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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： yong-Chang Zeng Jun-Hong wu Dan-Dan Xu kang He Chang-qing Liu Li-Fei Song Zheng-Zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： qing-Yun Fang Chengyihan Gu yinghan Chen Wencheng Yan yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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Penetration Resistance of Skirt-Tip with Rough Base for Suction Caissons in Clay

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China Ocean Engineering 2020年第6期34卷 784-794页

作者： wu Yu-qi LI Da-yong yang qing State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China College of Civil Engineering Fuzhou UniversityFuzhou 350108China College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China

Suction caissons can readily penetrate into the seabed under the combination of the self-weight and suction resulted from the encased water being increasingly pumped out. During suction-assisted penetration, the equivalent overburden at the skirt-tip level outside the caisson is generally higher than that inside because the vertical stress within the soil plug is reduced by the exerted suction. This may result in a uniform shear stress developing over the base of the skirt-tip as the soil below the skirt-tip tends to move into the caisson, which leads to an asymmetric failure wedge existing below the base of the skirt-tip. Besides, different adhesion factors along the inside(αi) and outside(αo) of the skirt wall will cause asymmetric plastic zones inside and outside the caisson. Accordingly, an asymmetric failure mechanism is therefore proposed to calculate the penetration resistance of the skirt-tip. The proposed failure mechanism is the first to consider the effect of different adhesion factors(αi) and(αo) on the failure mechanism at the skirt-tip, and involves the contribution from the weighted average of equivalent overburdens inside and outside caisson at the skirt-tip level. The required suction pressure can be obtained in terms of force equilibrium of the caisson in a vertical direction. Finally, the asymmetric failure mechanism at the skirt-tip is validated with the FE calculations. By comparing with the measured data, the predictions of the required suction pressure are found to be in good agreement with the experimental results.

关键词： suction caisson required suction pressure penetration resistance skirt-tip rough base clay

Situational continuity-based air combat autonomous maneuvering decision-making

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Defence Technology（防务技术） 2023年第11期29卷 66-79页

作者： Jian-dong Zhang yi-fei Yu Li-hui Zheng Qi-ming yang Guo-qing Shi yong wu School of Electronics and Information Northwestern Polytechnical UniversityXi'an710129China Military Representative Office of Haizhuang wuhan Bureau in Luoyang Region 471000China

In order to improve the performance of UAV's autonomous maneuvering decision-making,this paper proposes a decision-making method based on situational *** algorithm in this paper designs a situation evaluation function with strong guidance,then trains the Long Short-Term Memory(LSTM)under the framework of Deep Q Network(DQN)for air combat maneuvering *** the continuity between adjacent situations,the method takes multiple consecutive situations as one input of the neural *** reflect the difference between adjacent situations,the method takes the difference of situation evaluation value as the reward of reinforcement *** different scenarios,the algorithm proposed in this paper is compared with the algorithm based on the Fully Neural Network(FNN)and the algorithm based on statistical principles *** results show that,compared with the FNN algorithm,the algorithm proposed in this paper is more accurate and *** with the algorithm based on the statistical principles,the decision-making of the algorithm proposed in this paper is more efficient and its real-time performance is better.

关键词： UAV Maneuvering decision-making Situational continuity Long short-term memory(LSTM) Deep Q network(DQN) Fully neural network(FNN)

Research and Realization of a Master-Slave Robotic System for Retinal Vascular Bypass Surgery

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 48-57页

作者： Chang-Yan He Long Huang yang yang qing-Feng Liang yong-kang Li School of Mechanical Engineering and Automation Beihang University Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual Sciences

Retinal surgery continues to be one of the most technical demanding surgeries for its high manipulation accuracy requirement, small and constrained workspace, and delicate retinal tissue. Robotic systems have the potential to enhance and expand the capabilities of surgeons during retinal surgery. Thus, focusing on retinal vessel bypass surgery, a master-slave robot system is developed in this paper. This robotic system is designed based on characteristics of retinal vascular bypass surgery and analysis of the surgical workspace in eyeball. A novel end-effector of two degrees of freedom is designed and a novel remote center of motion mechanism is adopted in the robot *** kinematics and the mapping relationship are then established, the gravity compensation control strategy and the hand tremor elimination algorithm are applied to achieve the high motion accuracy. The experiments on an artificial eyeball and an in vitro porcine eye are conducted, verifying the feasibility of this system.

