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Efficacy and Safety of Chinese Herbal Medicines Combined with Chemical Drugs for Alzheimer's Disease:A Systematic Review and Meta-Analysis

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 1-13页

作者： Li Xu Wen-Jun Chen Cai-Jun Tian yan Zhang yan Ma Tian-Hao Li Hong-jie Liu Zhe Zhang Department of the First College English College of Foreign LanguageShandong University of Traditional Chinese MedicineJinanChina Department of Oncology Linyi People's HospitalLinyiChina Department of Internal Medicine of Traditional Chinese Medicine The First Clinical CollegeShandong University of Traditional Chinese MedicineJinanChina Department of Chinese Materia Medica College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina Department of Medicinal Chemistry College of PharmacyShandong University of Traditional Chinese MedicineJinanChina Community Healthcare Center Shenzhen Traditional Chinese Medicine HospitalShenzhenChina Department of Fundamentals of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Shandong Co-Innovation Center of Classic TCM Formula College of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJinanChina

Objective:To evaluate the efficacy and safety of Chinese herbal medicines(CHMs)combined with chemical drugs for the treatment of Alzheimer's disease(AD).Materials and Methods:Databases were searched to retrieve randomized controlled trials(RCTs)of CHMs combined with tacrine,galantamine,rivastigmine,donepezil,or memantine,following strict inclusion and exclusion *** research papers published in English,Chinese,and Japanese were *** primary outcome was the mini-mental state examination(MMSE)score and the secondary outcomes were AD assessment scale cognitive subscale(ADAS-Cog)score and safety ***-analysis was carried out using Rev Man 5.3 and subgroup analysis was conducted to identify the sources of ***:A total of 15 RCTs with 1386 participants were included in this *** donepezil was used in the retrieved ***-analyses showed that the combination of CHMs with donepezil led to significant improvement in the MMSE score(Z=9.45;P<0.00001;weighted mean difference[WMD]=2.68,95%confidence interval[CI]:2.12-3.24)and a significant decrease in the ADAS-Cog score(Z=5.53;P<0.00001;WMD=-3.79;95%CI:-5.13--2.44).Safety evaluation demonstrated that these combination treatments relieved adverse events such as insomnia(risk ratio[RR]=0.20,95%CI:0.06-0.68;P=0.01)and hive(RR=0.10;95%CI:0.01-0.73;P=0.02).Conclusions:The combination of CHMs with a chemical drug like donepezil led to significant improvements in patient cognition as well as a better safety profile when compared to the application of a chemical drug alone.

关键词： Alzheimer's disease Chinese herbal medicine donepezil memantine meta-analysis randomized controlled trials rivastigmine

Enhanced photothermal dehydration of methanol over W_(18)O_(49)/Au/SAPO-34 catalysts with broadened light absorption

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Rare Metals 2024年第3期43卷 1139-1152页

作者： Ya-Qin Tang Meng-Xia yan Chang-Qian Lu Shao-Yuan Li Kui-Xian Wei Tao Qu Wen-HuiMa Yong-nian Dai Kong-Zhai Li Da-Jun Luo Xue-Liang Zhang Yi-Ke Liu Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China School of Materials and Energy Engineering Guizhou Institute of TechnologyGuiyang550003China

Methanol-to-olefins(MTO)process is one of the most critical pathways to produce low carbon ***,the reaction is driven by thermal catalysis,which inevitably needs to consume large amounts of fossil *** a new technique to substitute for the fuel burning is urgent for MTO process to improve the industry prospects and ***,we report a novel W_(18)O_(49)/Au/SAPO-34(W/Au/S),a multifunctional photothermal catalyst for the MTO reaction.A high methanol conversion was achieved under xenonum(Xe)lamp irradiation,yielding methyl ether(ME)and ethylene as the main *** optimized W/Au/S catalysts showed ethylene yield as high as 250μmol in 60 min,which was 2.5 times higher than that of Au/*** physiochemical characterization revealed that the SAPO-34 molecular sieves were surrounded by Au and W_(18)O_(49)nanoparticles,which exhibited a strong localized surface plasmon resonance excitation around 540 nm and light absorption beyond 500 *** multifunctional catalysts showed a strong photothermal effect,arising from the broadened light absorption of Au and W_(18)O_(49)nanoparticles,leading to a temperature as high as 250℃on the surface of the *** study showed that the superior ethylene selectivity of W/Au/S catalysts was attributed to the moderating acidic sites of W_(18)O_(49)for methanol dehydration to *** research may provide new insight for designing heterostructures to improve photo-to-chemical conversion performance and is expected to accelerate progress toward the excellent multifunctional photothermal catalysts with broad light absorption for methanol activation and C-C bond formation.

