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Recent advances in cell sheet technology for bone and cartilage regeneration: from preparation to application

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International Journal of Oral Science 2019年第2期11卷 90-102页

作者： Yuezhi Lu Wenjie Zhang Jie Wang guangzheng yang Shi Yin Tingting Tang Chunhua Yu Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology & Shanghai Research Institute of StomatologyShanghaiChina Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Bone defects caused by trauma,tumour resection,infection and congenital deformities,together with articular cartilage defects and cartilage–subchondral bone complex defects caused by trauma and degenerative diseases,remain great challenges for *** strategies utilising cell sheet technology to enhance bone and cartilage regeneration are being *** cell sheet technology has shown great clinical potential in regenerative medicine due to its effective preservation of cell–cell connections and extracellular matrix and its scaffold-free *** review will first introduce several widely used cell sheet preparation systems,including traditional approaches and recent improvements,as well as their advantages and *** advances in utilising cell sheet technology to regenerate bone or cartilage defects and bone–cartilage complex defects will be *** key challenges and future research directions for the application of cell sheet technology in bone and cartilage regeneration will also be discussed.

关键词： cartilage regeneration preparation application

Orchestration of energy metabolism and osteogenesis by Mg^(2+)facilitates low-dose BMP-2-driven regeneration

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Bioactive Materials 2022年第12期7卷 116-127页

作者： Sihan Lin Shi Yin Junfeng Shi guangzheng yang Xutao Wen Wenjie Zhang Mingliang Zhou Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai JiaoTong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical Research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering Research Center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral and Maxillofacial Surgery College and Hospital of StomatologyGuangxi Medical UniversityNo.10 Shuangyong RoadQingxiu DistrictNanningGuangxi530021People’s Republic of China

The clinical application of bone morphogenetic protein-2(BMP-2)is limited by several factors,including ineffectiveness at low doses and severe adverse effects at high *** address these efficacy and safety limitations,we explored whether orchestration of energy metabolism and osteogenesis by magnesium ion(Mg^(2+))could reduce the dose and thereby improve the safety of *** results demonstrated that rapid metabolic activation triggered by BMP-2 was indispensable for subsequent ***,inadequate metabolic stimulation was shown to be responsible for the ineffectiveness of low-dose ***,we identified that Mg^(2+),as an"energy propellant",substantially increased cellular bioenergetic levels to support the osteogenesis via the Akt-glycolysis-Mrs2-mitochondrial axis,and consequently enhanced the osteoinductivity of *** on the mechanistic discovery,microgel composite hydrogels were fabricated as low-dose BMP-2/Mg^(2+)codelivery system through microfluidic and 3D printing *** in vivo study further confirmed that rapid and robust bone regeneration was induced by the codelivery ***,these results suggest that this bioenergetic-driven,cost-effective,low-dose BMP-2-based strategy has substantial potential for bone repair.

关键词： Biomaterials Bone morphogenetic protein-2 Magnesium Energy metabolism Bone regeneration

Preservation of alveolar ridge height through mechanical memory: A novel dental implant design

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Bioactive Materials 2021年第1期6卷 75-83页

作者： Shi Yin Wenjie Zhang Yanmei Tang guangzheng yang Xiaolin Wu Sihan Lin Xuanyong Liu Huiliang Cao Xinquan Jiang Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of ScienceBeijing100049China

Irreversible marginal bone loss can hinder recovery around dental *** alveolar osteogenesis and stress concentration during chewing contribute to marginal bone resorption and can result in implant failure.A biomaterial with a micropore-channel structure was developed using 3D printing *** design facilitated bony ingrowth and provided similar mechanical stimulation at the implant neck during mastication to a natural *** micropore channels provided a guiding structure for bone mesenchymal stem cell proliferation and differentiation without the need for growth ***,this was achieved through mechanical transduction by F-actin remodeling and the activation of Yes-associated protein(YAP).The implants were verified in a canine dental implant surgery model,which demonstrated the promising use of biomaterialbased dental implants in future clinical applications.

关键词： 3D-printing Alveolar bone Pore-channel YAP Mechanical transduction

Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels

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Bioactive Materials 2021年第11期6卷 3976-3986页

作者： Xiaolin Wu Mingliang Zhou Fei Jiang Shi Yin Sihan Lin guangzheng yang Yuezhi Lu Wenjie Zhang Xinquan Jiang Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011China

Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue *** particular,the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue ***,a novel design of an integral bilayer scaffold combined with a photocurable silk sealant for osteochondral repair is ***,we fabricated a bilayer silk scaffold with a cartilage layer resembling native cartilage in surface morphology and mechanical strength and a BMP-2-loaded porous subchondral bone layer that facilitated the osteogenic differentiation of ***,a TGF-β3-loaded methacrylated silk fibroin sealant(Sil-MA)exhibiting biocompatibility and good adhesive properties was developed and confirmed to promote chondrocyte migration and ***,this TGF-β3-loaded Sil-MA hydrogel provided a bridge between the cartilage layer of the scaffold and the surrounding cartilage and then guided new cartilage to grow towards and replace the degraded cartilage layer from the surrounding native cartilage in the early stage of knee ***,osteochondral regeneration and superior lateral integration were achieved in vivo by using this *** results demonstrate that the new approach of marginal sealing around the cartilage layer of bilayer scaffolds with Sil-MA hydrogel has tremendous potential for clinical use in osteochondral regeneration.

关键词： Integral bilayer scaffold Photocurable Sil-MA hydrogel Marginal sealing Lateral integration Osteochondral regeneration

A rapidly magnetically assembled stem cell microtissue with“hamburger”architecture and enhanced vascularization capacity

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Bioactive Materials 2021年第11期6卷 3756-3765页

作者： Yuezhi Lu Chun-Hua Yu guangzheng yang Ningjia Sun Fei Jiang Mingliang Zhou Xiaolin Wu Jiaxin Luo Cui Huang Wenjie Zhang Xinquan Jiang Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory for Oral Biomedical Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhanHubei430079China

With the development of magnetic manipulation technology based on magnetic nanoparticles(MNPs),scaffold-free microtissues can be constructed utilizing the magnetic attraction of MNP-labeled *** rapid in vitro construction and in vivo vascularization of microtissues with complex hierarchical architectures are of great importance to the viability and function of stem cell *** cells are indispensable for the formation of blood vessels and can be used in the prevascularization of engineered tissue ***,safe and rapid magnetic labeling of cells was achieved by incubation with MNPs for 1 h,and ultrathick scaffold-free microtissues with different sophisticated architectures were rapidly assembled,layer by layer,in 5 min *** in vivo transplantation results showed that in a stem cell microtissue with trisection architecture,the two separated human umbilical vein endothelial cell(HUVEC)layers would spontaneously extend to the stem cell layers and connect with each other to form a spatial network of functional blood vessels,which anastomosed with the host ***“hamburger”architecture of stem cell microtissues with separated HUVEC layers could promote vascularization and stem cell *** study will contribute to the construction and application of structural and functional tissues or organs in the future.

关键词： Microtissue Magnetic nanoparticle Stem cell Human umbilical vein endothelial cell Vascularization

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法国主题学批评理论的教学与实践

外语教学理论与实践 2016年第4期 71-77,90页

作者：杨光正华东师范大学

主题学批评是法国文学批评理论中的一个重要流派,它是积极和创新的批评,为文学的研究拓展了新的疆域。它从意象切入作品,运用简约和重组梳理出抽象的主题,由表及里,挖掘深层次的网络结构,寻找作者的创作意识和想象世界。国内对于主题学... 详细信息

主题学批评是法国文学批评理论中的一个重要流派,它是积极和创新的批评,为文学的研究拓展了新的疆域。它从意象切入作品,运用简约和重组梳理出抽象的主题,由表及里,挖掘深层次的网络结构,寻找作者的创作意识和想象世界。国内对于主题学批评的介绍和研究不多,运用这一理论分析文学作品的论著更少。因此,研究主题学批评,介绍其解析作品的方法,对于外国文学专业研究生的指导和文学作品分析评论的培养都是一件具有开拓意义的工作。

关键词：主题学批评批评理论教学意象分析微观阅读

COMPUTER SIMULATION FOR AN ULTRA-LOW RANGE SIDELOBE PULSE COMPRESSION SCHEME

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Journal of Electronics(China) 1998年第2期15卷 116-124页

作者： yang guangzheng yang Xiangyu Xu Lijuan(Southwest China Research Institute of Electronic Technology, Chengdu 610036) Southwest China Research Institute of Electronic Technology Chengdu

A canceling range sidelobes scheme has been suggested by yang guangzheng, et al.,(1997) this technology is based on the fact that all sidelobe of group correlation function of ideal sets are zero. At first, this paper gives the best ideal sets (i. e. the best biphase code sets whose maximal sidelobe not more than 2) for all code length N≤12, which have been obtained from binary sequences by means of the best codes sieving method suggested by yang guangzheng, et al.(1997) Computer simulation for group correlation property of best ideal sets for code length N=12 on various conditions is made. Simulation result shows that the sidelobe level of best ideal set with no weighting is zero, under condition of zero-Doppler shift and has ultra-low sidelobe on Doppler up to 5kHz with no weighting and whose tolerance of phase and amplitude distortion is bigger too.

关键词： Ultra-low sidelobe pulse compression Ideal sets Group correlation property

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基于知识的人面器官边缘检测及特征抽取

模式识别与人工智能 1999年第3期12卷 340-346页

作者：王静儒吴岷杨光正中国科学技术大学自动化系合肥230027

为实现复杂图景中人面的识别,需要抽取有效的特征。本文提出对原始图像做多层直方图均衡化预处理,然后采用多阈值二值化抽取初始边缘,再利用知识指导获得较完善的器官轮廓线,从而抽取出特征用于识别。本文以人面嘴部的边缘检测及特征抽... 详细信息

为实现复杂图景中人面的识别,需要抽取有效的特征。本文提出对原始图像做多层直方图均衡化预处理,然后采用多阈值二值化抽取初始边缘,再利用知识指导获得较完善的器官轮廓线,从而抽取出特征用于识别。本文以人面嘴部的边缘检测及特征抽取为例,通过实验证明这个方法是可靠的,能够得到期望的有效特征。

关键词：人面识别边缘检测特征抽取图像识别

GROUP CORRELATION PROPERTIES OF THE BINARY SEQUENCE SETS

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Journal of Electronics(China) 1997年第3期14卷 193-199页

作者： yang guangzheng yang Xiangyu Xu Lijuan Xu Jianjun(Southwest China Research Institute of Electronic Technology, Chengdu 610036) (Tsinghua University, Beijing 100084) Southwest China Research Institute of Electronic Technology Chengdu Tsinghua University Beijing

The group correlation properties of binary sequences is studied, and a conclusion is drawn that not only the group correlation function of a binary sequence itself is ideal, but also some of its subsets, which code le... 详细信息

关键词： Group correlation function Binary sequence Pulse compression code