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Dynamics of morphological changes for mitochondrial fission and fusion

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Science china(Physics,mechanics & Astronomy) 2010年第4期53卷 680-689页

作者： WANG ShiQi 1,2.4 , FU ChangLiang 1,2., zhang yan 1,2., chen Quan 3 & {2. mian 1,2.1 Key laboratory of microgravity (national microgravity laboratory), beijing 100190, china 2.center for {12. and Bioengineering, institute of mechanics, chinese academy of sciences, beijing 100190, china 3 State Key laboratory of Biomembrane and Membrane Biotechnology, institute of Zoology, chinese academy of sciences, beijing 100101, china 4 institute of Vertebrate Paleontology and Paleoanthropology, chinese academy of sciences, beijing 100044, china 1. Key laboratory of microgravity ({2. microgravity laboratory) Beijing 100190 China2. Center for Biomechanics and Bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China4. Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044 China3. State Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.

关键词： mitochondria morphology fission fusion dynamics modeling

IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1

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chinese Science Bulletin 2009年第16期54卷 2786-2793页

作者： JIA XiaoLing1,2.3, chen juan1,2.& {2. mian1,2.1 national microgravity laboratory, institute of mechanics, chinese academy of sciences, beijing 100190, china 2.center of {12. and Bioengineering, institute of mechanics, chinese academy of sciences, beijing 100190, china 3 School of Biological Science and Medical Engineering, Beihang University, beijing 100083, china national microgravity {2. Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China center of biomechanics and Bioengineering Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School of Biological Science and Medical Engineering Beihang University Beijing 100083 China

L-selectin plays a crucial role in inflammation cascade by initiating the tethering and rolling of leukocytes on endothelium wall. While many L-selectin molecules are rapidly shed from the cell surface upon activation, the remaining membrane-anchored L-selectin may still play an important role in regulating leukocyte rolling and adhesion with different binding kinetics. Here we developed an in vitro model to activate Jurkat cells via interlukin-8 (IL-8) and quantified the two-dimensional (2.) binding kinetics, using a micropipette aspiration assay, of membrane-anchored L-selectin to P-selectin glycoprotein ligand 1 (PSGL-1) ligand coupled onto human red blood cells (RBCs). The data indicated that L-selectin shedding reduced the amount of membrane-anchored L-selectin and lowered both its reverse and forward rates. These results suggested that the rolling dynamics of activated leukocytes was determined by two opposite impacts: reducing the surface presentation would enhance the rolling but lowering the kinetic rates would decrease the rolling. This finding provides a new insight into under-standing how L-selectin shedding regulates leukocyte rolling and adhesion.

关键词：结合动力学选择素配体白细胞介素8 Jurkat细胞诱导细胞表面微管吸吮

Low Spring Constant Regulates P-selectin-PSGL-1 Bond Rupture

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生物物理学报 2009年第S1期25卷 91-92页

作者： yan zhang, Ganyun Sun, Shouqin Lü, Ning Li, and {2. long Key laboratory of microgravity(national microgravity laboratory) and center for biomechanics and Bioengineering, institute of mechanics,{12., beijing 100190, china

Forced dissociation of selectin-ligand bonds is crucial to such biological processes as leukocyte recruitment, thrombosis formation, as well as tumor metastasis. While

关键词： Selectin-ligand bonds Rupture Spring constant Optical trap

Developing a microfluidic-based portable system for cell-surface marker detection

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Developing a microfluidic-based portable system for cell-sur...

Differentiation of bone marrow mesenchymal stem cells on patterned surface

第八届全国生物力学学术会议

作者： yang fan,gao Yu-xin,zhang yan,chen juan,long mian (national microgravity laboratory/center for biomechanics and Bioengineering,institute of mechanics,chinese academy of sciences,beijing 100080,china)

The ability to identify cell-surface marker efficiently has become a significant analytical technology in biological studies and clinical *** fluorescence-activated cell sorting(FACS)is still the most applicable analytical method for marker quantification,the wide application of FACS has been seriously limited by the high cost,bulky size,low-through analysis,and even the requirement for trained *** is significant to move surface-marker detection technology toward a miniaturized and parallel assay system.

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Differentiation of bone marrow mesenchymal stem cells on pat...

Cell adhesion mediated by β_2.integrin-ICAM-1 interactions

2.08年全国生物流变学与生物力学学术会议

作者： Zhenhan Li,Shujin Sun,juan chen,{2. long(national microgravity laboratory and center for biomechanics and Bioengineering,institute of mechanics,chinese {12. of sciences,beijing 100190, china)

Cell spreading shape is constrained by extracellular spatial structure,which may have effects on cell’s physiological *** surface technology was used to control spreading shape of rat’s bone marrow mesenchymal stem cells(rMSCs) in in vitro experiments,and the effects of cell shape on differentiation of rMSCs were *** was found that differentiation of rMSCs to osteoblasts

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医用生物力学 2010年第S1期25卷 14-15页

作者： Changliang Fu,Dongying Zhan,Chunfang Tong,Manliu Wang,Shouqin Lü,yan zhang,mian long(1 Key laboratory of microgravity,institute of mechanics,chinese academy of sciences,2 national microgravity laboratory and 3 center of biomechanics,and Bioengineering,institute of mechanics,chinese academy of sciences,beijing 100190,china.)

