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Two triterpene glycosides from the sea cucumber Bohadschia marmorata Jaeger

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Chinese Chemical Letters 2008年第4期19卷 457-460页

作者： Wei hua yuan yang hua Yi Ling Li Bao Shu Liu Hong Wei Zhang Peng Sun Research Center for Marine Drugs School of PharmacySecond Military.Medical UniversityShanghai 200433PR China

Further studies on the sea cucumber Bohadschia marmorata Jaeger led to the isolation of a new holostan-type triterpene glycoside,Marmoroside C（1）together with a known triterpene glycoside（2）.On the basis of spectroscopic analyses,including two- dimensional NMR techniques,and chemical reactions,the structure of the new triterpene glycoside was elucidated as 3-O-[3-O- methyl-β-D-glucopyranosyl-（1→3）-β-D-glucopyranosyl-（1→4）-β-D-quinovopyranosyl-（1→2）-4-O-sodium-sulfato-β-D-xylo- pyranosyl]-25-acetoxy-22-oxo-9（11）-holostene-3β,12α,17α-triol.

关键词： Sea cucumber Bohadschia marmorata Triterpene glycoside

Recent research on venous thromboembolism in China： a brief report from China Venous Thromboembolism Study Group

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Chinese Medical Journal 2010年第4期123卷 485-490页

作者： ZHAI Zhen-guo ZHAN Xi yang yuan-hua WANG Chen Beijing Institute of Respiratory Medicine Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Venous thromboembolism （VTE）, including deep vein thrombosis （DVT） and pulmonary thrombo-embolism （PTE）, carries significant mortality and morbidity. As a result of the increasing awareness and improvement in diagnostic facilities, the hospital admissions have increased dramatically in China. Recent publications have reported the increasing incidences of PTE and DVT in hospitalized patients.1-3 A national project of multicenter studies on VTE has been carried out since 2002 by China Venous Thromboembolism Study Group. A broad spectrum of research including the epidemiology, diagnosis, management, and basic research of PTE and DVT was carded out in the past 10 years. We briefly summarized the current research on VTE in this group.

关键词： venous thromboembolism deep vein thrombosis pulmonary thromboembolism

Effects of simvastatin on cigarette smoke extract induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in human umbilical vein endothelial cells

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Chinese Medical Journal 2009年第19期122卷 2380-2385页

作者： HU Xiao-yun MA Yu-hui WANG Chen yang yuan-hua Department of Respiration Medicine First Hospital Shanxi Medical University Taiyuan Shanxi 030001 China Department of Respiratory Medicine Beijing Chaoyang Hospital Beijing Institute of Respiratory Medicine Capital Medical University Beijing 100020 China

Background Cigarette smoking has an influence on both arterial-type and venous-type thrombosis. However, little is known about the direct effect of cigarette smoke extract （CSE） on fibrinolytic activity of human umbilical vein endothelial cells （HUVECs）. Most recently, simvastatin has been marked in its effect on endothelial cells protection and anticoagulation. In this study, the effect of CSE on the expression of tissue-type plasminogen activator （t-PA） and plasminogen activator inhibitor-l（PAl-1） in HUVECs was addressed. The role of simvastatin in CSE-induced fibrinolytic activity changes was investigated as well. Methods The fourth to fifth generation of HUVECs were incubated respectively with 0, 5%, 10% and 20% CSE for 6 hours or exposed to 5% CSE for 0, 4, 6, 8, 12, 24 hours to determine the expression changes of t-PA and PAl-1 protein. Meanwhile, cells were also accordingly exposed either to 5% CSE alone or simvastatin pre-treated and 5% CSE for 24 hours to assess the role of simvastatin in CSE-induced t-PA and PAl-1 protein and mRNA expression in HUVECs. RT-PCR and ELISA techniques were used for detecting the t-PA or PAl-1 mRNA and protein. Results After 6-hour exposure to CSE, the expression levels of t-PA protein in 10% and 20% CSE-treated groups reduced significantly （（0.0365±0.0083） ng/ml, （0.0255±0.0087） ng/ml） when compared with that of control group （（0.0660±0.0120） ng/ml）（P 〈0.05）. In contrast, the levels of PAl-1 protein in 5%, 10% and 20% CSE-treated groups increased remarkably （（13.3225±0.5680） ng/ml, （14.2675±1.5380） ng/ml, （14.4292±1.6230） ng/ml） when compared with that of control group （（8.5193_±0.7537）ng/ml）（P〈0.05）. After stimulation with 5% CSE for 0, 4, 6, 8, 12, 24 hours, the levels of PAl-1 protein increased over time and reached the peak at 24 hours （（14.6400±1.0651） ng/ml）, which was significantly higher than that of control group （（12.0656±0.6148） ng/ml）（P 〈0.05）. Additionally, CSE could up-regulate PAl-1 expression at both the mRNA

