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Therapy of central pontine myelinolysis following livingdonor liver transplantation:Report of three cases

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World Journal of Gastroenterology 2009年第31期15卷 3960-3963页

作者： Zhong-Wei Zhang yan Kang li-jing Deng Chuan-Xing Luo yan Zhou Xin-Sheng Xue Dong Wang Wan-Hong Yin Intensive Care Unit West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

We analyzed the clinical manifestations and experiences of diagnosing and treating central pontine myelinolysis following living donor liver transplantation. The clinical data of three patients with central pontine myelinolysis following living donor liver transplantation from January 2005 to November 2007 were retrospectively analyzed at the West China Hospital, Sichuan University, China. The three patients developed hyponatremia prior to surgery. Case 1 suffered locked-in syndrome following surgery, and received a large dose of gamma globulin, and subsequently recovered. Case 2 was in a coma for three days, and received hyperbaric chamber treatment. This patient remained in a mild coma for six months following surgery. Case 3 developed consciousness disturbances, gradually went into a coma following surgery, and died due to pulmonary infection. Central pontine myelinolysis is a severe complication in patients following living donor liver transplantation. Large-dose gamma globulin treatment, as well as hyperbaric oxygen, might be effective therapeutic methods.

关键词： Cyclosporine Hyponatremia liver transplantation Myelinolysis Pontine

Potential therapeutic effect of epigenetic therapy on Ireatment-induced neuroendocrine prostate cancer

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Asian Journal of Andrology 2017年第6期19卷 686-693页

作者： Xiang Xu Yu-Hua Huang yan-jing li Alexa Cohen Zhen li Jill Squires Wei Zhang Xu-Feng Chen Min Zhang Jiao-Ti Huang School of life Sciences Anhui University Hefei China Department of Pathology and Laboratory Medicine University of California at Los Angeles Los Angeles California USA Department of Urology The First Affiliated Hospital of SooChow University Suzhou China Department of Medical Oncology Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USA Department of Pathology Beijing Hospital Beijing China

Although adenocarcinomas of the prostate are relatively indolent, some patients with advanced adenocarcinomas show recurrence of treatment-induced neuroendocrine prostate cancer, which is highly aggressive and lethal. Detailed biological features of treatment-induced neuroendocrine prostate cancer have not been characterized owing to limited biopsies/resections and the lack of a cellular model. In this study, we used a unique cellular model （LNCaP/NE1.8） to investigate the potential role of cancer stem cells in treatment-induced neuroendocrine prostate cancer with acquired resistance to hormonal therapy and chemotherapy. We also studied the role of cancer stem cells in enhancing invasion in treatment-induced neuroendocrine prostate cancer cells that recurred after long-term androgen-ablation treatment. Using an in vitro system mimicking clinical androgen-ablation, our results showed that the neuroendocrine-like subclone NE1.8 cells were enriched with cancer stem cells. Compared to parental prostate adenocarcinoma LNCaP cells, NE1.8 cells are more resistant to androgen deprivation therapy and chemotherapeutic agents and show increased cancer cell invasiveness. Results from this study also suggest a potential epigenetic therapeutic strategy using suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, as a chemotherapeutic agent for therapy-resistant treatment-induced neuroendocrine prostate cancer cells to minimize the risk of prostate cancer recurrence and metastasis.

关键词： cancer stem cell epigenetic therapy hormonal therapy neuroendocrine prostate cancer suberoylanilide hydroxamic acid

An Association between Immunosenescence and CD4^+CD25^+ Regulatory T Cells: A Systematic Review

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Biomedical and Environmental Sciences 2010年第4期23卷 327-332页

作者： liNG WANG yan XIE li-jing ZHU TING-TING CHANG yan-QING MAO JIE li Clinical Immunology Laboratory The First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu China

Objective Age-related increment of the prevalence of CD4^＋CD25^＋ regulatory T （Treg） cells were described controversially, and whether such changes explain immune dysfunction in the elderly is still unclear. The aim of this systematic review is to evaluate the role of the Tregs in immunosenescence. Methods Medline and manual searches were performed to identify all published epidemiological and animal studies investigating the efficacy of the association between immunosenescence and Treg cells. Results It was founded that the frequency, phenotypic characteristics, and number/function of Tregs were altered significantly with aging. Medical conditions in individuals with advanced ageas well as apoptosis intensity of Treg cells had an impact on the accumulation of Tregs which in turn could deteriorate cytotoxic activity of CD8＋ T and NK cells and production of IL-2. The range of immune cells that could be suppressed by Treg cells was quite wide and covered CD4^＋CD25^＋ T cells, NK cells, dendritic cells and even monocytes. These changes were observed both in humans and experimental animals. Besides, it was believed that frequency of Tregs increased with age and was accompanied by intensified suppressive activity for Tregs in patients, for example, with Alzheimer disease （AD） and Parkinson disease （PD）. The impaired condition of CD4＋ T cells, so-called immunosenescence, rendered transplant recipients less responsive to an allogeneic kidney graft, an effect that was limited to transplant recipients who were aged over 60 years. Conclusions Treg cells are associated with immunosenescence. All these changes contribute to the aging-related decline of immune responses and lead to the higher risk of immune-mediated diseases, cancer or infections in aged individuals.

