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Latest therapeutic target for gastric cancer:Anthrax toxin receptor 1

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 216-222页

作者： Ke-Ran Sun Hui-fang Lv bei-bei Chen Cai-Yun Nie Jing Zhao Xiao-Bing Chen Department of Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

Anthrax toxin receptor 1(ANTXR1),also known as tumor endothelial marker 8,is a highly conserved cell surface protein overexpressed in tumor-infiltrating *** was first found in vascular endothelial cells of human colorectal *** our understanding of its physiological function is limited,it has been found that ANTXR1 binds collagen and promotes migration of endothelial cells in ***1 is upregulated in vessels of different tumor types in mice and humans,and is also expressed by tumor cells themselves in some tumors,such as gastric,lung,intestinal and breast *** angiogenesis and wound healing were not disturbed in ANTXR1 knockout mice,but compared with wild-type mice,growth of melanoma was impaired after ANTXR1 knockout,indicating that host-derived ANTXR1 can promote tumor growth on the basis of immune *** studies have shown that ANTXR1 vaccines or sublethal doses of anthrax toxin can inhibit angiogenesis,slow tumor growth and prolong *** studies suggest that ANTXR1 is necessary for tumor rather than physiological *** has been found that ANTXR1 plays an important role in tumor angiogenesisas well as in the growth and metastasis of many kinds of *** article reviews the physiological function of ANTXR1 and its role in different kinds of cancer.

关键词： Gastric cancer Therapeutic target Biomarker Anthrax toxin receptor 1 Tumor endothelial marker 8 Immunotherapy

暗娼的行为特征及沙眼衣原体的PCR检测分析

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公共卫生与预防医学 2006年第3期17卷 31-33页

作者：杨北方许骏王夏姚中兆刘满清唐力周旺周敦金叶临湘武汉市疾病预防控制中心 430022 华中科技大学同济医学院公共卫生学院

目的了解暗娼的行为特征及沙眼衣原体的感染情况,为制定针对性的防治措施提供依据。方法问卷调查并采集宫颈拭子,用PCR方法对其进行衣原体检测。结果(1)最近1周平均商业性伴数为3.33名;最近1次和最近1个月每次使用安全套的分别占62.22%... 详细信息

目的了解暗娼的行为特征及沙眼衣原体的感染情况,为制定针对性的防治措施提供依据。方法问卷调查并采集宫颈拭子,用PCR方法对其进行衣原体检测。结果(1)最近1周平均商业性伴数为3.33名;最近1次和最近1个月每次使用安全套的分别占62.22%和31.20%;她们跟商业性伴和固定性伴在最近1次和最近1个月每次性接触时安全套使用率均有差异(均P<0.0001)。(2)衣原体感染率为14.21%。结论暗娼中存在感染H IV/A IDS的高危因素,沙眼衣原体的感染率较普通人群高。应加强宣传教育和行为干预工作。

关键词：暗娼行为特征沙眼衣原体 PCR

A Macroporous Cryogel with Enhanced Mechanical Properties for Osteochondral Regeneration In vivo

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Chinese Journal of Polymer Science 2023年第1期41卷 40-50页

作者： Xin-Yu Wu Jun yang fang-Hui Wu Wang-bei Cao Tong Zhou Zhao-Yi Wang Chen-Xi Tu Zhong-Ru Gou Lei Zhang Chang-You Gao Ministry of Education Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Orthopaedics the Third Hospital Affiliated to Wenzhou Medical University&Rui’an People’s HospitalRui’an325200China Bio-nanomaterials and Regenerative Medicine Research Division Zhejiang-California International Nanosystem InstituteZhejiang UniversityHangzhou310058China

