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中华眼科杂志 2005年第12期41卷 1149-1152页

作者：杨培增中山大学葡萄膜炎研究中心中山眼科中心广州510060

葡萄膜炎是发生于眼内组织的炎性反应,是一种世界范围内的常见致盲眼病之一。其病因和临床类型近年来已发生了一些变化,发病机制的研究取得了较大进展,一些新的诊断技术、免疫抑制剂及生物制剂的应用已提高了葡萄膜炎的治疗效果。

关键词：葡萄膜炎眼内组织炎性反应盲眼病免疫抑制剂

Outlier Robust Feature Correspondence by Learning Based Matching Process

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Journal of Systems Science & Complexity 2024年第4期37卷 1351-1367页

作者： yang Xu zeng Shaofeng LIU Zhiyong State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation of Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China

Feature correspondence is a crucial aspect of various computer vision and robot vision *** traditional optimization-based matching techniques,researchers have recently adopted a learning-based approach for matching,but these methods face challenges in dealing with outlier *** paper presents an outlier robust feature correspondence method that employs a pruned attentional graph neural network and a matching layer to address the outlier ***,the authors introduce a modified cross-entropy matching loss to handle the outlier *** a result,the proposed method significantly enhances the performance of learning-based matching algorithms in the presence of outlier *** experiments confirm the effectiveness of the proposed approach.

关键词： Feature correspondence graph neural network optimal transport problem pointmatching

Finite Groups with Some Bounded Codegrees

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1778-1784页

作者： Dong Fang yang Yu zeng Heng LV School of Mathematics and Statistics Southwest UniversityChongqing400715P.R.China Department of Mathematics Changshu Institute of TechnologyChangshu215500P.R.China

For a characterχof a finite group G,the number cod(χ) := ∣G:ker(χ)∣/χ(1)is called the codegree ofχ.In this paper,we give a solvability criterion for a finite group G depending on the minimum of the ratioχ(1)^(... 详细信息

关键词： Finite group codegree degree simple group

Disparity estimation for multi-scale multi-sensor fusion

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Journal of Systems Engineering and Electronics 2024年第2期35卷 259-274页

作者： SUN Guoliang pei Shanshan LONG Qian ZHENG Sifa yang Rui Suzhou Automotive Research Institute Tsinghua UniversitySuzhou 215000China Beijing Smarter Eye Technology Co. Ltd.Beijing 100023China College of Artifical Intelligence Tianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Department of Precision Instrument Tsinghua UniversityBeijing 100084China

The perception module of advanced driver assistance systems plays a vital *** schemes often use a single sensor for data processing and environmental perception or adopt the information processing results of various sensors for the fusion of the detection *** paper proposes a multi-scale and multi-sensor data fusion strategy in the front end of perception and accomplishes a multi-sensor function disparity map generation scheme.A binocular stereo vision sensor composed of two cameras and a light deterction and ranging(LiDAR)sensor is used to jointly perceive the environment,and a multi-scale fusion scheme is employed to improve the accuracy of the disparity *** solution not only has the advantages of dense perception of binocular stereo vision sensors but also considers the perception accuracy of LiDAR *** demonstrate that the multi-scale multi-sensor scheme proposed in this paper significantly improves disparity map estimation.

关键词： stereo vision light deterction and ranging(LiDAR) multi-sensor fusion multi-scale fusion disparity map

Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

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International Journal of Extreme Manufacturing 2024年第1期6卷 296-311页

作者： Cijun Shuai Xiaoxin Shi Feng yang Haifeng Tian pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017People’s Republic of China

Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe *** this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser *** results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant *** accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative *** antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(***)and Gram-positive Staphylococcus aureus(***).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.

关键词： bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties

Photocontrolled polymer adhesives facilitate the assembly of hydrogels for soft robotics

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Science China Chemistry 2024年第10期67卷 3184-3186页

作者： Diling yang Hao Zhang Hongbo zeng School of Materials and Environmental Engineering Hunan University of HumanitiesScience and TechnologyLoudi 417000China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada

Both Sun Wukong in eastern mythology and Transformers in western science fiction animation have profoundly inspired the design of deformable materials and modern *** application scope of intelligent materials,also known as smart materials,which are capable of responding to external stimuli to achieve shape changes,structural reorganization,and functional reconfiguration,is wide-ranging,and it covers areas such as soft robotics and flexible electronics[1–3],4D printing[4,5],biomedical equipment[6,7],sensing devices[8],and energy harvesting systems[9].