关键词： Methanol conversion Ethylene Photothermal catalysis W_(18)O_(49) BrΦnsted-acid

A deep learning interatomic potential suitable for simulating radiation damage in bulk tungsten

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Tungsten 2024年第2期6卷 304-322页

作者： Chang-jie Ding Ya-Wei Lei Xiao-yang Wang Xiao-Lin Li Xiang-yan Li yan-Ge Zhang Yi-Chun Xu Chang-Song Liu Xue-Bang Wu Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Science Island University of Science and Technology of ChinaHefei 230026China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China

So far, it has been a challenge for existing interatomic potentials to accurately describe a wide range of physical properties and maintain reasonable efficiency. In this work, we develop an interatomic potential for simulating radiation damage in body-centered cubic tungsten by employing deep potential, a neural network-based deep learning model for representing the potential energy surface. The resulting potential predicts a variety of physical properties consistent with first-principles calculations, including phonon spectrum, thermal expansion, generalized stacking fault energies, energetics of free surfaces, point defects, vacancy clusters, and prismatic dislocation loops. Specifically, we investigated the elasticity-related properties of prismatic dislocation loops, i.e., their dipole tensors, relaxation volumes, and elastic interaction energies. This potential is found to predict the maximal elastic interaction energy between two 1/2 loops better than previous potentials, with a relative error of only 7.6%. The predicted threshold displacement energies are in reasonable agreement with experimental results, with an average of 128 eV. The efficiency of the present potential is also comparable to the tabulated gaussian approximation potentials and modified embedded atom method potentials, meanwhile, can be further accelerated by graphical processing units. Extensive benchmark tests indicate that this potential has a relatively good balance between accuracy, transferability, and efficiency.

关键词： Machine learning Deep learning Interatomic potential Radiation damage Tungsten

Multi-omics analyses provide insights into the evolutionary history and the synthesis of medicinal components of the Chinese wingnut

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Plant Diversity 2024年第3期46卷 309-320页

作者： Zi-yan Zhang He-Xiao Xia Meng-jie Yuan Feng Gao Wen-Hua Bao Lan Jin Min Li Yong Li College of Life Science and Technology Inner Mongolia Normal UniversityHohhot 010020China Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region Hohhot 010022China College of Landscape and Art Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China

Chinese wingnut(Pterocarya stenoptera)is a medicinally and economically important tree species within the family ***,the lack of high-quality reference genome has hindered its in-depth *** this study,we successfully assembled its chromosome-level genome and performed multiomics analyses to address its evolutionary history and synthesis of medicinal components.A thorough examination of genomes has uncovered a significant expansion in the Lateral Organ Boundaries Domain gene family among the winged group in *** notable increase may be attributed to their frequent exposure to flood-prone *** further differentiation between Chinese wingnut and Cyclocarya paliurus,significant positive selection occurred on the genes of NADH dehydrogenase related to mitochondrial aerobic respiration in Chinese wingnut,enhancing its ability to cope with waterlogging *** genomic analysis revealed Chinese wingnut evolved more unique genes related to arginine synthesis,potentially endowing it with a higher capacity to purify nutrient-rich water *** of terpene synthase families enables the production of increased quantities of terpenoid volatiles,potentially serving as an evolved defense mechanism against herbivorous *** combined transcriptomic and metabolomic analysis,we identified the candidate genes involved in the synthesis of terpenoid *** study offers essential genetic resources for Chinese wingnut,unveiling its evolutionary history and identifying key genes linked to the production of terpenoid volatiles.

关键词： Genome Medicinal components Metabolome Pterocarya stenoptera Transcriptome

Hsa_circ_0007099 and PIP4K2A coexpressed in diffuse large B-cell lymphoma with clinical significance

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Genes & Diseases 2024年第4期11卷 98-101页

作者： Jinghan Wang Xin Ku Qiuling Ma Haikuo Li Sujuan Huang Liping Mao Fang Yu jie Jin Wei yan Department of Hematology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Key Laboratory of Hematologic Malignancies Diagnosis and TreatmentHangzhouZhejiang 310003China Zhejiang Provincial Clinical Research Center for Hematologic Diseases HangzhouZhejiang 310003China Cancer Center Zhejiang UniversityHangzhouZhejiang 310003China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai JiaoTong UniversityShanghai 200240China The Second School of Clinical Medicine Henan University of Chinese MedicineZhengzhouHenan 450046China Department of Pathology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China

Diffuse large B-cell lymphoma(DLBCL)is the most common subtype of B-cell lymphoma in adult *** to the clinical and molecular heterogeneity of DLBCL patients,robust biomarkers in clinical practice are still ***,the int... 详细信息

关键词： clinical lymphoma patients

Primary pancreatic peripheral T-cell lymphoma:A case report

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1668-1675页

作者： yan-Liang Bai Li-jie Wang Hui Luo Ya-Bin Cui Jin-Hui Xu Hui-jie Nan Pei-Yao yang Jun-Wei Niu Ming-Yue Shi Department of Hematology Zhengzhou University People's Hospital and Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Hematology Henan University People's Hospital and Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008Henan ProvinceChina

BACKGROUND Primary pancreatic lymphoma(PPL)is an exceedingly rare tumor with limited mention in scientific *** clinical manifestations of PPL are often nonspecific,making it challenging to distinguish this disease from other panc-reatic-related *** remains the primary treatment for these *** SUMMARY In this case study,we present the clinical details of a 62-year-old woman who initially presented with vomiting,abdominal pain,and dorsal *** further evaluation through positron emission tomography-computed tomography,the patient was considered to have a pancreatic head ***,subsequent endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA)revealed that the patient had pancreatic peripheral T-cell lymphoma,not otherwise specified(PTCL-NOS).There was a substantial decrease in the size of the pancreatic mass after the patient underwent a cycle of chemotherapy comprised of brentuximab vedotin,decitabine,and oxaliplatin(brentuximab vedotin and Gemox).The patient had significant improvement in radiological findings at the end of the first *** Primary pancreatic PTCL-NOS is a malignant and heterogeneous lymphoma,in which the clinical manifestations are often *** is difficult to diagnose,and the prognosis is *** can only be used for auxiliary diagnosis of other *** the help of immunostaining,EUS-FNA could be used to aid in the diagnosis of *** a clear diagnosis,chemotherapy is still the first-line treatment for such patients,and surgical resection is not recommended.A large number of recent studies have shown that the CD30 antibody drug has potential as a therapy for several types of ***,identifying new CD30-targeted therapies for different types of lymphoma is urgently *** the future,further research on antitumor therapy should be carried out to improve the survival prognosis of such patients.

关键词： Pancreatic cancer Lymphoma Chemotherapy Primary pancreatic lymphoma Case report

Cathodic corrosion as a facile and universal method for scalable preparation of powdery single atom electrocatalysts

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Nano Research 2024年第6期17卷 4943-4950页

作者： Rui Li Xiayan yan Meng Liu Qingkai Zhao jie Du Xinxin Tan Jingwen Ba Rongguang Zeng Wenhua Luo Jingsong Xu Institute of Materials China Academy of Engineering PhysicsJiangyou 621907China Science and Technology on Surface Physics and Chemistry Laboratory Jiangyou 621908China

Top-down strategy has been widely applied for synthesis of metal single atom catalysts(SACs)via converting metal nanoparticles or bulk metals into atomically dispersed ***,we report a simple electrochemical atomic migration strategy for top-down synthesis of SACs via a facile cathodic corrosion process without involving high temperature or harsh *** of metal nanoparticles on cathode are firstly disbanded under high negative voltage,and emitted into the electrolyte in the form of atomic metal anions in Zintl *** escaped atomically dispersed metal species are then oxidized by water molecules and captured by the defects on the pre-added nitrogen doped carbon carriers in the *** cathodic corrosion strategy is confirmed to be suitable for scalable synthesis of kinds of metal SACs(e.g.,Pt,Pd,and Ir)on doped carbon ***,the as-prepared nitrogen doped carbon powder supported Pt SACs exhibit superior catalytic activity toward hydrogen evolution reaction(HER)with a low overpotential of 0.024 V at 10 mA·cm^(−2)and a low Tafel slope of 29.7 mV·dec^(−1)as well as a long-term durability.

关键词： cathodic corrosion top-down strategy powdery single atom catalysts hydrogen evolution reaction scalable synthesis

Phosphatidic acid-enabled MKL1 contributes to liver regeneration:Translational implication in liver failure

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Acta Pharmaceutica Sinica B 2024年第1期14卷 256-272页

作者： Jiawen Zhou Xinyue Sun Xuelian Chen Huimin Liu Xiulian Miao yan Guo Zhiwen Fan jie Li Yong Xu Zilong Li State Key Laboratory of Natural Medicines Department of PharmacologyChina Pharmaceutical UniversityNanjing 211198China Institute of Biomedical Research Liaocheng UniversityLiaocheng 252200China Department of Pathology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Infectious Diseases Nanjing Drum Tower Hospital Affiliated with Nanjing University Medical SchoolNanjing 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjing 210008China

Liver regeneration following injury aids the restoration of liver mass and the recovery of liver *** the present study we investigated the contribution of megakaryocytic leukemia 1(MKL1),a transcriptional modulator,to liver *** report that both MKL1 expression and its nuclear translocation correlated with hepatocyte proliferation in cell and animal models of liver regeneration and in liver failure *** with MKL1 deletion exhibited defective regenerative response in the *** analysis revealed that MKL1 interacted with E2F1 to program pro-regenerative ***2 mediated phosphorylation primed MKL1 for its interaction with *** interest,phospholipase d2 promoted MKL1 nuclear accumulation and liver regeneration by catalyzing production of phosphatidic acid(PA).PA administration stimulated hepatocyte proliferation and enhanced survival in a MKL1-dependent manner in a pre-clinical model of liver ***,PA levels was detected to be positively correlated with expression of pro-regenerative genes and inversely correlated with liver injury in liver failure *** conclusion,our data reveal a novel mechanism whereby MKL1 contributes to liver *** for small-molecule compounds boosting MKL1 activity may be considered as a reasonable approach to treat acute liver failure.

关键词： Liver failure Liver regeneration Transcription regulation Transcription factor Hepatocytes Phosphatidic acid Phospholipase d2 Translational medicine

Characteristics and source apportionment of ambient volatile organic compounds and ozone generation sensitivity in urban Jiaozuo,China

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Journal of Environmental Sciences 2024年第4期138卷 607-625页

作者： Pengzhao Li Chun Chen Dan Liu jie Lian Wei Li Chuanyi Fan Liangyu yan Yue Gao Miao Wang Hang Liu Xiaole Pan Jing Mao State Centre for International Cooperation on Designer Low-Carbon and Environmental Materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Henan Key Laboratory of Environmental Monitoring Technology Henan Ecological Environment Monitoring and Safety CenterZhengzhou 450046China Jiaozuo Ecological Environment Monitoring Center of Henan Province Jiaozuo 454003China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

In recent years,many cities have taken measures to reduce volatile organic compounds(VOCs),an important precursor of ozone(O_(3)),to alleviate O_(3) pollution in China.116 VOC species were measured by online and offline methods in the urban area of Jiaozuo from May to October in 2021 to analyze the compositional *** sources were analyzed by a positive matrix factorization(PMF)model,and the sensitivity of ozone generation was determined by ozone isopleth plotting research(OZIPR)*** results showed that the average volume concentration of total VOCs was 30.54 ppbv and showed a bimodal feature due to the rush-hour traffic in the morning and at *** most dominant VOC groups were oxygenated VOCs(OVOCs,29.3%)and alkanes(26.7%),and the most abundant VOC species were acetone and ***,based on the maximum incremental reactivity(MIR)method,the major VOC groups in terms of ozone formation potential(OFP)contribution were OVOCs(68.09μg/m^(3),31.5%),aromatics(62.90μg/m^(3),29.1%)and alkene/alkynes(54.90μg/m^(3),25.4%).This indicates that the control of OVOCs,aromatics and alkene/alkynes should take *** sources of VOCs were quantified by PMF,including fixed sources of fossil fuel combustion(27.8%),industrial processes(25.9%),vehicle exhaust(19.7%),natural and secondary formation(13.9%)and solvent usage(12.7%).The empirical kinetic modeling approach(EKMA)curve obtained by OZIPR on O_(3) exceedance days indicated that the O_(3) sensitivity varied in different *** results provide theoretical support for O_(3) pollution prevention and control in Jiaozuo.

关键词： Volatile organic compounds(VOCs) Online and offline measurement Ozone formation potential(OFP) Positive matrix factorization(PMF) Ozone isopleth plotting research(OZIPR) Jiaozuo