Introduction During the inflammatory responses,leukocytes are recruited at the site of high endothelial venule,roll over the endothelium surface,form the firm adhesion to spread out,and finally transmigrate across the... 详细信息

关键词： ICAM PMN

The chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2.2.

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Cancer Communications 2024年第1期44卷 127-172页

作者： Feng-Hua Wang Xiao-Tian zhang Lei Tang Qi Wu Mu-yan Cai Yuan-{2.g Li Xiu-juan Qu Hong Qiu Yu-Jing zhang Jie-Er Ying Jun zhang Ling-Yu Sun Rong-Bo Lin Chang Wang Hao Liu Miao-Zhen Qiu Wen-long Guan Sheng-Xiang Rao Jia-Fu Ji yan Xin Wei-Qi Sheng Hui-mian Xu Zhi-Wei Zhou Ai-Ping Zhou Jing Jin Xiang-Lin Yuan Feng Bi Tian-Shu Liu Han Liang yan-Qiao zhang Guo-Xin Li Jun Liang Bao-Rui Liu Lin Shen Jin Li Rui-Hua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer HospitalBeijingP.R.China Department of Radiology Peking University Cancer HospitalBeijingP.R.China Department of Endoscopy center Peking University Cancer HospitalBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhouGuangdongP.R.China Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology The First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Medical Oncology Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Radiotherapy Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Surgical Oncology The Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Medical Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Tumor center The First Hospital of Jilin UniversityChangchunJilinP.R.China Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Department of Radiology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of

The 2.2. update of the chinese Society of Clinical Oncology(CSCO)Clini-cal Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in china,reflecting the latest advancements in evidence-based medicine,healthcare resource availability,and precision *** updates address the differences in epidemiological characteristics,clinicopatho-logical features,tumor biology,treatment patterns,and drug selections between Eastern and Western gastric cancer *** revisions include a structured template for imaging diagnosis reports,updated standards for molecular marker testing in pathological diagnosis,and an elevated recommendation for neoadju-vant chemotherapy in stage III gastric *** advanced metastatic gastric cancer,the guidelines introduce new recommendations for immunotherapy,anti-angiogenic therapy and targeted drugs,a{2. with updated management strategies for human epidermal growth factor receptor 2.HER2.-positive and deficient DNA mismatch repair(dMMR)/microsatellite instability-high(MSI-H)***,the guidelines offer detailed screening recommendations for hereditary gastric cancer and an appendix listing drug treatment regimens for various stages of gastric *** 2.2. CSCO Clinical Guidelines for Gastric Cancer updates are based on both chinese and international clinical research and expert consensus to enhance their applicability and relevance in clinical practice,particularly in the heterogeneous healthcare landscape of china,while maintaining a commitment to scientific rigor,impartiality,and timely revisions.

关键词： chinese Society of Clinical Oncology(CSCO) gastric cancer diagnosis surgery neoadjuvant adjuvant radiotherapy chemotherapy targeted therapy immunotherapy

Low Spring Constant Regulates P-selectin-PSGL-1 Bond Rupture

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Low Spring Constant Regulates P-selectin-PSGL-1 Bond Rupture

Effects of oriented substrates on cell morphology,the cell cycle,and the cytoskeleton in Ros 17/2.8 cells

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： yan zhang,Ganyun Sun,Shouqin Lü,Ning Li,and {2. long Key laboratory of microgravity(national microgravity laboratory)and center for biomechanics and Bioengineering,institute of {12.,chinese academy of sciences,beijing 100190,china

＜正＞Forced dissociation of selectin-ligand bonds is crucial to such biological processes as leukocyte recruitment,thrombosis formation,as well as tumor *** forced bond

关键词： Selectin-ligand bonds Rupture Spring constant Optical trap

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Science china(Life sciences) 2010年第9期53卷 1085-1091页

作者： LI Hong chen juan {2. yan SUN ShuJin TAO ZuLai&long mian Key laboratory of microgravity Institute of MechanicsChinese Academy of Sciencesand National Microgravity Laboratory and Center for Biomechanics and BioengineeringInstitute of MechanicsChinese Academy of SciencesBeijing 100190China

Absence of gravity or microgravity influences the cellular functions of bone forming *** underlying mechanism,however,of cellular sensing and responding to the gravity vector is poorly *** work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-,downward-or edge-on-oriented *** morphology and nuclear translocation,cell proliferation and the cell cycle,and cytoskeletal reorganization were found to vary significantly in the three *** of the responses were *** results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity.

关键词： substrate orientation osteoblasts cell shape cell cycle cytoskeleton