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Pudilan xiaoyan oral liquid regulates tissue inflammation and apoptosis in mice with influenza virus pneumonia

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Traditional Medicine Research 2024年第6期9卷 55-63页

作者： Shan Cao Shuang-Rong Gao Chen Ni Zi-Han Geng Ying-li xu Bo Pang Meng-Ping Chen yu zhang Shan-Shan Guo yu-Jing Shi li-qi Ni Kun Wang Rong-Hua Zhao xiao-Lan Cui yan-yan Bao Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Jumpcan Pharmaceutical Group Co. Ltd.Taizhou 225400China

Background:The influenza A virus is the primary cause of respiratory infections and poses a global health *** xiaoyan oral liquid(PDL)exhibits anti-inflammatory and immunomodulatory *** is commonly employed in clinical practice to manage upper respiratory tract ***,there is still much to uncover regarding its potential therapeutic ***:Institute of cancer research mice were infected with influenza A virus via nasal *** general state of the mice,lung index,and lung index inhibition rate were used to evaluate the efficacy of ***-linked immunosorbent assay,western blotting,and immunohistochemistry were used to observe the presence of proteins and cytokines in the lung *** was evaluated using the TUNEL ***:PDL improved the mental state of influenza A virus-infected mice,reduced the lung index,and inhibited viral *** expression of interleukin-1βand tumor necrosis factor-αwere decreased,whereas the expression of interleukin-10 in the lung tissue was increased due to PDL *** addition,PDL treatment modulated Toll-like receptor 4 and MyD88 expressions in the lung *** significantly reduced apoptosis and decreased cleaved caspase-3 and PARP levels,whereas increased B-cell lymphoma-2 expression in the lung ***,the moderate-dose group of PDL exhibited a more pronounced *** findings indicate that PDL exerts a protective effect against pneumonia injury in influenza A virus-infected ***:PDL inhibited the inflammatory response and regulated apoptosis by regulating Toll-like receptor 4 and MyD88 protein expressions,thereby protecting the lung tissue from viral infection-induced lung tissue injury.

关键词： Pudilan xiaoyan oral liquid influenza A virus immune response apoptosis Toll-like receptors

Knockdown of Stat3 expression using RNAi inhibits growth of laryngeal tumors in vivo

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Acta Pharmacologica Sinica 2006年第3期27卷 347-352页

作者： li-fang GAO~1 lian-ji WEN~2 Hao yu~1 ling zhang~1 yan MENG~1 yue-ting SHAO~1 De-qi xu~(3,4) xue-jian ZHAO~(1,4) ~1Department of Pathophysiology.Basic School of Medicine,jilin university,changchun 130021.china.~2Department of ENT.Secona Hospital of jilin university.changchun 130012,china ~3laboratory of Enteric and Sexually Transmitted Diseases.Center for Biologies Evaluation and Research.Food and Drug Administration,Bethesda.Maryland,USA DepartmentofPathophysiology BasicSchoolofMedicineJilinUniversityChangchun130021China DepartmentofENT SecondHospitalofJilinUniversityChangchun130012China

Aim:To study the effect of pSilencer1.0-U6-siRNA-stat3 on the growth of humanlaryngeal tumors in nude ***:Hep2 cells were transplanted into nudemice,then at the time of tumor formation,growth rates were *** thetumor formed,pSilencer1.0-U6-siRNA-stat3 was *** volumes werecalculated,and growth curves were *** histological sectionswere taken from mice bearing transplantation tumors in both treated and controlgroups,and stat3,pTyr-stat3,Bcl-2,cvclin D1,and survivin expression weredetected by Western blotting,survivin mRNA levels were detected by Northernblotting,hematoxylin and eosin staining and terminal deoxyribonucleotidyl trans-ferase-mediated dUTP-digoxigenin nick end-labeling(TUNEL)assay to confirmthe apoptosis of ***:In nude mice,pSilencer1.0-U6-siRNA-stat3significantly suppressed the growth of tumors compared with controls(P1).It suppressed stat3 expression,and downregulated BcL2,cyclin *** survivinexpression within the *** significantly induced apoptosis of the ***:pSilencer1.0-U6-siRNA-stat3 was able to inhibit the growth of trans-planted human laryngeal tumors in nude mice and induce apoptosis.

关键词： RNA interference Stat3 protein laryngeal neoplasms nude mice

Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-10 experiment

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Science china(Physics,Mechanics & Astronomy) 2024年第10期67卷 83-91页

作者： Zhenhua zhang litao yang qian yue Kejun Kang yuanjing li Haipeng An Greeshma C. Jianping Chang yunhua Chen Jianping Cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui Gong qiuju Guo Tao Guo xuyuan Guo li He Shengming He Jinwei Hu Hanxiong Huang Tuchen Huang lin Jiang S.Karmakar Haubin li Hanyu li Jianmin li Jin li qianyun li Renmingjie li xueqian li yulan li Yifan liang Bin liao FongKay lin ShinTed lin Jiaxuan liu Shukui liu yandong liu yu liu yuanyuan liu Hao Ma yucai Mao qiyuan Nie Jinhua Ning Hui Pan Ningchun qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang yang Tian Guangfu Wang Junzheng Wang li Wang qing Wang yufeng Wang yunxiang Wang Henry Tsz-King Wong Shiyong Wu yucheng Wu Haoyang Xing Rui xu Yin xu Tao xue yulu yan Nan Yi Chunxu yu Haijun yu Jianfeng yue Ming Zeng Zhi Zeng Bingtao zhang Fengshou zhang Lei zhang Zhenyu zhang Jizhong Zhao Kangkang Zhao Minggang Zhao Jifang Zhou Zuying Zhou Jingjun Zhu CDEX Collaboration key laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China 不详

Dark matter(DM)is a major constituent of the ***,no definite evidence of DM particles(denoted as“χ”)has been found in DM direct detection(DD)experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes(PBHs).We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1×10^(15)to 7×10^(16)g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-10 experiment conducted in the china Jinping Underground laboratory,we exclude theχ-electron(χ-e)elastic-scattering cross sectionσ_(χe)~5×10^(-29)cm^(2)forχwith a mass■keV from our *** the higher radiation background but lower energy threshold(160 eV),CDEX-10 fills a part of the gap in the previous ***(m_(χ),σ_(χe))can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

关键词： CDEX primordial black hole light dark matter particle dark matter-electron scattering high purity germanium detector

Searching for^(76)Ge neutrinoless double beta decay with the CDEX-1B experiment

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Chinese Physics C 2024年第10期48卷 11-22页

作者： Bing-Tao zhang Jun-Zheng Wang li-Tao yang qian yue Ke-Jun Kang yuan-Jing li Hai-Peng An C.Greeshma Jian-Ping Chang yun-Huan Chen Jian-Ping Cheng Wen-Han Dai Zhi Deng Chang-Hao Fang Xin-Ping Geng Hui Gong qiu-Ju Guo xu-yuan Guo li He Sheng-Ming He Jin-Wei Hu Han-Xiong Huang Tu-Chen Huang Hai-Tao Jia Xi Jiang S.Karmakar Hao-Bin li Jian-Min li Jin li qian-yun li Ren-Ming-Jie li xue-qian li yu-Lan li Yi-Fan liang Bin liao Fong-Kay lin Shin-Ted lin Jia-xuan liu Shu-Kui liu yan-Dong liu yu liu yuan-yuan liu Zhong-Zhi liu Hao Ma yu-Cai Mao qi-yuan Nie Jin-Hua Ning Hui Pan Ning-Chun qi Jie Ren Xi-Chao Ruan Ze She Manoj Kumar Singh Tian-Xi Sun Chang-Jian Tang Wei-You Tang yang Tian Guang-Fu Wang li Wang qing Wang yu-Feng Wang yun-Xiang Wang Henry-Tsz-King Wong Shi-Yong Wu yu-Cheng Wu Hao-yang Xing Rui xu Yin xu Tao xue yu-Lu yan Nan Yi Chun-xu yu Hai-Jun yu Jian-Feng yue Ming Zeng Zhi Zeng Feng-Shou zhang Lei zhang Zhen-Hua zhang Zhen-yu zhang Kang-Kang Zhao Ming-Gang Zhao Ji-Fang Zhou Zu-Ying Zhou Jing-Jun Zhou key laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084 Department of Physics Tsinghua UniversityBeijing 100084 Institute of Physics Academia SinicaTaipei 11529 NUCTECH Company Beijing 100084 YaLong River Hydropower Development Company Chengdu 610051 College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 College of Physics Sichuan UniversityChengdu 610065 School of Physics Peking UniversityBeijing 100871 Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413 Sino-French Institute of Nuclear and Technology Sun Yat-sen UniversityZhuhai 519082 School of Physics Nankai UniversityTianjin 300071 Department of Physics Banaras Hindu UniversityVaranasi 221005 Department of Physics Beijing Normal UniversityBeijing 100875

We operated a p-type point contact high purity germanium(PPCGe)detector(CDEX-1B,1.008 kg)in the china Jinping Underground laboratory(CJPL)for 500.3 days to search for neutrinoless double beta(0νββ)decay of^(76)Ge.A total of 504.3 kg⋅day effective exposure data was *** anti-coincidence and the multi/single-site event(MSE/SSE)discrimination methods were used to suppress the background in the energy region of interest(ROI,1989–2089 keV for this work)with a factor of 23.A background level of 0.33 counts/(keV⋅kg⋅yr)was *** lower limit on the half life of^(76)Ge 0νββdecay was constrained as T_(1/2)^(0ν)>1.0×10^(23)yr(90%C.L.),corresponding to the upper limits on the effective Majorana neutrino mass:<3.2–7.5 eV.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector ^(76)Ge

Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

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Chinese Physics C 2024年第9期48卷 1-7,300页

作者： xiaoying Lu Abdusalam Abdukerim Zihao Bo Wei Chen xun Chen yunhua Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang lisheng Geng Karl Giboni xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Junting Huang Zhou Huang Ruquan Hou yu Hou Xiangdong Ji Yonglin Ju Chenxiang li Jiafu li Mingchuan li Shuaijie li Tao li qing lin Jianglai liu Congcong Lu lingyin Luo yunyang Luo Wenbo Ma yugang Ma Yajun Mao yue Meng xuyang Ning Binyu Pang Ningchun qi Zhicheng qian Xiangxiang Ren Nasir Shaheed xiaofeng Shang Xiyuan Shao Guofang Shen Manbin Shen lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang xu Wang Zhou Wang yuehuan Wei Mengmeng Wu Weihao Wu yuan Wu Mengjiao xiao Xiang xiao Kaizhi Xiong Binbin yan Xiyu yan Yong yang Chunxu yu Ying yuan Zhe yuan Youhui yun Xinning Zeng Minzhen zhang Peng zhang Shibo zhang Shu zhang Tao zhang Wei zhang yang zhang Yingxin zhang yuanyuan zhang li Zhao Jifang Zhou Ning Zhou xiaopeng Zhou yubo Zhou Zhizhen Zhou Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China key laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China New Cornerstone Science laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong university Sichuan Research Institute Chengdu 610213China Jinping Deep Underground Frontier Science and Dark Matter key laboratory of Sichuan Province Liangshan 615000China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China key laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Beijing key laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA state key laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Physics Peking UniversityBeijing 100871Ch

The proton-proton(pp)fusion chain dominates the neutrino production in the *** uncertainty of the predicted pp neutrino flux is at the sub-percent level,whereas that of the best measurement is O(10%).In this study,for the first time,we measure solar pp neutrinos in the electron recoil energy range from 24 to 144 keV using the PandaX-4T commissioning data with 0.63 tonne×year *** pp neutrino flux is determined as(8.0±3.9(stat)±10.0(syst))×1010 s^(-1)cm^(-2),which is consistent with the Standard Solar Model and existing measurements,corresponding to an upper flux limit of 23.3×10^(10)s^(-1)cm^(-2)at 90%C.L..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen xun Chen xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-yun Dai Xinchen Dai xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Serum Total Bilirubin and Risk of Progressing Diabetes:A Prospective Cohort Study

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Biomedical and Environmental Sciences 2021年第8期34卷 632-636页

作者： zhang Jie zhang Yin Fei HU Chun yan zhang Yi qi Hong yan liN lin xu yu xu Min LU Jie li BI yu Fang WANG Wei qing NING Guang CHEN yu Hong Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrinology Jiading Central HospitalShanghai University of Medicine&Health SciencesShanghai 201800China

Diabetes has become a serious public health concern worldwide,and china is the epidemic *** china,the prevalence of type 2 diabetes(T2D)was 11.6%among adults aged≥18 years[1].Cardiovascular disease(CVD)occurs earlier and with greater severity in patients with T2D than in individuals without T2D[2].Thus,potential risk factors for screening T2D are needed to prevent such poor clinical outcomes.

关键词： Diabetes Serum clinical

Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance

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Biomedical and Environmental Sciences 2020年第4期33卷 260-268页

作者： WANG qi qi yu Shi Cheng xu Cheng Dong liU Jian Jun li yuan qiu zhang Man Hui LONG xiao Juan liU yun Ning BI yu Fang ZHAO Wen Hua YAO Hong yan Chinese Center for Disease Control and Prevention Beijing 102206China state key laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Peking university Third Hospital Beijing 100191China National Center for Chronic and Non communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 *** Data for this study were derived from the china Chronic Diseases and Behavioral Risk Factors Surveillance 2010 *** concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in china.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/*** A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the *** of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,*** adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was *** significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference *** Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years.

关键词： Selenium Diabetes Odds ratio Behavioral risk factors Survey

Association of Early-life Famine Exposure with Metabolic Dysfunction-Associated Fatty liver Disease and Fibrosis in Adulthood

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Biomedical and Environmental Sciences 2022年第6期35卷 558-562页

作者： WEI Ran qi Hong yan liN lin ZHU yuan yue zhang Yi zhang Jie WU xue yan HU Chun yan WANG Shuang yuan liN Hong xu yu xu Min BI yu Fang WANG Wei qing LU Jie li NING Guang CHEN yu Hong Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is known for its insidious onset and chronic nature,which have jeopardized the health and life of 29.2%of adults in china[1].In 2020,metabolic dysfunctionassociated fatty liver disease(MAFLD),a more accurate nomenclature to replace NAFLD,was put forward in an international consensus of experts involving 22 countries[2].In china,at least 300 million people will suffer from MAFLD by 2030,which will be a heavy burden on national health[3].

关键词： NAFLD liver Metabolic