检索结果-南通市图书馆

Preparation,characterization and antioxidant activity analysis of three Maillard glycosylated bone collagen hydrolysates from chicken,porcine and bovine

引用

Food Science and Human Wellness 2024年第4期13卷 2002-2013页

作者： Liwei Qi Hongru Zhang Yujie Guo Hong Liu chunhui Zhang Key Laboratory of Agro-Products Processing Ministry of Agriculture and Rural AffairsInstitute of Food Science and TechnologyChinese Academy of Agricultural SciencesBeijing 100193China Laboratory of Biomass and Green Technologies University of Liege-Gembloux Agro-Bio TechPassage des déportés 2Gembloux B-5030Belgium

Bone collagen hydrolysates(peptides)derived from byproduct of animal product processing have been used to produce commercially valuable products due to their potential antioxidant *** glycosylated reaction is considered as a promising method to enhance the antioxidant activity of ***,this research aims at investigating the Maillard glycosylation activity and antioxidant activity of bone collagen hydrolysates from different *** this study,3 glycosylated bone collagen hydrolysates were prepared and characterized,and cytotoxicity and antioxidant activity were analyzed and *** free amino groups loss,browning intensity,and fluorescence intensity of G-Cbcp(glycosylated chicken bone collagen hydrolysates(peptides))were the heaviest,followed by G-Pbcp(glycosylated porcine bone collagen hydrolysates(peptides))and G-Bbcp(glycosylated bovine bone collagen hydrolysates(peptides)).The results of amino acid analysis showed that amino acid composition of different bone collagen hydrolysates was significantly different and the amino acid decreased to different degrees after Maillard glycosylated reaction,which may lead to differences in Maillard glycosylated reaction ***,the 3 glycosylated hydrolysates showed no significant *** results showed that glycosylation process significantly increased the antioxidant activity of bone collagen hydrolysates,and G-Cbcp showed the strongest antioxidant activity,followed by G-Pbcp and ***,compared with the bone collagen hydrolysates,3 glycosylated hydrolysates showed significant characteristic and structural changes,and higher antioxidant activity.

关键词： Bone collagen hydrolysates Glycosylation reaction Antioxidant activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于满意度的贮备多阶段任务系统可靠性优化

引用

北京航空航天大学学报 2011年第3期37卷 374-378页

作者：俞建胡涛杨春辉海军工程大学管理工程系武汉430033

分析了多阶段任务系统成功运行的条件;在冷贮备系统的可靠性计算模型的基础上提出了单元是二态,失效率服从指数分布的冷贮备多阶段任务系统的可靠性计算模型;建立了系统可靠度、体积、重量和价格的子满意度函数,并利用层次分析法确定各... 详细信息

分析了多阶段任务系统成功运行的条件;在冷贮备系统的可靠性计算模型的基础上提出了单元是二态,失效率服从指数分布的冷贮备多阶段任务系统的可靠性计算模型;建立了系统可靠度、体积、重量和价格的子满意度函数,并利用层次分析法确定各个子满意度函数的影响因子;构建了基于综合满意度函数的贮备多阶段任务系统可靠性冗余优化模型,应用微粒群算法对模型进行求解.算例通过一个3个阶段的冷贮备系统来阐述该方法的应用,并验证了模型的合理性及算法的有效性.

关键词：冗余优化可靠性分析微粒群算法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

加味千金苇茎汤联合高压氧对急性呼吸窘迫综合征大鼠肺肠的保护作用及机制研究

引用

上海中医药杂志 2024年第3期58卷 58-64,71页

作者：马赞颂张蕾邵贵强贾圣洁朱行利江林昕尹雪吴春荣李英华杨春辉复旦大学附属上海市第五人民医院中医科上海200240 复旦大学附属上海市肿瘤医院闵行分院护理部上海200240 复旦大学附属上海市第五人民医院急诊科上海200240 复旦大学附属上海市第五人民医院中心实验室上海200240

目的基于肺肠相表里中医药经典腑脏理论,观察加味千金苇茎汤联合高压氧对急性呼吸窘迫综合征(ARDS)大鼠肺肠的保护作用及机制。方法选择Wistar大鼠40只,32只构建ARDS模型后随机分为4组,每组8只,即模型对照组、中药组、高压氧组及高压氧... 详细信息

