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Changes of paired-pulse evoked responses during the development of epileptic activity in the hippocampus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 704-711页

作者： Zhou-yan FENG Xiao-jing ZHENG Cong TIAN yang WANG hao-yu XING Ministry of Education Key Lab of Biomedical Engineering College of Biomedical Engineering & Instrument ScienceZhejiang UniversityHangzhou 310027China

Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons,thereby inducing epileptic *** aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity induced in the absence of ***-pulse orthodromic and antidromic stimulations were used to test the changes in the evoked responses in the ***(PTX),γ-aminobutyric acid(GABA) type A(GABA A) receptor antagonist,was added to block the inhibitory synaptic transmission and to establish the epileptic *** evoked population spike(PS) was recorded in the CA1 region of the *** results showed that the application of PTX induced a biphasic change in the paired-pulse ratio of PS amplitude.A short latency increase of the second PS(PS2) was later followed by a reappearance of PS2 *** type of depression was observed in both orthodromic and antidromic paired-pulse responses,whereas the GABAergic PS2 depression [called paired-pulse depression(PPD)] during baseline recordings only appeared in orthodromic-evoked *** addition,the depression duration at approximately 100 ms was consistent with a relative silent period observed within spontaneous burst discharges induced by prolonged application of *** conclusion,the neurons may ignore the excitatory inputs and intrinsically generate bursts during epileptic *** depolarization block could be the mechanisms underlying the PPD in the absence of GABA A *** distinct neuronal responses to stimulations during different epileptic stages may implicate the different antiepileptic effects of electrical stimulation.

关键词： Epilepsy Paired-pulse depression γ-Aminobutyric acid(GABA) Picrotoxin(PTX) CA1 region In-vivo

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磁场下碳化物析出的热力学机制

原子与分子物理学报 2025年第4期42卷 121-130页

作者：廖已莹侯廷平杨雨豪郑一航于涛刘伍明吴开明武汉科技大学理学院武汉430081 冶金工业过程系统科学湖北省重点实验室武汉430081 省部共建耐火材料与冶金国家重点实验室武汉430081 江汉大学光电材料与技术学院光电化学材料与器件教育部重点实验室武汉430056 中国科学院物理研究所北京100190

钢中碳化物的形成主要由合金元素的种类以及含量的决定,碳化物对钢铁材料的显微组织形态和力学性能有重要影响.磁场是影响碳化物析出规律发生改变的重要因素之一.以常见的碳化物M_(6)C(M=Fe,Mo)作为研究对象,利用第一性原理计算η-Fe_(... 详细信息

钢中碳化物的形成主要由合金元素的种类以及含量的决定,碳化物对钢铁材料的显微组织形态和力学性能有重要影响.磁场是影响碳化物析出规律发生改变的重要因素之一.以常见的碳化物M_(6)C(M=Fe,Mo)作为研究对象,利用第一性原理计算η-Fe_(2)C、Fe_(3)C、Fe_(2)Mo_(4)C、Fe_(3)Mo_(3)C-Ⅰ、Fe_(3)Mo_(3)C-Ⅱ和Fe_(4)Mo_(2)C等合金碳化物的磁矩,计算结果表明其中Fe_(4)Mo_(2)C的磁矩最大,达到了7.04μB.磁矩不仅由碳化物晶胞中Fe原子个数有关,还与Fe Wyckoff占位紧密相关.通过模拟计算碳化物的磁致磁热熔、磁熵、磁焓和磁自由能,从热力学角度对各碳化物进行分析,结果表明磁场会使碳化物的磁致磁热熔和磁熵增加;强磁场会降低M_(6)C的磁自由能进而提高其稳定性.此工作为研究核聚变材料磁性能提供理论基础和技术参考.

