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基于Laplacian正则和协同训练的抽油井故障诊断方法

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机电工程技术 2024年第6期53卷 216-220页

作者：杨浩然袁春华沈阳理工大学自动化与电气工程学院沈阳110159

单一视角下部分不同类型的工况样本相似会导致故障诊断准确率不高、无标记样本未被使用等问题,为进一步提高有杆泵抽油井故障诊断准确率,有效利用无标记样本,充分利用示功图和电功率两种数据,采用Laplacian正则和协同训练算法设计了抽... 详细信息

单一视角下部分不同类型的工况样本相似会导致故障诊断准确率不高、无标记样本未被使用等问题,为进一步提高有杆泵抽油井故障诊断准确率,有效利用无标记样本,充分利用示功图和电功率两种数据,采用Laplacian正则和协同训练算法设计了抽油井故障诊断方法。首先,将Laplacian正则引入到协同训练模型中,以提高初始分类器精度;其次,以示功图和电功率作为特征视角,利用三层小波包变换提取视角特征,使用特征数据训练出对应的初始分类器,两者之间交换未知信息并更新分类器,提高模型的精确性;最后,应用该方法对某采油厂抽油机井的6种典型工况进行识别,并与标准协同训练、有监督学习方法进行比较。结果表明:在有标记样本较少时,该方法识别准确率优于仅使用示功图的SVM、仅使用电功率的SVM、标准协同训练,分别提高了约23.4%、20.83%、3.42%,验证了该方法的有效性。

关键词：故障诊断协同训练 Laplacian正则抽油井

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筑牢新经济组织领导力基石——以华贸中心为例

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中国领导科学 2024年第2期 107-113页

作者：黎明吉乐杨皓然华贸集团北京建筑大学城市经济与管理学院

作为新时代新经济组织的杰出代表--华贸集团秉承“对城市负责、对社会负责、对历史负责”的初心使命,创建了“四个融合”新经济组织党建品牌,在一片约230亩的土地上打造了城市综合体的世界级品牌--华贸中心。位于华贸中心的商业主力店北... 详细信息

作为新时代新经济组织的杰出代表--华贸集团秉承“对城市负责、对社会负责、对历史负责”的初心使命,创建了“四个融合”新经济组织党建品牌,在一片约230亩的土地上打造了城市综合体的世界级品牌--华贸中心。位于华贸中心的商业主力店北京SKP,2020年单店销售额达177亿元,首超英国哈罗德百货问鼎全球第一;2021年和2022年进阶至240亿元,2023年超过260亿元,连续4年稳居全球第一。这组数据表明,华贸中心以党建筑牢新型经济组织领导力的基石,在百年变局加速演进、世界经济增长动能不足的大环境下,创造了“全球店王”和“全球第一商圈”,为全球商业和时尚业的发展提供了中国方案。

关键词：新经济组织领导力华贸中心三个负责四个融合

基于随机森林和人工神经网络构建种植体周炎的诊断模型

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华西口腔医学杂志 2024年第2期42卷 214-226页

作者：杨浩然陈宇翔赵安娜程婷婷周建忠李自良昆明医科大学附属口腔医院昆明650000 云南省口腔医学重点实验室昆明650000

目的本研究旨在揭示种植体周炎发生发展过程中参与调控的关键基因,并通过随机森林(RF)和人工神经网络(ANN)构建种植体周炎的诊断模型。方法本研究从GEO数据库中获取GSE33774、GSE106090和GSE57631数据集。对GSE33774和GSE106090数据集... 详细信息

目的本研究旨在揭示种植体周炎发生发展过程中参与调控的关键基因,并通过随机森林(RF)和人工神经网络(ANN)构建种植体周炎的诊断模型。方法本研究从GEO数据库中获取GSE33774、GSE106090和GSE57631数据集。对GSE33774和GSE106090数据集进行差异表达和功能富集分析,通过蛋白质互作网络(PPI)和RF筛选出关键基因,利用ANN建立种植体周炎的诊断模型,并在GSE33774和GSE57631数据集中进行验证。同时,构建转录因子-基因相互作用网络和转录因子-微小RNA (miRNA)调控网络。结果本研究共筛选出124个参与调控种植体周炎的差异表达基因(DEGs)。富集分析结果表明,DEGs主要和免疫受体活性蛋白及细胞因子受体活性相关,主要参与白细胞和中性粒细胞迁移的过程。PPI和RF筛选出6个关键基因,分别为CD38、CYBB、FCGR2A、SELL、TLR4和CXCL8。受试者操作特征曲线(ROC)表明ANN模型具有较好的诊断性。本研究还发现FOXC1、GATA2和NF-κB1可能是种植体周炎中重要的转录因子,hsa-miR-204可能是关键的miRNA。结论 RF和ANN构建的种植体周炎的诊断模型可信度高,CD38、CYBB、FCGR2A、SELL、TLR4和CXCL8是潜在的诊断标志物。FOXC1、GATA2和NF-κB1可能是种植体周炎中重要的转录因子,hsa-miR-204作为关键的miRNA在其中扮演着重要角色。

