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顺铂诱导肾损伤模型在C57BL/6小鼠J和N亚型中的差异性研究

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中国药理学通报 2024年第4期40卷 792-797页

作者：王婵邱会琴唐亚婷朱方媛范彦英杨彩红山西医科大学基础医学院药理学教研室山西太原030001

目的探讨C57BL/6 J和N亚型小鼠在顺铂诱导肾损伤模型中的易感性差异,为选择药物肾损伤模型提供理论依据。方法雄性C57BL/6小鼠J和N两种亚型,各随机分为正常组(Control)、模型组(cisplatin,CDDP)。模型组腹腔注射顺铂(3.33 mg·kg^(-1))... 详细信息

目的探讨C57BL/6 J和N亚型小鼠在顺铂诱导肾损伤模型中的易感性差异,为选择药物肾损伤模型提供理论依据。方法雄性C57BL/6小鼠J和N两种亚型,各随机分为正常组(Control)、模型组(cisplatin,CDDP)。模型组腹腔注射顺铂(3.33 mg·kg^(-1)),隔天给药,持续2周,记录小鼠体重变化、存活率;检测Scr、BUN和β2-MG评价肾功能;HE、Masson和PAS染色法观察肾皮质病理改变。IL-6、IL-1β和IL-18等炎症因子检测顺铂导致的肾脏炎症反应。结果与Control组相比,CDDP组两种亚系小鼠Scr、BUN和β2-MG均明显升高;组织学结果显示肾小管损伤,胶原纤维化和糖原沉积均增加;IL-6、IL-1β和IL-18炎症因子含量和肾皮质蛋白表达均明显升高。C57BL/6N与C57BL/6J系小鼠比较,C57BL/6N系小鼠肾功能指标Scr和BUN均值明显偏高(P<0.01),组织学评分各病理损伤较C57BL/6J亚系小鼠明显偏高,反映纤维化的Masson染色差异具有统计学意义(P<0.01);IL-6、IL-1β和IL-18均值明显偏高,但差异无统计学意义。结论C57BL/6 J和N亚型小鼠均可使用顺铂诱导成功肾损伤模型,相比于C57BL/6J小鼠,C57BL/6N亚系小鼠在肾功能、组织学以及炎症因子等方面损伤明显,提示C57BL/6N亚系小鼠更适于作为药物或者其他肾功能损伤模型的建立。

关键词：顺铂亚急性肾损伤 C57BL/6亚系炎症因子 IL-6 IL-1β IL-18

Engineering porous organic polymers for carbon dioxide capture

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Science China Chemistry 2017年第8期60卷 1007-1014页

作者： Ning Huang Gregory Day Xinyu yang Hannah Drake hong-cai Zhou Department of Chemistry Texas A＆M University College Station TX 77843 US

As atmospheric CO_2 levels rise, the development of physical or chemical adsorbents for CO_2 capture and separation is of great importance on the way towards a sustainable low-carbon future. Porous organic polymers are promising candidates for CO_2 capture materials owing to their structural flexibility, high surface area, and high stability. In this review, we highlight high-performance porous organic polymers for CO_2 capture and summarize the strategies to enhance CO_2 uptake and selectivity, such as increasing surface area, increasing interaction between porous organic polymers and CO_2, and pore surface functionalization.

关键词： porous organic polymers C02 capture nanomaterials post-synthesis polymer

Bioinspired nanotransducers for neuromodulation

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Nano Research 2024年第2期17卷 618-632页

作者： Fan yang Xiang Wu Sa cai Guosong hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

Use of chlorophyll fluorescence and P700 absorbance to rapidly detect glyphosate resistance in goosegrass(Eleusine indica)

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Journal of Integrative Agriculture 2015年第4期14卷 714-723页

作者： ZHANG Tai-jie FENG Li TIAN Xing-shan yang cai-hong GAO Jia-dong Institute of Plant Protection Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of High Technology for Plant Protection

The rapid detection of glyphosate resistance in goosegrass（Eleusine indica） will enhance our ability to respond to new resistant populations of this major weed. Chlorophyll fluorescence（Fluo） and P700（reaction center chlorophyll of photosystem I） absorbance were analyzed in one biotype of goosegrass that is resistant to glyphosate and in another that remains sensitive to the herbicide. Both biotypes were treated with a foliar spray of glyphosate. Differences in photosystem II maximum quantum yield（Fv/Fm）, effective photochemical quantum yield（Y（II））, and non-photochemical quenching（NPQ） between the biotypes increased over time. Values for Fv/Fm and Y（II） differed between the two biotypes 24 h after treatment（HAT）. Differentiated activities and energy dissipation processes of photosystem II（PSII） and energy dissipation processes of photosystem I（PSI） were manifested in the two biotypes 24 HAT with 20 mmol L–1 glyphosate. Differentiated energy dissipation processes of PSI were still apparent 24 HAT with 200 mmol L–1 glyphosate. These results indicate that the Fluo parameters related to PSII activity and energy dissipation and the P700 parameters related to energy dissipation are suitable indicators that enable rapid detection of glyphosate resistance in goosegrass.

关键词： Eleusine indica glyphosate resistance chlorophyll fluorescence P700

Effect of Direct Ageing Treatment on Stress-Rupture Properties of GH761 Alloy

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Journal of Iron and Steel Research International 2008年第3期15卷 61-64页

作者： yang Shu-lin SUN Wen-ru LIU Fang GUO Shou-ren yang hong-cai HU Zhuang-qi School of Materials and Metallurgy Northeastern University Shenyang 110004 Liaoning China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 Liaoning China

The effect of direct ageing treatment on microstructure and stress-rupture properties of GH761 alloy was studied. Phosphorus was added to the tested alloy for its beneficial effect on stress-rupture life. It was found that the grain size of the tested alloy became much finer after direct ageing treatment, in comparison with the commercial GH761 alloy under standard heat treatment condition. The optimum direct ageing treatment has been determined as follows： 830 ℃ × 4 h, air cooling＋ 720 ℃ × 24 h, air cooling. After such treatment, the higher stress-rupture prop- erties of the test alloy at 650 ℃, 690 MPa were obtained. The role of phosphorus is still effective under the condition of direct ageing treatment.

关键词： direct ageing treatment GH761 mechanical property precipitate

Heavier Group 14 Congeners of Metalla-isobenzenes:Access to Metalla-isosilabenzene and Metalla-isogermabenzene by One-Pot Reactions

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Chinese Journal of Chemistry 2024年第10期42卷 1121-1127页

作者： Jinyu Zhao Yapeng cai Xin yang hong Zhang Department of Chemistry Xiamen UniversityXiamenFujian 361005China

Metalla-isosilabenzenes and metalla-isogermabenzenes have been successfully synthesized by the formal[5+1]-cycloaddition of diethynylsilane or diethynylgermane with simple metal *** is the first example of a heavier Group 14 metalla-isobenzene isomer bearing a cumulative double bond motif within a *** novel complexes were fully characterized by NMR spectroscopy and single-crystal X-ray diffraction *** stabilization of the cyclic metal-vinylidene complexes has been analyzed using density functional theory(DFT)*** the metalla-isosilabenzenes bearing Si—H bond were treated with the trityl salt as a hydride scavenger,the formation of silylium cation was observed *** of metalla-isosilabenzenes and metalla-isogermabenzenes can readily undergo migratory insertion reactions to furnish siloles or germoles.

关键词： Metalla-isosilabenzene Metalla-isogermabenzene Density functional calculations Cycloaddition Metallacycles

Investigating the mechanisms of glyphosate resistance in goosegrass(Eleusine indica) population from South China

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Journal of Integrative Agriculture 2015年第5期14卷 909-918页

作者： ZHANG Chun FENG Li HE Ting-ting yang cai-hong CHEN Guo-qi TIAN Xing-shan Guangdong Provincial Key Laboratory of High Technology for Plant Protection Institute of Plant ProtectionGuangdong Academy of Agricultural Sciences

Glyphosate has been used worldwide for nearly 40 years,and 30 types of resistant weeds have been *** is mass-produced and widely used in China,but few studies and reports on glyphosate-resistant weeds and resistance mechanisms *** studies found a goosegrass species with high glyphosate resistance from orchards in South China and its glyphosate resistant mechanism was described in this *** cDNAof 5-enolpyruvylshikimate-3-phosphate synthase（EPSPS,EC 2.***.1.19）,the target enzyme of glyphosate,was cloned from the glyphosate-resistant and-susceptible goosegrass,respectively,and referred as EPSPS-R and *** Pro106 residue was known to be involved in the glyphosate resistance in most goosegrass ***,sequence analysis did not find the mutation at the Pro106 residue in the R biotype EPSPS amino acid *** residue 133 and 382 was mutated in the R biotype EPSPS amino acid sequence instead,but it did not affect the EPSPS-S and EPSPS-R genes sensitivities to ***-PCR and Western blot analyses suggested that EPSPS mRNA and protein are mainly present in the shoot tissues both in the R and S goosegrass *** EPSPS-R rapidly responds to the glyphosate in R-biotype goosegrass and the induced expression was detected at 12 h post glyphosate *** mRNA and protein expression of EPSPS-R increased constantly as the increasing concentration of ***,the expression of the EPSPS-S was not induced significantly by glyphosate in the S goosegrass *** of real-time PCR results showed that the copy number of the EPSPS in R-biotype goosegrass was 4.7 times higher than that in the S goosegrass *** the results implied that EPSPS gene amplification might mainly caused the glyphosate resistance of a goosegrass population collected from orchards in South China.

关键词： populations shoot residue susceptible constantly translocation instead implied confer chlorophyll

2015—2023年乌鲁木齐市哨点医院内镜清洗消毒质量和管理现况调查

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中华医院感染学杂志 2024年第18期34卷 2853-2857页

作者：张段段赵国玉雒涛肖锦秀吾力肯·吐尔达力杨洪彩傅虹艾山江·哈得尔新疆维吾尔自治区疾病预防控制中心新疆乌鲁木齐830002

目的调查乌鲁木齐市哨点医院内镜室工作人员构成和内镜室设置情况,了解哨点医院内镜消毒质量,为内镜消毒工作和内镜室管理提供参考和改进方向。方法2015年-2023年3月,对新疆乌鲁木齐市9家哨点医院清洗消毒后内镜合格率、细菌污染情况进... 详细信息

目的调查乌鲁木齐市哨点医院内镜室工作人员构成和内镜室设置情况,了解哨点医院内镜消毒质量,为内镜消毒工作和内镜室管理提供参考和改进方向。方法2015年-2023年3月,对新疆乌鲁木齐市9家哨点医院清洗消毒后内镜合格率、细菌污染情况进行监测,同时对内镜室工作人员构成和设备配置情况进行调查,监测频率为每季度一次。结果2015年-2023年3月对9家哨点医院共采集内镜样本425份,合格413份,合格率为97.18%,2018年合格率最低为79.31%,不同年份合格率差异有统计学意义(χ^(2)=24.241,P<0.001);除2023年外,其他年份内镜均有菌落检出,2019年内镜检出菌量在1~20 CFU/件的内镜占比达到66.67%,占比较高,对部分样本进行微生物鉴定,共检测样本96份,1份检出致病菌铜绿假单胞菌,检出率为1.03%;内镜手工清洗消毒和机械清洗消毒合格率差异无统计学意义(χ^(2)=3.049,P=0.081),二级医院和三级医院内镜消毒合格率差异无统计学意义(χ^(2)=2.391,P=0.122);对哨点医院内镜室设备设施配备情况和工作人员学历职称等内容进行调查,内镜室超声清洗器和终末漂洗水净化设备配备率为71.43%,其他设备设施配备率均为100%;内镜室工作人员普遍存在学历和职称偏低情况。结论乌鲁木齐市哨点医院内镜整体消毒状况较好,但部分医院内镜消毒仍旧存在不合格情况,需要积极采取干预措施,提高内镜消毒质量,避免医院感染发生,同时要加强对工作人员清洗消毒过程中的培训和管理,确保内镜清洗消毒工作规范开展。

关键词：哨点医院内镜消毒消毒质量管理微生物污染铜绿假单胞菌内镜室管理现况调查乌鲁木齐

Combinatorial reasoning-based abnormal sensor recognition method for subsea production control system

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Petroleum Science 2024年第4期21卷 2758-2768页

作者： Rui Zhang Bao-Ping cai Chao yang Yu-Ming Zhou Yong-hong Liu Xin-yang Qi College of Mechanical and Electronic Engineering China University of Petroleum BGP Inc. China National Petroleum Corporation

The subsea production system is a vital equipment for offshore oil and gas production. The control system is one of the most important parts of it. Collecting and processing the signals of subsea sensors is the only way to judge whether the subsea production control system is normal. However, subsea sensors degrade rapidly due to harsh working environments and long service time. This leads to frequent false alarm incidents. A combinatorial reasoning-based abnormal sensor recognition method for subsea production control system is proposed. A combinatorial algorithm is proposed to group sensors. The long short-term memory network(LSTM) is used to establish a single inference model. A counting-based judging method is proposed to identify abnormal sensors. Field data from an offshore platform in the South China Sea is used to demonstrate the effect of the proposed method. The results show that the proposed method can identify the abnormal sensors effectively.

关键词： Abnormal sensor Combinatorial algorithm Fault identification Subsea production control system