关键词：磁场碳化物析出相热力学机制

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AN EFFICIENT APPROACH TO IMPORTANT BLOGGERS DISCOVERY

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Journal of Electronics(China) 2008年第2期25卷 218-225页

作者： yang yuhang yu hao Zhao Tiejun Tan Hongye Zheng Dequan MOE-MS Key Laboratory of Natural Language Processing and Speech Harbin Institute of Technology Harbin 150001 China

Popularity of blogs and the amount of information in the blogosphere increase so fast that it is difficult for Internet users to search the information they care about. Compared with conventional webs,links in the blogosphere are more abundant and conversations between bloggers are more fre-quent. This paper proposes a method of ranking bloggers based on link analysis,which can exemplify the characteristics of blogs,and reduce the influence of link spamming. This method can also bring convenience to users to read blogs,and it can supply a new methodology for information retrieval in the blogosphere. To ensure the reliability of the ranking results,some evaluation indicators of the im-portant bloggers are proposed,and the grading results of bloggers using the proposed method is compared with that using other indicators. At last,correlation analysis is used to verify the consistency between the proposed method and the evaluation indicators.

关键词： Important blogger Link analysis Evaluation indicator Correlation analysis

Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing hao Jin-Hui yang Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

Composition design of high yield strength points in single-phase Co-Cr-Fe-Ni-Mo multi-principal element alloys system based on electronegativity,thermodynamic calculations,and machine learning

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Tungsten 2023年第1期5卷 169-178页

作者： Jiao-Hui Yan Zi-Jing Song Wei Fang Xin-Bo He Ruo-Bin Chang Shao-Wu Huang Jia-Xin Huang hao-yang yu Fu-Xing Yin Research Institute for Energy Equipment Materials School of Materials Science and EngineeringHebei University of TechnologyTianjin 300132China Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology Tianjin 300132China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China

A method which combines electronegativity difference,CALculation of PHAse Diagrams(CALPHAD) and machine learning has been proposed to efficiently screen the high yield strength regions in Co-Cr-Fe-Ni-Mo multi-component phase ***,the single-phase region at a certain annealing temperature is obtained by combining CALPHAD method and machine learning,to avoid the formation of brittle *** high yield strength points in the single-phase region are selected by electronegativity *** yield strength and plastic deformation behavior of the designed Co_(14)Cr_(30)Ni_(50)Mo_(6)alloy are measured to evaluate the proposed *** validation experiments indicate this method is effective to predict high yield strength points in the whole compositional ***,the interactions between the high density of shear bands and dislocations contribute to the high ductility and good work hardening ability of Co_(14)Cr_(30)Ni_(50)Mo_(6)*** method is helpful and instructive to property-oriented compositional design for multi-principal element alloys.

关键词： High entropy alloys Multi-principal element alloys Yield strength Electronegativity difference CALculation of PHAse Diagrams Machine learning

Management with the insufficient proximal landing zone for endovascular repair in aortic dissection

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Chinese Medical Journal 2011年第19期124卷 3003-3007页

作者： MA hao yang Hong-yu ZOU Jun-jie ZHANG Xi-wei Department of General Surgery the First Affiliated HospitalNanjing Medical University Department of General Surgery Jiangsu Province Hospital Nanjing Jiangsu 210029 China

Background Sufficient length of the proximal landing zone （PLZ） is the key for a successful thoracic endovascular aortic repair （TEVAR） of an aortic lesion. The aim of this research was to investigate the safety, feasibility, efficacy, and problems of endovascular repair for aortic dissection with insufficient *** The clinical data between August 2005 and February 2010 from patients with insufficient PLZ for endovascular repair of aortic dissection were retrospectively reviewed. According to the classification proposed by Ishimaru, aortic zone 0 was involved in 3 cases, zone 1 in 10 cases, and zone 2 in 11 cases. A hybrid surgical procedure of supraortic debranching and revascularization, directly coverage the orifice of left subclavian artery, or a left common carotid artery chimney graft technique were performed to obtain an adequate proximal aortic landing *** There was no significant difference in risk factors and diameter of the PLZ between Zone 0, Zone 1, and Zone 2. But the length of the PLZ was significantly different in the three groups （P 〈0.01）. There was no significant difference in technical and clinical success rate between the *** The procedure for extending an insufficient PLZ for endovascular repair for aortic arch pathology is feasible and relatively safe. The applicability of TEVAR in such aortic disorders may be expanded.

关键词： endovascular procedures aortic dissection proximal landing zone aorta, thoracic

Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： yang Mei ZHANG Mingzhe CHEN hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol

Adiponectin Attenuates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury Through Inhibition of Endoplasmic Reticulum Stress

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中国动脉硬化杂志 2011年第3期19卷 274-275页

作者： BIAN yun-Fei yang Hui-yu hao Xiao-Yan GAO Feng ZHANG Na-Na XIAO Chuan-Shi Department of Cardiology the Second Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China

Background and Aim Adiponectin(APN) is a potent cardioprotective *** present study aims to investigate the under-lying mechanism(s) for its cardioprotective *** Primary cardiomyocytes were isolated from neonatal rats and an invitro model of hypoxia-reoxygenation(H/R) was *** cardiomyocytes were randomly divided into six groups: salinegroup(control),dithiothreitol(DTT) group(5 mmol/L DTTfor 2 h),H/R group,H/R +APN group(incubation with 30 mg/LAPN,followed by H/R),H/R +APN +SB203580(SB) group(treatment with 30 mg/L APN and 5μmol/L SB,followed by H/R),and H/R +SB group(exposure to 5μmol/L SB and then H/R).Cell death was detected by measuring lactate dehydrogenase(LDH) *** expression levels of hypoxia-inducible factor-1alpha(HIF-1α) and endoplasmic reticulum(ER) stress-relatedgenes including GRP78,caspase-12,C/EBP homologus protein(CHOP),and p38 mitogen-activated protein kinase(MAPK) *** Cardiomyocytes exposed to H/R showed a significant increase in LDH leakage and HIF-1αprotein levelscompared with the control cells(P<0.05).The H/R-provoked cell death was profoundly attenuated by the pretreatment with APNalone,SB alone,or both,which was coupled with decreased expression of GRP78,caspase-12,CHOP,and p38 ***-sions These results provide new insights into the mechanism of APN-mediated cardioprotection,which may be partially due to inhibi-tion of ER stress response.

关键词：心脏治疗方法临床分析应激反应

Whether Fire-Needle Therapy Bene?ts Plaque Psoriasis:A Multicenter,Randomized,and Controlled Trial

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Chinese Journal of Integrative Medicine 2019年第4期25卷 259-263页

作者： PAN Hu-dan QI Xiao-li WANG Lei HE Jing-yan LIU Jiu-li ZHANG yun-bi TIAN Ye DUAN Xing-wu yang hao-yu BAI Yan-ping Department of Dermatology China-Japan Friendship HospitalBeijing(100029)China Macao University of Science and Technology Macao(999078)China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin(300120)China Department of Dermatology Shunyi District Branch of Beijing Hospital of Traditional Chinese MedicineBeijing(101300)China Department of Dermatology Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing(100700)China Department of Dermatology Beijing Hospital of Traditional Chinese MedicineBeijing(100010)China

Objective: To observe the clinical effectiveness and safety of fire-needle therapy,an external approach of Chinese medicine in treating plaque ***: This study was a two-parallel-arm randomized controlled trial.A total of 151 participants with plaque psoriasis were randomly assigned to the ?re-needle therapy group(treatment group,76 cases) or the control group(75 cases) at a 1:1 allocation ratio using SAS *** participants received Oral Huoxue Jiedu Decoction(活血解毒汤,HXJDD) and applied externally vaseline cream twice a *** in the treatment group received ?re-needle therapy once weekly for 4 weeks plus HXJDD and vaseline cream applied the same as the control *** primary outcome measure was Psoriasis Area and Severity Index(PASI) score,and the secondary outcomes were Dermatology Life Quality Index(DLQL),and Hamilton Anxiety Rating Scale(HAMA),as well as Chinese medicine(CM) syndrome score and photos of target *** indices were evaluated before and after ***: Sixty-eight patients in each group completed the *** treatment group has not yet achieved signi?cant improvement in PASI score(P>0.05)compared to the control ***,signi?cant differences were found between the two groups in relieving CM syndrome(P<0.05) and improving quality of life(P<0.05).Conclusions: Fire-needle appears to be safe and may have bene?t for psoriasis,the short-term treatment and small sample size limit the conclusions of this *** rigorous randomized controlled trials with longer treatment are recommended.

关键词： fire-needle therapy Chinese medicine Huoxue Jiedu Decoction plaque psoriasis randomized controlled trial