The dense networks of conventional hydrogel hinder the efficient cell penetration and thus tissue *** this study,a macroporous cryogel with excellent mechanical properties was designed and fabricated through cryogelation and crosslinking of methacrylated gelatin(Gel-MA)and gelatin grafted with 2-ureido-4[1H]-6-methyl-pyrimidinone(Gel-UPY).The successful modification of the two functional units on the side chain of gelatin was confirmed by ^(1)H-NMR and infrared *** macroporous structure of cryogel was verified by scanning electron microscopy and confocal *** compressive modulus of cryogel(110 kPa)was 2 magnitudes higher than that of the conventional hydrogel of the same chemical compositions(8 kPa).Both the hydrogel and cryogel exhibited excellent stress-recovery *** cryogel could well maintain the viability of chondrocytes and facilitated their migration into the scaffold *** being implanted into osteochondral defects in rabbits for 12 w,the Gel-MA/Gel-UPY cryogel better facilitated the regeneration of upper cartilage and subchondral bone compared to the conventional hydrogel.

关键词： Macroporous Cryogel Gelatin Ureido pyrimidinone Osteochondral regeneration

Nuclear AhR and membranous PD-L1 in predicting response of non-small cell lung cancer to PD-1 blockade

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2485-2488页

作者： Si-Chong Han Gui-Zhen Wang Ya-Ning yang Wen-Feng fang bei-bei Sun Jian-Dong Zhang Hua-Qiang Zhou Li Zhang Yan Wang Guang-Biao Zhou State Key Laboratory of Molecular Oncology and Department of Internal Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Lung Cancer Research Centre and State Key Laboratory of Oncology in South China Sun Yat-Sen University Cancer CenterGuangzhouChina Shanxi Bethune Hospital Affiliated with Shanxi Academy of Medical Sciences TaiyuanChina

Dear Editor,Programmed cell death 1 ligand 1(PD-L1)has been used as a biomarker for immune checkpoint inhibitors(ICIs)which exert durable efficacy in non-small cell lung cancer(NSCLC).^(1,2)However,many PD-L1-high pat... 详细信息

关键词： lung cancer death

Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies

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Cellular & Molecular Immunology 2021年第4期18卷 1061-1063页

作者： Jie Hu Pai Peng Kai Wang Liang fang Fei-yang Luo Ai-shun Jin bei-zhong Liu Ni Tang Ai-long Huang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious Diseasesthe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Yong-Chuan Hospital Chongqing Medical UniversityChongqingChina Department of Immunology College of Basic MedicineChongqing Medical UniversityChongqingChina

Coronaviruses are enveloped,positive-stranded RNA viruses that contain the largest known RNA genomes to *** severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to circulate in the human population,mul... 详细信息

关键词： acute monoclonal respiratory

湖北省儿童预防接种信息管理系统运行效果评估

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公共卫生与预防医学 2010年第5期21卷 28-29,35页

作者：蔡碧张迟赵明江郑景山李斌李琼郑丽李书华唐险峰杨北方湖北省疾病预防控制中心武汉430079

目的评估湖北省儿童预防接种信息管理系统(Childhood Immunization Information Management System,CIIMS)运行效果,为进一步推进湖北省按时完成CIIMS建设,建立健全省、市、县、乡儿童预防接种信息报告网络系统,实现全省范围内儿童预防... 详细信息

目的评估湖北省儿童预防接种信息管理系统(Childhood Immunization Information Management System,CIIMS)运行效果,为进一步推进湖北省按时完成CIIMS建设,建立健全省、市、县、乡儿童预防接种信息报告网络系统,实现全省范围内儿童预防接种信息共享与管理的目标。方法采取听汇报、现场实地调查、走访儿童等定量和定性相结合的方法,对全省CIIMS建设情况采用统一设计的调查表进行评估。结果湖北省所有乡镇以上预防接种单位全部完成CIIMS的建设,市、县、乡系统建设的覆盖率均达到100%,各地2005年后出生儿童预防接种个案信息录入率均达到95.00%以上。结论全省各市、县、乡CIIMS建设工作基本达到了国家CIIMS建设阶段性目标,但发展不平衡,主要存在系统平台建设滞后,系统维护保障不足,关键设备配备不全,需加大系统建设投入的力度,加强人员培训和进一步完善系统建设。

