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“体医融合”背景下残疾人康复体育发展路径——以陕西省为例

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陕西学前师范学院学报 2022年第10期38卷 119-124页

作者：杨春霞陕西学前师范学院体育学院陕西西安710100

通过对陕西省残疾人的“体医融合”发展现状进行探究,发现其存在残疾人体育意识不强烈,医疗和体育不能紧密联系,残疾人锻炼设施不完善,残疾人自身康复体育观念薄弱等问题。基于这些问题,提出了以下发展对策:一是构建完善的配套保障制度... 详细信息

通过对陕西省残疾人的“体医融合”发展现状进行探究,发现其存在残疾人体育意识不强烈,医疗和体育不能紧密联系,残疾人锻炼设施不完善,残疾人自身康复体育观念薄弱等问题。基于这些问题,提出了以下发展对策:一是构建完善的配套保障制度,通过社区推广实现康复指导;二是利用新媒体进行科普,提升残疾人科学健身意识;三是体医融合复合型人才的培养。

关键词：体医融合残疾人康复路径

Gene signatures to therapeutics:Assessing the potential of ivermectin against t(4;14)multiple myeloma

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World Journal of Clinical Oncology 2024年第1期15卷 115-129页

作者： yang Song Hao-Jun Zhang xia Song Jie Geng Hong-Yi Li Li-Zhong Zhang Bo yang Xue-chun Lu School of Basic Medicine Medical School of Chinese PLABeijing 100853China School of Basic Medicine Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematology The Second Medical CentreChinese PLA General HospitalBeijing 100853China

BACKGROUND Multiple myeloma(MM)is a terminal differentiated B-cell tumor disease characterized by clonal proliferation of malignant plasma cells and excessive levels of monoclonal immunoglobulins in the bone *** translocation,(t)(4;14),results in high-risk MM with limited treatment ***,there is an urgent need for identification and validation of potential treatments for this MM *** data and sequencing information from public databases could offer opportunities for the discovery of new diagnostic or therapeutic *** To elucidate the molecular basis and search for potential effective drugs of t(4;14)MM subtype by employing a comprehensive *** The transcriptional signature of t(4;14)MM was sourced from the Gene Expression *** datasets,GSE16558 and GSE116294,which included 17 and 15 t(4;14)MM bone marrow samples,and five and four normal bone marrow samples,*** the differentially expressed genes were identified,the Cytohubba tool was used to screen for hub ***,the hub genes were analyzed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** the STRING database and Cytoscape,protein–protein interaction networks and core targets were *** small-molecule drugs were identified and validated using the Connectivity Map database and molecular docking analysis,*** In this study,a total of 258 differentially expressed genes with enriched functions in cancer pathways,namely cytokine receptor interactions,nuclear factor(NF)-κB signaling pathway,lipid metabolism,atherosclerosis,and Hippo signaling pathway,were *** hub genes(cd45,vcam1,ccl3,cd56,app,cd48,btk,ccr2,cybb,and cxcl12)were *** drugs,including ivermectin,deforolimus,and isoliquiritigenin,were predicted by the Connectivity Map database to have potential therapeutic effects on t(4;14)*** molecular docking,ivermectin showed strong binding affinity to all 10 ide

关键词： Multiple myeloma Functional enrichment analysis Molecular docking simulation Gene expression profiling Therapeutic target Ivermectin

基于词级交互注意力机制的方面级情感分类模型

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小型微型计算机系统 2022年第7期43卷 1432-1437页

作者：杨春霞瞿涛李欣栩南京信息工程大学自动化学院南京210044 江苏省大数据分析技术重点实验室南京210044 江苏省大气环境与装备技术协同创新中心南京210044

方面级情感分类旨在判断句子中每个具体方面的情感极性.传统的注意力机制模型可能会给句子中重要情感词分配过低的注意力权重,而且很少考虑上下文与方面词的交互信息.针对第1个问题,本文改进了传统的输入方式,以方面词为界限,将句子划... 详细信息

方面级情感分类旨在判断句子中每个具体方面的情感极性.传统的注意力机制模型可能会给句子中重要情感词分配过低的注意力权重,而且很少考虑上下文与方面词的交互信息.针对第1个问题,本文改进了传统的输入方式,以方面词为界限,将句子划分成包含方面词的上文、方面词和包含方面词的下文3部分作为输入,分别提取上文或下文中的重要情感特征.针对第2个问题,本文提出了词级交互注意力机制,分别学习上文与方面词、下文与方面词的词级交互,得到特定于方面的上文表示和下文表示向量,最后将它们拼接得到特定于方面的上下文表示向量,作为方面级情感分类特征.通过在3个标准数据集上的实验证明,本文的模型性能优于基线模型.

关键词：方面级情感分类上下文方面词双向长短期记忆网络词级交互注意力机制

Research and practice of varied GPS receiver working together

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中国有色金属学会会刊：英文版 2005年第S1期15卷 200-203页

作者： JI Chang-dong, QIAO yang-wen, xia chun-lin (Liaoning Technical University, Fuxin 123000, China)

The GPS receiver working together was researched and practiced deeply, which mainly included the choice of scheme how to lay the network and the development of software use during the data processing. The software exa... 详细信息

关键词： Ashtech receiver Trimble receiver integration of operation RINEX

One-step controlled electrodeposition nickel sulfides heterointerfaces favoring the desorption of hydroxyl groups for efficient hydrogen generation

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Rare Metals 2024年第9期43卷 4377-4386页

作者： Ru-chun Li Xin-Yue Zhang Ze-Yue Qu Feng-Yi Liu Quan-Qing Xu Zhao-xia Hu Jing-Wei Li Mohamed-Nawfal Ghazzal Jin-Li Yu Faculty of Chemistry and Chemical Engineering Yunnan Normal University Foshan Gaoke Hechuang Technology Co. Ltd. School of Chemistry and Chemical Engineering Guangzhou University Universite′Paris-Saclay UMR 8000 CNRSInstitut de Chimie Physique Department of Chemistry City University of Hong Kong

The heterointerface engineering involving different components or phases represents a desirable strategy for enhancing the sluggish kinetics of hydrogen evolution reaction （HER）.However,constructing desired heterointerfaces and elucidating the reaction mechanisms on the interface remains a considerable *** this work,we propose a straightforward electrochemical synthesis strategy to prepare the nickel sulfide-based heterointerfaces for *** mechanism of electrochemical synthesis is revealed,wherein metal-thiourea species can be formed at the cathode potential and subsequently oxidized to nickel sulfides at the anode *** this mechanism,a range of nickel sulfides,including NiS,Ni3S2/NiS,Ni/Ni3S2and Ni3S2,have been successfully synthesized by tuning the potential range of cyclic *** these,the obtained Ni3S2/NiS@CC（CC:carbon cloth） exhibits the smallest overpotential of84 mV at 10 mA·cm-2and high *** calculations further reveal that the combination of NiS and Ni3S2induces electron redistribution at the interface,and thus the Volmer process is effectively promoted with faster water dissociation and OH desorption ***,the simplicity method coupled with a clear synthesis mechanism and outstanding HER performance highlights its promising potential for practical applications.

关键词： Electrochemical synthesis Heterointerfaces Hydrogen evolution reaction OH desorption kinetics

血糖、糖化白蛋白、糖化血红蛋白在糖尿病诊断中的价值

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医学信息 2023年第13期36卷 141-143页

作者：杨春霞天津市蓟州区人民医院检验科

目的研究空腹血糖（FPG）、糖化白蛋白（GA）、糖化血红蛋白（HbA1c）在糖尿病诊断中的价值。方法将2021年5月-2022年5月天津市蓟州区人民医院收治的52例糖尿病患者设为糖尿病组，另取同期50名体检健康者设为健康组，比较两组FPG、GA... 详细信息

目的研究空腹血糖（FPG）、糖化白蛋白（GA）、糖化血红蛋白（HbA1c）在糖尿病诊断中的价值。方法将2021年5月-2022年5月天津市蓟州区人民医院收治的52例糖尿病患者设为糖尿病组，另取同期50名体检健康者设为健康组，比较两组FPG、GA、HbA1c水平，分析FPG、GA、HbA1c在糖尿病诊断中的价值。结果糖尿病组FPG、GA、HbA1c水平高于健康组（P0.05），三者联合检测糖尿病的检出率高于单独检测，漏诊率低于单独检测（P<0.05）;GA、HbA1c单独诊断糖尿病的灵敏度与特异度高于FPG (P<0.05)，三者联合诊断糖尿病的灵敏度与特异度高于单独诊断（P<0.05）。结论 FPG、GA、HbA1c在糖尿病诊断中均具有较高的价值，其中GA、HbA1c的检验效果相当，均优于FPG，但三者联合检测效果更为理想。

关键词：糖尿病空腹血糖糖化白蛋白糖化血红蛋白

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D-二聚体检测及临床应用研究

医学信息 2023年第12期36卷 189-192页

作者：杨春霞天津市蓟州区人民医院检验科

D-二聚体是可溶的纤维蛋白降解产物，是由纤维蛋白溶解系统对血栓的有序分解产物，是临床凝血和纤溶激活的重要检测指标。因D-二聚体检测具有高度敏感性和阴性预测能力，使其在临床静脉血栓形成、弥漫性血管内凝血、急性冠脉综合征等疾... 详细信息

D-二聚体是可溶的纤维蛋白降解产物，是由纤维蛋白溶解系统对血栓的有序分解产物，是临床凝血和纤溶激活的重要检测指标。因D-二聚体检测具有高度敏感性和阴性预测能力，使其在临床静脉血栓形成、弥漫性血管内凝血、急性冠脉综合征等疾病的鉴别诊断和治疗监测方面得到广泛应用。但D-二聚体检测多样化，不同检测方法检测结果存在差异；且D-二聚体表达水平受个体差异影响，一定程度限制了D-二聚体在临床的应用。本文主要就D-二聚体的形成机制、检测方法以及在临床的应用进行综述，以期为D-二聚体检测的合理应用提供参考依据。

关键词： D-二聚体纤维蛋白血栓急性冠脉综合征

地诺前列酮法和Foley导管联合缩宫素法促宫颈成熟的临床研究

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医药论坛杂志 2023年第9期44卷 97-100页

作者：杨春霞巩义瑞康医院产科河南巩义451200

目的探讨宫颈不成熟的足月妊娠阴道分娩初产妇适合的引产方式。方法回顾性分析2018年6月—2022年6月有引产指征在巩义瑞康医院引产的足月妊娠阴道分娩初产妇,宫颈Bishop评分<6分。其中,应用地诺前列酮栓75例,简称药物组;应用Foley导... 详细信息

目的探讨宫颈不成熟的足月妊娠阴道分娩初产妇适合的引产方式。方法回顾性分析2018年6月—2022年6月有引产指征在巩义瑞康医院引产的足月妊娠阴道分娩初产妇,宫颈Bishop评分<6分。其中,应用地诺前列酮栓75例,简称药物组;应用Foley导尿管球囊联合人工破膜、静滴缩宫素65例(包含10例有一次子宫手术史者),简称球囊组。对比两组宫颈Bishop评分、促宫颈成熟引产成功率、阴道分娩率、转剖宫产率、住院天数及母婴安全性。结果药物组引产成功率97.33%,球囊组引产成功率95.38%,两组引产成功率无明显差异。两组在母婴结局上比较无明显差异:产后出血率、新生儿窒息率相当,均无产褥感染及其他严重并发症发生。母婴结局良好。结论两者均为有效的促宫颈成熟引产方式。临床工作中要详细告知患者两者的风险与差别、结合患者宫颈Bishop评分、对住院待产时间、疼痛耐受等情况的接受程度,综合评估,选择合适的促宫颈成熟引产方式。

关键词：地诺前列酮栓 Foley导尿管球囊阴道分娩初产妇足月妊娠引产

Sinomenine increases osteogenesis in mice with ovariectomyinduced bone loss by modulating autophagy

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World Journal of Stem Cells 2024年第5期16卷 486-498页

作者： Hai-xiang xiao Lei Yu Yu xia Kai Chen Wen-Ming Li Gao-Ran Ge Wei Zhang Qing Zhang Hong-Tao Zhang De-chun Geng Department of Orthopedics The Fourth Affiliated Hospital of Soochow UniversitySuzhou Dushu Lake HospitalMedical Centre of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Orthopedics Jingjiang People’s Hospital Affiliated to Yangzhou UniversityJingjiang 214500Jiangsu ProvinceChina Department of Orthopedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Orthopedics Hai’an People’s HospitalHai’an 226600Jiangsu ProvinceChina Department of Orthopedics The Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’an Second People’s HospitalXuzhou 223002Jiangsu ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND A decreased autophagic capacity of bone marrow mesenchymal stromal cells(BMSCs)has been suggested to be an important cause of decreased osteogenic differentiation.A pharmacological increase in autophagy of BMSCs is a potential therapeutic option to increase osteoblast viability and ameliorate *** To explore the effects of sinomenine(SIN)on the osteogenic differentiation of BMSCs and the underlying *** For in vitro experiments,BMSCs were extracted from sham-treated mice and ovariectomized mice,and the levels of autophagy markers and osteogenic differentiation were examined after treatment with the appropriate concen-trations of SIN and the autophagy inhibitor *** vivo,the therapeutic effect of SIN was verified by establishing an ovariectomy-induced mouse model and by morphological and histological assays of the mouse *** SIN reduced the levels of AKT and mammalian target of the rapamycin(mTOR)phosphorylation in the phosphatidylinositol 3-kinase(PI3K)/AKT/mTOR signaling pathway,inhibited mTOR activity,and increased autophagy ability of BMSCs,thereby promoting the osteogenic differentiation of BMSCs and effectively alleviating bone loss in ovariectomized mice in *** The Chinese medicine SIN has potential for the treatment of various types of osteoporosis,bone homeostasis disorders,and autophagy-related diseases.

关键词： Sinomenine Osteogenesis Autophagy Ovariectomy Osteoporosis