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Atrial fibrillation:mechanism and clinical management

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Chinese Medical Journal 2023年第22期136卷 2668-2676页

作者： Zhicheng Hu Ligang Ding YAN Yao Cardiac Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Atrial fibrillation(AF),the most common sustained arrhythmia,is associated with a range of symptoms,including palpitations,cognitive impairment,systemic embolism,and increased mortality.It places a significant burden on healthcare systems worldwide.Despite decades of research,the precise mechanisms underlying AF remain elusive.Current understanding suggests that factors like stretch-induced fibrosis,epicardial adipose tissue(EAT),chronic inflammation,autonomic nervous system(ANS)imbalances,and genetic mutations all play significant roles in its development.In recent years,the advent of wearable devices has revolutionized AF diagnosis,enabling timely detection and monitoring.However,balancing early diagnosis with efficient resource utilization presents new challenges for healthcare providers.AF management primarily focuses on stroke prevention and symptom alleviation.Patients at high risk of thromboembolism require anticoagulation therapy,and emerging pipeline drugs,particularly factor XI inhibitors,hold promise for achieving effective anticoagulation with reduced bleeding risks.The scope of indications for catheter ablation in AF has expanded significantly.Pulsed field ablation,as a novel energy source,shows potential for improving success rates while ensuring safety.This review integrates existing knowledge and ongoing research on AF pathophysiology and clinical management,with emphasis on diagnostic devices,next-generation anticoagulants,drugs targeting underlying mechanisms,and interventional therapies.It offers a comprehensive mosaic of AF,providing insights into its complexities.

关键词： Atrial fibrillation Pathophysiology Clinical management Wearable device Anticoagulant

Ultrasound-guided stellate ganglion blockade: an appealing tactic for cardiac electrical storm

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Journal of Geriatric Cardiology 2023年第5期20卷 376-382页

作者： Zi-Hao LAI Li-Hui ZHENG YAN Yao Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Ventricular arrhythmia(VA)is a life-threatening cardiac emergency.When VA occurs three times or more within 24 h and interventions are required,it is defined as an electrical storm(ES)characterized by refractoriness and recurrence.[1]For patients with implantable cardioverter defibrillator(ICD),the notion is redefined as no fewer than three appropriate and separate(at least 5 min for each interval)ICD interventions given within 24 h.

关键词： cardiac storm electrical

Taming lithium metal through seeded growth

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National Science Review 2017年第1期4卷 17-18页

作者： YAN Yao Department of Electrical and Computer Engineering University of Houston

Recently,there has been worldwide enthusiasm in applying lithium metal as an anode material to bateries.Lithium metal batery could triple the speciic energy of today’s typical electric vehicle(EV)bateries from 170–200 Wh/kg to500 Wh/kg.In fact,lithium metal has been intensively studied as an anode material since the 1970s due to its high theoretical capacity(3860 m Ah/g)and lowest redox potential(–3.040 V vs.stan-

关键词： Li Taming lithium metal through seeded growth

CFD Analysis of Spiral Flow Fields in Proton Exchange Membrane Fuel Cells

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Fluid Dynamics & Materials Processing 2023年第6期19卷 1425-1445页

作者： Jian yao Fayi yan Xuejian Pei College of Mechanical and Electrical Engineering Shandong Jianzhu UniversityJinan250101China

Proton exchange membrane fuel cells(PEMFCs)are largely used in various applications because of their pollution-free products and high energy conversion efficiency.In order to improve the related design,in the present work a new spiral flow field with a bypass is proposed.The reaction gas enters the flow field in the central path and diffuses in two directions through the flow channel and the bypass.The bypasses are arranged incrementally.The number of bypasses and the cross-section size of the bypasses are varied parametrically while a single-cell model of the PEMFC is used.The influence of the concentration of liquid water and oxygen in the cell on the performance of different flow fields is determined by means of Computational fluid dynamics(COMSOL Multiphysics software).Results show that when the bypass number is 48 and its cross-sectional area is 0.5 mm^(2),the cell exhibits the best performances.

关键词： Proton exchange membrane fuel cells(PEMFCs) new spiral flow field square plate CFD simulation analysis

BAP60 plays an opposite role to the MRT-NURF complex in regulating lipid droplet size

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Journal of Genetics and Genomics 2022年第4期49卷 377-379页

作者： YAN Yao Mengyao Xu Lianyong Qiao Hu Nie Falong Lu Xun Huang State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The lipid droplet(LD)is a unique cellular organelle with a phospholipid monolayer coated with resident proteins.LDs are important for cellular neutral lipid storage and utilization.As spherical balls,LDs accommodate a lot more neutral lipids with a small increase of size.Disrupted LD dynamics,which can be reflected by abnormal LD size alteration,has been linked to many important metabolic diseases,including obesity,neutral lipid storage disease(NLSD).

关键词： neutral size opposite

Reynolds number dependence of particle transport in a 90°bend with electrostatic effects

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颗粒学报:英文版 2023年第6期77卷 91-104页

作者： Yudong yan yanlin Zhao Min Liu Jun yao International Joint Laboratory on Clean Energy Science and Technology Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of Petroleum-BeijingBeijing102249China

In this work,particle transport in a fully developed turbulent 90°bend flow at the"electrostatic equi-librium"state is simulated using large eddy simulation coupled with Lagrangian particle tracking technique.The flow Reynolds numbers(based on bulk velocity)considered is from 34000 to 58000.Three particle size 5,10 and 50μm are considered and their corresponding St number are from 2.2 to 547.Simulation results of the bend flow agree well with experimental data.The electrostatic field formed in the bend is symmetric in the spanwise direction but asymmetric in the vertical direction and radial direction,which is independent of Reynolds number.The minimum electrostatic field strength occurs at r/ra=0.25 near the inner wall of the bend.Particles transported in a bend gradually accumulate near the wall due to turbophoresis,such trend is improved by electrostatics.In addition,under the effect of electrostatics,the plume pattern of particle distribution disappeared.Particle concentration at the inner wall of the bend is higher than that at the outer wall,which depends on the combined effect of elec-trostatics and Dean vortices in the bend.

关键词： Electrostatics Bend Turbulent flow Particle transport Largeeddy simulation

Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： YAN Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone tissue.Our previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP Mg.However,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further application.In this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively analyzed.In addition,bone osteointegration around HP Mg was explored preliminar-ily.Tensile stress increases the degradation rate of HP Mg in vivo and in vitro.HP Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion time.The volume loss rate of HP Mg is multilinear with the applied stress and degradation time.The volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation time.These results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load conditions.This will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

Selection Method for New Energy Output Guaranteed Rates Considering Optimal Energy Storage Configuration

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 539-547页

作者： Xin Cheng Tong Wu Wei yao yan yang Guangdong Power Grid Corporation Guangzhou 510620China State Key Laboratory of Advanced Electromagnetic Engineering and Technology and School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The output of new energy represented by wind power and photovoltaic power features volatility and randomness. It is a practical approach to use the guaranteed rate with statistical characteristics to analyze the output coefficient of new energy. However, there is a lack of analysis and demonstration on the value of the new energy output guaranteed rate. To solve this problem, a selection method for the new energy output guaranteed rate considering optimal energy storage configuration is proposed. First, the influence of the new energy output guaranteed rate on the new energy output coefficient is analyzed. Secondly, with the goal of minimizing the comprehensive costs, an optimal configuration model of energy storage based on the output guaranteed rate of new energy is constructed, and particle swarm optimization is used for the optimization solution. Then, according to the optimal energy storage configuration results under different guaranteed rates, a reasonable new energy output guaranteed rate is determined by maximizing the comprehensive benefits obtained from energy storage. Finally, an example applied to the power grid in an area of Guangdong in Southern China is provided to illustrate the effectiveness of the proposed method.

关键词： Energystorage optimization guaranteed output guaranteed rate new energy consumption

A Modified Iterative Learning Control Approach for the Active Suppression of Rotor Vibration Induced by Coupled Unbalance and Misalignment

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 242-253页

作者： Yifan Bao Jianfei yao Fabrizio Scarpa yan Li College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of High-end Compressor and System Technology Beijing 100029China Beijing Key Laboratory of High-end Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China Key Lab of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Bristol Composites Institute(ACCIS) University of BristolBristol BS81TRUK Dynamics and Control Research Group(DCRG) University of BristolBristol BS81TRUK

This paper proposes a modified iterative learning control(MILC)periodical feedback-feedforward algorithm to reduce the vibration of a rotor caused by coupled unbalance and parallel misalignment.The control of the vibration of the rotor is provided by an active magnetic actuator(AMA).The iterative gain of the MILC algorithm here presented has a self-adjustment based on the magnitude of the vibration.Notch filters are adopted to extract the synchronous(1×Ω)and twice rotational frequency(2×Ω)components of the rotor vibration.Both the notch frequency of the filter and the size of feedforward storage used during the experiment have a real-time adaptation to the rotational speed.The method proposed in this work can provide effective suppression of the vibration of the rotor in case of sudden changes or fluctuations of the rotor speed.Simulations and experiments using the MILC algorithm proposed here are carried out and give evidence to the feasibility and robustness of the technique proposed.

关键词： Rotor vibration suppression Modified iterative learning control Unbalance Parallel misalignment Active magnetic actuator