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Changes in renal function and morphological variations of kidney diseases in rheumatoid arthritis patients

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Asian Journal of Urology 2024年第2期11卷 304-310页

作者： yan tang Yuliya Varavko Raisa Aringazina Irina Menshikova College of Medical Technology Yongzhou Vocational Technical CollegeYongzhouChina Department of Internal Diseases Propaedeutics Irkutsk State Medical UniversityIrkutskRussian Federation Department of Internal Diseases No.1 Non-Commercial Joint-Stock Society“West Kazakhstan Marat Ospanov Medical University”AktobeKazakhstan Department of Hospital Therapy No.1 I.M.Sechenov First Moscow State Medical University of Ministry of Health of Russian Federation(Sechenov University)MoscowRussian Federation

Objective:Rheumatoid nephropathy is one of the most severe extra-articular manifestations of rheumatoid arthritis(RA)associated with a very unfavorable *** study aimed to identify changes in renal function and morphological variations of kidney diseases in RA ***:The study enrolled patients(126 patients)between 18 and 55 years of age with a confirmed active RA of more than 12 *** patient underwent the following range of laboratory and instrumental research methods:general clinical analysis of blood and urine,performing urinalysis according to Nechiporenko method;determining daily proteinuria;determining the blood content of glucose,urea,creatinine,uric acid,total bilirubin,liver transaminase level,ionogram,lipidogram,and coagulogram;determining the blood content of rheumatoid factor,anti-streptolysin O,and C-reactive protein;and X-ray of the joints of hands and *** function was examined by estimating glomerular filtration rate,tubular reabsorption index,and renal functional *** studying the morphological changes in the kidneys under ultrasound examination,renal biopsy was performed in 31 patients with RA with urinary syndrome(proteinuria more than 0.3 g per day and hematuria).Results:Nephropathy in RA is characterized by impaired renal function and manifested by an increased blood creatinine and a decrease in glomerular filtration rate and renal functional *** morphological variations of nephropathy at RA,mesangial proliferative glomerulonephritis prevails,accounting for 48.4%of *** disorders include the secondary amyloidosis(29.0%of patients),tubulointerstitial nephritis(16.1%),membranous glomerulonephritis(3.2%),and focal-segmental glomerulosclerosis(3.2%).Conclusion:Kidney damage is a common systemic manifestation of RA with a long and active course,a major nephropathy trigger.

关键词： Rheumatoid nephropathy Secondaryrenal amyloidosis Mesangial proliferative glomerulonephritis Renal functional reserve

Effect of Al content on modification behavior of non-metallic inclusions in high-strength steel treated with rare earth

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Journal of Iron and Steel Research International 2024年第8期31卷 1886-1899页

作者： Zhan-peng Tie Xue-yuan Jiang Hai-yan tang ·Gen Li Yu-hang Wang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Continuous Casting Business Section CISDI Engineering Co.Ltd.Chongqing 401122China Special Steel Institute Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

The influence of Al content(0.0053,0.0171,and 0.0578 wt.%)on the modification behavior of non-metallic inclusions in 20CrMoVTiB steel treated with rare earth elements was studied through high-temperature experiments and thermodynamic *** results showed that the modification products varied with the Al content in steel under 0.01 wt.%of Ce *** formation sequence of typical rare earth inclusions in steel with the increase in Al content was Ce_(2)O_(3)→CeAlO_(3)→CeAl_(11)O_(18),and the final stable products were highly Al content *** the Al content was 0.0053 wt.%,the stable phase in steel was Ce2O3;while the[Al]reached 0.0171 wt.%,the stable phase became CeA1O_(3).As the A1 content reached 0.0578 wt.%,CeAl_(11)O_(18) became the stable *** a result,increasing the Al content could inhibit the precipitation of Ce_(2)O_(3) inclusions in steel while promote the formation of CeAIO3 and CeAl_(11)O_(18) *** addition,both Ca treatment and Ce treatment could effectively refine the size of inclusions in steel by changing their ***,the feeding amount of Ca wire into molten steel should be appropriately reduced under the condition of adding Ce simultaneously,which is expected to be beneficial for an improved Ce treatment effect.

关键词： Rare earth Al content Steel Inclusion Thermodynamics Ca treatment

Effect of defatted flaxseed gum powder addition on the quality of sesame paste

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Oil Crop Science 2024年第1期9卷 1-7页

作者： Haichao He Mingkai Sun Jiahui Wang yan tang Yashu Chen Qianchun Deng Qingde Huang Hu tang Oil Crops Research Institute Chinese Academy of Agricultural SciencesWuhanChina Hubei Key Laboratory of Lipid Chemistry and Nutrition WuhanChina Oil Crops and Lipids Process Technology National&Local Joint Engineering Laboratory WuhanChina

The study explored the influence of defatted flaxseed gum powder(DFGP) on the stability and quality of sesame paste by measuring and analyzing its composition, color, texture, particle size, centrifugal oil separation rate,rheological properties, and microstructure. The results showed that the moisture and polysaccharide content of sesame paste was increased as the DFGP increased. Additionally, the hardness, gumminess, and chewiness of the sesame paste was improved, while the presence of particles with small particle size(1–100 μm) was *** rate of oil precipitation was reduced by 28.99% when the amount of DFGP was 6%. The sesame paste samples exhibited pseudoplastic behavior, demonstrating shear thinning. As the shear rate increased, the apparent viscosity of sesame paste gradually decreased. Both the storage modulus(G’) and the loss modulus(G’’) increased as the shear frequency increased. The microstructure observation revealed that protein and oil were evenly distributed in the sesame paste system, and the addition of DFGP enhanced the bonding between oil and *** study can provide valuable references for high-quality sesame paste products in the food industry.

关键词： Flaxseed gum powder Sesame paste Quality Addition

Microstructure and Mechanical Property of Mg‑13Gd‑0.2Ni Alloy Processed by Extrusion and Aging

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1367-1376页

作者： Hang Zhang Jiaying Zhao Rongguang Li Boshu Liu Shanshan Li Sha Sha Yuehong Zhang Man Xu yan tang School of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang 110142China Instrumental Analysis Center Shenyang University of Chemical TechnologyShenyang 110142China

In this work,a good combination of strength and ductility is achieved in a Mg-13Gd-0.2Ni alloy by conventional extrusion and following aging *** aged Mg-13Gd-0.2Ni alloy exhibits a yield strength(YS)of 363 MPa,an ultimate tensile strength(UTS)of 433 MPa,and an elongation of 11.9%.The aged Mg-13Gd-0.2Ni alloy contains a microstructure with a 95%proportion of dynamically recrystallized(DRXed)grains with a micron size,weak texture,and a high number density of prismaticβ′precipitates within *** bulk compounds enriched with Ni element which are mainly formed during casting and stable in the extruded and aged *** dynamic compounds are formed during extrusion,and a high density of prismaticβ′precipitates are formed during *** high density of prismaticβ′precipitates results in a significant increase in the strength of the Mg-13Gd-0.2Ni alloy,and the YS and UTS are increased by 153 and 136 MPa,*** high proportion of DRXed grains with a weak texture contributes mainly to the high ductility and the fine compounds with a low density at grain boundaries formed during aging have no significant adverse effect on ductility of the aged Mg-13Gd-0.2Ni *** findings for the novel Mg-Gd-Ni alloy can provide guidance for the design of wrought Mg alloys with superior mechanical properties.

关键词： Mg-Gd-Ni alloy Extrusion Aging Strength Ductility

THE BOUNDEDNESS OF OPERATORS ON WEIGHTED MULTI-PARAMETER LOCAL HARDY SPACES

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Acta Mathematica Scientia 2024年第1期44卷 386-404页

作者：丁卫汤彦朱月萍 School of Sciences Nantong UniversityNantong226007China Department of Mathematics Nantong Normal CollegeNantong226010China

Though atomic decomposition is a very useful tool for studying the boundedness on Hardy spaces for some sublinear operators,untill now,the boundedness of operators on weighted Hardy spaces in a multi-parameter setting has been established only by almost orthogonality *** this paper,we mainly establish the boundedness on weighted multi-parameter local Hardy spaces via atomic decomposition.

