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Journal of Systems Engineering and Electronics 2024年第1期35卷 1-13页

作者： yang Yong yang Boyu School of Electronic Science National University of Defense TechnologyChangsha 410073China

In this paper,a comprehensive overview of radar detection methods for low-altitude targets in maritime environments is presented,focusing on the challenges posed by sea clutter and multipath *** performance of the radar detection methods under sea clutter,multipath,and combined conditions is categorized and summarized,and future research directions are outlined to enhance radar detection performance for low-altitude targets in maritime environments.

关键词： radar sea clutter multipath scattering detection low altitude target

Fresh-Keeping Decision and Coordination of Fresh Agricultural Product Supply Chain Considering Carbon Cap-and-Trade under Different Dominance

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 30-51页

作者： yang yang Guanxin Yao China Institute for Agricultural Equipment Industrial Development Jiangsu UniversityZhenjiang212013China Jiangsu Modern Logistics Research Base Yangzhou UniversityYangzhou225009China

In the context of low carbon,this paper discussed the impact of the carbon cap-and-trade policy on the fresh-keeping decision-making of two-echelon fresh agricultural product supply chains under different dominance,and designed cost-sharing contracts to coordinate the supply chain of fresh agricultural products dominated by suppliers and retailers *** results showed that:dominance has no effect on the fresh-keeping decision and total revenue of fresh agricultural product supply chain,but it affects the internal income distribution,and dominance does not always bring more benefits;the implementation of carbon cap-and-trade reduces the fresh-keeping decision-making of fresh agricultural products supply chain and reduces the free-rider income of followers;the role of higher carbon trading price is twofold,which not only brings about the speculation of leading enterprises,but also promotes the application of low-carbon technologies;consumers’high preference for freshness,low-cost and high-efficiency low-carbon technology are all conducive to improving the fresh-keeping efforts and benefits of the supply chain;cost-sharing contracts can coordinate the supply chain of fresh agricultural products.

关键词： Dominant power carbon cap-and-trade policy fresh agricultural product supply chain fresh-keeping decision-making

Effects of capsaicin on intestinal health under antibiotic exposure

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Food Science and Human Wellness 2024年

作者： Qingying Fang leilei Yu Fengwei Tian Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University National Engineering Research Center for Functional Food， Jiangnan University

Antibiotic exposure has adverse effects on intestinal immunity， metabolism， and gut microbiota (GM) composition， particularly by disturbing GM composition without short-term recovery. Capsaicin， a dietary irritant， is generally avoided during antibiotic therapy， but its mechanism remains unclear. To explore the effects of capsaicin on intestinal health during antibiotic administration， we conducted experiments in specific pathogen free (SPF) and germ-free (GF) mice and correlation analyses using 16S rRNA sequencing and non-targeted metabolomics to explore the protective role of the intestinal biological barrier. The results showed that additional supplementation of capsaicin under antibiotic exposure did not cause serious damage to the intestine， but had potential adverse effects on the structure， function， and metabolites of GM， including increasing the abundance of opportunistic pathogens (Mucispirillum and Aeromonas)， enriching metabolic pathways (arachidonic acid metabolism and lipopolysaccharide biosynthesis)， and metabolites associated with colon inflammation (N-acetylhistamine). In the absence of GM barrier， the beneficial function of capsaicin on the intestine was weakened and even induced adverse effects， suggesting that GM may have a certain mediating mechanism in the physiological function of capsaicin.

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SMAD PATHWAY PLAY A ROLE OF IN THE ABNORMALITIES OF LUNG FIBROBLASTS INDUCED BY γ RAY IRRADIATION

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SMAD PATHWAY PLAY A ROLE OF IN THE ABNORMALITIES OF LUNG FIB...

2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway

第十三届国际体视学大会

作者： yang Li,Ruiyun Peng,Liangwen Song,leilei yang,Shaoxia Wang,Dewen Wang Beijing Institute of Radiation Medicine No.27 Taiping Road,Beijing 100850,China

