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Treatment of polycystic liver disease with resection-fenestration and a new classification

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World Journal of Gastroenterology 2008年第32期14卷 5066-5072页

作者： Tuan-jie Li hai-Bin Zhang Jun-Hua Lu Jun Zhao Ning yang Guang-Shun yang Eastern Hepatobiliary Hospital Second Military Medical University Shanghai 200438 China

AIM: To evaluate outcomes in patients with autosomal dominant polycyst liver disease (APLD) treated by combined hepatic resection and fenestration. A new classification was recommended to presume postoperative complications and long outcome of patients. METHODS: Twenty-one patients with APLD were treated by a combined hepatic resection and fenestration technique. All patients were reviewed retrospectively, and clinical symptoms, performance status and morbidity were recorded. A new classifi cation of APLD is recommended here. RESULTS: All patients were discharged when free of symptoms. The mean follow-up time was 55.7 mo and three patients had a recurrence of symptoms at 81, 68 and 43 mo after operation, respectively. The overall morbidity rate was 76.2%. Two patients with Type B-Ⅱ and Type B-Ⅰ developed biliary leakage. Four patients had severe ascites, including three with Type B-Ⅲ and one with Type B-Ⅱ, Nine patients had pleural effusion, including one with Type A-Ⅰ; one with Type B-Ⅰ; fi ve with Type B-Ⅱ; one with Type A-Ⅲ and one with Type B-Ⅲ. Three patients with Type B had recurrence of symptoms, while none with Type A had severe complications. CONCLUSION: Combined hepatic resection and fenestration is an acceptable procedure for treatment of APLD. According to our classifi cation, postoperative complications and long outcome can be predicted before surgery.

关键词： Autosomal dominant polycyst liverdisease Autosomal dominant polycyst kidney disease Fenestration

^(60)Co辐射对网织红细胞微观流变学特性的影响

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生物化学与生物物理进展 2004年第7期31卷 666-670页

作者：谢利德杨海杰张卫光孙大公文宗曜谭文长北京大学力学与工程科学系北京100871 承德体育运动学校承德067000 北京大学基础医学院物理教研室北京100083

采用 60 Co大剂量全身均匀急性辐射的方法 ,造成一种辐射贫血的动物模型 .以便在几天内连续研究 60 Co辐射对新生的网织红细胞及红细胞流变学特性的影响 .采用一种在低粘切变流场中能将红细胞变形指数DI分解为取向指数 (DI) or和小变形... 详细信息

采用 60 Co大剂量全身均匀急性辐射的方法 ,造成一种辐射贫血的动物模型 .以便在几天内连续研究 60 Co辐射对新生的网织红细胞及红细胞流变学特性的影响 .采用一种在低粘切变流场中能将红细胞变形指数DI分解为取向指数 (DI) or和小变形指数 (DI) d 的新型激光衍射法 ,对网织红细胞及红细胞的变形指数、取向指数、综合变形指数 (IDI)等血液流变学特性参数进行测量 ,发现在 60 Co大剂量辐射后 ,新生的网织红细胞及红细胞流变学特性存在明显异常 .将这种 60 Co辐射造成的贫血模型与文宗曜等提出的用抗体诱导的大量同步化的球形红细胞贫血模型相比较 ,后者更具有明显的优点 .同时为研究辐射对血液流变特性的影响及正确地挑选红细胞衰老模型提供了理论与实验的基础 .

关键词：新型激光衍射法网织红细胞微观流变特性变形指数取向指数

Expression signatures of long non-coding RNA and mRNA in human traumatic brain injury

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Neural Regeneration Research 2019年第4期14卷 632-641页

作者： Li-Xiang yang Li-Kun yang jie Zhu Jun-Hui Chen Yu-hai Wang Kun Xiong Department of Neurosurgery 101st Hospital of People's Liberation Army Department of Anatomy and Neurobiology School of Basic Medical Sciences Central South University