目的基于肺肠相表里中医药经典腑脏理论,观察加味千金苇茎汤联合高压氧对急性呼吸窘迫综合征(ARDS)大鼠肺肠的保护作用及机制。方法选择Wistar大鼠40只,32只构建ARDS模型后随机分为4组,每组8只,即模型对照组、中药组、高压氧组及高压氧联合中药组,模型对照组不进行干预,高压氧组采用高压氧干预,高压氧联合中药组采用高压氧联合中药进行干预,剩余8只为正常对照组。观察各组的存活率并监测各组血氧饱和度和血气分析值,检测大鼠血浆D-乳酸、内毒素及二胺氧化酶(DAO)水平,同时光镜下观察肺、结肠组织的病理变化,采用酶联免疫吸附测定(ELISA)检测肺灌洗液中的肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)、白介素-10(IL-10)表达水平的变化,进行肺组织病理评分分析和计算肺湿/干重比(W/D),并测定肺组织脂质过氧化水平。结果高压氧组和高压氧联合中药组存活率为100%,模型对照组存活率为50%,中药组存活率为75%。正常对照组大鼠肺、结肠组织结构完整,模型对照组大鼠肺组织存在大量炎症细胞,高压氧联合中药组大鼠肺肠组织炎症水平显著低于中药组和高压氧组,其D-乳酸、内毒素、DAO水平、肺W/D、肺组织病理评分明显低于中药组和高压氧组,差异有统计学意义(P0.05)。结论加味千金苇茎汤联合高压氧能有效减轻ARDS大鼠的肺肠组织病理损伤,高压氧干预可以提高大鼠存活率,其机制可能与增强局部黏膜免疫和黏膜屏障功能有关;本研究结果可为中药联合高压氧在ARDS的临床应用提供理论依据和技术支持。

关键词：呼吸衰竭急性呼吸窘迫综合征高压氧加味千金苇茎汤肠-肺轴作用机制中药研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

La∶PbWO_4晶体闪烁性能研究

引用

高技术通讯 2000年第5期10卷 78-80页

作者：杨春晖陈刚哈尔滨工业大学应用化学系北京玻璃研究院山东大学晶体材料国家重点实验室济南250100

在PbWO4 晶体中掺进La2 O3生长La∶PbWO4 晶体。测试La∶PbWO4 晶体的透射光谱、激发发射光谱、发光效率、衰减时间和辐射硬度。La∶PbWO4 晶体的透过率增大 ,峰位发生红移 ,发光效率增加一倍 ,较大幅度提高抗辐照损伤能力。

关键词： La:PbWO4 晶体闪烁性能衰减时间

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

引用

Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui yang chunhui Li Guoguo Ye Chenguang Shen Huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin yang Jun yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wmic-GMTS and Wmic-GMERR criteria for micron-scale crack propagation in red-bed soft rocks under hydraulic action

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3641-3660页

作者： Guangjun Cui chunhui Lan Cuiying Zhou Zhen Liu Chang Xia Institute of Estuarine and Coastal Research School of Ocean Engineering and TechnologySun Yat-sen UniversityGuangzhou510275China Guangdong Provincial Engineering Research Center of Coasts Islands and ReefsSun Yat-sen UniversityGuangzhou510275China Guangdong Engineering Research Center for Major Infrastructure Safety Sun Yat-sen UniversityGuangzhou510275China The Hong Kong Polytechnic University Hong KongChina

Micron-scale crack propagation in red-bed soft rocks under hydraulic action is a common cause of engineering disasters due to damage to the hard rockesoft rockewater *** studies have not provided a theoretical analysis of the length,inclination angle,and propagation angle of micron-scale cracks,nor have they established appropriate criteria to describe the crack propagation *** propagation mechanism of micron-scale cracks in red-bed soft rocks under hydraulic action is not yet fully understood,which makes it challenging to prevent engineering disasters in these types of *** address this issue,we have used the existing generalized maximum tangential stress(GMTS)and generalized maximum energy release rate(GMERR)criteria as the basis and introduced parameters related to micron-scale crack propagation and water *** GMTS and GMERR criteria for micronscale crack propagation in red-bed soft rocks under hydraulic action(abbreviated as the Wmic-GMTS and Wmic-GMERR criteria,respectively)were established to evaluate micron-scale crack propagation in redbed soft rocks under hydraulic *** influence of the parameters was also *** process of micron-scale crack propagation under hydraulic action was monitored using uniaxial compression tests(UCTs)based on digital image correlation(DIC)*** study analyzed the length,propagation and inclination angles,and mechanical parameters of micron-scale crack propagation to confirm the reliability of the established *** findings suggest that the Wmic-GMTS and Wmic-GMERR criteria are effective in describing the micron-scale crack propagation in red-bed soft rocks under hydraulic *** study discusses the mechanism of micron-scale crack propagation and its effect on engineering disasters under hydraulic *** covers topics such as the internal-external weakening of nano-scale particles,lateral propagation of micron-scale cracks,weakening of the mechanical properties

关键词： Red-bed soft rocks Hydraulic action Micron-scale cracks Generalized maximum tangential stress (GMTS)criterion Generalized maximum energy release rate (GMERR)criterion Digital image correlation(DIC)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design and Development of Automobile Hydraulic Servo Test System

Design and Development of Automobile Hydraulic Servo Test Sy...

引用

2021中国汽车工程学会年会暨展览会

作者： Cui Mingyu yang chunhui Liu Fuqiang Wang Yulei Li Hongdong General Research and Development Institute China FAW Corporation Limited State Key Laboratory of Comprehensive Technology on Automobile Vibration and Noise & Safety Control

The test bench driven by hydraulic servo has been widely used in the test of vehicle and parts,and plays an important role in automobile material test,new material research and development,product part structure design and quality *** mainstream suppliers in the field of automotive high-end hydraulic servo test equipment are foreign manufacturers,with serious technical blockade,difficult maintenance,long procurement cycle and high price of equipment body and accessories;In order to improve the test efficiency of automotive products and reduce the test cost,a set of high-precision automotive hydraulic servo test system is developed *** on the basic principle of hydraulic servo control,the test system independently developed the test software,control accuracy reached the level of first-class hydraulic servo equipment,completed the fatigue life test of truck saddle,and provided guarantee for the performance and life test of subsequent vehicle and parts.

关键词： high-precision hydraulic servo testing system

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

平行板型柔性移动副的刚度计算及分析

引用

现代制造工程 2013年第12期 30-32,68页

作者：杨春辉华东交通大学轨道交通学院南昌330013

柔性铰链是目前被广泛用于微动机器人的主要部件之一,其刚柔度性能直接影响微动机器人的终端定位。以材料力学理论为基础,推导了平行板型柔性移动副刚度的解析公式,利用有限元方法对柔性移动副刚度进行验证,分析结果与解析公式的计算结... 详细信息

柔性铰链是目前被广泛用于微动机器人的主要部件之一,其刚柔度性能直接影响微动机器人的终端定位。以材料力学理论为基础,推导了平行板型柔性移动副刚度的解析公式,利用有限元方法对柔性移动副刚度进行验证,分析结果与解析公式的计算结果基本一致。对柔性移动副的刚度特性进行分析,并分析了结构参数对其刚度性能的影响,为柔性移动副设计优化提供了有价值的参考。

关键词：平行板柔性移动副刚度有限元

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

三自由度平面并联微动机器人运动学模型及工作空间分析

引用

机械传动 2010年第1期34卷 16-18页

作者：杨春辉华东交通大学江西南昌330013

运动学分析是并联机器人机构分析中的首要问题,是进行机构动力学分析、精度分析的基础,而全柔性微动机器人机构的首要目标就是精确实现所需的运动。介绍了平面并联微动机器人伪刚性模型的建立方法,并采用闭环矢量原理建立理论运动学线... 详细信息

运动学分析是并联机器人机构分析中的首要问题,是进行机构动力学分析、精度分析的基础,而全柔性微动机器人机构的首要目标就是精确实现所需的运动。介绍了平面并联微动机器人伪刚性模型的建立方法,并采用闭环矢量原理建立理论运动学线性模型,得到理论Jacobian矩阵,其次对该机构进行实验分析,得到工作平台的实验输出位移和方位角(Jacobian矩阵);然后用ANSYS软件对其进行有限元分析,得到有限元运动学模型(Jacobian矩阵值),最后通过MATLAB7.1软件对该机构的三种运动学模型进行工作空间分析,并进行误差分析,得到输出平台适用的运动学方程。

关键词：三自由度平面并联机器人微动机器人运动学模型工作空间

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Peptidome data-driven comprehensive individualized monitoring of membranous nephropathy with machine learning

引用

Chinese Chemical Letters 2024年第5期35卷 402-406页

作者： Zixing Xu Ruiying Chen Chuanming Hao Qionghong Xie chunhui Deng Nianrong Sun Department of Gastroenterology and Hepatology Zhongshan Hospitaland Department of ChemistryFudan UniversityShanghai 200433China Division of Nephrology Huashan HospitalFudan UniversityShanghai 200040China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

As the most common pathological type of nephrotic syndrome,membranous nephropathy(MN)presents diversity in progression trends,facing severe *** precise discrimination of MN from healthy people,other types of nephrotic syndrome or those with therapeutic remission has always been huge challenge in clinics,not to mention comprehensive individualized monitoring relied on minimally invasive molecular detection ***,we construct a functionalized pore architecture to couple with machine learning to aid all-round peptidome enrichment and data profiling from hundreds of human serum samples,and finally establish a set of defined peptide panel consisting of 12 specific feature *** addition to the realization of above-mentioned precise discrimination with more than 97%of sensitivity,88%of accuracy and f1 score,the simultaneously comprehensive individualized monitoring for MN can also be achieved,including conventionally screening diagnosis,congeneric distinction and prognostic *** work greatly advances the development of peptidome data-driven individualized monitoring means for complex diseases and undoubtedly inspire more devotion into molecular detection field.

关键词： Membranous nephropathy Serum peptidome Machine learning Disease diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：