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Synchronous formation of the‘forearc’Bay of Islands ophiolite and its basal high-temperature metamorphic sole constrained by U-Pb zircon ages

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Geoscience Frontiers 2023年第6期14卷 234-272页

作者： weiyao yan John F.Casey Department of Earth and Atmospheric Sciences University of HoustonHoustonTXUSA

The welded metamorphic sole at the base of the Bay of Islands Ophiolite Complex(BOIC)in the Northern Appalachians of Newfoundland shows a typical inverted pressure-temperature(P-T)metamorphic gradient from HT-MP granulite to LT-LP greenschist *** incorporates mafic volcanic/plutonic protoliths mixed with pelagic,hemi-pelagic and coarser epiclastic sedimentary *** LA-ICP-MS U–Pb concordia ages,trace elements,and Ti-in-zircon geothermometry for -250 zircon analyses from three metabasites of the upper HT sole amphibolites with N-MORB-like protoliths are *** samples collected within meters of the ophiolite peridotite-sole contact of the Blow Me Down Mountain and North Arm Mountain massifs yielded the oldest comparable concordia ages of 487.7±2.6 Ma and 489.1±3.1 Ma,respectively,that are both within error of the igneous age of 488.3±1.5 Ma of the directly overlying BOIC ophiolite,which formed at a supra-subduction zone(SSZ)forearc spreading center.A third slightly younger age of 484.2±2.4 Ma was obtained for an upper HT amphibolite sample with similar phase assemblages but collected30 m below the peridotite contact of the Table Mountain *** crystals analyzed have similar size and morphologies,subparallel rare earth element(REE)variation patterns,and steep heavy REE-enrichments((Lu/Gd)_(cn)>20),significant positive Ce anomalies(dominantly>5)and slight positive to dominantly negative Eu anomalies(1.2–0.4).Zircon shows Th/U mean values of 0.37–0.48 with little to no rim to core *** Ti-in-zircon mean crystallization temperatures range from764–787℃.These neocrystallized zircon crystals appear to be derived from thin leucosomes within the three *** other samples also from the upper HT sole show evidence of inherited detrital zircon with core dates spanning the Cambrian Notre Dame Arc through older Laurentian-like basement and rift age *** of the sole took place below a hot forearc asthenospheric wed

关键词： Ophiolite metamorphic sole U-Pb zircon ages Hot subduction interface Supra-subduction forearc spreading center Arc-continent collision Taconic Orogeny

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Immure response induced by oral DNA vaccination against FMDV delivered by attenuated Salm onella choleraesuis C500

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Frontiers in Biology 2006年第2期1卷 110-114页

作者： Liu Mingqiu Niu Xiaofeng yan Jingran yan weiyao Zheng Zhaoxin State Key Laboratory of Genetic Engineering Institute of GeneticsSchool of Life ScienceFudan UniversityShanghai 200433China Institute of Biochemistry and Cell Biology SIBSChinese Academy of SciencesShanghai 200031China

A recombinant strain of Salmonella choleraesuis C500,containing a eukaryotic expression plasmid pBO1 with the immune-dominant epitope of foot-and-mouth disease virus,was *** immune response to this recombinant strain was evaluated by oral administration of the recombinant live bacteria pBO1/*** in *** showed that T cell response and specific antibody production were *** approach may present a general strategy for eliciting immune responses with DNA vaccine delivered by live bacterial *** stimulated indexes of T lymphoproliferation by specific antigens of FMDV in rabbits,can reach up to 11.0 and an antibody titer of 1/32 as detected in the erum with liquid block ELISA.

关键词： Salmonella choleraesuis foot-and-mouth disease virus recombinant live vaccine

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水下大盾构隧道受力特性分析及变形控制值讨论——以南京五桥夹江水下盾构隧道工程为例

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隧道建设（中英文） 2022年第5期42卷 863-872页

作者：严伟垚丁鸿志周全南京市公共工程建设中心江苏南京210019

为指导南京五桥夹江隧道运营安全评估,建立结构受力三维仿真计算模型,分析粉质黏土、粉砂等典型地层隧道结构在“横鸭蛋”和“竖鸭蛋”2种变形模式下的损伤演化过程,结合混凝土、螺栓、钢筋及结构整体受力状态,讨论运营期断面收敛变形... 详细信息

为指导南京五桥夹江隧道运营安全评估,建立结构受力三维仿真计算模型,分析粉质黏土、粉砂等典型地层隧道结构在“横鸭蛋”和“竖鸭蛋”2种变形模式下的损伤演化过程,结合混凝土、螺栓、钢筋及结构整体受力状态,讨论运营期断面收敛变形的控制值。主要结论如下:1)江中强透水地段极端7 m冲刷工况下,隧道整体上浮2.85 mm,螺栓应力变幅最为敏感,下调27.6%,混凝土应力变化最小。2)不考虑纵向差异沉降问题时,冲刷使结构向高轴压受力模式转变,对承载有利。3)水位升高引起隧道竖向变形增大0.22 mm,螺栓应力减小3.8 MPa;而水位降低引起隧道竖向变形减小0.05 mm,螺栓应力增大2 MPa。4)对比不同地质区段分析结果可知,“横鸭蛋”变形模式下,陆域段和江中段分别以10‰和12‰作为控制值;“竖鸭蛋”变形模式下,以9‰作为控制值。夹江隧道运营过程中,可依据上述标准评价变形的检测、监测数据,判定结构安全状态。

关键词：水下盾构隧道结构损伤演化变形模式直径变形比控制标准

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CpG DNA enhances the im-mune responses elicited by the DNA vaccine against foot-and-mouth disease virus in guinea pigs

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Chinese Science Bulletin 2001年第16期46卷 1376-1379页

作者： LI Guangjin LI Yingjie yan weiyao XU Quanxin WU Yongqing XIE Yong YOU Yongjin ZHENG Zhaoxin State Key Laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200433China Institute of Veterinary Science Shanghai Academy of Agricultural SciencesShanghai 201106China Department of Biology Hong Kong University of Science and TechnologyHong KongChina

CpG DNA is DNA sequence that has immune stimulatory effects. Several lines of investigation over the past few years indicate that CpG DNA plays an important role in the induction of immune responses to DNA vaccines. In this study, CpG DNA-containing synthetic oligodeoxynucleotide (CpG-ODN) was cloned into the eukaryotic expression plasmid encoding a fusion protein containing b- galactosidase from E. coli and immunogenic epitopes of foot- and-mouth disease virus (FMDV) type O, and the immune responses induced by the plasmid were assayed. The results showed that guinea pigs immunized with the recombinant plasmid containing CpG-ODN generated a higher level of FMDV-neutralizing antibody and a stronger T cell proliferative response and protection against viral challenge than those receiving the plasmid containing no CpG-ODN. Our study demonstrated that it is an effective route to enhance the efficacy of DNA vaccines by inserting exogenous CpG DNA into the plasmids, and the DNA vaccine developed here is a promising candidate to prevent FMDV infection.

关键词： CpG DNA DNA vaccine foot-and-mouth disease virus immnostimulatory sequence.

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Large eddy simulation study of 3D wind field in a complex mountainous area under different boundary conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 541-556页

作者： yan LI Lei yan Xuhui HE School of Civil Engineering Central South UniversityChangsha410075China National Engineering Research Center for High-speed Railway Construction Changsha410075China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structures Changsha410075China

Large eddy simulations generally are used to predict 3D wind field characteristics in complex mountainous *** simulation boundary conditions,such as the height and length of the computational domain or the characteristics of inflow turbulence,can significantly impact the quality of *** this study,we examined these boundary conditions within the context of the mountainous terrain around a long-span cable-stayed bridge using a wind tunnel *** sizes of computational domains and turbulent incoming wind velocities were used in large eddy *** results show that when the height of the computational domain is five times greater than the height of the terrain model,there is minimal influence from the top wall on the wind field characteristics in this complex mountainous *** the length of the wake region of the computational domain has negligible effects on the wind *** in the inlet boundary reduces the length of the wake region on a leeward hill with a low slope,but has less impact on the mean wind velocity of steep hills.

关键词： Large eddy simulation(LES) Spectral representation method Recycling method High mountainous canyon Wind characteristics Atmospheric boundary layer Computational domain

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Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin Chai yan Sun yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning

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Forward to the Special Topic on“Solving Differential Equations with Deep Learning”

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Journal of Systems Science & Complexity 2024年第2期37卷 389-390页

作者： yan Zhenya Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

The concept of artificial intelligence(AI)was first presented at the Dartmouth SummerResearch Project on AI hosted by McCarthy and Minsky in *** that,the developmentof AI has experienced ups and downs due to some limited conditions including intelligentcomputing techniques,computer and hardware and software^([1,2]).In particular,with the rapidof deep artificial neural networks,machine learning(ML)and deep learning(DL)techniques^([3,4])have been applied in many fields of science and engineering,including machine translation,image recognition,genomics,scientific computing and atmospheric science,etc^([5]).

关键词： has artificial hardware

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Electromagnetic characteristic analysis and design of a linear motor used for ultra-high-speed EMS maglev train

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Science China(Technological Sciences) 2024年第6期67卷 1957-1973页

作者： GAO Han SHI TingNa GAO XinMai LEI yanXiao yan Dong GUO Liyan yan yan College of Electrical Engineering Zhejiang UniversityHangzhou310027China Zhejiang University Advanced Electrical Equipment Innovation Center Hangzhou311107China State Key Laboratory of High-speed Maglev Transportation Technology Qingdao266100China CRRC Qingdao Sifang Co.Ltd. Qingdao266111China

The operating speed of the commercial electromagnetic suspension(EMS)maglev train has been over 430 km/h,making it the fastest means of land *** the increasing demands of people traveling,it is necessary to further improve the operating speed of maglev *** to examine whether the existing EMS system can meet the requirements of ultra-highspeed operation(more than 600 km/h),the electromagnetic characteristics of an EMS linear motor under the operating speed of 600–1000 km/h fed by a square-wave voltage supply is investigated in this ***,an electromagnetic field model of the EMS system under the square-wave voltage supply is established to investigate its electromagnetic performance,e.g.,the characteristics of phase current,the magnetic flux density,and the electromagnetic ***,the relationship between the harmonic components of the air-gap magnetic flux density and electromagnetic force is investigated using the two-dimensional fast Fourier transform(2D-FFT)to reveal the mechanism of electromagnetic force ***,to address the issues of excessive armature current density and significant electromagnetic force ripple,the linear motor is re-designed by enlarging the stator slot area and reshaping the mover's main magnetic ***,the Taguchi method is used to further improve the electromagnetic characteristics of the linear electric ***,the effectiveness of the proposed optimal design is validated by the finite-element analysis(FEA)based co-simulation.

关键词： ultra-high-speed maglev transportation electromagnetic suspension(EMS) linear motor electromagnetic force ripple suppression

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Research on Modeling and Parameter Identification of Comprehensive Load Model of Distribution Network in Industrial Park

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Chinese Journal of Electronics 2024年第1期33卷 264-273页

作者： Tingling WANG Xiaohe yan School of Electric Engineering North China University of Water Resources and Electric Power Wenzhou Polytechnic

With the rapid development of industrial parks, its load model research has become a hot spot. In order to study the load of power system in industrial park, based on the characteristics of the industrial park load, a comprehensive load admittance static model with full voltage range adaptability is considered, and a comprehensive load model of distribution network of the industrial park is established. A complete parameter identification of the model is carried out through chaos particle swarm optimization. The simulation results show that the model can effectively describe the load characteristics of the distribution network in industrial parks.

关键词： Chaos Adaptation models Analytical models Parameter estimation Induction motors Simulation Distribution networks

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Thermal and mechanical behavior of casting copper alloy wheel during wheel and belt continuous casting process

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China Foundry 2024年第1期21卷 82-90页

作者： Kun Gao yan Peng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

To investigate the thermal and mechanical behavior of casting wheel,a two-dimensional thermoelastic-plastic finite element model was used to predict the temperature,stress and distortion distribution of the casting wheel during the wheel and belt continuous casting *** effects of grinding thickness and casting speed on the thermal and mechanical behaviors of the center of the hot face of the casting wheel were discussed in *** each rotation,the casting wheel passes through four different spray *** results show that the temperature distribution of the casting wheel in different spray zones is similar,the temperature of the hot face is the highest and the temperature reaches the peak in the spray zoneⅢ.The stress and distortion depend on the temperature distribution,and the maximum stress and distortion of the hot face are 358.2 MPa and 1.82 mm,*** temperature at the center of the hot face decreases with increasing grinding thickness and increases with increasing casting speed.

关键词： casting wheel finite element model grinding thickness casting speed hot face spray zones

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