关键词： Retinal robotic system Mechanism design Kinematics Gravity compensation

A Method with Parameter for Solving the Spectral Radius of Nonnegative Tensor

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Journal of the Operations Research Society of China 2017年第1期5卷 3-25页

作者： yi-yong Li qing-Zhi yang Xi He School of Mathematical Sciences and Lab of Pure Mathematics and Combinatic Nankai UniversityTianjin 300071China

In this paper,a method with parameter is proposed for finding the spectral radius of weakly irreducible nonnegative *** is more,we prove this method has an explicit linear convergence rate for indirectly positive ***,the algorithm is exactly the NQZ method(proposed by Ng,Qi and Zhou in Finding the largest eigenvalue of a non-negative tensor SIAM J Matrix Anal Appl 31:1090–1099,2009)by taking a specific ***,we give a modified NQZ method,which has an explicit linear convergence rate for nonnegative tensors and has an error bound for nonnegative tensors with a positive Perron ***,we promote an inexact power-type ***,some numerical results are reported.

关键词： Nonnegative tensor Indirectly positive tensors Linear convergence Perturbation Complexity

High-Order Dispersion Coefficients for Alkali-metal Atoms

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Communications in Theoretical Physics 2013年第7期60卷 73-79页

作者： kang Shuai DING Chi-Kun CHEN Chang-yong wu Xue-qing School of Physics and Mechanical & Electrical Engineering Zunyi Normal College Zunyi 563002 China Department of Physics and Information Engineering Hunan Institute of Humanities Science and Technology Loudi 417000 China School of Physics and Electronics Science Guizhou Normal University Guiyang 550001 China

High-order dispersion coefficients C9, C11, C12, and C13 for the ground-state alkali-metals were calculated by combining the 1-dependent model potential of alkali-metal atoms and linear variation method based on B-spl... 详细信息

关键词： dispersion coefficient alkali-metal atom B-spline polarizability

TDDFT-SOS Studies on the Polarizabilities and Second-order Hyperpolarizabilities of Zn_3O_3 II-VI Semiconductor Clusters

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Chinese Journal of Structural Chemistry 2006年第11期25卷 1359-1364页

作者： QIU yong-qing LIU yi-Chun Advanced Center for Opto-electronic Functional MaterialResearch Northeast Normal University Changchun 130024 China Key Laboratory of Excited State Physics Change＇hun Institute of OpticsFine Mechanics and Physics The Chinese Academy of Sciences Changchun 130021 China

The geometrical structure of semiconductor clusters including Zn3O3 was optimized by the DFT B3LYP method. With the same basis sets, dipole moments, polarizabilities and secondorder hyperpolarizabilities have been calculated and compared with the results obtained by TDDFT B3LYP method combined with sum-over-state （SOS） formula. The calculation results indicate that the dipole moments of the ground state depend on the atom radius and electronegative differences between elements and are their balance point as well. The polarizabilities of the clusters accord with the rule of the corresponding energy transformation from ground to excited state. The results predict an increase of second-order hyperpolarizabilities with increasing the distances between atoms in the clusters as well as a decrease of the polarizabilities and second-order hyperpolarizabilities in the same serial of semiconductor clusters with increasing the dipole moments of the ground states. The changes of dipole moments in ground states are inconsistent with transition moments. Spatial structure, charge transfer and other factors play an important role in composing the transition moments.

关键词： Ⅱ-Ⅵ semiconductor clusters TDDFT method polarizabilities second-order hyperpolarizabilities

Projection-based 3D bioprinting for hydrogel scaffold manufacturing

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Bio-Design and Manufacturing 2022年第3期5卷 633-639页

作者： Yuan Sun kang Yu qing Gao yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Engineering for Life Group(EFL) Suzhou 215101China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Cancer Center Zhejiang UniversityHangzhou 310058China

Projection-based 3D bioprinting(PBP):a powerful method to fabricate 3D cellular structures Three-dimensional(3D)bioprinting has played an important role in tissue engineering and regenerative medicine areas over the past decade[1].Different from traditional cell cultures in Petri dishes,3D bioprinting can build bionic structures with a better potential to become artificial organ substitutes[2–4].With the development of photocurable biomaterials,the projection-based 3D printing method has been successfully applied in biological research[5,6].

关键词： printing biomaterials projection