关键词： cigarette smoke extract simvastatin tissue-type plasminogen activator plasminogen activator inhibitor-1 human umbilical vascular endothelial cells

BASIC STUD Peculiar Phenomena During Resistance Detection of Acupoints

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Journal of Acupuncture and Tuina Science 2013年第3期11卷 138-141页

作者： Liu Tang-yi Li Rui-xia yang hua-yuan Gao Ming Xu Gang Tang Wen-chao College of Acupuncture-moxibustion and Tuina Shanghai University of Traditional Chinese Medicine

Studying on resistance specificity of human acupoints is one of the major subjects in the research on acupoint specificity. Even since a long time ago, many methods have been put forward in the detection of acupoint resistance specificity. From the vertical lengthways of the acupoint structure, the methods and means are put forward to detect the acupoint resistance in a series of studies. In the studies, some peculiar phenomena are found out in the detection of the acupoint resistance, and some phenomena are interrelated with the volume conductor characteristics of the human body, and some phenomena might be interrelated with the detecting methods and means. By the summary and analysis of those peculiar phenomena, references are offered to the relevant researchers engaged in the detection of the acupoint resistance.

关键词： Specificity of Acupoints Acupoint Physiology Research on Acupoints, Resistance

基于观测器的不确定广义时滞系统鲁棒预测控制

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控制与决策 2009年第4期24卷 606-610,616页

作者：刘晓华杨园华鲁东大学数学与信息学院山东烟台264025 山东大学控制科学与工程学院济南250061

针对一类不确定广义时滞系统,讨论了其基于观测器的鲁棒预测控制问题,给出了系统观测器型预测控制器的设计方法.通过构造带有误差项的Lyapunov函数,应用线性矩阵不等式,将无穷时域二次性能指标"min-max"优化问题转化为凸优化问题,得到... 详细信息

针对一类不确定广义时滞系统,讨论了其基于观测器的鲁棒预测控制问题,给出了系统观测器型预测控制器的设计方法.通过构造带有误差项的Lyapunov函数,应用线性矩阵不等式,将无穷时域二次性能指标"min-max"优化问题转化为凸优化问题,得到了鲁棒预测控制器存在的充分条件和显式表达式.证明了优化问题在初始时刻的可行解能保证广义闭环系统渐近稳定且正则无脉冲.仿真实例验证了所提出方法的有效性.

关键词：预测控制广义时滞系统线性矩阵不等式状态观测器不确定性

Treatment of 30 Cases of Apoplectic Language Disorders by Electroacupuncture

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Journal of Acupuncture and Tuina Science 2003年第5期1卷 33-34页

作者： KUAI Le WANG Yan-hong yang hua-yuan Shanghai Research Institute of Acupuncture and Meridian Shanghai China 200030 Shanghai Research Institute of Acupuncture and Meridian Shanghai China 200030 College of Acup-moxi and Tuina Shanghai university of TCM Shanghai China 200032

Objective: To discuss the therapeutic method of apoplectic patients with language ***: Sixty cases of apoplexy were classified into electroacupuncture group of 30 cases and acupuncture group of 30 cases. In electroacupuncture group, acupoints Lianquan (CV 23), Tongli (HT 5) and lower 2/5 part of motor area and sensory area were selected. In acupunc -ture group, acupoints Lianquan (CV 23) and Tongli (HT 5) were selected. Results and conclusions: After 2 courses of treatment, the total effective rate in electroacu -puncture group was 93.3% and that in acupuncture group was 76.6%. There was a significant difference in the therapeutic effect between the two groups (P＜0.05).

关键词： Cerebral Hemorrhage/complications Hemiplegia Acupuncture Therapy Language Disorders Cerebral Infarction/complications

Value of transthoracic echocardiography combined with cardiac troponin I in risk stratification in acute pulmonary thromboembolism

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Chinese Medical Journal 2007年第1期120卷 17-21页

作者： ZHU Ling yang yuan-hua WU Ya-feng ZHAI Zhen-guo WANG Chen Department of Respiratory Medicine Shandong ProvincialHospital Shandong University School of Medicine Jinan 250021China Beijing Institute of Respiratory Medicine Beijing ChaoyangHospital Capital University of Medical Sciences Beijing 100020China Department of Echocardiography. Beijing Chaoyang Hospital Capital University of Medical Sciences Beijing 100020 China

