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Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain

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Acta Pharmacologica Sinica 2004年第10期 45-51页

作者： Cai-zhen yan, yan-ning HOU Bathune International Peace Hospital, Hebei Medical University,Shijiazhuang 050082, China

AIM: To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain. METHODS: A method of simultaneous quantification of neurosteroids by gas chromatography-mass spectrometry (GC-MS) had been established. RESULTS: The chronic morphine administration (ip) resulted in a marked decrease in the brain concentrations of pregnenolone (PREG), progesterone (PROG), and pregenenolone sulfate (PREGS) in rats killed 6 h after the last treatment. In contrast, there were no significant effects of morphine dependence on the brain concentrations of allopregnanolone (AP), dihydroepiandrosterone (DHEA), and dihydroepiandrosterone sulfate (DHEAS). Naloxone-induced withdrawal produced a significant increase in the concentrations of PREG, PROG, AP, DHEA, PREGS, and DHEAS as compared with the control group. CONCLUSION: Morphine dependence and withdrawal affected the concentrations of neurosteroids in rat brain, which suggests that endogenous neurosteroids in brain might be

关键词： morphine dependence withdrawal steroids mass fragmentography

含苯并噁唑基的硫桥杯[4]芳烃衍生物的合成及结构

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有机化学 2009年第10期29卷 1682-1686页

作者：赵邦屯周振颜振宁洛阳师范学院化学系洛阳471022 郑州大学化学系郑州450001

在碳酸钾存在下,对叔丁基硫桥杯[4]芳烃(1)分别与端基二溴代烷和碘甲烷反应,生成硫桥杯[4]芳烃衍生物2～4.含端基溴代的硫桥杯[4]芳烃衍生物2和4分别与2-巯基苯并噁唑在碳酸钾存在下反应,生成硫桥杯[4]芳烃衍生物5a～5d.通过1HNMR,13CNM... 详细信息

在碳酸钾存在下,对叔丁基硫桥杯[4]芳烃(1)分别与端基二溴代烷和碘甲烷反应,生成硫桥杯[4]芳烃衍生物2～4.含端基溴代的硫桥杯[4]芳烃衍生物2和4分别与2-巯基苯并噁唑在碳酸钾存在下反应,生成硫桥杯[4]芳烃衍生物5a～5d.通过1HNMR,13CNMR,IR,MS和元素分析等手段对产物进行了表征.同时,X射线分析确定了硫桥杯[4]芳烃5b的晶体结构.

关键词：硫桥杯芳烃 2-巯基苯并噁唑合成晶体结构

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新构造运动对西南地区石漠化形成的影响

西南师范大学学报（自然科学版） 2010年第3期35卷 114-118页

作者：严宁珍西南大学资源环境学院重庆400716

近年来,西南地区的石漠化现象已引起学术界的广泛关注,有关石漠化的特点、成因、治理、演化等方面已有大量的研究,但新构造运动对石漠化形成的影响,前人研究甚少.新构造运动在中国青藏高原形成高大的喜马拉雅山,而西南地区位于青藏高原... 详细信息

近年来,西南地区的石漠化现象已引起学术界的广泛关注,有关石漠化的特点、成因、治理、演化等方面已有大量的研究,但新构造运动对石漠化形成的影响,前人研究甚少.新构造运动在中国青藏高原形成高大的喜马拉雅山,而西南地区位于青藏高原的东南翼,处于升降过渡区,在地质历史时期该地区沉积了巨厚碳酸盐岩,由于大幅度的差异升降运动,导致西南地区的气候、地貌、地质构造等方面发生了巨大的变化,为岩溶的发育提供了必要的前提,加之这一时期人类不合理的干扰加速了石漠化的进程.

关键词：新构造运动石漠化形成西南地区

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生物合成FeS及其稳定性柱迁移研究

岩石矿物学杂志 2024年第1期43卷 117-124页

作者：任霞严宁珍刘璟西南大学资源环境学院重庆400716

金属纳米硫化亚铁(FeS)在重/类金属修复上具有广阔的应用前景。使用嗜酸性铁还原菌(JF-5)和硫酸盐还原菌(SRB)合成生物纳米FeS,探讨其自然沉降规律,并使用羧甲基纤维素钠(CMC)作为稳定剂,探讨CMC-FeS在石英砂柱中的迁移特性。结果表明,... 详细信息