Long non-coding RNAs(lncRNAs) play a key role in craniocerebral disease, although their expression profiles in human traumatic brain injury are still unclear. In this regard, in this study, we examined brain injury tissue from three patients of the 101 st Hospital of the People's Liberation Army, China(specifically, a 36-year-old male, a 52-year-old female, and a 49-year-old female), who were diagnosed with traumatic brain injury and underwent brain contusion removal surgery. Tissue surrounding the brain contusion in the three patients was used as control tissue to observe expression characteristics of lncRNAs and mRNAs in human traumatic brain injury tissue. Volcano plot filtering identified 99 lncRNAs and 63 mRNAs differentially expressed in frontotemporal tissue of the two groups(P 1.2). Microarray analysis showed that 43 lncRNAs were up-regulated and 56 lncRNAs were down-regulated. Meanwhile, 59 mRNAs were up-regulated and 4 mRNAs were down-regulated. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analyses revealed 27 signaling pathways associated with target genes and, in particular, legionellosis and influenza A signaling pathways. Subsequently, a lncRNA-gene network was generated, which showed an absolute correlation coefficient value > 0.99 for 12 lncRNA-mRNA pairs. Finally, quantitative real-time polymerase chain reaction confirmed different expression of the five most up-regulated mRNAs within the two groups, which was consistent with the microarray results. In summary, our results show that expression profiles of mRNAs and lncRNAs are significantly different between human traumatic brain injury tissue and surrounding tissue, providing novel insight regarding lncRNAs' involvement in human traumatic brain injury. All participants provided informed consent. This research was registered in the Chinese Clinical Trial Registry(registration number: ChiCTR-TCC-13004002) and the protocol version number is 1.0.

关键词： nerve regeneration human traumatic brain injuries long noncoding RNA messenger RNA GO analysis real-time quantitative polymerase chain reaction biomarkers microarray analysis biological processes medical informatics neural regeneration

An iterative approach to Bayes risk decoding and system combination

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第3期12卷 204-212页

作者： hai-hua XU jie ZHU Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

We describe a novel approach to Bayes risk(BR) decoding for speech recognition,in which we attempt to find the hypothesis that minimizes an estimate of the BR with regard to the minimum word error(MWE) *** achieve this,we propose improved forward and backward algorithms on the lattices and the whole procedure is optimized *** remarkable characteristics of the proposed approach are that the optimization procedure is expectation-maximization(EM) like and the formation of the updated result is similar to that obtained with the confusion network(CN) decoding *** results indicated that the proposed method leads to an error reduction for both lattice rescoring and lattice-based system combinations,compared with CN decoding,confusion network combination(CNC),and ROVER methods.

关键词： Bayes risk(BR) Confusion network Speech recognition Lattice rescoring System combination

Influence of intensification pressures on pores in die-cast ADC12 alloys

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China Foundry 2019年第3期16卷 184-189页

作者： Chun-tao Wang jie Yao hai-dong Zhao Run-sheng yang Ningbo Heli Mould Technology Co. Ltd. Industrial Park Xiangshan County Ningbo 315700 China National Engineering Research Center of Near-net Shape Forming for Metallic Materials South China University of Technology Guangzhou 510641 China

Die casting process is widely applied in making Al parts. However, due to high speed of liquid metal flow in the die cavity, gases are prone to be entrapped in the filling, resulting in porosity defects. The X-ray computed tomography scanning technique was used to detect the pores in die-cast ADC12 alloys with different intensification pressures. The three-dimensional features of pores including pore size, number, sphericity have been obtained. The effect of different intensification pressures on two different kinds of pores, namely gas-pores and shrinkage pores, was analyzed. The results show that with increasing the pressure, the pore fractions and quantity gradually decrease. When the pressure increased to 85 MPa, the pores from gas entrapment during the mold filling were compressed, leading to a lower porosity fraction. The pressure cannot affect the pores in the samples with a thin wall (2 mm) due to a great solidification rate.