关键词： printing harvesting smart

Modelling and simulation study on dynamic pollution accumulation process of composite insulator

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HIGH VOLTAGE 2024年第3期9卷 601-613页

作者： yang, Zhongyi Liu, Dongxiong zeng, Xiangjun Fan, Caijin yang, Xin Huang, Yafei Changsha Univ Sci & Technol Sch Elect & Informat Engn Changsha Peoples R China Changsha Univ Sci & Technol Sch Elect & Informat Engn Changsha 410114 Peoples R China CSG Elect Power Res Inst State Key Lab HVDC Guangzhou Peoples R China

With the widespread application of composite insulators in transmission lines, exploring the accumulation mechanism of pollution particles on composite insulator surfaces is of importance to ensure the safe and steady operation of the power system. Addressing the current theoretical shortcomings, this study categorises the accumulation process of particles on the insulator surface into three stages, namely 'spatial motion', 'surface collision', and 'surface motion'. The motion and rotation velocities in a multi-physics field are calculated in the spatial motion stage. In the surface collision stage, a parameter called 'neck height' is introduced to determine the optimum mechanics theory, and the normal deposition criterion is established. For the surface motion stage, the sliding displacement and rolling displacement on the surface are calculated based on the rotation speed of the particles. A dynamic pollution accumulation model of the composite insulator is established based on the normal deposition criterion and tangential displacement. Finally, numerical simulations are performed by using the finite element method. Simulation results show that the proposed model agrees with the actual insulator pollution accumulation, and the deposition model is still applicable for various types of composite insulators operating in different applied voltages. The deposition probability of particles increases with the increasing particle size. In the surface motion stage, particle displacement increases with particle size and wind velocity.

关键词： SURFACE-CHARGE ACCUMULATION DISCRETE-ELEMENT METHOD EPOXY INSULATOR METAL-PARTICLE ADHESIVE CONTAMINATION ENERGY COLLISION

Hybridization-mediated quasiparticle and phonon dynamics in single crystal cerium films

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 146-153页

作者： Yunhe pei Yi Wu Kai Hu Zhengxing Wei YiFeng yang yang Liu Jingbo Qi State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731China Center for Correlated Matter and Department of Physics Zhejiang UniversityHangzhou 310058China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

We report the ultrafast optical pump-probe spectroscopy measurements on the single-crystal cerium *** experimental results of temperature-dependent quasiparticle dynamics reveal development of the hybridization between localized f moments and conduction electrons,i.e.,evolving from fluctuating hybridization to collective *** phonon renormalization is discovered to appear at the emerging temperature(T^(+))of fluctuating hybridization apart from its known presence at the coherent temperature(T^(*)),and can hardly be explained by the mean-field *** quasiparticle relaxation at high temperatures indicates coexistence of nonthermal electron-electron scattering and inelastic Kondo scattering,while its behavior at low temperatures suggests onset ofαphase in theγ-phase dominated *** also extract the indirect gap below T^(*),representing the appearance of collective *** findings provide novel information about the hybridization and phase evolution in the heavy fermion systems.

关键词： cerium quasiparticle dynamics hybridization phonon renormalization

Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： yang Tong pei An Puxian Tang Rui Mu Yuteng zeng Hang Sun Mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu Zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration

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Chinese Chemical Letters 2024年第6期35卷 358-364页

作者： Xin Zhang Junyu Chen Xiang pei Linxin yang Liang Wang Luona Chen Guangmei yang Xibo pei Qianbing Wan Jian Wang State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChengdu 610041China Department of Prosthodontics West China Hospital of StomatologySichuan UniversityChengdu 610041China

Surface modification of microporous bone scaffolds using nanoparticles has been broadly studied in bone tissue *** at improving vascularized bone regeneration(VBR),zeolitic imidazolate framework-8(ZIF-8)was encapsulated with dimethyloxallyl glycine(DMOG)and the drug-carrying nanoparticles(D@Z)could be uniformly coated onto the surface of the bone *** osteogenic and angiogenic actions of D@Z are closely correlated with the amount of slowly released DMOG,and in general,exhibited a favorable ***,the D7.5@Z group,which showed the greatest capacity to induce in vitro osteogenesis-angiogenesis coupling,was utilized for surface modification of the bone *** processes including phosphate-containing compound metabolic process,cell differentiation,cell proliferation and cell motility might contribute to enhanced ability to induce VBR by the coated scaffold and signaling pathways such as Rap1,Ras,phosphatidylinositol 3-kinase/protein kinase B(PI3K-AKT)and vascular endothelial growth factor(VEGF)signaling pathways participated in these ***,as depicted by in vitro real time-polymerase chain reaction(RT-PCR),Western blot(WB)and in vivo cranial bone defect model,the microporous scaffold coated with nano-D7.5@Z greatly promoted *** conclude,nano-D@Z has significant promise for practical application in modification of microporous bone scaffolds to enhance VBR,and DMOG loading quantity has a beneficial influence on D@Z to improve osteogenesis-angiogenesis coupling.

关键词： Drug-loading nanoparticles Surface coating Microporous bone scaffold Vascularization bone regeneration