Background Acute pulmonary thromboembolism （APE） causes right ventricular dysfunction （RVD） and cardiac troponin I （cTnl） elevation. Patients with RVD and cTnl elevation have a worse prognosis. Thus, early detection of RVD and cTnl elevation is beneficial for risk stratification. In this study, we assessed 14-day adverse clinical events and combined RVD on transthoracic echocardiography （TTE） with cTnl in risk stratification among a broad spectrum of APE patients. Methods The prospective multi-centre trial included 90 patients with confirmed APE from 12 collaborating hospitals. Acute RVD on TTE was diagnosed in the presence of at least 2 of the following： right ventricular dilatation （without hypertrophy）, loss of inspiratory collapse of inferior vena cava （IVC）, right ventricular （RV） hypokinesis, tricuspid regurgitant jet velocity 〉2.8 m/s. The study patients were divided into two groups according to clinical and echocardiographic findings at presentation： Group Ⅰ： 50 patients with RVD; Group Ⅱ：40 patients without RVD. Results More than half of the patients （50/90, 55.6%） had RVD. Nearly one third （26/90, 28.9%） of patients had elevated cTnl at presentation and only 4.2% on the fourth day after initial therapy. A multiple Logistic regression model implied RVD, right and left ventricular end-diastolic diameter ratio （RVED/LVED）, and cTnl independently predict an adverse 14-day clinical outcome （P〈0.01）. Receiver operating characteristics （ROC） curves revealed that the cut-off values of RVED/LVED and cTnl yielding the highest discriminating power were 0.65 and 0.11 ng/ml, respectively. Furthermore, the incidence of an adverse 14-day clinical event in patients with RVD and elevated cTnl was greater （40.7%） than in patients with elevated cTnl or positive RVD alone （0% and 8.3%, respectively）（P〈0.001）. Conclusions RVD, RVED/LVED, and cTnl are independent predictors of 14-day clinical outcomes. The patients with RVED/LVED greater than 0.65 and cTnl higher than 0.11 ng/

关键词： pulmonary thromboembolism right ventricular dysfunction cardiac troponin I risk stratification transthoracic echocardiography

Clinical features and imaging findings in pulmonary capillary hemangiomatosis： report of two cases and a pooled analysis

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Chinese Medical Journal 2012年第17期125卷 3069-3073页

作者： XIE Wan-mu DAI hua-ping JIN Mu-lan WANG Zhen yang yuan-hua ZHAI Zhen-guo WANG Chen Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Pathology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Bei)ing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory MedicineBeijing 100020China Beijing Hospital of Ministry of Health Beijing 1007-30China

Background Pulmonary capillary hemangiomatosis （PCH） is a rare disease and no Chinese case has been reported yet. The disease is often misdiagnosed and its clinical characteristics are incompletely described. The aim of this study was to describe two Chinese cases and to clarify the clinical and radiographic parameters of patients with PCH. Methods Two PCH cases were presented and other cases were searched from the English literature. All available clinical and radiographic data were collected from 62 literature reported PCH cases. A pooled analysis of total 64 cases was made. Results Dyspnea and hemoptysis were the most common clinical symptoms of PCH. Pulmonary hypertension （PH） was found in 78% of the reported cases. PCH typically showed characteristic diffuse or patchy ground-glass opacities （GGOs） and/or multiple ill-defined centrilobular nodules in the computed tomography. Conclusions The diagnosis of PCH requires a high clinical suspicion. However, both clinical presentations and radiographic studies often provide clues to the diagnosis, which may prompt early lung biopsy for a definite diagnosis.

关键词： pulmonary capillary hemangiomatosis pulmonary hypertension lung biopsy

Chorea in a Chinese adult after pulmonary endarterectomy with deep hypothermia and circulatory arrest

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Chinese Medical Journal 2013年第19期126卷 3794-3795页

作者： HAO Yong-gang GU Song ZHAI Ying-hui yuan Jun-liang yang yuan-hua HU Wen-li Department of Neurology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Cardiac Surgery Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Department of Internal Medicine Beijing Puren Hospital Beijing 100061 China Department of Respiratory and Critical Care Medicine Beijing Chaoyang HospitalCapital Medical University Beijing 100020 China

We report a rare case about chorea in a Chinese adult after pulmonary thromboendarterectomy （PTE） with deep hypothermia and circulatory arrest.A 41-year-old male was admitted to our hospital because of breathing difficulties for about three years and intermittent hemoptysis for about two *** examination revealed mild cyanotic lips,lower extremity *** was classified as grade III heart failure according the classification system of the New York Heart Association （NYHA）.

关键词： chorea pulmonary endarterectomy deep hypothermia circulatory arrest