金属纳米硫化亚铁(FeS)在重/类金属修复上具有广阔的应用前景。使用嗜酸性铁还原菌(JF-5)和硫酸盐还原菌(SRB)合成生物纳米FeS,探讨其自然沉降规律,并使用羧甲基纤维素钠(CMC)作为稳定剂,探讨CMC-FeS在石英砂柱中的迁移特性。结果表明,SRB和JF-5菌液在一定比例下混合即能生成纳米FeS,且当混合菌液中n(Fe)/n(S)=0.2时FeS生成量最多,颗粒物浓度达2400 mg/L;FeS的自然沉降速率在0.1%CMC溶液中得到有效减缓。对流扩散模型能很好地描述CMC-FeS悬浮颗粒在石英砂柱中的迁移行为,相比于纯水-FeS体系(R^(2)=0.20),其模型相关性最高达0.85;在90、180和360 mL/h这3种输入流速下,中等流速180 mL/h能够获得最佳渗透性,其渗透系数平均值为243.97 cm/h。实验结果表明,CMC-FeS的稳定性和迁移性较纯水-FeS均得到加强,可为土壤污染修复提供理论参考。

关键词：生物合成FeS 沉降柱迁移

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng yan zhen Wang Guansheng Ma Dechang Jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu zhen Gu Hua yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

中性载体双(N-乙基-N-苯基氨基二硫代甲酸)1,4-丁二醇酯PVC膜银离子选择电极的研制

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分析测试学报 2006年第5期25卷 7-10页

作者：颜振宁陆艳琦李霞郑州大学化学系河南郑州450052 郑州铁路职业技术学院河南郑州450052

采用双层膜电位法直接测定了溶剂聚合物膜中载体双（N-乙基-N-苯基氨基二硫代甲酸）1，4-丁二醇酯与金属离子生成的络合物生成常数。制备并考察了以双（N-乙基-N-苯基氨基二硫代甲酸）1，4-丁二醇酯为载体的银离子选择性电极的性能。实... 详细信息

采用双层膜电位法直接测定了溶剂聚合物膜中载体双（N-乙基-N-苯基氨基二硫代甲酸）1，4-丁二醇酯与金属离子生成的络合物生成常数。制备并考察了以双（N-乙基-N-苯基氨基二硫代甲酸）1，4-丁二醇酯为载体的银离子选择性电极的性能。实验结果表明：该选择电极对银离子有良好的灵敏度和高选择性，在1×10^-3～1×10^-6mol／L的浓度范围内响应斜率为60．2mV／pαAg^＋，检出限为2．3×10^-7mol／L，碱金属、碱土金属及过渡金属离子不干扰银的测定。该电极可作为Ag^＋准确滴定卤素阴离子的电位滴定指示电极，用于维生素B1药片中维生素B1含量的测定。

关键词：双(N-乙基-N-苯基氨基二硫代甲酸)1,4-丁二醇酯离子选择电极银离子

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新型PVC膜银离子选择电极的研制及应用

河南师范大学学报（自然科学版） 2006年第3期34卷 111-114页

作者：颜振宁崔凤灵崔延瑞郑州大学化学系郑州450052 河南师范大学化学与环境科学学院河南新乡453007

以合成的双（N-乙基-N-苯基氨基二硫代甲酸）1，3-丙二醇酯为载体，采用双层膜电位法直接测定了溶剂聚合物膜中载体与金属离子的络合物生成常数．制备并考察了以双（N-乙基-N-苯基氨基二硫代甲酸）1，3-丙二醇酯为载体的银离子选择电极... 详细信息

以合成的双（N-乙基-N-苯基氨基二硫代甲酸）1，3-丙二醇酯为载体，采用双层膜电位法直接测定了溶剂聚合物膜中载体与金属离子的络合物生成常数．制备并考察了以双（N-乙基-N-苯基氨基二硫代甲酸）1，3-丙二醇酯为载体的银离子选择电极的性能．实验结果表明：该选择电极对银离子有良好的响应性能和高选择性，在10^-3～10^-6mol／L的浓度范围内响应斜率为56．0mV／paAg^＋，检测下限为3．7×10^-7mol／L，碱金属、碱土金属及过渡金属离子不干扰银的测定．该电极可作为测定维生素B1药片中维生素B1含量的电位滴定指示电极和水样中银离子含量的直接测定．

关键词：双(N-乙基-N-苯基氨基二硫代甲酸)1,3-丙二醇酯离子选择电极银离子

Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian Yu Jane Howe Kaiwen Chen ning yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors