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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang yanlin Fu Peiyan Long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan Qi Wei Hong yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Primary Studies on Burnup Estimation of Irradiated Uranium by Dtermining 236U/238U in Contaminated Environmental Samples JIANG xiao-yan,ZHANG Ji-long,ZOU Wei,Chang Zhi-yuan

Primary Studies on Burnup Estimation of Irradiated Uranium b...

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作者： JIANG xiao-yan ZHANG Ji-long ZOU Wei Chang Zhi-yuan

U/U of the environmental sample can indicate the existence of uranium irradiation,and even can be uesd to estimate the burnup of nuclear spent fuel.A study on the burnup estimation of irradiated uranium which was mixed with natural uranium was carried out by measuring the U/U and U/U in the samples by using MC-ICP-MS. According to the equation(1) and(2),a programme for calculating the burnup of the irradiated

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Ko⁃LLaMA:基于LLaMA的朝鲜语大语言模型

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外语学刊 2025年第1期 1-8页

作者：庞杰闫晓东赵小兵中央民族大学北京100081 国家语言资源监测与研究民族语言中心北京100081 民族语言智能与安全治理教育部重点实验室北京100081

在本文中,我们通过扩展LLaMA现有的词表,增加额外的20,000个朝鲜语Token,从而提高其对朝鲜语的编码和语义理解的能力;并且进一步使用朝鲜语数据进行继续预训练,使用朝鲜语指令微调数据集对模型进行SFT(Supervised Fine⁃Tuning),并分析... 详细信息

在本文中,我们通过扩展LLaMA现有的词表,增加额外的20,000个朝鲜语Token,从而提高其对朝鲜语的编码和语义理解的能力;并且进一步使用朝鲜语数据进行继续预训练,使用朝鲜语指令微调数据集对模型进行SFT(Supervised Fine⁃Tuning),并分析不同数据量对指令精调效果的影响,经过继续预训练和指令微调后的模型显著提高了理解和遵循朝鲜语指令的能力。实验结果表明,新提出的模型Ko⁃LLaMA显著提高了原版LLaMA在理解和生成朝鲜语内容方面的能力。此外,在朝鲜语文本分类数据集YNAT上对Ko⁃LLaMA与擅长少数民族语言的CINO模型及CINO的多种模型组合以及原版LLaMA和GPT⁃3.5进行了效果对比。结果表明,Ko⁃LLaMA的朝鲜语文本分类能力远超CINO和CINO的组合模型以及LLaMA和GPT⁃3.5等未经过朝鲜语语料进行词表扩充和继续预训练的大语言模型。

关键词：朝鲜语大语言模型词表扩充继续预训练指令微调

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基于固定化金属亲和整体柱的痕量微囊藻毒素富集分析

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分析测试学报 2025年第1期44卷 155-162,171页

作者：陈小燕杨玲苏立燊吴晓苹福州大学化学学院食品安全与生物分析教育部重点实验室福建福州350116 泉州市晋江环境监测站福建泉州362200 福建省妇幼保健院福建福州350001

基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体... 详细信息

基于固定化金属亲和色谱(IMAC)识别原理,采用后修饰法在热引发自由基聚合反应得到的有机基质整体柱上直接固定Cu^(2+),设计并合成表征了poly(VIM-co-DVB)-Cu^(2+)亲和毛细管整体柱,用于微囊藻毒素(MCs)的富集研究。详细优化了亲和整体柱的萃取条件,在最优条件下,将poly(VIM-co-DVB)-Cu^(2+)整体柱用于毛细管微萃取(CME),并与高效液相色谱-质谱(HPLC-MS)检测技术联用,建立了环境水样品中3种MCs的高效富集分析方法。方法检出限为0.89~1.23 ng/L,加标回收率为80.0%~105%,相对标准偏差(RSD)不大于6.8%。该方法灵敏度高、准确性好,可为污染水体中微囊藻毒素的监测分析提供有效手段。

关键词：微囊藻毒素固定化金属亲和整体柱毛细管微萃取高效液相色谱-质谱

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毛竹PheTCP19b基因可变剪接体对芽发育的影响

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农业生物技术学报 2025年第1期33卷 43-54页

作者：郝琴申孜闫小玲周敏舒郭小勤浙江农林大学竹子研究院/省部共建亚热带森林培育国家重点实验室

可变剪接(alternative splicing, AS)是一种转录后的修饰过程，在生物体各种生理过程中发挥重要作用。TCP是一种植物特有的转录因子，参与植物多种生长发育调控过程。为深入探究毛竹(Phyllostachys edulis) TCP19b基因可变剪接体的表达... 详细信息

可变剪接(alternative splicing, AS)是一种转录后的修饰过程，在生物体各种生理过程中发挥重要作用。TCP是一种植物特有的转录因子，参与植物多种生长发育调控过程。为深入探究毛竹(Phyllostachys edulis) TCP19b基因可变剪接体的表达特性及生物学功能，本研究采用RT-PCR技术克隆了毛竹TCP19b基因全长CDS，采用qRT-PCR技术和GUS组织染色分析了可变剪接体的表达量及表达部位，通过亚细胞定位及遗传转化分析了可变剪接体编码蛋白的定位及生物学功能。结果显示，毛竹PheTCP19b基因发生了可变剪接，产生了2种可变剪接体PheTCP19bα和PheTCP19bβ，分别编码346和382个氨基酸，2种可变剪接体都包含保守的bHLH结构域。PheTCP19b与水稻(Oryza sativa) OsTCP19亲缘关系最近。2个可变剪接体的组织特异性表达模式存在一定差异，PheTCP19bα的组织特异性强，而PheTCP19bβ表现出组成型表达特性，油菜素内酯(brassinolide, BR)可诱导2个可变剪接体的表达。2个可变剪接体蛋白均富集在细胞核。PheTCP19bα和PheTCP19bβ均可以将拟南芥(Arabidopsis thaliana) brc1突变体多分枝表型回补到野生型表型。本研究为进一步探讨PheTCP19b基因不同剪接体在芽发育过程中的分子机制提供了基础资料。

关键词：毛竹 TCP转录因子可变剪接(AS) 芽发育油菜素内酯(BR)

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Notes on Proper Class of Triangles

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Acta Mathematica Sinica,English Series 2013年第11期29卷 2137-2154页

作者： xiao yan yanG Department of Mathematics Northwest Normal University

Let T be a triangulated category and ζ a proper class of triangles. Some basics properties and diagram lemmas are proved directly from the definition of ζ.

关键词： Proper class of triangles triangulated category

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Effects of microplastic polystyrene,simulated acid rain and arbuscular mycorrhizal fungi on Trifolium repens growth and soil microbial community composition

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Pedosphere 2024年第2期34卷 424-437页

作者： Wanlin LI yan xiao College of Agro-grassland Science Nanjing Agricultural UniversityNanjing 210095China

Microplastic pollution is a global and ubiquitous environmental problem in the oceans as well as in the terrestrial *** examined the fate of microplastic polystyrene(MPS)beads in experimental soil in the presence and absence of symbiotic arbuscular mycorrhizal fungi(AMF)and simulated acid rain(SAR)to determine whether the combinations of these three factors altered the growth of white clover Trifolium *** found that MPS,SAR,or AMF added singly to soil did not alter *** growth or *** contrast,MPS and AMF together significantly reduced shoot biomass,while SAR and MPS together significantly reduced soil available phosphorus independent of AMF *** polystyrene,AMF,and SAR together significantly reduced soil NO_(3)^(-)-*** mycorrhizal fungi added singly also enriched the beneficial soil bacteria(genus Solirubrobacter),while MPS combined with AMF significantly enriched the potential plant pathogenic fungus *** mycorrhizal fungi inoculation with MPS increased the abundance of soil hydrocarbon degraders independent of the presence of *** addition,the abundance of soil nitrate reducers was increased by MPS,especially in the presence of AMF and ***,SAR alone increased the abundance of soil pathogens within the fungal community including antibiotic *** findings indicate that the coexistence of MPS,SAR,and AMF may exacerbate the adverse effects of MPS on soil and plant health.

