检索结果-南通市图书馆

早期伊伐布雷定治疗急性失代偿性心力衰竭的有效性与安全性观察

在线全文

学校读者我要写书评

暂无评论

山西医药杂志 2024年第9期53卷 657-660页

作者：胡小露李小英李晶朱燕贺桂彬上海市宝山区罗店医院心内科 201908 上海市宝山区罗店医院儿科 201908

目的观察早期伊伐布雷定治疗急性失代偿性心力衰竭的有效性与安全性观察。方法选择我院2020年6月至2022年6月100例18岁以上因急性失代偿性心力衰竭住院患者为本次研究对象,按照是否行早期伊伐布雷定治疗将患者分为对照组(心衰标准化治疗... 详细信息

目的观察早期伊伐布雷定治疗急性失代偿性心力衰竭的有效性与安全性观察。方法选择我院2020年6月至2022年6月100例18岁以上因急性失代偿性心力衰竭住院患者为本次研究对象,按照是否行早期伊伐布雷定治疗将患者分为对照组(心衰标准化治疗)与研究组(心衰标准化治疗+早期伊伐布雷定治疗),比较2组患者治疗180 d后死亡率、不良心血管事件发生率、不良事件发生情况以及2组患者治疗前、治疗180 d后6 min步行距离试验、明尼苏达心力衰竭生活质量评分、静息心率、超声心动图左心室重构指标(左心射血分数、左室等容舒张时间、左室搏出量)。结果研究组患者治疗后180 d后死亡率(0%)、不良心血管事件发生率(6%)均低于对照组180 d后死亡率(12%)、不良心血管事件发生率(22%)(P0.05)。结论在心衰标准化治疗基础上,早期使用伊伐布雷定对于急性失代偿性心力衰竭患者有效性高,安全性高。

关键词：伊伐布雷定心力衰竭有效性研究安全性

改革开放以来中国海洋经济地理研究进展与展望

在线全文

学校读者我要写书评

暂无评论

经济地理 2021年第10期41卷 117-126页

作者：孙才志李博郭建科彭飞闫晓露盖美刘天宝刘锴王泽宇狄乾斌赵良仕刘桂春钟敬秋孙康辽宁师范大学海洋经济与可持续发展研究中心辽宁大连116029

海洋经济地理属于区域经济地理范畴,作为一个新兴的、众多学科交叉的研究领域,其已建立了较为清晰的理论框架与研究体系,且仍处于关键的发展时期。此外,地理学的研究范畴已由陆域系统延伸到了海域系统,使得人海关系地域系统研究充实了... 详细信息

海洋经济地理属于区域经济地理范畴,作为一个新兴的、众多学科交叉的研究领域,其已建立了较为清晰的理论框架与研究体系,且仍处于关键的发展时期。此外,地理学的研究范畴已由陆域系统延伸到了海域系统,使得人海关系地域系统研究充实了经济地理学的理论与内容。基于对海洋资源环境经济、海洋区域经济、海洋部门经济、海洋经济制度及文化、海洋地缘经济及政治的研究和海洋经济地理研究的方法及其应用的详尽阐述,文章对海洋经济地理的研究进展进行了全面剖析,并提出了未来应围绕海洋经济高质量发展、海洋空间规划、海洋经济发展的地缘环境、海洋经济的制度与文化、海洋经济地理的技术方法创新及强化海洋服务社会决策能力等方面的研究构想,进而更好地推动海洋经济学科的发展,从而尽早达到实现"海洋强国"战略目标。

关键词：海洋经济地理研究进展人海关系地域系统海洋资源环境陆海统筹海洋地缘经济与政治海洋经济高质量发展

How China’s Aid Helps Recipient Countries Build Export Capacity

在线全文

学校读者我要写书评

暂无评论

China Economist 2021年第2期16卷 2-16页

作者： yan Hongrong Zhang xiaolu Huang Meibo International Development Cooperation Academy Shanghai University of International Business and EconomicsShanghaiChina School of Social Science and Institute for Innovation and Development Tsinghua UniversityBeijingChina

Based on data of China’s aid to 120 countries and recipient countries’export data between 2002-2014,this paper investigated the export effects of China’s *** found that China’s aid was conducive to recipient countries’exports to China,helping recipient countries boost their development capacity and meet China’s consumption demand at the same *** this manner,China’s foreign aid has lived up to the principle of“mutually beneficial cooperation”.Heterogeneity test found that China’s aid helped recipient countries increase their exports of manufacturing goods of their comparative advantage,mainly medium-and low-end manufacturing products,to China without increasing the exports of non-manufacturing goods,such as agricultural produce as well as primary and resource *** findings have thoroughly refuted criticisms like the“resource exploitation”narrative by Western countries against *** from increasing African countries’exports to China,China’s aid also helped other recipient countries outside Africa,mostly medium-and low-income recipient countries,to export more to ***’s aid-fortrade(AfT)programs did not significantly increase recipient countries’capacity to export to China.A test of the mechanism of action found that industrial development in recipient countries exerted only a partial intermediate effect in enhancing recipient countries’capacity to export to China.

关键词： foreign aid recipient countries export capacity mutually beneficial cooperation

Phosphorylation of Ago2 is required for its role in DNA double-strand break repair

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第4期48卷 333-340页

作者： xiaolu Hu yan Li Tianfang Zhang Lin Li She Chen Xiaohong Wu Haijun Li Binjie Qi Zuobing Chen Department of Rehabilitation Medicine The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000China Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China National Institute of Biological Sciences Zhongguancun Life Science ParkBeijing 102206China

Repair of DNA double-strand break(DSB)is critical for the maintenance of genome integrity.A class of DSB-induced small RNAs(di RNAs)has been shown to play an important role in DSB *** humans,di RNAs are associated with Ago2 and guide the recruitment of Rad51 to DSB sites to facilitate repair by homologous recombination(HR).Ago2 activity has been reported to be regulated by phosphorylation under normal and hypoxic ***,the role of Ago2 phosphorylation in DNA damage repair is ***,we show that S672,S828,T830,and S831 of human Ago2 are phosphorylated in response to ionizing radiation(IR).S672 A mutation of Ago2 leads to significant reduction in Rad51 foci formation and HR *** further show that defective association of Ago2 S672 A variant with DSB sites,instead of defects in di RNA and Rad51 binding,may account for decreased Rad51 foci formation and HR *** study reveals a novel regulatory mechanism for the function of Ago2 in DNA repair.

关键词： Ago2 diRNA DNA repair Phosphorylation Small RNA

改良术中配合方案在胸腔镜下三切口食管癌根治术患者中的应用效果

在线全文

学校读者我要写书评

暂无评论

癌症进展 2024年第15期22卷 1705-1709页

作者：张小路闫蓓蓓张可可谷萌萌段冬郑州大学第一附属医院手术部郑州4500000

目的探讨改良术中配合方案在胸腔镜下三切口食管癌根治术患者中的应用效果。方法根据干预方法的不同将106例胸腔镜下三切口食管癌根治术患者分为常规组(n=49,常规术中配合方案)和改良组(n=57,改良术中配合方案)。比较两组患者的手术... 详细信息

目的探讨改良术中配合方案在胸腔镜下三切口食管癌根治术患者中的应用效果。方法根据干预方法的不同将106例胸腔镜下三切口食管癌根治术患者分为常规组(n=49,常规术中配合方案)和改良组(n=57,改良术中配合方案)。比较两组患者的手术相关指标、应激反应指标[白细胞介素(IL)-6、IL-1β、IL-8、C反应蛋白(CRP)]、肺功能指标[第1秒用力呼气量占预计值百分比(FEV1%)、用力呼气量占预计值百分比(FEV%)、用力肺活量占预计值百分比(FVC%)、肺活量占预计值百分比(VC%)、最大自主通气量占预计值百分比(MVV%)]、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]及并发症发生情况。结果改良组患者手术时间、首次排气时间、住院时间均短于常规组,差异均有统计学意义(P﹤0.05)。术后24 h,两组患者IL-6、IL-1β、IL-8、CRP水平均高于本组术前,改良组患者IL-6、IL-1β、IL-8、CRP水平均低于常规组,差异均有统计学意义(P﹤0.05)。出院前1天,两组患者MVV%、VC%、FVC%、FEV%、FEV1%均低于本组术前,改良组患者MVV%、VC%、FVC%、FEV%、FEV1%均高于常规组,差异均有统计学意义(P﹤0.05)。出院前1天,改良组患者躯体功能、情绪功能、认知功能及总体健康状况评分均高于常规组,差异均有统计学意义(P﹤0.05)。改良组患者术后并发症总发生率低于常规组,差异有统计学意义(P﹤0.05)。结论改良术中配合方案应用于胸腔镜下三切口食管癌根治术患者,可提高手术效率,促进患者术后恢复,减轻应激反应,改善肺功能和生活质量,降低并发症发生率。

关键词：胸腔镜下三切口食管癌根治术改良术中配合方案应激反应肺功能生活质量

电生理监测^(125)I粒子治疗癌性臂丛神经损伤临床疗效的价值

在线全文

学校读者我要写书评

暂无评论

中华核医学与分子影像杂志 2024年第9期44卷 545-548页

作者：裴晓路高贞宋林敬底彦张利娟刘泽洲张宏涛河北省人民医院肿瘤科石家庄050051 河北省人民医院神经内科石家庄050051

目的通过神经电生理监测来探讨^(125)I粒子植入术对癌性臂丛神经压迫所致疼痛及运动障碍的临床疗效。方法回顾性选择2021年1月至2023年8月河北省人民医院肿瘤科行^(125)I粒子治疗癌性臂丛神经损伤的8例患者(男女各4例, 年龄58~63岁), ... 详细信息

目的通过神经电生理监测来探讨^(125)I粒子植入术对癌性臂丛神经压迫所致疼痛及运动障碍的临床疗效。方法回顾性选择2021年1月至2023年8月河北省人民医院肿瘤科行^(125)I粒子治疗癌性臂丛神经损伤的8例患者(男女各4例, 年龄58~63岁), 采用疼痛数字评价(NRS)量表及运动功能评定(F-M)量表评估患者的患肢疼痛及运动障碍情况, 应用电生理监测肌皮神经、腋神经、正中神经、尺神经、桡神经感觉及运动支于治疗前及治疗后3个月的传导速度。采用配对样本t检验分析数据。结果 8例患者均为中重度疼痛(6例伴运动功能障碍), 术前及术后3个月NRS评分分别为(5.9±1.0)和(3.3±1.7)分(t=4.93, P=0.002), F-M评分分别为(44.8±7.6)和(54.8±5.7)分(t=-3.52, P=0.017)。电生理结果显示, 7例患者病灶累及臂丛下干, 1例患者累及臂丛上干。术前及术后3个月尺神经运动支传导速度分别为(47.2±2.6)和(59.7±8.2) m/s(t=-3.17, P=0.034), 感觉支传导速度为(41.8±1.2)和(56.0±5.7) m/s(t=-5.82, P=0.001), 神经传导速度较术前升高。结论 ^(125)I粒子植入术对因臂丛神经受压导致的癌性疼痛及运动障碍具有良好临床疗效, 电生理前后变化可定量监测臂丛神经的感觉及运动功能恢复。

关键词：臂丛神经病肿瘤近距离放射疗法碘放射性同位素神经电生理监测

Nitrate in the Changjiang diluted water:an isotopic evaluation on sources and reaction pathways

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2021年第3期39卷 830-845页

作者： Shan JIANG Jie JIN Guosen ZHANG yan CHANG Zhaoru ZHANG Meng ZHOU xiaolu WANG Jing ZHANG Ying WU State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200062China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China

A cruise covering two transects in the Changjiang(yangtze)estuary in July 2017 was conducted,aiming to explore the sources for riverine NOˉ3 and identify reactions involved in the NO_(3)^(-)transformations along the transport of the Changjiang diluted water(CDW).In the river water,NO_(3)^(-)was fundamentally contributed by chemical fertilizer leakage in the watershed according to isotope *** discharge may also be significant on riverine NO_(3)^(-)inventory,while the isotope signal was masked by *** with the transport of the CDW,NO_(3)^(-)production was observed in waters with low salinities(<20)and high *** resulted from the mineralization of riverine organic nitrogen;therefore,the high turbidity was linked to active *** the outer plume,coupled with stratification,a significant decrease in NO_(3)^(-)concentration was observed in the surface *** parallel,enrichment inδ^(15)N-NO_(3)^(-)andδ^(18)O-NO_(3)^(-)was found,indicating biological consumption by *** difference in the stratification intensity between two transects led to variations in NO_(3)^(-)concentrations and isotope *** the benthic water,denitrification(sediment-water interface)and nitrification(bottom water)***,accumulations of NH4+and dissolved organic nitrogen in the bottom water were observed,indicating that nitrification was constrained by oxidant(mainly dissolved oxygen)supplies.

关键词： Changjiang diluted water(CDW) denitrification and nitrification estuary production and removal stable isotope

Serum Sodium Fluctuation Prediction among ICU Patients Using Neural Network Algorithm:Analysis of the MIMIC-IV Database

在线全文

学校读者我要写书评

暂无评论

Journal of Beijing Institute of Technology 2023年第2期32卷 188-197页

作者： Haotian Yu Tongpeng Guan Jiang Zhu Xiao Lu xiaolu Fei Lan Wei yan Zhang Yi Xin School of Life Science Beijing Institute of TechnologyBeijing 100081China Xuanwu Hospital Capital Medical UniversityBeijing 100053China

Sodium homeostasis disorder is one of the most common abnormal symptoms of elderly patients in intensive care unit(ICU),which may lead to physiological disorders of many *** current prediction of serum sodium in ICU is mainly based on the subjective judgment of doctors’*** study aims at this problem by studying the clinical retrospective electronic medical record data of ICU to establish a machine learning model to predict the short-term serum sodium value of ICU *** data set used in this study is the open-source intensive care medical information set Medical Information Mart for Intensive Care(MIMIC)-*** time point of serum sodium detection was selected from the ICU clinical records,and the ICU records of 25risk factors related to serum sodium were extracted from the patients within the first 12 h for statistical analysis.A prediction model of serum sodium value within 48 h was established using a feedforward neural network,and compared with previous *** research results show that the neural network learning model can predict the development of serum sodium in patients using physiological indicators recorded in clinical electronic medical records within 12 h,and has better prediction effect than the serum sodium formula and other machine learning models.

关键词： serum sodium structured electronic medical record hypernatremia hyponatremia neural network machine learning

A Q-switched erbium-doped fiber laser based on ZrS2 as a saturable absorber

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2019年第8期17卷 21-25页

作者： Ping Hu yan Huang Fangfang Liu Ying Liu Liping Guo xiaolu Ge Xiaojuan Liu School of Physics and Optoelectronic Engineering Shandong University of Technology

A passively Q-switched erbium-doped fiber(EDF) laser is proposed and demonstrated utilizing a zirconium disulfide(ZrS2)-based saturable absorber(SA). ZrS2 nanosheets are prepared, whose modulation depth,saturation intensity, and nonsaturable absorbance are measured to be 14.7%, 0.34 MW/cm^2, and 17.4%, respectively. Then, a Q-switched EDF laser is implemented by the ZrS2-SA. The pulse repetition rate varies from 40.65 to 87.1 k Hz when the pump power changes from 55 to 345 mW. The shortest pulse width is 1.49 μs with pulse energy of 33.5 nJ. As far as we know, this is the shortest pulse width obtained by a ZrS2-SA so far.

关键词： EDF ZrS2 SA