关键词： Aging Immunosenescence CD4^+CD25^+ T cell Treg Case-control studies Cohort studies Cross-sectional studies

A suspended sediment satellite sensing algorithm based on gradient transiting from water-leaving to satellite-detected reflectance spectrum

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Chinese Science Bulletin 2000年第10期45卷 925-931页

作者： li yan & li jing1. Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China 2. Institute of Remote Sensing Technology and Application, Peking University, Beijing 100871, China Second Institute of Oceanography State Oceanic Administration Hangzhou China Institute of Remote Sensing Technology and Application Peking University Beijing China

In order to remove the fluctuating atmospheric effects from the Case 2 water, an algorithm for retrieval of suspended sediment concentration from NOAA weather satellite imagery was developed under a new approach. This model is based on the linear response from water-leaving to satellite-detected reflectance spectra, simply reflected by the gradient for correlation curve between reflectance of the advanced very high resolution radiometer (AVHRR) channels 1 (R1, 580-680 nm) and 2 (R2, 720-1 100 nm). Proportional factor for this gradient transiting, mathematically represented as (td2/td1) (toz2/toz1), depends on a ratio of atmospheric transmittance for such two channels, including ozone and diffuse transmittance. As a simple but efficient algorithm of gradient, the algorithm of αR1-R2 is selected to retrieve gradient a and then sea surface suspendend sediment concentration.

关键词： marine remote sensing suspended sediment atmospheric effect removal gradient transit AVHRR.

Study on fluctuations of plume front and turbidity maximum in the Hangzhou Bay by remote sensing data

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Acta Oceanologica Sinica 1993年第1期12卷 51-62页

作者： li yan li jing Su Jilan and Ren Fuhu Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012. China Institute of Remote Sensing, Peking University, Beijing 100871, China China

On the basis of the time series of AVHRR data from NOAA satellites and the geographical information system PURSIS, fluctuations of the plume front and the turbidity maximum in the Hangzhou Bay, reflected by the distributions of temperature and suspended sediment concentration respectively, are studied in view of long-term behaviors or seasonal and tidal cycles. The data suggest that the effect of front plays an important role in the development of the turbidity maximum close to the Changjiang Estuary > while the effect of tide dominates over the development of another very turbid water situated in the shoal areas in the southern Hangzhou Bay.

关键词： esturary front suspended sediment remote sensing geographical information system Hangzhou Bay

Tackling China＇s Noncommunicable Diseases： Shared Origins, Costly Consequences and the Need for Actior

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Chinese Medical Journal 2015年第6期128卷 839-843页

作者： yan Min li-Xin Jiang li-jing L yan lin-Hong Wang Sanjay Basu yang-Feng Wu Randall S Stafford Wellness living Laboratory Stanford Prevention Research Center Stanford University School of Medicine Stanford CA 94305-5411 USA China's National Centre for Cardiovascular Diseases Fuwai Hospital Beijing 100037 China Global Health Research Center Duke Kunshan University Kunshan Jiangsu 215316 China The George Institute for Global Health Peking University Health Science Center Beijing 100088 China National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

Noncommunicable diseases （NCDs） have become the leading causes of death worldwide. As a concerning example, China＇s NCD prevalence is accelerating. As elsewhere, hypertension, diabetes, heart diseases, stroke, and obesity are the major contributors to this increasing trend. A common set of preceding risk factors is responsible for these different conditions, including physical inactivity, unhealthy eating habits, altered patterns of sleep, environmental pollution, and tobacco and alcohol abuse.

关键词： Non-communicable Diseases China Prevention Translational Research Policy Implications

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岭澳核电站二期汽轮发电机轴承消防系统分析

核动力工程 2009年第S2期30卷 23-25页

作者：裴燕阎丽静姜成仁中广核工程有限公司广东深圳518124

分析了岭澳核电站一期汽轮机轴承消防系统设计及存在的问题,介绍了岭澳核电站二期汽轮机轴承消防系统设计方案、启动方式。岭澳核电站一期、二期汽轮机轴承消防系统对比分析结果表明,岭澳核电站二期汽轮机轴承消防系统设计满足各方面规... 详细信息

分析了岭澳核电站一期汽轮机轴承消防系统设计及存在的问题,介绍了岭澳核电站二期汽轮机轴承消防系统设计方案、启动方式。岭澳核电站一期、二期汽轮机轴承消防系统对比分析结果表明,岭澳核电站二期汽轮机轴承消防系统设计满足各方面规范的要求,系统设计安全、可靠。

关键词：核电站汽轮机消防控制方式

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礼乐、雅乐词义之比较辨析

艺术百家 2013年第A02期29卷 300-302页

作者：李妍静南京师范大学音乐学院江苏南京210097

礼乐与雅乐这两个词语,在中国古代音乐史书中频繁出现,二者之间既有各自特定所指,又相互关联。礼乐是中国古代特有的一种官方意识形态;雅乐与俗乐相对,继西周之后其原始音乐形态日渐式微,同时被后世历代文人儒臣赋予其意识形态含义。二... 详细信息

礼乐与雅乐这两个词语,在中国古代音乐史书中频繁出现,二者之间既有各自特定所指,又相互关联。礼乐是中国古代特有的一种官方意识形态;雅乐与俗乐相对,继西周之后其原始音乐形态日渐式微,同时被后世历代文人儒臣赋予其意识形态含义。二者之间关系是:就音乐角度而言,礼乐涵盖雅乐,雅乐作为礼乐制度用乐的核心,是礼乐用乐之典范;就意识形态层面而言,皆用以规范古代宫廷上层音乐,追求音乐风格纯正典雅,以达到维护阶级统治的目的。明晰这两个中国古代常用音乐词汇的词义,有助于更好的理解中国古代音乐史。

关键词：音乐艺术礼乐雅乐中国古代音乐史中国传统文化

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors