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THE FACTORS AFFECTING THE PRODUCTIVITY OF HORIZONTAL WELLS

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石油勘探与开发 1994年第5期 105-115页

作者： Hu Dong-hui yan jie-nian(Petroleum University,Donying 257062, P.R. China)(Checked by Qin Tong-luo)

ＴＨＥ　ＦＡＣＴＯＲＳ　ＡＦＦＥＣＴＩＮＧ　ＴＨＥ　ＰＲＯＤＵＣＴＩＶＩＴＹ　ＯＦ　ＨＯＲＩＺＯＮＴＡＬ　ＷＥＬＬＳＴＨＥＦＡＣＴＯＲＳＡＦＦＥＣＴＩＮＧＴＨＥＰＲＯＤＵＣＴＩＶＩＴＹＯＦＨＯＲＩＺＯＮＴＡＬＷＥＬＬ... 详细信息

ＴＨＥ　ＦＡＣＴＯＲＳ　ＡＦＦＥＣＴＩＮＧ　ＴＨＥ　ＰＲＯＤＵＣＴＩＶＩＴＹ　ＯＦ　ＨＯＲＩＺＯＮＴＡＬ　ＷＥＬＬＳＴＨＥＦＡＣＴＯＲＳＡＦＦＥＣＴＩＮＧＴＨＥＰＲＯＤＵＣＴＩＶＩＴＹＯＦＨＯＲＩＺＯＮＴＡＬＷＥＬＬＳ￥ＨｕＤｏｎｇ－ｈｕｉ；ＹａｎＪ...

关键词： Horizontal well Production index Productivity Formation damage

Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma

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Frontiers of Medicine 2024年第4期18卷 690-707页

作者： Zhe nian Dan Wang Hao Wang Wenxu Liu Zhenyi Ma jie yan yanna Cao jie Li Qiang Zhao Zhe Liu Department of Immunology School of Basic Medical SciencesTianjin Medical UniversityTianjin300070China Zhejiang Key Laboratory of Medical Epigenetics Department of Cell BiologySchool of Basic Medical SciencesHangzhou Normal UniversityHangzhou311121China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin300060China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing211166China

Neuroblastoma(NB)is one of the most common childhood *** percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor ***,the molecular mechanisms triggering NB metastasis remain largely *** this study,we generated a transcriptomic atlas of 15447 NB cells from eight NB samples,including paired samples of primary tumors and bone marrow *** used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common‘starter’subpopulation that initiates tumor development and ***‘starter’population exhibited high expression levels of multiple cell cycle-related genes,indicating the important role of cell cycle upregulation in NB tumor *** addition,our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition(p-EMT)along the metastatic route from the primary site to the bone *** study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.

关键词： single-cell RNA sequencing metastasis neuroblastoma epithelial-to-mesenchymal transition

Study on an novel composite gel material solving serious lost circulations and pressurization sealing

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Journal of Energy and Power Engineering 2007年第1期1卷 68-75页

作者： YE yan yan jie-nian GUO Jian-hua XIE You-xin Department of Oil and Gas Engineering Petroleum University of China Beijing 102249 China Drilling Engineering Institute of Zhongyuan Oilfield Puyang 457001 China Tarim Oilfield Company Korla Xinjiang 841000 China

Lost circulations have presented great challenges to the petroleum industry, causing great expenditures of cash and time to fighting the problem. Probably the most problematic situations are the naturally fractured formations where the operator may face total loss with no mud return in the annular. The voids or large fracture encountered in this case are often far too large to be plugged with conventional Lost Circulation Material. This paper will give a detailed introduction on a novel composite gel material usable to control severe losses and pressurization sealing. The plugging mechanics of this new composite gel material, which is different from conventional lost circulation materials, were elaborated as well. In addition, the properties of the new composite gel material such as thermostability, sealing strength and bearing resistance are characterized with specific experimental devices. The experimental results proved that the breakdown pressure of the new plugging reached more than 20MPa, and the maximum degraded temperature can be exceed 130℃. The field application at 4 wells in Puguang gas field, SINOPEC, demonstrated that the new composite gel material solved the serious loss in Ordovician carbonate fractured formation successfully and guaranteed the following completion cement operation smoothly. The composite gel sealing slurries, which was easily prepared on site, gives remarkable properties regarding pumping through drill pipes, adjustment of setting time and excellent sealing strength of the lost zone sealing, additionally, the whole pressurization sealing process was complicated within only ten hours. The on-site results show that the plugging ratio of the new composite gel was reached 100%, and the success rate of sealing operation kept above 80%.Thus the new LCM can guarantee safe drilling jobs and save operation cost more effectively.