Objective:Radiation pulmonary fibrosis(RPF) is a sequel of both radiotherapy and accidental *** predominant characteristics are massive deposition of extracellular matrix and excessive fibroblast proliferation. Lung fibroblasts(LFs) play a central role in the pathogenesis of ***β1 is a master switch and therapeutic target of *** pathway is the key signal transducer downstream TGFβ*** the studies on the role of Smad pathway in the abnormalities of irradiated LFs might get a new insight into the pathogenesis of RPF. Methods:Rat lung fibroblasts(RLFs ) were isolated from rat lung by trypsin disaggregation to establish a stable model.γray,SB203580 or WP631 were used to treat *** changes of the Smad pathway and cellular biological behaviors of RLFs were determined by immunoblotting,immunohistochemistry,coimmunoprecipitation, EMSA,MTT and image anylasis. Results:γray irradiation could stimulate the proliferation,transformation,typeⅠcollagen and PAI-1 expressions of *** the same time,the formation and nucleus translocation of Smad3-4 complex were enhanced. Moreover,γray could facilitate the activation of transcription factors Smad3-4,SP1 and *** with SB203580 or WP631,irradiated RLFs expressed less typeⅠcollagen and P-Smad3,and also the activation of transcription factors Smad3-4,SP1 and AP1 in RLFs were inhibited. Conclusions:γray can facilitate the activation of Smad signal pathway in RLFs,and that the activation of this pathway play a role in the proliferation,transformation and typeⅠcollagen expressions of irradiated RLFs.

关键词： γray lung fibroblast Smad pathway

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Food Science and Human Wellness 2024年第5期13卷 2543-2561页

作者： Shikai Yan leilei Yu Fengwei Tian Jianxin Zhao Wei Chen Qixiao Zhai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Immune checkpoint blockade(ICB)therapeutics are highly effective in cancer immunotherapy,but gastrointestinal toxicity limited the *** microbiota plays a crucial role in ICB-associated colitis.2’-Fucosyllactose(2’FL)is most abundance prebiotic in human milk that can reshape gut microbiota and exert immune regulatory *** study aimed to determine the effects of 2’FL on ICB-associated colitis and to uncover the mediating ***-associated colitis was induced by the ipilimumab and dextran sulfate *** administration of 2’FL(0.6 g/(kg∙day))ameliorated ICB-induced colitis by enhancing regulatory T cells(Treg)and the M2/M1 ratio of macrophages in colon.2’FL treatment also increased the expression of tight junction proteins(zonula occludens-1(ZO-1)and mucin 2(MUC2))and antioxidant stress indicators(superoxide dismutase(SOD)and catalase(CAT)).In addition,administration of 2’FL increased the abundance of Bifidobacterium and Lactobacillus,and elevated the levels of microbial metabolites,such as indole-3-lactic acid(ILA),which activated the aryl hydrocarbon receptor ligands(AHR)*** protective effect of 2’FL was abolished upon depletion of gut microbiota,and ILA treatment partially simulated the protective effect of 2’***,2’FL did not exhibit inhibition of antitumor *** findings suggest that 2’FL could serve as a potential protective strategy for ICB-associated colitis by modulating the intestinal microbiota and bacterial metabolites.

关键词： 2’-Fucosyllactose Immune checkpoint blockade-associated colitis Gut microbiota Metabolomics Regulatory T cells(Treg)

饮食添加益生元菊粉改善烧伤大鼠肠道菌群紊乱和骨骼肌分解代谢

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华中科技大学学报（医学版） 2023年第1期52卷 60-67页

作者：高珊杨镭镭施媛夏艳琼彭坚武汉市第三医院麻醉科武汉430060

目的观察饮食调节肠道菌群能否改善烧伤模型大鼠的骨骼肌分解代谢。方法100只雄性Sprague-Dawley(SD)大鼠随机分为4组:假烧伤组(S组)、30%体表面积Ⅲ度烧伤模型的烧伤组(B组)、烧伤干预组(I组)和干预验证组(V组)(V组抗生素预处理2周后... 详细信息

目的观察饮食调节肠道菌群能否改善烧伤模型大鼠的骨骼肌分解代谢。方法100只雄性Sprague-Dawley(SD)大鼠随机分为4组:假烧伤组(S组)、30%体表面积Ⅲ度烧伤模型的烧伤组(B组)、烧伤干预组(I组)和干预验证组(V组)(V组抗生素预处理2周后制作烧伤模型),烧伤后I组和V组饮用水中添加菊粉(7 g/L)。记录大鼠每日体重和进食量;取烧伤后第4天的胫骨前肌(tibialis anterior,TA),趾长伸肌(extensor digitorum longus,EDL),腓肠肌(gastrocnemius,GAS),比目鱼肌(soleus,SO)和粪便进行分析。苏木精-伊红(hematoxylin-eosin,HE)染色和TUNEL染色观察胫骨前肌形态学改变和细胞凋亡情况;Western blot和RT-PCR检测胫骨前肌的肌肉萎缩盒F蛋白(muscle atrophy F-box,MAFbx)、肌肉环状指蛋白1(muscle ring finger 1,MuRF-1)的蛋白和mRNA的表达情况;对粪便进行宏基因测序建库,得到的数据进行质控和去冗余后,进行物种分析。结果与S组对比,B组和V组TA、GAS、SO相对重量下降,MAFbx和MuRF-1的mRNA表达和蛋白表达量均增加。与B组对比,I组的TA和GAS相对重量增加,MAFbx和MuRF-1的mRNA表达和蛋白表达量下降。宏基因分析发现烧伤导致大鼠的肠道菌群改变,种水平的物种丰度柱状图显示,与S组相比,B组的大肠埃希菌(***)和狄氏副拟杆菌(***)相对丰度明显升高;I组的***和***相对丰度与B组比较下降。LEfSe分析发现***的LDA值大于其它分类单元,在B组中被显著富集,丰度最高。结论烧伤导致大鼠骨骼肌高分解代谢和肠道菌群改变,通过饮食添加益生元菊粉可以缓解大鼠骨骼肌分解,同时部分改善肠道菌群紊乱。

关键词：烧伤骨骼肌分解肠道菌群宏基因测序

Selective nano-buckling improves the performance of graphene logic transistors

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National Science Review 2024年第2期11卷 95-96页

作者： Tong yang Ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

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脉冲介质阻挡放电等离子体热效应实验

航空动力学报 2019年第12期34卷 2663-2676页

作者：田永强蔡晋生杨磊磊张正科西北工业大学翼型叶栅空气动力学国家级重点实验室西安710072 西北工业大学航空学院西安710072

为了研究介质阻挡放电的热效应,将介质阻挡放电等离子体激励器(DBDPA)安装在一个小型量热风洞中,采用微秒级脉冲等离子体电源驱动DBDPA产生放电等离子体。分别应用Lissajous图形分析方法和量热学原理获得了DBDPA的放电功率特性和热功率... 详细信息

为了研究介质阻挡放电的热效应,将介质阻挡放电等离子体激励器(DBDPA)安装在一个小型量热风洞中,采用微秒级脉冲等离子体电源驱动DBDPA产生放电等离子体。分别应用Lissajous图形分析方法和量热学原理获得了DBDPA的放电功率特性和热功率特性。结果表明:①脉冲介质阻挡放等离子体的放电功率、热功率和热效率均随着激励电压峰-峰值和激励频率的升高而逐渐增大;②脉冲介质阻挡放电等离子体的放电功率和热功率与激励电压和激励频率之间均存在幂函数关系,即脉冲式介质阻挡放电等离子的放电功率正比于激励电压峰-峰值的1.75次方,正比于激励频率的1次方,其热功率正比于激励电压峰-峰值的5.0次方,正比于激励频率的1.5次方;③在激励电压和激励频率这两个参数中,优先选择提高激励电压峰-峰值更有利于提高热效率,也可更快地提升介质阻挡放电等离子热功率中气体加热功率的比例。

关键词：介质阻挡放电等离子体放电功率热功率 Lissajous图量热

弧比变化对电火花沉积Ni201修复层界面行为的影响

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中国机械工程 2016年第10期27卷 1399-1403页

作者：赵运才刘宗阳杨雷雷江西理工大学赣州341000

再制造修复设备工艺参数选择是决定修复层质量的关键因素。利用电火花沉积技术,在Q235钢表面制备Ni201修复改性层,对比分析弧比取不同值时对修复层质量的影响,并利用扫描电镜（SEM）、能谱仪（EDS）、X射线衍射（XRD）等检测方法,研究... 详细信息

再制造修复设备工艺参数选择是决定修复层质量的关键因素。利用电火花沉积技术,在Q235钢表面制备Ni201修复改性层,对比分析弧比取不同值时对修复层质量的影响,并利用扫描电镜（SEM）、能谱仪（EDS）、X射线衍射（XRD）等检测方法,研究了修复层与基体结合界面的微观结构、元素分布及相组成。结果表明：弧比取值在35%~45%之间时,修复层组织均匀致密,基体元素与修复层元素相互扩散形成冶金结合,修复层主要由Fe19Ni、Co3Fe7、Fe0.9Si0.1和C0.055Fe1.945相组成。

关键词：电火花沉积弧比 Q235钢界面行为