关键词： weighted multi-parameter local Hardy spaces atomic decomposition boundedness inhomogeneous Journéclass

Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： yan-NAN LI YUN-HONG XIU yan-JUN tang JING-LONG CAO WEN-SHUANG HOU AN-QI WANG TIAN-ZHU LI CHENG-HAO JIN Department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina Department of Food Science and Engineering Heilongjiang Bayi Agricultural UniversityDaqingChina Department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals Engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3β(GSK-3β)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing yang Wen-Jing Zhang Yi-Ling Zhou Gui-Jun Zhao Ya Huang Shu-yan tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

TRIANGLE operation,combined with adequate adjuvant chemotherapy,can improve the prognosis of pancreatic head cancer:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1773-1786页

作者： Jia-Hao Chen Li-Yong Zhu Zhi-Wei Cai Xiao Hu Abousalam Abdoulkader Ahmed Jie-Qiong Ge Xiao-yan tang Chun-Jing Li Yun-Long Pu Chong-Yi Jiang Department of Hepato-Biliary-Pancreatic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Fudan UniversityShanghai 200040China Department of Nursing Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein,celiac axis-common hepatic artery,and superior mesenteric artery to improve patient *** previously promising in patients with locally advanced pancreatic ductal adenocarcinoma(PDAC),data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy(PD).AIM To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable *** This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023,with or without the TRIANGLE *** were divided into the PD_(TRIANGLE)and PD_(non-TRIANGLE)*** and survival outcomes were compared between the two *** adjuvant chemotherapy was defined as adjuvant chemotherapy≥6 *** The PD_(TRIANGLE)and PD_(non-TRIANGLE) groups included 52 and 55 patients,*** were no significant differences in the baseline characteristics or perioperative indexes between the two ***,the recurrence rate was lower in the PD_(TRIANGLE) group than in the PD_(non-TRIANGLE) group(48.1%vs 81.8%,P<0.001),and the local recurrence rate of PDAC decreased from 37.8%to 16.0%.Multivariate Cox regression analysis revealed that PD_(TRIANGLE)(HR=0.424;95%CI:0.256-0.702;P=0.001),adequate adjuvant chemotherapy≥6 months(HR=0.370;95%CI:0.222-0.618;P<0.001)and margin status(HR=2.255;95%CI:1.252-4.064;P=0.007)were found to be independent factors for the recurrence *** The TRIANGLE operation is safe for PDAC patients undergoing ***,it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.

关键词： TRIANGLE operation Pancreatic ductal adenocarcinoma Heidelberg triangle Adjuvant chemotherapy Prognosis Pancreaticoduodenectomy

建设用地规划方案的碳排放核算与低碳优化方法

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China City Planning Review 2024年第2期33卷 15-29页

作者：杨一苇闫凤英田华 tang yan School of Architecture Tianjin UniversityTianjinP.R.China State Key Laboratory of Engines Tianjin UniversityTianjinP.R.China 不详

Built-up area(BUA)significantly contributes to global greenhouse gas emissions,making strategic spatial planning crucial for carbon emission *** the diverse land use patterns and carbon emission sources in BUAs,this study proposed a land-based strategy system for carbon emission assessment and optimization.A three-step method was devised to create a planner-friendly tool for implementing the system,which involves carbon emission intensity calculation based on current land use,spatial illustration of carbon emission intensities based on land use planning,and planning program optimization and emission reduction effect *** method was applied to the central urban area of Changxing County(Zhejiang)in *** results showed that the structures and emission intensities of urban land use substantially influenced the overall carbon emissions in the central urban *** comprehensive land use optimization strategies reduced the overall carbon emissions of the central urban area by 36.9%when compared to the original planning *** Monte Carlo simulation indicated that land use structure optimization and emission intensity control measures could reduce carbon emission rate by 5.20%to 18.28%,and 18.44%to 31.67%,*** results underlined the importance of making specific adjustments to land use structure and implementing intensity control measures for effective carbon *** conclusion,this study offers methods and insights for urban planners in creating sustainable and low-carbon urban spaces.

关键词： land use carbon emission effect spatial planning built-up area(BUA) carbon accounting planning program optimization