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Effect of Curcumin on Aged Drosophila Melanogaster:A Pathway Prediction Analysis

Chinese Journal of Integrative Medicine 2015年第2期21卷 115-122页

作者：张治国牛旭艳吕爱平 Gary guishan Xiao Institute of Basic Theory China Academy of Chinese Medical Sciences Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Genomics and Functional Proteomics Laboratories Osteoporosis Research CenterCreighton University Medical Center

Objective： To re-analyze the data published in order to explore plausible biological pathways that can be used to explain the anti-aging effect of curcumin. Methods： Microarray data generated from other study aiming to investigate effect of curcumin on extending lifespan of Drosophila melanogaster were further used for pathway prediction analysis. The differentially expressed genes were identified by using GeneSpdng GX with a criterion of 3.0-fold change. Two Cytoscape plugins including BisoGenet and molecular complex detection （MCODE） were used to establish the protein-protein interaction （PPI） network based upon differential genes in order to detect highly connected regions. The function annotation clustering tool of Database for Annotation, Visualization and Integrated Discovery （DAVID） was used for pathway analysis. Results： A total of 87 genes expressed differentially in D. melanogaster treated with curcumin were identified, among which 50 were up-regulated significantly and 37 were remarkably down-regulated in D. melanogaster treated with curcumin. Based upon these differential genes, PPI network was constructed with 1,082 nodes and 2,412 edges. Five highly connected regions in PPI networks were detected by MCODE algorithm, suggesting anti-aging effect of curcumin may be underlined through five different pathways including Notch signaling pathway, basal transcription factors, cell cycle regulation, ribosome, Wnt signaling pathway, and p53 pathway. Conclusion： Genes and their associated pathways in D. rnelanogaster treated with anti-aging agent curcumin were identified using PPI network and MCODE algorithm, suggesting that curnumin may be developed as an alternative therapeutic medicine for treating aging-associated diseases.

关键词： anti-aging curcumin Drosophila Melanogaster pathway prediction analysis protein-protein interaction network

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沉积岩中黄铁矿含量及其硫同位素组成连续测定方法研究

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世界核地质科学 2024年第1期41卷 73-81页

作者：韩娟刘汉彬金贵善张建锋石晓李军杰张佳刘小桐核工业北京地质研究院北京100029

沉积岩中黄铁矿的含量和硫同位素组成研究可以用于判断沉积环境特征,反演成岩成矿过程。设计了一套多通道的黄铁矿硫提取装置,确定了装置的加热温度为130℃,实验时间为2h,优化了实验流程,实现一次提取同时满足黄铁矿含量及其同位素组成... 详细信息

沉积岩中黄铁矿的含量和硫同位素组成研究可以用于判断沉积环境特征,反演成岩成矿过程。设计了一套多通道的黄铁矿硫提取装置,确定了装置的加热温度为130℃,实验时间为2h,优化了实验流程,实现一次提取同时满足黄铁矿含量及其同位素组成测定需要。采用亚甲基蓝分光光度法测定硫含量和元素分析仪-气体同位素质谱法测定黄铁矿硫同位素组成。亚甲基蓝分光光度法的标准曲线的线性相关性R^(2)=0.9999,黄铁矿样品的加标回收率介于94%~100%之间,10次测量的相对标准偏差为1.9%。黄铁矿经过铬还原法提取生成的硫化银的硫同位素组成的测试结果和本身的测试结果在误差范围内一致,精度≤0.2‰,可以满足沉积岩中黄铁矿硫同位素测试需求。

关键词：沉积岩黄铁矿含量硫同位素组成亚甲基蓝分光光度法元素分析仪-气体同位素质谱法

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Selenium and Sulfur Systematics of Mafic Dykes in Western Fujian Province,Southern China

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Acta Geologica Sinica(English Edition) 2008年第4期82卷 884-895页

作者： FAN Haifeng WEN Hanjie ZHANG guishan HU Ruizhong State key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang Guizhou 550002 China The Graduate School of Chinese Academy of Sciences Beijing 100039 China College of Earth Science and Land Resources Chang＇an University Xi＇an Shanxi 710054 China

