobial peptides from the cigarette beetle(Lasioderma serricorne)

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Insect Science 2024年第4期31卷 1121-1134页

作者： Yue Zhang Yi Yan Guy Smagghe hong yang Ren-huai Dai Wen-jia yang Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

Antimicrobial peptides(AMPs)in insects are endogenous peptides that are effector components of the innate defense system of the *** may serve as antimicrobial agents because of their small molecular weight and broad-spectrum antimicrobial *** this study,we performed transcriptome analysis of cigarette beetle(Lasioderma serricorne)larvae,parasitized by the ectoparasitic wasp,Anisopteromalus *** AMP genes were significantly upregulated following *** parasitism,postulating the hypothesis that the parasitization enhanced the host's resistance against pathogenic microorganisms through the regulation of host AMP ***,3 AMP genes(LsDef1,LsDef2,and LsCole)were significantly upregulated and we studied their immune function in *** challenge and functional analysis showed that LsCole was responsible for the immune response against Gram-negative and Gram-positive bacteria,while LsDef1 and LsDef2 were involved in insect defense against Gram-positive *** recombinant LsCole exhibited antimicrobial activities against the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus ***2 showed an antibacterial effect against *** and LsDef2 exhibited antibiofilm activity against *** 2 AMPs disrupted cell membranes and caused leakage of *** cell *** results indicated that the 3 AMPs in *** are involved in the innate immunity of this pest *** AMPs may have potential as antimicrobial agents for bacterial infection ***,data are discussed in relation to new control strategies with greater biosafety against pest insects with use of microbial biocontrol agents in combination with RNA interference against the insect's defensive AMP genes.

关键词： antimicrobial activity antimicrobial peptides innate immune response Lasioderma serricorne RNA interference

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Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： hong-hong Liu Yunbo Xie Bao-Peng yang Huan-Yue Wen Peng-Hui yang Jin-E Lu Yan Liu Xi Chen Meng-Meng Qu yang Zhang Wei-Guo hong Yong-Gang Li Junliang Fu Fu-Sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

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Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

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Current Medical Science 2024年第1期44卷 223-231页

作者： hong-li ZHANG Na LI Lin DONG hong-xia MA Mo-chi yang Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinoblastoma(RB)is a prevalent type of eye cancer in *** homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,hepatocyte,pancreatic,heart,lens,retinal,and cancer *** goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance,as well as to explore the underlying Notch1 *** Human RB cell lines(SO-RB50 and Y79)and a primary human retinal microvascular endothelial cell line(ACBRI-181)were used in this *** expression of Prox1 and Notch1 mRNA and protein in RB cells was detected using quantitative real time-polymerase chain reaction(RT-qPCR)and Western *** proliferation was assessed after Prox1 overexpression using the Cell Counting Kit-8 and the MTS ***-resistant cell lines(SO-RB50/vincristine)were generated and treated with Prox1 to investigate the role of Prox1 in drug *** employed pcDNA-Notch1 to overexpress Notch1 to confirm the role of Notch1 in the protective function of ***,a xenograft model was constructed to assess the effect of Prox1 on RB in *** Prox1 was significantly downregulated in RB *** of Prox1 effectively decreased RB cell growth while increasing the sensitivity of drug-resistant cells to ***1 was involved in Prox1’s regulatory ***1 was identified as a target gene of Prox1,which was found to be upregulated in RB cells and repressed by increased Prox1 *** pcDNA-Notch1 was transfected,the effect of Prox1 overexpression on RB was ***,by downregulating Notch1,Prox1 overexpression slowed tumor development and increased vincristine sensitivity in *** These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1,implying that Prox1 could be a potential therapeutic target for RB.

关键词： Proxl Notch1 retinoblastoma cells proliferation drug resistance

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Origin of the near-room temperature resistance transition in lutetium with H2/N2 gas mixture under high pressure

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National Science Review 2024年第7期11卷 26-32页

作者： Di Peng Qiaoshi Zeng Fujun lan Zhenfang Xing Zhidan Zeng Xiaoxing Ke yang Ding Ho-kwang Mao Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical Science(HFIPS)Chinese Academy of Sciences Science Island Branch Graduate School of University of Science and Technology of China Center for High Pressure Science and Technology Advanced Research Shanghai Key Laboratory of Material Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS) State Key Laboratory of Superhard Materials Institute of PhysicsJilin University College of Materials Science&Engineering Beijing University of Technology

The recent report of room-temperature superconductivity at near-ambient pressure in nitrogen-doped lutetium hydride（Lu-H-N） by Dasenbrock-Gammon et al. [Nature 615, 244–250（2023）] has attracted tremendous attention due to its anticipated great impact on technology. However, the results could not be independently reproduced by other groups worldwide in follow-up studies, which elicited intense controversy. Here, we develop a reliable experimental protocol to minimize the extensively concerned extrinsic influences on the sample by starting the reaction from pure lutetium loaded with an H2/N2gas mixture in a diamond anvil cell under different pressures and temperatures and simultaneously monitoring the entire chemical reaction process using in situ four-probe resistance measurements. Therefore, we could repeatedly reproduce the near-room temperature upsurge of electrical resistance at a relatively early stage of the chemical reaction. However, the mechanism is suggested to be a metal-to-semiconductor/insulator transition associated with the structural modulation in the non-stoichiometric Lu-H-N, rather than superconductivity.

关键词： superconductivity high pressure lutetium hydride resistance transition metal-to-semiconductor/insulator transition

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