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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-Xing Guan Wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo yan-Qiang Huang Zan-Song Huang Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

Effect of substrate temperature and oxygen plasma treatment on the properties of magnetron-sputtered CdS for solar cell applications

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中国科学技术大学学报 2024年第6期54卷 22-33,I0010页

作者： Runxuan Zang Haolin Wang Xiaoqi Peng Ke Li Yuehao Gu Yizhe dong Zhihao yan Zhiyuan Cai Huihui Gao Shuwei Sheng Rongfeng Tang Tao Chen Department of Materials Science and Engineering School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China

Cadmium sulfide(CdS)is an n-type semiconductor with excellent electrical conductivity that is widely used as an electron transport material(ETM)in solar *** present,numerous methods for preparing CdS thin films have emerged,among which magnetron sputtering(MS)is one of the most commonly used vacuum *** this type of technique,the substrate temperature is one of the key deposition parameters that affects the interfacial properties between the target film and substrate,determining the specific growth habits of the ***,the effect of substrate temperature on the microstructure and electrical properties of magnetron-sputtered CdS(MS-CdS)films was studied and applied for the first time in hydrothermally deposited antimony selenosulfide(Sb_(2)(S,Se)_(3))solar *** the substrate temperature not only results in the design of the flat and dense film with enhanced crystallinity but also leads to the formation of an energy level arrangement with a Sb_(2)(S,Se)_(3)layer that is more favorable for electron *** addition,we developed an oxygen plasma treatment for CdS,reducing the parasitic absorption of the device and resulting in an increase in the short-circuit current density of the solar *** study demonstrates the feasibility of MS-CdS in the fabrication of hydrothermal Sb_(2)(S,Se)_(3)solar cells and provides interface optimization strategies to improve device performance.

关键词： magnetron sputtering CdS substrate heating plasma treatment Sb_(2)(S,Se)_(3) thin film solar cell

Performance improvements in complementary metal oxide semiconductor devices and circuits based on fin field-effect transistors using 3-nm ferroelectric Hf_(0.5)Zr_(0.5)O_(2)

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Rare Metals 2024年第7期43卷 3242-3249页

作者： Zhao-Hao Zhang yan-Na Luo Gao-Bo Xu Jia-Xin Yao Zhen-Hua Wu Hong-Bin Zhao Qing-Zhu Zhang Hua-Xiang Yin Jun Luo Wen-Wu Wang Hai-Ling Tu Integrated Circuit Advanced R&D Center Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous MetalsBeijing 100088China

In this work,a conventional HfO_(2) gate dielectric layer is replaced with a 3-nm ferroelectric(Fe) HZO layer in the gate stacks of advanced fin field-effect transistors(FinFETs).Fe-induced characteristics,e.g.,negative drain induced barrier lowering(N-DIBL) and negative differential resistance(NDR),are clearly observed for both p-and n-type HZO-based *** characteristics are attributed to the enhanced ferroelectricity of the 3-nm hafnium zirconium oxide(HZO) film,caused by Al doping from the TiAlC capping *** mechanism is verified for capacitors with structures similar to the *** to the enhanced ferroelectricity and N-DIBL phenomenon,the drain current(I_(DS))of the HZO-FinFETs is greater than that of HfO_(2)-FinFETs and obtained at a lower operating ***,circuits based on HZO-FinFET achieve higher performance than those based on HfO_(2)-FinFET at a low voltage drain(V_(DD)),which indicates the application feasibility of the HZO-FinFETs in the ultralow power integrated circuits.

关键词： FinFET Ferroelectric Hafnium zirconium oxide Subthreshold swing Low power

Interface engineering of 2D NiFe LDH/NiFeS heterostructure for highly efficient 5-hydroxymethylfurfural electrooxidation

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Chinese Chemical Letters 2024年第9期35卷 514-520页

作者： Lili Wang Ya yan Rulin Li Xujie Han Jiahui Li Ting Ran Jialu Li Baichuan Xiong Xiaorong Song Zhaohui Yin Hong Wang Qingjun Zhu Bowen Cheng Zhen Yin State Key Laboratory of Separation Membranes and Membrane Processes School of ChemistryTiangong UniversityTianjin 300387China School of Chemical Engineering and Technology Tiangong UniversityTianjin 300387China College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyTianjin 300457China State Key Laboratory of Biobased Fiber Manufacturing Technology Tianjin University of Science and TechnologyTianjin 300457China School of Materials Science and Engineering Tiangong UniversityTianjin 300387China Deutsches Elektronen-Synchrotron DESY Platanenallee 6Zeuthen 15738Germany Department of Chemistry and The Center for the Science of Materials Berlin Humboldt-Universitäzu BerlinBerlin 12489Germany

The electrochemical oxidation of 5-hydroxymethylfurfural(HMF)to valuable chemicals is an efficient way to upgrade biomass molecules and replace traditional catalytic *** is crucial to develop efficient and low-cost earth-abundant electrocatalysts to enhance catalytic performance of HMF ***,a new type of two-dimensional(2D)hybrid arrays consisting of Ni Fe layered double hydroxides(LDH)nanosheets and bimetallic sulfide(Ni Fe S)is constructed via interface engineering for efficient electrocatalytic oxidation of HMF to 2,5-furandicarboxylic acid(FDCA).The preparation process of 2D Ni Fe LDH/NiFeS with ultrathin heterostructure involves in anchoring a Co-based metal-organic framework(Co MOF)as template onto the carbon cloth(CC)via in-situ growth,formation of NiFe LDH on the surface of Co MOF and subsequent partial *** electrocatalyst of Ni Fe LDH/Ni Fe S exhibits outstanding performance towards HMF oxidation,about 98.5%yield for FDCA and 97.2%Faraday efficiency(FE)in the alkaline electrolyte with 10 mmol/L HMF,as well as excellent stability retaining 90.1%FE for FDCA after six cycles ***,even at an HMF concentration of 100 mmol/L,the yield and FE for FDCA remain high at 83.6%and 93.6%,*** findings highlight that 2D heterostructure containing abundant interfaces between Ni Fe LDH nanosheets and Ni Fe S can enhance the intrinsic activity of LDH and thus promote the oxidation reaction ***,the synergistic effect of the bimetallic Ni Fe compounds also improved the selectivity of HMF conversion to *** present work demonstrates that constructing 2D ultrathin heterostructure of Ni Fe LDH/Ni Fe S is a facile strategy via interface engineering to enhance the intrinsic activity of LDH electrocatalysts,which would open new avenues toward low-cost and advanced 2D nanocatalysts for sustainable energy conversion and electrochemical valorization of biomass derivatives.

关键词： Electrocatalytic oxidation Interface engineering 2D ultrathin heterostructure Layered double hydroxides 5-Hydroxymethylfurfural

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炸药爆轰环境中铝粉非等温燃烧模型

含能材料 2024年第10期32卷 1110-1117页

作者：聂建新刘正阚润哲郭学永焦清介闫石北京理工大学爆炸科学与安全防护全国重点实验室北京100081 清华大学合肥公共安全研究院安徽合肥230000

为研究铝粉在爆轰环境中的燃烧特性,基于爆轰环境中铝粉燃烧模型,综合考虑了爆轰产物气体组分和爆轰环境体系温度对铝粉燃烧释能过程的影响,建立了爆轰环境中铝粉非等温燃烧模型,提出了包括铝粉燃烧过程、爆轰产物气体组分和爆轰环境体... 详细信息

为研究铝粉在爆轰环境中的燃烧特性,基于爆轰环境中铝粉燃烧模型,综合考虑了爆轰产物气体组分和爆轰环境体系温度对铝粉燃烧释能过程的影响,建立了爆轰环境中铝粉非等温燃烧模型,提出了包括铝粉燃烧过程、爆轰产物气体组分和爆轰环境体系温度在内的爆轰环境铝粉非等温燃烧控制方程,并通过激光诱导击穿光谱实验进行了验证。结果表明,铝粉非等温燃烧模型控制方程的计算值与激光诱导击穿光谱实验值的偏差在12%以内,验证了理论模型计算的准确性,获得了铝粉粒度和铝氧比对炸药中铝粉燃烧特性的影响规律。

关键词：爆轰环境铝粉非等温燃烧模型激光诱导击穿光谱

外周血T淋巴细胞亚群与接受卡瑞利珠单抗治疗的晚期非小细胞肺癌患者预后的关系

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肿瘤防治研究 2024年第3期51卷 185-190页

作者：董长鸿封岩江艳婷高洁蒋晓东徐州医科大学附属连云港医院连云港市第一人民医院肿瘤科连云港222006 南京医科大学连云港临床医学院连云港市第一人民医院呼吸与危重症医学科连云港222006 南京医科大学连云港临床医学院连云港市第一人民医院肿瘤科连云港222006

目的探索外周血T淋巴细胞亚群与接受卡瑞利珠单抗治疗的晚期非小细胞肺癌(NSCLC)患者预后的关系。方法回顾性收集接受卡瑞利珠单抗治疗的88例晚期NSCLC患者资料。分别收集患者治疗前和治疗后2个月的外周血淋巴细胞亚群相对计数,使用Kapl... 详细信息

目的探索外周血T淋巴细胞亚群与接受卡瑞利珠单抗治疗的晚期非小细胞肺癌(NSCLC)患者预后的关系。方法回顾性收集接受卡瑞利珠单抗治疗的88例晚期NSCLC患者资料。分别收集患者治疗前和治疗后2个月的外周血淋巴细胞亚群相对计数,使用Kaplan-Meier曲线和Cox回归分析研究外周血T淋巴细胞亚群与PFS和OS之间的关系。结果有反应组患者治疗前外周血CD4+/CD8+比值高于无反应组(P=0.038),而CD8+T淋巴细胞百分比低于无反应组(P=0.036);生存分析显示治疗前CD4+/CD8+比值越高,患者PFS和OS越长(P=0.001,P=0.023)。多变量Cox分析显示,治疗前CD4+/CD8+比值是预测PFS和OS的因素。此外,治疗后CD4+/CD8+比值、CD4+T淋巴细胞百分比越高,患者PFS越长(P=0.005,0.015);CD8+T淋巴细胞百分比越低,患者PFS和OS越长(P=0.001,P=0.016)。结论外周血CD4+/CD8+比值能够预测接受卡瑞利珠单抗治疗的NSCLC患者的生存情况。

关键词：非小细胞肺癌 CD4+/CD8+比值 CD4+T淋巴细胞 CD8+T淋巴细胞抗PD-1治疗卡瑞利珠单抗

Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： Jia-Lin Wang Li-Ming Zhang Kai Zhang Jian Wang Jian-Ping Zhou Wen-Feng Peng Fa-Liang Yin Chao Zhong Xia yan Pi-yang Liu Hua-Qing Zhang Yong-Fei yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization ***,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in *** the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is ***,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different *** address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization *** consists of two *** the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization *** the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical *** two stages are combined using sequential transfer *** the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir *** verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based *** res

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

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Chinese Journal of Integrative Medicine 2024年第9期30卷 842-851页

作者： GAO Kai-xin yanG Yi-hong LIANG Qi MEI Li-yan LIANG You-bang WANG Mao-jie CHEN Xiu-min HUANG Qing-chun WEN Ze-huai HUANG Run-yue Section of Rheumatology and Immunology Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou510405China State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou University of Chinese MedicineGuangzhou510405China Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou510120China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510120China The Key Unit of Methodology of Clinical Research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China

Rheumatoid arthritis(RA)is a worldwide public health *** to delay or prevent the onset of RA have attracted much attention in recent years,and researchers are now exploring various prevention *** present,there is still no unified consensus for RA prevention,but targeting therapeutic windows and implementing interventions for at-risk individuals are extremely *** to the limited number of clinical trials on pharmacologic interventions,further studies are needed to explore and establish optimal intervention regimens and effective measures to prevent progression to *** this review,we introduce the RA disease process and risk factors,and present research on the use of both Western and Chinese medicine from clinical perspectives regarding RA ***,we describe several complete and ongoing clinical studies on the use of Chinese herbal formulae for the prevention of RA.

关键词： rheumatoid arthritis prevention Chinese medicine review

某三级甲等教学医院2020-2022年烧伤患者创面病原体分布及耐药性

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中国感染控制杂志 2024年第9期23卷 1126-1134页

作者：李秀存孙恩华董艳艳单慧翠周红霞栾晓嵘山东大学齐鲁医院医院感染管理处山东济南250012 山东大学齐鲁医院检验科山东济南250012

目的分析烧伤患者创面微生物分布及耐药性,为抗菌药物的合理使用和医院感染防控提供参考。方法回顾性分析某三级甲等教学医院2020年1月-2022年12月收治的烧伤住院患者的临床资料,对创面病原体进行培养、鉴定及药敏分析。结果2020-2022... 详细信息

目的分析烧伤患者创面微生物分布及耐药性,为抗菌药物的合理使用和医院感染防控提供参考。方法回顾性分析某三级甲等教学医院2020年1月-2022年12月收治的烧伤住院患者的临床资料,对创面病原体进行培养、鉴定及药敏分析。结果2020-2022年共收治烧伤住院患者588例,共检出病原体734株,其中革兰阴性菌415株(56.54%),革兰阳性菌306株(41.69%),真菌13株(1.77%)。居前5位的病原菌分别为金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌和阴沟肠杆菌;其中金黄色葡萄球菌对青霉素G耐药率较高(93.02%~97.37%),对苯唑西林的耐药率由11.63%上升至21.92%;铜绿假单胞菌主要表现为对替卡西林/克拉维酸、氨曲南、左氧氟沙星耐药,对亚胺培南和美罗培南的耐药率分别为15.00%~38.10%、10.00%~33.33%;肠杆菌目细菌对头孢类抗生素敏感性随头孢类代数的增加而增高,对常用抗菌药物表现出较高的耐药性。结论3年间该院烧伤患者创面检出主要病原体和耐药情况变化不明显,金黄色葡萄球菌和肠杆菌目细菌的耐药形势较为严峻,有必要开展相应地区的烧伤创面病原体监测。

关键词：烧伤创面细菌分布耐药