关键词： acid deposition arbuscular mycorrhizal fungi symbiosis hydrocarbon degradation microbial alpha diversity microplastic pollution pathogen

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A Reverse Auction Framework for Hybrid Access in Femtocell Network

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Journal of Computer Science & Technology 2017年第6期32卷 1250-1264页

作者： yan-Jiao Chen xiao-yan Yin Jin Zhang State Key Laboratory of Software Engineering School of Computer Wuhan University Wuhan 430072 China School of Information Science and Technology Northwest University Xi'an 710127 China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen 518055 China

In the two-tier macro-femto heterogeneous network, hybrid access is regarded as the most ideal access con- trol approach to mitigating macro-femto cross-tier interference and enhancing overall network performance. However, the implementation of hybrid access is hindered by a lack of incentive market mechanism to motivate private femtocell owners to offer access permissions to macro users. In this paper, we propose a reverse auction framework for access permission transaction between a macrocell operator and multiple femtocell owners to promote hybrid access. Our goal is to maximize social welfare while guaranteeing the truthfulness of the auction. Since the coverage of multiple femtocells may overlap, we partition each cell to adjust the granularity of access permission availability. We first propose a Vickery-Clarke-Grove （VCG）-based mechanism, which costs the least among all auction mechanisms that produce maximum social welfare. As the VCG mechanism is too time-consuming, we propose two alternative truthful mechanisms, namely, generalized second- price and suboptimal mechanism. We further extend the auction framework to the scenario where femtocell owners have heterogeneous valuations for access permissions in different locations.

关键词： femtocell hybrid access reverse auction

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A simple image-based method for online moisture content estimation of iron ore green pellets

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Journal of Iron and Steel Research International 2023年第5期30卷 851-863页

作者： Shu-yi Zhou xiao-yan Liu College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362006FujianChina

Moisture content(MC)is an important quality metric of iron ore green pellets in pelletizing process in ironmaking *** image-based methods for MC estimation may result in big errors for gray-scale pellet images captured under various lighting *** proposed a simple image-based method to improve the MC estimation accuracy by illumination correction and linear regression ***,the illumination of the pellet image was transformed into the reference illumination by use of a color checker chart and piecewise linear interpolation,so that the influence of different illuminations could be greatly *** experimental analysis,it was found that MC is approximately adversely proportional to the average intensity of the transformed images.A simple model for MC prediction was then established by linear *** demonstrated that the proposed method has good robustness to different lighting conditions and achieves the best performance in metrics of mean square error,mean absolute error and maximum absolute error in comparison with five state-of-art MC estimating *** on a working disk pelletizer shows that the proposed method can predict well the change of moisture content with time,and its computing efficiency can satisfy the requirement for online MC monitoring during the pelletizing process.

关键词： Green pellet Moisture content Image processing Pelletizing process

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Phase behavior of undecane–tetradecane mixtures confned in SBA-15

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Chinese Chemical Letters 2013年第10期24卷 885-888页

作者： xiao yan xiao-Zheng Lan College of Chemistry and Materials Science Shandong Agriculture University

Phase behavior of undecane-tetradecane （n-C11H24-C14H3o, C11-C14） mixtures in bulk and confined in SBA-15 have been studied using differential scanning calorimetry. The bulk C11-C14 system shows multiple phase regions due to rotator phase. Confined in the pores of SBA-15 （pore diameters 3.8- 7.8 rim）, the mixtures only show a melting boundary of a straight line and a curve, respectively. In SBA- 15 （ 17.2 nm）, phase behavior of the mixtures has some similarity to that of the bulk. Under confinement, the phase diagrams of the mixtures vary with the pore size, temperature, and compositions.

关键词： Confinement Undecane-tetradecanemixtures Size effect Phase diagram

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