关键词： die casting intensification pressure porosity X-ray computed tomography

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气象短信投诉管理平台设计

软件 2013年第5期34卷 30-32页

作者：顾润香刘星燕杨海杰赵海江孙晓霞张树勇张家口市气象局河北张家口075000 河北省怀安县气象局河北怀安076100

随着气象短信用户的不断增加,气象短信投诉也就在所难免,为了做好投诉服务工作,设计开发了气象短信投诉管理平台。平台针对投诉内容多样性特点,结合实际工作需求,主要采用Visual Basic6.0语言编程,实现对关键字段进行投诉分类查找,进而... 详细信息

随着气象短信用户的不断增加,气象短信投诉也就在所难免,为了做好投诉服务工作,设计开发了气象短信投诉管理平台。平台针对投诉内容多样性特点,结合实际工作需求,主要采用Visual Basic6.0语言编程,实现对关键字段进行投诉分类查找,进而达到快速查询手机用户的定制、取消以及历史投诉记录信息。通过多次测试及实际工作试运行,证明了本平台的可行性和有效性。

关键词：气象短信投诉定制和取消程序设计

Morphologies of a spherical bimodal polyelectrolyte brush induced by polydispersity and solvent selectivity

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Chinese Physics B 2021年第6期30卷 637-647页

作者： Qing-hai Hao jie Cheng College of Science Civil Aviation University of ChinaTianjin 300300China

It is commonly realized that polydispersity may significantly affect the surface modification properties of polymer brush systems. In light of this, we systematically study morphologies of bidisperse polyelectrolyte brush grafted onto a spherical nanocolloid in the presence of trivalent counterions using molecular dynamics simulations. Via varying polydispersity, grafting density, and solvent selectivity, the effects of electrostatic correlation and excluded volume are focused, and rich phase behaviors of binary mixed polyelectrolyte brush are predicted, including a variety of pinned-patch morphologies at low grafting density and micelle-like structures at high grafting density. To pinpoint the mechanism of surface structure formation, the shape factor of two species of polyelectrolyte chains and the pair correlation function between monomers from different polyelectrolyte ligands are analyzed carefully. Also, electrostatic correlations, manifested as the bridging through trivalent counterions, are examined by identifying four states of trivalent counterions. Our simulation results may be useful for designing smart stimuli-responsive materials based on mixed polyelectrolyte coated surfaces.

关键词： surface morphologies polydisperse polyelectrolyte brush solvent selectivity molecular dynamics simulation

Water modeling of molten steel flow in a multi-strand tundish with gas blowing

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 143-148页

作者： Jing Jiang Jing-she Li Hua-jie Wu Shu-feng yang Tao Li hai-yan Tang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Engineering Research Institute University of Science and Technology Beijing Beijing 100083 China

Fluid flow characteristics in a four-strand tundish with gas blowing were studied by water modeling *** is found that gas blowing can greatly improve the flow characteristics in the tundish with a turbulence *** dramatically increases the peak concentration time,and greatly decreases the dead volume,and reduces the minimum residence *** gas blowing location,gas flow rate,and porous plug area greatly influence the flow characteristics in the tundish; the gas blowing location near the baffle,smaller gas flow rate,and smaller porous plug area are better for improving the fluid flow *** gas blowing can reduce the difference of flows at the middle outlets and side outlets for the multi-strand *** produced by gas blowing can absorb small inclusions and provide the condition for inclusion collision and ***,introducing gas blowing into a tundish and combining the turbulence inhibitor can improve inclusion floating and removal,and the cleanness of molten steel can be advanced.

关键词： continuous casting tundish water modeling gas blowing porous plug

Synthesis of bacillamide 3 and its analogue

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Chinese Chemical Letters 2009年第10期20卷 1195-1197页

作者： Duo Li hai Shen yang Qing Cui Shen jie Mao Xiao Hua Xu State Key Laboratory of Elemento-Organic Chemistry Nankai University Tlanjin 300071 China

The bacillamide 1 is a new algaecide from the marine bacterium Bacillus sp. SY-1. Its analogues bacillamide 3 and alkaloid 4 were firstly synthesized effectively from D-alanine. The key step was a coupling reaction via the mixed anhydride. All structures were confirmed by IH NMR and 13C NMR. The final compounds were confirmed by 1H NMR, 13C NMR and HRMS and the results are consistent with the reported natural products.

关键词： Bacillamide Thiazole rings Tryptamide Synthesis