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CT-based radiomics-deep learning model predicts occult lymph node metastasis in early-stage lung adenocarcinoma patients:A multicenter study

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Chinese Journal of Cancer Research 2025年第01期 12-30页

作者： Xiaoyan Yin Yao Lu Yongbin Cui Zichun Zhou Junxu Wen Zhaoqin Huang yuanyuan yan Jinming Yu Xiangjiao Meng Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Science School of Computer Science and Engineering Sun Yat-sen University Department of Radiology Shandong Provincial Hospital Shandong First Medical University Department of Radiology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Science

Objective: The neglect of occult lymph nodes metastasis(OLNM) is one of the pivotal causes of early non-small cell lung cancer(NSCLC) recurrence after local treatments such as stereotactic body radiotherapy(SBRT) or surgery. This study aimed to develop and validate a computed tomography(CT)-based radiomics and deep learning(DL) fusion model for predicting non-invasive ***: Patients with radiologically node-negative lung adenocarcinoma from two centers were retrospectively analyzed. We developed clinical, radiomics, and radiomics-clinical models using logistic regression. A DL model was established using a three-dimensional squeeze-and-excitation residual network-34(3D SE-ResNet34) and a fusion model was created by integrating seleted clinical, radiomics features and DL features. Model performance was assessed using the area under the curve(AUC) of the receiver operating characteristic(ROC) curve, calibration curves, and decision curve analysis(DCA). Five predictive models were compared; SHapley Additive exPlanations(SHAP) and Gradient-weighted Class Activation Mapping(Grad-CAM) were employed for visualization and ***: Overall, 358 patients were included: 186 in the training cohort, 48 in the internal validation cohort, and 124 in the external testing cohort. The DL fusion model incorporating 3D SE-Resnet 34 achieved the highest AUC of 0.947 in the training dataset, with strong performance in internal and external cohorts(AUCs of 0.903 and 0.907, respectively), outperforming single-modal DL models, clinical models, radiomics models, and radiomicsclinical combined models(DeLong test: P<0.05). DCA confirmed its clinical utility, and calibration curves demonstrated excellent agreement between predicted and observed OLNM probabilities. Features interpretation highlighted the importance of textural characteristics and the surrounding tumor regions in stratifying OLNM ***: The DL fusion model reliably and accurately predicts OLNM in

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Co-fermentation of waste activated sludge with food waste for short-chain fatty acids production:effect of pH at ambient temperature

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Frontiers of Environmental Science & Engineering 2011年第4期5卷 623-632页

作者： Leiyu FENG yuanyuan yan Yinguang CHEN State Key Laboratory of Pollution Control and Resources Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Effect of pH ranging from 4.0 to 11.0 on cofermentation of waste activated sludge(WAS)with food waste for short-chain fatty acids(SCFAs)production at ambient temperature was investigated in this *** results showed that the addition of food waste significantly improved the performance of WAS fermentation system,which resulted in the increases of SCFAs production and substrate *** SCFAs production at pH 6.0,7.0,8.0,and 9.0 and fermentation time of 4 d was respectively 5022.7,6540.5,8236.6,and 7911.7 mg COD·L^(-1),whereas in the blank tests(no pH adjustment,pH 8.0(blank test 1),no food waste addition,pH 8.0(blank test 2),and no WAS addition(blank test 3))it was only 1006.9,971.1,and 1468.5 mg COD·L^(-1),*** composition of SCFAs at pH from 6.0 to 9.0 was also different from other conditions and propionic acid was the most prevalent SCFA,which was followed by acetic and n-butyric acids,while acetic acid was the top product under other *** pH 8.0 a higher volatile suspended solids(VSS)reduction of 16.6%for the mixture of WAS and food waste than the sole WAS indicated a synergistic effect existing in fermentation system with WAS and food *** influence of pH on the variations of nutrient content was also studied during anaerobic fermentation of the mixture of WAS and food waste at different pH *** release of NH_(4)^(+)-N increased with fermentation time at all pH values investigated except 4.0,5.0 and in blank test *** concentrations of soluble phosphorus at acidic pHs and in the blank test one were higher than those obtained at alkaline *** and phosphorus need to be removed before the SCFAsenriched fermentation liquid from WAS and food waste was used as the carbon source.