关键词：预防接种信息管理系统评估

我国棉花产业转型升级提质增效的途径、方法和措施（一）——棉花产业的新情况、新问题

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绿洲农业科学与工程 2016年第4期2卷 3-11页

作者：毛树春李亚兵王占彪王国平韩迎春冯璐杨北方支晓宇李鹏程中国农业科学院棉花研究所/棉花生物学国家重点实验室河南安阳455000

本文系统分析了中国棉花产业当前面临的新情况、新问题，即棉花产能从前几年的生产量增、进口量增和库存量增（即“三量齐增”）演进成近几年的生产量减、进口量减和消费量减（即“三量齐减”）到进一步出现当前和今后的“高等级棉短缺... 详细信息

本文系统分析了中国棉花产业当前面临的新情况、新问题，即棉花产能从前几年的生产量增、进口量增和库存量增（即“三量齐增”）演进成近几年的生产量减、进口量减和消费量减（即“三量齐减”）到进一步出现当前和今后的“高等级棉短缺”与“低等级棉过剩”的这一新情况和新问题。明确指出西北内陆棉区棉花产业应率先转型升级和提质增效，应承担国家中高端品质原棉生产的任务。

关键词：棉花产业供给新情况、新问题品质中高端

Deciphering the degradation discrepancy in Ni-rich cathodes with a diverse proportion of[003]crystallographic textures

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Carbon Energy 2023年第7期5卷 15-26页

作者： Lang Qiu Mengke Zhang yang Song Zhenguo Wu Yan-fang Zhu Jun Zhang Dong Wang Hai-Yan Hu Hong-Wei Li Hang-Rui Liu Xin-bei Jia Jian Peng Shuangqiang Chen Zuguang yang Yao Xiao Xiaodong Guo Department of Chemical Engineering College of Chemical EngineeringSichuan UniversityChengduChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouZhejiangChina Ruyuan Dongyang Guangcixing Material Limited CompanyShaoguanGuangdongChina Department of Chemical Engineering School of Environmental and Chemical EngineeringShanghai UniversityShanghaiChina Department of Aerospace Engineering College of Aerospace EngineeringChongqing UniversityChongqingChina State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi'an Jiaotong UniversityXi'anShaanxiChina

The crystal plane plays a very important role in the properties of Ni-rich cathodes.[003]crystallographic texture regulation has been proven to improve structural stability,and yet,the discrepancy of particles with different exposed ratios of[003]in structural attenuation has not been ***,we have unraveled comprehensively the structural decay difference for Ni-rich cathodes’primary particles with the different percentages of exposed[003]by regulating the precursor coprecipitation *** findings based on structural characterization,first-principles calculations,finite element analysis,and electrochemical test reveal that the length and width of particles represent[110]and[003]directions,respectively,and show that cathode particles with a higher[110]/[003]ratio can effectively inhibit structure degradation and intergranular/intragranular crack formation owing to the low oxygen vacancy formation energy on(003)planes and the small local stress on secondary/primary *** study may provide guidance for the structural design of layered cathodes.

关键词： cracks crystal plane Ni-rich cathodes oxygen vacancy structure degradation

Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis

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Chinese Journal of Chemistry 2024年第7期42卷 711-718页

作者： fang-bei Ge Qi-Kun Yin Chuan-Jun Lu Xuan Xuan Jia Feng Ren-Rong Liu College of Chemistry and Chemical Engineering Qingdao UniversityQingdaoShandong 266071China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationYantai UniversityYantaiShandong 264005China

Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still ***,the first enantioselective synthesis of N-N benzimidazole atropisomers via the palladium-catalyzed de novo construction of benzimidazole skeleton is *** readily available palladium catalyst and biphosphine ligand,a broad range of nonbiaryl benzimidazole and indole-benzimidazole atropisomers were conveniently ac-cessed in high yields and with excellent ***,these N-N benzimidazole atropisomers showed great anti-tumor activity and selectivity to breast cancer MCF-7 *** simple catalytic system,broad substrate scope,high enantioselectivi-ty,and good bioactivity make this approach highly attractive.

关键词： Asymmetric synthesis Atropisomerism Palladium Benzimidazole Antitumor