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Facile synthesis of hierarchical NiO/NiFe_(2)O_(4) microsphere composite as efficient visible photocatalyst for 2,4-DCP degradation

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Rare Metals 2024年第4期43卷 1580-1588页

作者： Shabana Shaheen Shuai Xu Ji Bian Amir Zada Zi-Qing Zhang yang Qu Li-Qiang Jing Key Laboratory of Functional Inorganic Materials Chemistry(Ministry of Education) International Joint Research Center and Lab for Catalytic TechnologySchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin150080China Department of Chemistry Abdul Wali Khan UniversityMardan23200Pakistan

It is highly desired to develop efficient photocatalysts with recycling property for practical application to degrade toxic ***,nanosheet-assembled NiFe_(2)O_(4)microspheres with commendable activity are successfully synthesized by a facile solvothermal reaction with NH4F as the modifier,and their photoactivities are further improved by coupling with NiO through an in situ growth *** optimized nickel oxide(NiO)/nickel ferrite(NiFe_(2)O_(4))microsphere composite(5NiO/NFO-4)exhibits a satisfactory photocatalytic activity for 2,4-dichlorophenol(2,4-DCP)degradation under visible-light irradiation,which is attributed to its wide visible-light response,well-designed hierarchical structure and enhanced charge transfer and separation by coupling NiO as a high-level energy platform to accept ***,it is found that the NiO/NiFe_(2)O_(4)microsphere photocatalysts can be easily collected and recycled owing to the distinctive magnetic *** work provides a feasible route to rational design visible-light-driven photocatalysts with high-activity for environmental remediation and purification with good recyclability.

关键词： NiFe_(2)O_(4) microspheres NiO/Fe_(2)O_(4) composite Charge separation Visible-light photocatalysis 2 4-Dichlorophenol degradation

Phosphatidic acid-enabled MKL1 contributes to liver regeneration:Translational implication in liver failure

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Acta Pharmaceutica Sinica B 2024年第1期14卷 256-272页

作者： Jiawen Zhou Xinyue Sun xuelian Chen Huimin Liu Xiulian Miao Yan Guo Zhiwen Fan Jie Li yong Xu Zilong Li State Key Laboratory of Natural Medicines Department of PharmacologyChina Pharmaceutical UniversityNanjing 211198China Institute of Biomedical Research Liaocheng UniversityLiaocheng 252200China Department of Pathology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Infectious Diseases Nanjing Drum Tower Hospital Affiliated with Nanjing University Medical SchoolNanjing 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjing 210008China

Liver regeneration following injury aids the restoration of liver mass and the recovery of liver *** the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver *** report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure *** with MKL1 deletion exhibited defective regenerative response in the *** analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative ***2 mediated phosphorylation primed MKL1 for its interaction with *** interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver ***,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure *** conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver *** for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure.

关键词： Liver failure Liver regeneration Transcription regulation Transcription factor Hepatocytes Phosphatidic acid Phospholipase d2 Translational medicine

Delayed diagnosis in inflammatory bowel disease:Time to consider solutions

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World Journal of Gastroenterology 2024年第35期30卷 3954-3958页

作者： Hao Lv Hao-Yu Li Hao-Nan Zhang yang Liu Department of General Surgery Xi'an Jiaotong University Second Affiliated HospitalXi'an 710004Shaanxi ProvinceChina

In this editorial,we discuss a recently published manuscript by Blüthner et al in the World Journal of Gastroenterology,with a specific focus on the delayed diagnosis of inflammatory bowel disease(IBD).IBD,which includes Crohn's disease and ulcerative colitis,is a chronic intestinal disorder.A time lag may exist between the onset of inflammation and the appearance of signs and symptoms,potentially leading to an incorrect or delayed diagnosis,a situation referred to as the delayed diagnosis of *** diagnosis is crucial for effective patient treatment and prognosis,yet delayed diagnosis remains *** reasons for delayed diagnosis of IBD are numerous and not yet fully *** key factor is the nonspecific nature of IBD symptoms,which can easily be mistaken for other ***,the lack of specific diagnostic methods for IBD contributes to these *** diagnosis of IBD can result in numerous adverse consequences,including increased intestinal damage,fibrosis,a higher risk of colorectal cancer,and a decrease in the quality of life of the ***,it is essential to diagnose IBD promptly by raising physician awareness,enhancing patient education,and developing new diagnostic methods.

关键词： Inflammatory bowel disease Delayed diagnosis Diagnostic methods Early diagnosis Consequences of inflammatory bowel disease

Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

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World Journal of Clinical Cases 2024年第14期12卷 2359-2369页

作者： Wei-Ming Xu Hai-Fu Zhang yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle *** studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty *** To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this *** Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant *** After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric ***,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,P<0.01),bipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,P<0.01),and PTSD(OR:5.66,95%CI:5.33-6.01,P<0.01).Meanwhile,NAFLD significantly increased the risk of developing bipolar disorder(OR:55.08,95%CI:3.59-845.51,P<0.01),OCD(OR:61.50,95%CI:6.69-565.45,P<0.01),and PTSD(OR:52.09,95%CI:4.24-639.32,P<0.01).CONCLUSION Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders,namely bipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psy

关键词： Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms

A novel integrated microfluidic chip for on-demand electrostatic droplet charging and sorting

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Bio-Design and Manufacturing 2024年第1期7卷 31-42页

作者： Jinhui Yao Chunhua He Jianxin Wang Canfeng yang Ye Jiang Zhiyong Liu Guanglan Liao Tielin Shi State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

On-demand droplet sorting is extensively applied for the efficient manipulation and genome-wide analysis of individual ***,state-of-the-art microfluidic chips for droplet sorting still suffer from low sorting speeds,sample loss,and labor-intensive preparation ***,we demonstrate the development of a novel microfluidic chip that integrates droplet generation,on-demand electrostatic droplet charging,and high-throughput *** charging electrode is a copper wire buried above the nozzle of the microchannel,and the deflecting electrode is the phosphate buffered saline in the microchannel,which greatly simplifies the structure and fabrication process of the ***,this chip is capable of high-frequency droplet generation and sorting,with a frequency of 11.757 kHz in the drop *** chip completes the selective charging process via electrostatic induction during droplet ***-demand charged microdroplets can arbitrarilymove to specific exit channels in a three-dimensional(3D)-deflected electric field,which can be controlled according to user requirements,and the flux of droplet deflection is thereby significantly ***,a lossless modification strategy is presented to improve the accuracy of droplet deflection or harvest rate from 97.49% to 99.38% by monitoring the frequency of droplet generation in real time and feeding it back to the charging *** chip has great potential for quantitative processing and analysis of single cells for elucidating cell-to-cell variations.

关键词： Copper wire Droplet generation Droplet sorting Microfluidic chips On-demand charging

Promoting grain production through high-standard farmland construction:Evidence in China

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Journal of Integrative Agriculture 2024年第1期23卷 324-335页

作者： Shuai Hao Guogang Wang Yantao yang Sicheng Zhao Shengnan Huang Liping Liu Huanhuan Zhang Institute of Agricultural Economics and Development Chinese Academy of Agricultural SciencesBeijing 100081China

Food security is a strategic priority for a country’s economic *** China,high-standard farmland construction(HSFC)is an important initiative to stabilize grain production and increase grain production *** on panel data from 31 sample provinces,autonomous regions,and municipalities in China from 2005–2017,this study explored the impact of HSFC on grain yield using the difference-in-differences(DID)*** results showed that HSFC significantly increased total grain production,which is robust to various *** increased grain yield through three potential ***,it could increase the grain replanting ***,it could effectively reduce yield loss due to droughts and ***,HSFC could strengthen the cultivated land by renovating the low-and medium-yielding *** analysis found that the HSFC farmland showed a significant increase in grain yield only in the main grain-producing areas and balanced *** addition,HSFC significantly increased the yields of rice,wheat,and maize while leading to a reduction in soybean *** findings suggest the government should continue to promote HSFC,improve construction standards,and strictly control the“non-agriculturalization”and“non-coordination”of farmland to increase grain production *** the same time,market mechanisms should be used to incentivize soybean farming,improve returns and stabilize soybean yields.

关键词： high-standard farmland farmland construction food security food production area difference-in-differences

Geochemistry of cherts from the northern Jiangxi region, South China: Implication for paleoenvironment

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Journal of Palaeogeography 2024年第4期13卷 823-838页

作者： Guo-Liang Xie Gao-Jie Zhou Yu-yong Sun Yan-Ran Hu Wei-Duo Hao School of Civil Engineering and Architecture Tongling University State Key Laboratory of Oil and Gas Reservoir Geology and Exploration Chengdu University of Technology Department of Geology Northwest University

The extensive bedded cherts deposited during the Ediacaran-Cambrian (E-C) transition period play a crucial role in understanding the geological evolution of this period, yet the origin of these cherts remains disputed. Here, we present new geochemical data for cherts of the Piyuancun (PYC) Formation deposited during the Late Ediacaran and the Hetang (HT) Formation deposited during the Early Cambrian in northern Jiangxi region, Lower yangtze region, South China. The PYC cherts contain a small amount of monaxons sponge spicules and radiolarian fragments, while the HT cherts lack siliceous organism evidence. Major and trace element analysis, coupled with discriminant diagrams, indicate a possible shift in redox conditions of seawater during the E-C transition in the northern Jiangxi region. The shift suggests a change from weakly-moderately restricted euxinic conditions to strongly restricted euxinic conditions. Furthermore, the location of both cherts are distant from the source area of siliceous organisms. Fossil evidence, as well as the values of Fe/Ti and Fe/(Mn+Ti), Eu anomalies, Post-Archean Australian Shale (PAAS) normalized REE+Y patterns, and various discriminant diagrams,support the conclusion that the PYC and HT cherts originated primarily from direct seawater precipitation, with the PYC cherts exhibiting weak hydrothermal evidence. Upwelling contributes to the formation of HT cherts and organic matter (OM) accumulation. Ocean acidification, triggered by OM degradation and biodegradation processes during the E-C transition period, leads to the extensive silica precipitation and preservation. These results enhance our understanding of the geological processes during the E-C transition.

关键词： Redox condition Origin of cherts E–C transition Lower yangtze Jiangxi

Chaiqin Chengqi Decoction as an adjuvant treatment for mild/moderately severe hypertriglyceridemic acute pancreatitis: A retrospective study

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World Journal of Clinical Cases 2024年第11期12卷 1918-1928页

作者： Hai-Fu Zhang Ze-Xuan Su yong-Hang Feng Shuo-Jun Li Bi-Yun Xie Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

Hypertriglyceridemia is the third leading cause of acute pancreatitis(AP),and its incidence is *** to its relatively insidious etiology,it is easy to be ignored in the early *** China,Chaiqin Chengqi Decoction(CQCQD)has long been employed for treating *** To evaluate the effectiveness of CQCQD in patients diagnosed with mild/moderately severe hypertriglyceridemic AP(HTG-AP).METHODS In this study,the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were *** changes of blood lipids,gastrointestinal symptoms,and abdominal pain before and after treatment were analyzed and compared between the two *** Twenty patients were treated with the conventional HTG-AP regimen,and 19 patients were additionally treated with *** receiving treatment,the triglycerides(TG)level of the CQCQD group was lower than that of the CQCQD group(3.14±0.25 mmol/L vs 4.96±0.47 mmol/L,P<0.01).After 3 d of treatment,the patients in the CQCQD group had more bowel movements than the control group(2.51±0.25 times vs 1.00±0.17 times,P=0.01).The gastrointestinal function of most patients returned to normal,and the acute gastrointestinal injury score was significantly lower than that of the control group(0.11±0.07 vs 0.42±0.11,P<0.01).CONCLUSION In patients with HTG-AP,CQCQD can significantly reduce the TG level,shorten the recovery time of defecation,significantly improve the gastrointestinal function.

关键词： Hypertriglyceridemic acute pancreatitis Chinese medicine Chaiqin Chengqi Decoction Serum lipid Triglycerides

中国式现代化视域下民族地区共同富裕的内涵要素和实践路径

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贵州民族研究 2024年第2期45卷 106-114页

作者：高永久杨龙文南开大学民族事务研究中心天津300350 南开大学周恩来政府管理学院天津300350

共同富裕是中国式现代化的核心要义和本质特征。中国式现代化与民族地区共同富裕之间存在紧密的互构逻辑,前者是后者的发展轨迹导向,后者则是前者的生动实践样本。在中国式现代化推进过程中,区域要素、民族要素、精神要素构成了民族地... 详细信息

共同富裕是中国式现代化的核心要义和本质特征。中国式现代化与民族地区共同富裕之间存在紧密的互构逻辑,前者是后者的发展轨迹导向,后者则是前者的生动实践样本。在中国式现代化推进过程中,区域要素、民族要素、精神要素构成了民族地区共同富裕的三大要素。民族地区的共同富裕内涵,是区域与整体相协调的共同富裕,是各民族与中华民族共同体相融入的共同富裕,也是物质与精神相统一的共同富裕。基于此,需要围绕区域建设、民族建设和精神建设三条路径,推进民族地区共同富裕。在区域建设路径方面,要依托差别化区域支持政策有效整合外部资源,全面推进乡村振兴达致内部协同,从而减小民族地区内外部的发展不平衡性。在民族建设路径方面,要整合各民族利益与中华民族共同体利益关系,促使各民族互嵌式发展,从而推动民族地区各民族共同走向社会主义现代化。在精神建设路径方面,则要强化铸牢中华民族共同体意识宣传教育,动员各民族共同参与中华民族现代文明建设,从而不断铸牢中华民族共同体意识。最终,在多要素、多路径的同频共振、统筹兼顾中,推动民族地区稳步迈向共同富裕。

关键词：中国式现代化民族地区共同富裕铸牢中华民族共同体意识