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The application of the strip-shaped cymba conchae orthosis in the nonsurgical correction of complex auricular deformity

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Journal of Otology 2024年第1期19卷 24-29页

作者： Huijuan Xu Shaoguang Ding Fei Zhang Zhifeng Zhang Xiangyu Chen Mingyang Li haitao yang Fugen Han Hongjian Liu Department of Otolaryngology Head and Neck Surgery People’s Hospital of Henan UniversityHenan Provincial People’s HospitalZhengzhouChina Department of Otolaryngology Head and Neck Surgery Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhouChina Department of Otolaryngology Head and Neck Surgery Henan Children’s HospitalZhengzhouChina Department of Otolaryngology Head and Neck Surgery The Third People’s Hospital of ZhengzhouZhengzhouChina Zheng Dong Mihuan Clinic ZhengzhouChina

Objective: This study aims to evaluate the efficacy and safety of using a strip-shaped cymba conchae orthosis for the nonsurgical correction of complex auricular deformities. Methods: Clinical data were collected from 2020 to 2021 for 6 patients who underwent correction using a stripshaped cymba conchae orthosis. The indications, corrective effects, and complications associated with use of the orthosis were analyzed. Results: There were four indications for treatment: cryptotia with helix adhesion;cryptotia with grade I microtia;cryptotia with excessive helix thickness;and auricular deformity beyond the treatment time window(≥6 months). Excellent corrective effects were observed in all 6 patients. Complications occurred in one patient, who recovered after symptomatic treatment. Conclusion: The use of a strip-shaped cymba conchae orthosis alone or combined with a U-shaped helix orthosis presents a feasible approach for correcting complex auricular deformities or deformities beyond the treatment time window in pediatric patients.

关键词： Cymba conchae Auricular deformity Cryptotia Nonsurgical correction Orthosis

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新冠病毒对蛋白酶药物产生耐药的分子机制

科学通报 2024年第15期69卷 1970-1972页

作者：孙浩然周浩杨海涛上海科技大学免疫化学研究所上海201210

新型冠状病毒(SARS-CoV-2,以下简称新冠病毒)是引起肆虐全球的新冠病毒肺炎感染疫情的病原体,携带30 kb左右的单股正链RNA基因组[1].在进入细胞后,它会利用宿主细胞质中的蛋白质翻译机器翻译出2种多聚蛋白pp1a(polyprotein1a)与pp1ab(po... 详细信息

新型冠状病毒(SARS-CoV-2,以下简称新冠病毒)是引起肆虐全球的新冠病毒肺炎感染疫情的病原体,携带30 kb左右的单股正链RNA基因组[1].在进入细胞后,它会利用宿主细胞质中的蛋白质翻译机器翻译出2种多聚蛋白pp1a(polyprotein1a)与pp1ab(polyprotein 1ab).

关键词：多聚蛋白病毒分子机制蛋白酶机器翻译病原体

Observation of parabolic electron bands on superconductor LaRu2As2

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Chinese Physics B 2024年第7期33卷 70-75页

作者：周兴泰李更潘禄禄陈子超李萌时延昊杨海涛高鸿钧 Beijing National Center for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Hefei National Laboratory

Ru-based superconductor LaRu2As2has been discovered exhibiting the highest critical temperature of ～ 7.8 K among iron-free transition metal pnictides with the ThCr2Si2-type crystal structure. However, microscopic research on this novel superconducting material is still lacking. Here, we utilize scanning tunneling microscopy/spectroscopy to uncover the superconductivity and surface structure of LaRu2As2. Two distinct terminating surfaces are identified on the cleaved crystals, namely, the As surface and the La surface. Atomic missing line defects are observed on the La surface. Both surfaces exhibit a superconducting gap of ～ 1.0 me V. By employing quasiparticle interference techniques, we observe standing wave patterns near the line defects on the La atomic plane. These patterns are attributed to quasiparticle scattering from two electron type parabolic bands.

关键词： superconductivity line defect quasi-particle scattering electron band

全国人大常委会援引宪法精神的实践类型与规范路径

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河南财经政法大学学报 2024年第3期39卷 10-23页

作者：杨海涛中共中央党校(国家行政学院)政治和法律教研部北京100091

2023年最新修正的《立法法》第五条将宪法精神与宪法规定、宪法原则并列使用,在拓展依宪立法原则内涵的同时,也引发了如何规范理解和运用宪法精神的难题。考察全国人大常委会援引宪法精神的实践,可以总结为三种类型:立法过程中援引宪法... 详细信息

2023年最新修正的《立法法》第五条将宪法精神与宪法规定、宪法原则并列使用,在拓展依宪立法原则内涵的同时,也引发了如何规范理解和运用宪法精神的难题。考察全国人大常委会援引宪法精神的实践,可以总结为三种类型:立法过程中援引宪法精神,践行依宪立法理念;备案审查中援引宪法精神,作为合宪性标准的认定依据;宪法法律缺位时援引宪法精神,创制性解决实践难题。全国人大常委会援引宪法精神的逻辑理据在于推动宪法全面实施、补足宪法解释缺位、探索人大行权空间,同时也面临缺乏统一规范、论证说理不充分、工具主义倾向明显等困境。为避免宪法精神的泛化运用,应从援引理念、援引技术、援引情形方面规范全国人大常委会援引宪法精神的实践。

关键词：宪法精神全国人大常委会依宪立法立法说明

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实用类书籍的阅读策略研究

装备制造与教育 2024年第2期38卷 65-68页

作者：杨海涛四川工程职业技术大学四川德阳618000

每一种文本或书籍,都有自身的文本特征和阅读规律。因此,阅读不同读物,应有不同的阅读思路和阅读策略。阅读实用性文本也不例外。文章基于阅读指导角度,归纳出实用类书籍要遵循的阅读思路,即“把握目的、主题和结构——理解原理和方法... 详细信息

每一种文本或书籍,都有自身的文本特征和阅读规律。因此,阅读不同读物,应有不同的阅读思路和阅读策略。阅读实用性文本也不例外。文章基于阅读指导角度,归纳出实用类书籍要遵循的阅读思路,即“把握目的、主题和结构——理解原理和方法——评判实用性——付诸行动”,并着重分析了适合实用类书籍的四种阅读策略,即“检视阅读、分析阅读、批判阅读和操作阅读”。

关键词：实用类书籍阅读策略阅读方法阅读指导

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计算机公共课程的混合式教学分析

电子技术（上海） 2024年第1期53卷 192-193页

作者：杨海涛沈阳师范大学新闻与传播学院辽宁110034

阐述计算机公共课程的特点、存在的问题,探讨混合式教学模式的应用,分析混合式教学流程,帮助学生更好地学习计算机公共课程知识,提高学习兴趣。

关键词：计算机技术混合式教学教学流程

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi Zhao Sulin Zhang Lu Liu Yumin Zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian Li Wenhao Dai Zhen Ge Shulei Hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng haitao yang Gengfu Xiao Zihe Rao Lu Lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

四苯乙烯酰胺类化合物的合成及其高灵敏度、高选择性识别Cu2+

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有机化学 2024年第8期44卷 2581-2587页

作者：苏小龙李健鹏刘孟鑫邹莉杨得锁冯海涛宝鸡文理学院化学化工学院聚集诱导发光研究中心

设计合成了一种四苯乙烯基酰胺类荧光探针TPE-Py,并对其结构进行了表征.通过荧光发射光谱和He La细胞成像实验研究了其金属离子识别性能.结果表明:探针TPE-Py对Cu2+具有较好的选择性和灵敏性,在H2O/THF （V∶V=9∶1）溶液中对Cu2+显示... 详细信息

设计合成了一种四苯乙烯基酰胺类荧光探针TPE-Py,并对其结构进行了表征.通过荧光发射光谱和He La细胞成像实验研究了其金属离子识别性能.结果表明:探针TPE-Py对Cu2+具有较好的选择性和灵敏性,在H2O/THF （V∶V=9∶1）溶液中对Cu2+显示出荧光淬灭效应,且不受其他金属离子干扰.细胞成像实验表明,探针TPE-Py可以检测细胞脂滴中的Cu2+.

关键词：聚集诱导发光荧光探针离子识别细胞成像

车载变压器轴向油道宽度对油流分布的影响研究

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铁道学报 2024年第6期46卷 65-72页

作者：王路伽沈逸超张建文胡雪陈婷杨海涛中国矿业大学电气工程学院江苏徐州221116 珠海澳大科技研究院广东珠海519085 国网安徽省电力公司电力科学研究院安徽合肥230601

为探究不同几何结构的车载牵引变压器绕组内各径向油道的流量分布,基于量纲分析方法提出结合雷诺数和曲折式绕组几何参数的流量比例关联式。重点加入内外侧轴向油道宽度之比β,更准确预测不同几何结构变压器绕组内的油流分布,为变压器... 详细信息

为探究不同几何结构的车载牵引变压器绕组内各径向油道的流量分布,基于量纲分析方法提出结合雷诺数和曲折式绕组几何参数的流量比例关联式。重点加入内外侧轴向油道宽度之比β,更准确预测不同几何结构变压器绕组内的油流分布,为变压器内部热点评估与定位奠定理论基础。基于计算流体力学数值仿真技术,对所构建关联式的准确性进行验证,结果表明,绝对误差小于油流总体积的0.7%。针对绕组底部的油流停滞及逆转区,研究β参数对绕组区域油流分布均匀度和冷却油反向流动的影响:β取值在1.4~1.5范围时油流分布均匀程度最好且不易发生逆转。研究结果为工业生产中车载牵引变压器的设计与制造提供理论依据。

关键词：牵引变压器量纲分析计算流体力学油流分布