关键词： waste activated sludge(WAS) food waste cofermentation short-chain fatty acids(SCFAs) pH synergistic effect

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Agent-based dynamic simulation of an electricity market with multilateral bidding

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第3期10卷 15-27页

作者： Jiahui Wu Jidong Wang yuanyuan yan Key Laboratory of the Ministry of Education on Smart Power Grids Tianjin University Tianjin 300072P.R.China Department of Automation Tsinghua University Beijing 100084P.R.China

The electricity market is a complex system in which participants interact and compete with each other,which makes description of them with mathematical models *** solve these difficulties,computer simulation has become one of the main methods for studying electricity market *** to establish a reasonable electricity market has always been a major research issue in the electric power industry,for which a key point is the bidding ***-based modeling and a simulation(ABMS)method are used in this paper to study the imperfect competitive electricity *** agent-based simulation method of multilateral bargaining game theory in the dynamics of the power bidding market is presented,and a multi-agent power market bidding dynamics simulation model based on game theory is *** dynamic bidding game behavior among the government,power grid companies,power plant companies,and consumer parties is simulated in the market,and the simulation method is realized by Anylogic ***,an agent-based four-party competitive dynamic game simulation in the electricity market is implemented,which provides a theoretical reference for further understanding resource optimization problems in the electricity market.

关键词： Agent-based simulation electricity market game theory

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The enhanced electronic communication in ferrocenemethanol molecular cluster based on intermolecular hydrogen-bonding

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Chinese Chemical Letters 2018年第1期29卷 179-182页

作者： Yifan yang Qing Zheng yuanyuan yan Yao Liu Huibo Shao Key Laboratory of Cluster Science (Ministry of Education) and Beijing Key Laboratory of Photoelectronic and Electrophotonic Conversion Materials School of Chemistry and Chemical Engineering Beijing Institute of Technology

This work presents an electrochemical study of enhanced electronic communication based on intermolecular hydrogen-bonding in ferrocenemethanol （described as FcCH2OH） molecular clusters. The enhanced electronic communication in FcCH2OH clusters is confirmed and further investigated by differential-pulse voltammetry and cyclic voltammetry. A key finding is that this enhanced electronic communication increases the standard rate constant of the electron transfer process. These results will provide us with a further understanding of the electronic communication within the ferrocenyl derivariv~ which it ha^pd nn rhp inr^rmnlpcldar hvdrn^en-hnndinct

关键词： Enhanced electronic communicationlntermolecular hydrogen-bondingMolecular clustersElectron transferCyclic voltammetry

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From surface loading to precise confinement of polyoxometalates for electrochemical energy storage

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Chinese Chemical Letters 2023年第12期34卷 29-41页

作者： Chongji Wang yanhui Song Wenhua Cong yuanyuan yan Meiling Wang Jiadong Zhou College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Instituteof TechnologyBeijing100081China Instrumental Analysis Center Taiyuan University of TechnologyTaiyuan 030024China

Because of abundant redox activity,broad tunability,and specific atomic structure,polyoxometalates(POMs or POM)clusters have attracted burgeoning interests in electrochemical especially energy stor-age ***,due to the high solubility and fully oxidized state,they often suffer from elec-trically insulation as well as chemical and electrochemical *** noncovalent loading or covalent grafting of POMs on conductive substrates have been successfully performed to overcome this ***,severe shedding or agglomeration of POMs arising from weak interactions with substrates or excessive entrapment or weak destruction in conductive supports cause significantly re-duced availability and *** this end,precise confinement of POMs into conductive supports has been tried to improve their dispersibility and ***,recent progress of PoMs from surface loading to precise confinement in the electrochemistry energy storage field is ***,we il-lustrate the typical non-confinement methods(*** and non-covalent)for supported POMs in energy storage ***,different strategies for precise confinement of PoMs in organic and inorganic materials for related applications are also ***,future research directions and opportunities for confined POMs,and derived ultrafine nanostructures are also *** re-view seeks to point out future research directions of supported PoMs in the electrochemistry-related fields.

关键词： Polyoxometalates Non-confinement Confinement Electrochemical energy storage Supercapacitor Battery

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Establishment of an efficient seed fluorescence reporter-assisted CRISPR/Cas9 gene editing in maize

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Journal of Integrative Plant Biology 2021年第9期63卷 1671-1680页

作者： yuanyuan yan Jinjie Zhu Xiantao Qi Beijiu Cheng Changlin Liu Chuanxiao Xie Institute of Crop Science Chinese Academy of Agricultural SciencesNational Key Facility for Crop Gene Resources and Genetic ImprovementBeijing 100081China School of Life Sciences Anhui Agricultural UniversityHefei 230036China

Genome editing by clustered regularly interspaced short palindromic sequences(CRISPR)/CRISPRassociated protein 9(Cas9)has revolutionized functional gene analysis and genetic *** reporter-assisted CRISPR/Cas systems can greatly facilitate the selection of genome-edited plants produced via stable transformation,this approach has not been well established in seed ***,we established the seed fluorescence reporter(SFR)-assisted CRISPR/Cas9 systems in maize(Zea mays L.),using the red fluorescent Ds RED protein expressed in the endosperm(En-SFR/Cas9),embryos(Em-SFR/Cas9),or both tissues(Em/En-SFR/Cas9).All three SFRs showed distinct fluorescent patterns in the seed endosperm and embryo that allowed the selection of seeds carrying the transgene of having segregated the transgene *** describe several case studies of the implementation of En-SFR/Cas9,Em-SFR/Cas9,and Em/En-SFR/Cas9 to identify plants not harboring the genomeediting cassette but carrying the desired mutations at target genes in single genes or in small-scale mutant libraries,and report on the successful generation of single-target mutants and/or mutant libraries with En-SFR/Cas9,Em-SFR/Cas9,and Em/En-SFR/***-assisted genome editing may have particular value for application scenarios with a low transformation frequency and may be extended to other important monocot seed crops.

关键词： CRISPR/Cas9 embryo-specific reporter endosperm-specific reporter genome editing maize seed fluorescence reporter

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西南医科大学学报 2025年第1期48卷 87-91,96页

作者：李梦迪娄君鸽张小艳闫媛媛郑州大学附属郑州中心医院超声医学科郑州450000

目的研究肺部超声B线评分联合膈肌功能相关参数对重症机械通气患者撤机成功的预测价值。方法选取2021年4月至2023年8月我院收治的重症机械通气患者115例,针对符合撤机条件患者行肺超声检查计算B线评分,并用T管行自主呼吸实验(spontaneou... 详细信息

目的研究肺部超声B线评分联合膈肌功能相关参数对重症机械通气患者撤机成功的预测价值。方法选取2021年4月至2023年8月我院收治的重症机械通气患者115例,针对符合撤机条件患者行肺超声检查计算B线评分,并用T管行自主呼吸实验(spontaneous breathing trial,SBT),SBT 30 min时通过床旁超声获取右侧膈肌移动度、膈肌厚度,计算呼吸浅快指数、膈肌呼吸浅快指数、膈肌厚度变化率。以患者撤机后48 h呼吸状况分为撤机成功组78例和撤机失败组37例,收集患者临床资料。通过多元logistic回归分析影响撤机成功的相关因素,并通过受试者工作特征曲线(receiver operating characteristic,ROC)评估肺部超声B线评分联合膈肌功能相关参数对撤机的预测价值。结果撤机失败组肺部超声B线评分、膈肌呼吸浅快指数大于撤机成功组,右侧膈肌移动度、膈肌厚度变化率小于撤机成功组(P<0.05)。撤机失败组急性生理学与慢性健康状况评分系统Ⅱ(Acute Physiology and Chronic Health Evaluation,APACHE-Ⅱ)评分、序贯器官衰竭评分(Sequen⁃tial Organ Failure Assessment,SOFA)、呼吸频率、呼吸浅快指数高于撤机成功组,机械通气时间少于撤机成功组(P<0.05)。经logistic回归结果得出,肺部超声B线评分、膈肌呼吸浅快指数、右侧膈肌移动度、膈肌厚度变化率、APACHE-Ⅱ评分、SOFA评分、呼吸频率、呼吸浅快指数是撤机成功重要影响因素(P<0.05)。经ROC曲线分析得出,肺部超声B线评分、膈肌呼吸浅快指数、右侧膈肌移动度、膈肌厚度变化率联合预测曲线下面积(area under curve,AUC)为0.931,优于单一预测结果(P<0.05)。结论肺部超声B线评分联合膈肌功能相关参数对重症机械通气患者撤机成功的预测价值较高。

关键词：肺部超声B线评分膈肌超声重症机械通气撤机

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癌症患者家庭照顾者心理脱离的研究进展(综述)

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中国健康心理学杂志 2025年第1期33卷 26-32页

作者：严园园袁方陈李楠胡永群常红娟武汉科技大学医学院 430081 中国人民解放军中部战区总医院湖北省妇幼保健院

有效的心理脱离对恢复癌症患者家庭照顾者身心资源至关重要。家庭照顾者高水平的心理脱离能够帮助其缓解身心疲劳、减轻照护压力、改善心理健康水平、提升患者的照护质量。本文对国内外癌症患者家庭照顾者心理脱离的概念、评估工具、影... 详细信息

有效的心理脱离对恢复癌症患者家庭照顾者身心资源至关重要。家庭照顾者高水平的心理脱离能够帮助其缓解身心疲劳、减轻照护压力、改善心理健康水平、提升患者的照护质量。本文对国内外癌症患者家庭照顾者心理脱离的概念、评估工具、影响因素及干预措施进行综述,以期为癌症患者家庭照顾者干预策略研究提供借鉴和参考。

关键词：家庭照顾者心理脱离心理护理学癌症

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Kinetic analysis of waste activated sludge hydrolysis and short-chain fatty acids production at pH 10

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Journal of Environmental Sciences 2009年第5期21卷 589-594页

作者： FENG Leiyu, yan yuanyuan, CHEN Yinguang State key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. [a]State key Laboratory of Pollution Control and Resources Reuse School of Environmental Science and Engineering Tongji University Shanghai 200092 China

The accumulation of short-chain fatty acids （SCFAs）, a preferred carbon source for enhanced biological phosphorus removal microbes, was significantly improved when waste activated sludge （WAS） was fermented at pH 10. The kinetics of WAS hydrolysis and SCFAs production at pH 10 was investigated. It was observed that during WAS anaerobic fermentation the accumulation of SCFAs was limited by the hydrolysis process, and both the hydrolysis of WAS particulate COD and the accumulation of SCFAs followed first-order kinetics. The hydrolysis and SCFAs accumulation rate constants increased with increasing temperature from 10 to 35℃, which could be described by the Arrhenius equation. The kinetic data further indicated that SCFAs production at pH 10 was a biological process. Compared with the experiment of pH uncontrolled （blank test）, both the rate constants of WAS hydrolysis and SCFAs accumulation at 20℃ were improved significantly when WAS was fermented at pH 10.

关键词： waste activated sludge hydrolysis short-chain fatty acids kinetics alkaline pH

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Cause of stamping cracks in pure iron magnetic shielding covers

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Baosteel Technical Research 2016年第4期10卷 12-17页

作者： yan yuanyuan LIANG Gaofei yanG Jian Research Institute Baoshan Iron & Steel Co.Ltd.

This study explores reasons for the random occurrence of stamping cracks during the production of pure iron magnetic shielding covers. Scanning electron microscopy and energy spectrum are used to observe cracks within parts, and results show significant brittle fracture morphology with chunks of manganese silicate and aluminum silicate inclusions present in the fracture surface. The chemical composition, mechanical properties, and microstructure are also analyzed for a corresponding batch of cold rolled pure iron sheet. The oxygen content of the material is found to be high,resulting in the random distribution of a large amount of long chain manganese silicate and aluminum silicate inclusions along the rolling direction, which corresponds to inclusions found on the fractured surface. The stamping cracks are thus assumed to be caused by the randomly distributed chain of inclusions within the cold rolled sheet. It is suggested that the amount of deoxidizer used should be more carefully controlled to decrease the inclusion contents and to thus avoid the recun＇ence of such defects.

关键词： pure iron cracking failure analysis inclusion

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