关键词：种植体周炎生物信息学随机森林人工神经网络诊断模型

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某核电厂国产电子个人剂量监测系统应用实践

辐射防护通讯 2024年第2期44卷 31-34页

作者：李辉杨浩然谢江山中核霞浦核电有限公司福建霞浦355100

针对国内核电厂电子个人剂量监测系统的现状及存在的问题,详细介绍了国内某核电厂应用首个国产电子个人剂量监测系统在数据接口、电子剂量计配发、电子剂量计开通方式、辐射控制区通行证管理、个人剂量管理软件功能、天然本底辐射扣除... 详细信息

针对国内核电厂电子个人剂量监测系统的现状及存在的问题,详细介绍了国内某核电厂应用首个国产电子个人剂量监测系统在数据接口、电子剂量计配发、电子剂量计开通方式、辐射控制区通行证管理、个人剂量管理软件功能、天然本底辐射扣除等方面的优化实践,以及整个系统的应用效果。给出了针对国产电子个人剂量监测系统的改进建议。

关键词：核电厂电子个人剂量监测系统管理

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某核电厂首次核清洁创新优化实践

中国核电 2024年第2期17卷 248-251页

作者：李辉杨浩然谢江山中核霞浦核电有限公司福建霞浦355100

研究了核电厂首次核清洁存在的常见问题,总结了某核电厂从核清洁实施策略、核清洁实施计划、核清洁脚手架搭建、核清洁安全管理、核清洁作业方法、核清洁验收方法、核清洁维持方法及核清洁质量控制等方面开展了创新优化实践,取得了较好... 详细信息

研究了核电厂首次核清洁存在的常见问题,总结了某核电厂从核清洁实施策略、核清洁实施计划、核清洁脚手架搭建、核清洁安全管理、核清洁作业方法、核清洁验收方法、核清洁维持方法及核清洁质量控制等方面开展了创新优化实践,取得了较好的效果,对提高我国核电厂首次核清洁管理及实施水平提供了参考和借鉴。

关键词：核电厂核清洁创新

Enhanced thermal performance from liquid metal in copper/graphite filled elastomer

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Journal of Materials Science & Technology 2023年第21期152卷 247-255页

作者： Yisimayili Tuersun Xu Huang Mingdeng Huang Weiguang Lin Pingjun Luo haoran yang Sheng Chu School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

With the increasing integration level of modern electronics,thermal management becomes an urgent issue for guaranteeing the work efficiency and lifespan of *** the basis of intrinsic high thermal conductivity nature,highly ordered graphite and copper stripes are densely aligned in the silicone gel pads in vertical(VCuGr)and oblique(@15°CuGr)directions to couple the high thermal conductivity and mechanical *** wetting nature of liquid metal(LM)on the chemically treated Cu surface is utilized to form a LM layer on the two surfaces of thermal *** obtained LM-pad TIMs possessed ultrahigh through-plane thermal conductivity(VCuGr:71.4 W/(m K),@15°CuGr:62.5 W/(m K))under the normal packaging *** thermal resistance decreased from 0.69 cm^(2) K/W to 0.25 cm^(2) K/W with the surface modification with *** simulation and practical thermal dissipation test results further demonstrate the excellent thermal management capability of these composites in high-power electronics.

关键词： Vertical copper/graphite High thermal conductivity Liquid metal modification Low thermal resistance Excellent thermal management

Rational design, synthesis, and biological evaluation of novel C6-modified geldanamycin derivatives as potent Hsp90 inhibitors and anti-tumor agents

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Chinese Chemical Letters 2023年第2期34卷 434-439页

作者： Ruxuan Wang Rentao Zhang haoran yang Nina Xue Xiaoguang Chen Xiaoming Yu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Heat shock protein 90(Hsp90) is an appealing anticancer drug target that provoked a tremendous wave of investigations. Geldanamycin(GA) is the first identified Hsp90 inhibitor that exhibited potent anticancer activity, but the off-target toxicity associated with the benzoquinone moiety hampered its clinical application. Until now, structure optimization of GA is still in need to fully exploit the therapeutic value of Hsp90. Due to the structural complexity and synthetic challenge of this compound family, conventional optimization is bound to be costly but high efficiency is expected to be reachable by combining the art of rational design and total synthesis. Described in this paper is our first attempt at this approach aiming at rational modification of the C6-position of GA. The binding affinities towards Hsp90 of compound 1(C6-ethyl) and 2(C6-methyl) were designed and predicted by using Discovery Studio. These compounds were synthesized and further subjected to a thorough in vitro biological evaluation. We found that compounds1 and 2 bind to Hsp90 protein with the IC_(50) of 34.26 nmol/L and 163.7 nmol/L, respectively. Both compounds showed broad-spectrum antitumor effects. Replacing by ethyl, compound 1 exhibited more potent bioactivity than positive control GA, such as in G2/M cell cycle arrest, cell apoptosis and client proteins degradations. The results firstly indicated that the docking study is able to provide a precise prediction of Hsp90 affinities of GA analogues, and the C6 substituent of GA is not erasable without affecting its biological activity.

关键词： Hsp90 inhibitors Geldanamycin derivatives Total synthesis Structure-activity relationship Anticancer

Prediction of Low-Permeability Reservoirs Performances Using Long and Short-Term Memory Machine Learning

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1521-1528页

作者： Guowei Zhu Kangliang Guo haoran yang Xinchen Gao Shuangshuang Zhang School of Geosciences Yangtze UniversityWuhan430100China

In order to overcome the typical limitations of numerical simulation methods used to estimate the production of low-permeability reservoirs,in this study,a new data-driven approach is proposed for the case of water-driven hypo-permeable *** particular,given the bottlenecks of traditional recurrent neural networks in handling time series data,a neural network with long and short-term memory is used for such a *** method can reduce the time required to solve a large number of partial differential *** such,it can therefore significantly improve the efficiency in predicting the needed production *** examples about water-driven hypotonic reservoirs are provided to demonstrate the correctness of the method and its ability to meet the requirements for practical reservoir applications.

关键词： Water flooding flow in porous media data-driven LSTM CFD

Numerical investigation on fire-induced indoor and outdoor air pollutant dispersion in an idealized urban street canyon

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Building Simulation 2022年第4期15卷 597-614页

作者： Shengzhong Zhao haoran yang Chaorui Li Imad Obadi Fei Wang Wenjun Lei Tiantian Xu Miaocheng Weng School of Thermal Engineering Shandong Jianzhu UniversityJinanChina School of Architecture Design and PlanningThe University of SydneySydneyAustralia School of Civil Engineering Chongqing UniversityChongqingChina

Fire-induced pollutant dispersion under the influence of buoyancy in urban street canyons has attracted wide attention given its adverse impact on human *** study analyzes the influences of fire source location and crossflowing wind(perpendicular to the canyon centerline)on indoor and outdoor air pollutant dispersion in an idealized urban street canyon by employing large eddy *** fire scenarios are defined according to the transverse location of the fire source:near the windward building(scenario 1),in the middle of the canyon(scenario 2),and near the leeward building(scenario 3).Results show that a re-entrainment phenomenon appears when the wind velocity reaches a critical value in scenarios 1 and 2,but it doesn't occur in scenario *** source location significantly influences the critical re-entrainment *** critical velocity in scenario 1 is approximate 1.2-1.5 m/s larger than that in scenario *** the heat release rate is large,the critical Fr numbers are less sensitive to changes in HRR,and remain approximately constant with values of 0.47(scenario 1)and 0.37(scenario 2).When the wind velocity is large,more compartments are expected to be affected in the upper floors in all of the three scenarios,and smoke is distributed in an inverted triangle within the *** indoor/outdoor temperature and pollutant concentrations are also *** findings can provide valuable information for both human and property safety in relation to urban street canyons and their surrounding buildings.

关键词： air pollutant dispersion fire smoke street canyon critical re-entrainment velocity fire source location