Fifteen samples from three study areas （the Bancun diabase dykes, the Bali hornblende gabbro dykes, the Linzifen gabbro-diabase dykes） were collected and analyzed for selenium （Se）, sulfur （S）, copper （Cu）, major and trace elements. In general, Se, S and Cu do positively correlate to each other. The concentration of S and Se and the S/Se ratio are higher than the corresponding value of primitive mantle （PM）, and the Cu/S ratio falls in a narrow range （0.04-0.29）, which is consistent with that of primitive mantle （0.05-0.20）. The Bancun diabase dykes and the Bali hornblende gabbro dykes were located in an intraplate environment during the Late Mesozoic. Oceanic subduction was closely related to magmatic activities. The magmatic activities play an important role in the transportation mechanism of Se and S. Because those two groups were closer to fault zones, which may affect the distribution of S and Se and other elements. In the two groups, no crustal contamination was observed, indicating that all analyzed elements may come from enriched mantle metasomtism associated with slab subduction. However, the Linzifen gabbro-diabase dykes were located in an intraplate rift environment, and its invading age is older than the other two groups, the primitive magma comes from mantle, and there is an anomalous relation between S, Se and Al2O3, （La/Sm）N, and all these factors could result in higher S and Se concentration.

关键词： selenium and sulfur systematics mafic dyke Mesozoic Fujian southern China

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早期胰腺癌分子诊断专家共识(2023年版)

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临床肝胆病杂志 2024年第3期40卷 473-477页

作者：中国医师协会临床精准医疗专业委员会中国抗癌协会肿瘤胰腺病学专业委员会肖桂山郭俊超郭晓钟不详大连理工大学中国医学科学院北京协和医院中国人民解放军北部战区总院

胰腺癌是一种较为常见的消化系统肿瘤,早期诊断困难,恶性程度极高。以肿瘤生物标志物为核心的分子辅助诊断技术,结合现有临床金标准,对于实现早期精准检测、及时治疗干预及降低病死率具有重要的临床意义。研究证实,微小RNA(miRNA)在胰... 详细信息

胰腺癌是一种较为常见的消化系统肿瘤,早期诊断困难,恶性程度极高。以肿瘤生物标志物为核心的分子辅助诊断技术,结合现有临床金标准,对于实现早期精准检测、及时治疗干预及降低病死率具有重要的临床意义。研究证实,微小RNA(miRNA)在胰腺肿瘤不同病理时期出现的种类和表达量变化呈现高度特异性,可用于胰腺肿瘤发生、发展的全程监测。单个miRNA的诊断潜力有限,miRNA组合或可有效提升对早期胰腺癌变的诊断性能。本共识基于近年相关研究进展,填补胰腺癌临床诊疗指南中关于分子诊断技术的空白,并提供专家指导意见。

关键词：胰腺肿瘤癌症早期检测生物标记,肿瘤微RNAs 专家共识

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基于中尺度气象模式分析的海陆风电场间尾流扰动影响评估

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中国电机工程学报 2022年第13期42卷 4848-4858页

作者：房方张效宁姚贵山胡阳郝雨辰华北电力大学控制与计算机工程学院北京市昌平区102206 国网江苏省电力有限公司江苏省南京市210017

海上风电在“双碳”目标的引领下快速发展,其选址布局若缺乏整体协调规划会因尾流效应损害已建成下游陆上风电场的发电量与经济效益。为提高区域资源利用率,保障风电产业的协调可持续发展,该文以中国盐城某海上风电场及相邻陆上风电场... 详细信息

海上风电在“双碳”目标的引领下快速发展,其选址布局若缺乏整体协调规划会因尾流效应损害已建成下游陆上风电场的发电量与经济效益。为提高区域资源利用率,保障风电产业的协调可持续发展,该文以中国盐城某海上风电场及相邻陆上风电场为研究对象,提出一种耦合风电场参数化方案(wind farm parameterization,WFP)和天气研究与预报模式(weather research and forecasting model,WRF)的海陆风电场间尾流扰动影响评估方法(WRF-WFP),通过比较有无海上风电场的算例输出间的差异,分析典型真实大气状况下海上风电场整体尾流强度的空间分布特性,并结合实测数据验证了WRF-WFP的有效性与参数灵敏度。量化评估了典型工况下海上风电场对下游陆上风电场的运行扰动作用的时空特性,归纳了陆上风电场的相对功率损失规律。结果表明在典型大气状况下,海上风电场的尾流可以延伸36~73km,最大宽度5.8~10km;尾流对下游陆上风电场的扰动作用在夜间的频次与强度更为显著,风速衰减达5.83%时,平均功率亏损可达15.47%。

关键词：海上风电尾流效应天气研究与预报模式风电场参数化中尺度仿真

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Effects of protein sources for milk replacers on growth performance and serum biochemical indexes of suckling calves

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Animal Nutrition 2015年第4期1卷 349-355页

作者： Kaiwu Huang Yan Tu Bingwen Si guishan Xu Jiangpeng Guo Feng Guo Chuntao yang Qiyu Diao College of Animal Science Tarim University Feed Research Institute Chinese Academy of Agricultural Sciences Beijing Key Laboratory of Dairy Nutrition The Animal Husbandry Station of Beijing

This study investigated the effects of protein sources for milk replacers on growth performance and serum biochemical indexes of suckling calves. Fifty Chinese Holstein bull calves with similar BW and age were randomly allocated to 5 groups(1 control and 4 treatments) of 10 calves in each group. Five types of milk replacers were designed to have the same level of energy and protein. The protein source for milk replacers of the control group was full milk protein(MP). The protein source of milk replacers of the 4 treatment groups was composed of MP and one vegetable protein(VP)(30 and 70% of total protein). The4 types of VP were soybean protein concentrate(SP), hydrolyzed wheat protein(WP), peanut protein concentrate(PP), and rice protein isolate(RP). Results of the experiment showed: 1) there was no significant difference on average daily gain(ADG) and feed:gain ratio(F:G) among the MP, SP and RP groups(P > 0.05), whereas the ADG and F:G of the WP and PP groups were significantly lower compared with the MP group(P 0.05). Thereby the 4 VP milk replacers had no adverse effects on body size of calves; 3) all groups showed no significant difference in the serum contents of urea nitrogen, total protein, albumin, globulin, β-hydroxybutyrate, growth hormone, insulin-like growth factor-1, and the ratio of albumin to globulin(A:G)(P> 0.05). In conclusion, SP or RP(accounts for 70% of the total protein) as calf milk replacers could substitute MP, whereas wheat gluten and PP had a significant adverse effect on growth performance in this experiment.

关键词： Calf Growth performance Milk replacer Milk protein replacement Serum biochemical parameters Vegetable protein

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沁水盆地郑庄区块煤层气水平井钻井体系优化

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煤炭科学技术 2023年第4期51卷 118-126页

作者：李贵山于振锋杨晋东宋新亚郭琛山西蓝焰煤层气工程研究有限责任公司山西晋城048000

郑庄区块位于沁水盆地西南部,主产气层位为山西组3号煤和太原组15号煤,区内煤层赋存特征以及含气性无论从垂向上还是横向上均差异较大。分别对3号煤和15号煤的主裂缝延伸方向以及含气性进行分析,在此基础上对该地层水平井钻井体系进行... 详细信息

郑庄区块位于沁水盆地西南部,主产气层位为山西组3号煤和太原组15号煤,区内煤层赋存特征以及含气性无论从垂向上还是横向上均差异较大。分别对3号煤和15号煤的主裂缝延伸方向以及含气性进行分析,在此基础上对该地层水平井钻井体系进行了优化,结果显示:3号煤的水平最大主应力方向应为北东45°~60°,南西225°~240°;15号煤的水平最大主应力方向应为北东60°~75°,南西240°~255°。15号煤水平最大主应力方向与3号煤的相差15°左右。3号煤层属特低硫~低硫无烟煤,煤厚基本在5~6 m。15号煤层属中高硫~高硫无烟煤,煤层厚度在横向上总体较稳定,一般为4~5 m,煤层结构较为复杂。3号煤层和15号煤层含气量由区块南部向北部略有增加的趋势,呈现北东向展布的相对富集区夹小面积零星分布的相对低含气量区。优化钻井体系主要从钻井设计方案优化和钻井过程优化两个方面来实施。钻井设计方案优化主要包括:钻井设计理念的优化、井位优化和钻井轨迹设计优化。钻井过程优化主要包括:钻井设备优化、钻井液体系优化和井眼轨迹控制。井眼轨迹控制包括:无导眼精准着陆、弯曲段井眼轨迹控制、着陆时井眼轨迹控制和着陆后水平段井眼轨迹控制。ZH-L36井运用优化后的钻井体系,最终煤层钻遇率达到99%,压裂后产气量达4万m3/d。区块运用优化后的钻井体系,日产气量提高了100万m3/d。

关键词：沁水盆地郑庄区块煤层气水平井钻井体系

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Twenty-seven-year nonunion of a Hoffa fracture in a 46-year-old patient

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Chinese Journal of Traumatology 2015年第1期18卷 54-58页

作者： Yirui Jiang Zhenyu Wang Debao Zhang guishan Gu Department of Bone and Joint. First Hospital of Jilin University. Changchun 130021 Jilin Province. China

A Hoffa fracture is an uncommon clinical entity typically seen in adults after high-energy trauma. Nonunion of a Hoffa fracture appears to be even more uncommon. To our knowledge, only three cases of nonunion of a Hoffa fracture have been documented in the literature to date, including two children and one adult. This article presents a case of an adult who had nonunion of a Hoffa fracture for 27 years and was treated by open reduction and internal fixation, and the varus deformity corrected with xenogenous bone graft. An excellent result has been achieved to date. This unusual case reminds us that we cannot neglect the possibility of nonunion of a cancellous bone fracture, especially the Hoffa fractures of the medial femoral condyle if they are treated nonoperatively. It also demonstrates that internal fixation with bone graft is effective, even for the 27-year Hoffa fracture.

关键词：不愈合骨折固定治疗手术治疗内固定术成年人骨移植松质骨

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风力发电机组数字孪生系统

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中国科学：技术科学 2022年第10期52卷 1582-1594页

作者：房方姚贵山胡阳吴旭涛刘吉臻华北电力大学控制与计算机工程学院北京102206 电站能量传递转化与系统教育部重点实验室北京102206 北京战未科技有限公司北京102206 新能源电力系统国家重点实验室北京102206

规模化并网风电是我国构建以新能源为主体的新型电力系统的主力电源,其智能化水平直接影响未来电力系统的安全、高效、经济运行.本文引入信息-物理实时映射思想,首次构建并实现了风力发电机组的数字孪生系统.设计了数字孪生系统整体架构... 详细信息

规模化并网风电是我国构建以新能源为主体的新型电力系统的主力电源,其智能化水平直接影响未来电力系统的安全、高效、经济运行.本文引入信息-物理实时映射思想,首次构建并实现了风力发电机组的数字孪生系统.设计了数字孪生系统整体架构,综合机理与数据方法搭建了各子系统实时动态模型;通过对数据信息流的有效组织,解决了风电机组和数字孪生系统之间的数据实时通信、精准映射及可视化呈现问题;应用多模型数字线程交互技术,实现了对风电机组整机动态载荷的实时模拟;通过与在役风电机组实际运行数据的量化对比,验证了该数字孪生系统的实时性与模型精度,探讨了其未来应用场景及功能拓展方向.

关键词：风力发电数字孪生复合建模信息-物理系统

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Net protein and metabolizable protein requirements for maintenance and growth of early-weaned Dorper crossbred male lambs

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Journal of Animal Science and Biotechnology 2017年第3期8卷 701-706页

作者： Tao Ma Kaidong Deng Yan Tu Naifeng Zhang Bingwen Si guishan Xu Qiyu Diao Feed Research Institute/Key laboratory of Feed Biotechnology of the Ministry of Agriculture Chinese Academy of Agricultural Sciences College of Animal Science Jinling Institute of Technology College of Animal Science Tarim University

Background： Dorper is an important breed for meat purpose and widely used in the livestock industry of the ***, the protein requirement of Dorper crossbred has not been investigated. The current paper reports the net protein（NP） and metabolizable protein（MP） requirements of Dorper crossbred ram lambs from 20 to 35 kg ***： Thirty-five Dorper × thin-tailed Han crossbred lambs weaned at approximately 50 d of age（20.3 ± 2.15 kg of BW） were used. Seven lambs of 25 kg BW were slaughtered as the baseline animals at the start of the trial. An intermediate group of seven randomly selected lambs fed ad libitum was slaughtered at 28.6 kg BW. The remaining 21 lambs were randomly divided into three levels of dry matter intake： ad libitum or 70% or 40% of ad libitum intake. Those lambs were slaughtered when the lambs fed ad libitum reached 35 kg BW. Total body N and N retention were ***： The daily NP and MP requirements for maintenance were 1.89 and 4.52 g/kg metabolic shrunk BW（SBW0.75）.The partial efficiency of MP utilization for maintenance was 0.42. The NP requirement for growth ranged from 12.1 to 43.5 g/d, for the lambs gaining 100 to 350 g/d, and the partial efficiency of MP utilization for growth was ***： The NP and MP requirements for the maintenance and growth of Dorper crossbred male lambs were lower than the recommendations of American and British nutritional systems.

关键词： Growth Lamb Maintenance Metabolizable protein Net protein

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