关键词： Lost Circulation Material (LCM) composite gel sealing strength breakdown pressure pressurized sealing Puguang gas field

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一种定量测定油藏岩石润湿性的新方法

石油勘探与开发 2001年第2期28卷 83-86页

作者：鄢捷年石油大学

在前人工作基础上，建立了一种定量测定油藏岩石润湿性的新方法，即经改进的自吸速率法。该测定方法所依据的原理是，当岩石与流体接触时，其表面的润湿性是影响自吸速率的一个关键因素。通过采用无因次时间（ｔＤ）代替实际自吸时间，... 详细信息

在前人工作基础上，建立了一种定量测定油藏岩石润湿性的新方法，即经改进的自吸速率法。该测定方法所依据的原理是，当岩石与流体接触时，其表面的润湿性是影响自吸速率的一个关键因素。通过采用无因次时间（ｔＤ）代替实际自吸时间，可以消除油／水界面张力、液体黏度、孔隙结构，以及岩心的形状与尺寸等其它因素对自吸速率的影响。由自叹过程中所测得的拟毛管压力曲线，可定量确定岩石表面在某一特定条件下的润湿指数（ＷＲ）。ＷＲ值越大，则水湿性越强。ＷＲ值的大小，既取决于自吸速率，又取决于自吸的液体总量。在进行自吸实验时，将岩样吊挂在电子天平上，并浸入盐水中。盐水组成应与建立束缚水饱和度时所用盐水相同。自岩样浸入盐水的瞬间开始，记录岩样质量随时间的变化，直至岩样质量保持恒定时为止（通常约需７２ｈ）。根据每一时刻岩样质量的变化和油、盐水的密度差，求出该时刻油相的自吸采收率（Ｒｉｍ），井绘制每一岩样的Ｒｉｍ与ｔＤ关系曲线。然后分别计算不同ｔＤ值所对应的拟毛管压力（Ｐｃ，ｐｓ）和水饱和度（Ｓｗ），并绘制出每一岩样的Ｐｃ，ｐｓ与Ｓｗ关系曲线。根据该曲线的下包面积，求出每一岩样的润湿指数（ＷＲ）。实测结果表明，使用该方法测得的润湿指数与使用传统?

关键词：油藏岩石润湿性定量测定岩心分析

PVR update:pathophysiology and clinical management

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1577-1580页

作者： Peter Wiedemann yan-nian Hui Medical Faculty Leipzig UniversityLeipzig 04103Germany Department of Ophthalmology Eye Institute of Chinese PLAXijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

Wound-healing diseases present complex challenges,and proliferative vitreoretinopathy(PVR)has been a problem in the surgical retina for *** is a prolonged and abnormal healing response to retinal injury,such as primary retinal detachment(RD)or post-RD surgery,characterized by the formation of pre/subretinal membranes,retinal gliosis and shortening,retinal pigment epithelium cell(RPE)proliferation,and increased activity of glial cells(mainly Müller cells).

关键词： healing epithelium diseases

Selective sintering of magnesia-calcia materials by utilizing hot spots during induction sintering process

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Journal of Iron and Steel Research International 2024年第8期31卷 1914-1922页

作者： Yun-jie Dong Zhou-fu Wang Hao Liu yan Ma Xi-tang Wang nian Yi Zhong-feng Xia Yu-xuan Zhu Cheng-ji Deng Ling Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 110325LiaoningChina

Magnesia-calcia refractories are widely used in the production process of clean steel due to their excellent high-tem-perature stability,slag resistance and ability to purify molten ***,there are still problems such as difficult sintering and easy ***-calcia materials with various calcium oxide contents were prepared by using induction sintering,and the sintering property combined with the hydration resistance of the materials was *** experimental results showed that the magnesia-calcia materials prepared under induction field had higher density,microhardness and hydration *** particular,the relative density of induction sintered magnesia-calcia materials with 50 mo1%CaO was greater than 98%,and the average grain size of CaO was 4.56μm,which was much larger than that of traditional sintered *** order to clarify the densification and microstructure evolution mechanism of the magnesia-calcia materials,the changes in temperature and magnetic field throughout the sintering process were analyzed by using finite element *** results showed that the larger heating rate and higher sintering temperature under the induction sintering mode were beneficial to the rapid *** addition,the hot spots generated within the material due to the difference in high-temperature electric conductivity between MgO and CaO were the critical factor to realize selective sintering in MgO-CaO system,which provides a novel pathway to solve the problem of difficult sintering and control the microstructure of high-temperature composite material used in the field of high-purity steel smelting.

关键词： Magnesia-calcia material Induction sintering Hot spot Selective sintering Density Microstructure control Hydration resistance

Mechanism of a dual-phase Ti-Nb alloy exhibiting near-linear elastic deformation

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Rare Metals 2024年第5期43卷 2282-2289页

作者： yan Guo Wang Ding Wen Ma Shun Guo Hao-Dong Meng nian-Yao Xu School of Automotive Engineering Changzhou Institute of TechnologyChangzhou 213032China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Youke Publishing Co. LtdChina Grinm Group Co.LtdBeijing 100088China

In this work,the underlying mechanism responsible for the near-linear elastic deformation behavior of a dual-phase Ti-Nb alloy consisting of β and α'' phase with large recoverable strain was systematically *** on in situ synchrotron X-ray diffraction(SXRD)analyses,it was found that besides intrinsic elastic deformation,a slight reversible β-α'' stress-induced martensitic(SIM)transformation,which proceeded in a consecutive mode under the retarding effect of micro-defects,took place during the near-linear elastic *** unloading,a small amount of residual macroscopic strain remained in the specimen due to the incomplete reverse α''→β transformation on *** high near-linear elastic deformability of the cold drawing(CD)Ti-Nb alloy has been revealed to be attributed to the coupling actions of intrinsic elasticity as well as the consecutive and reversible β-α'' SIM *** research may contribute to a new avenue for the design and development of novel dual-phase Ti-based alloys with desirable elastic deformability.

关键词： Titanium alloys Dual-phase Near-linear elastic deformation Martensitictransformation

Deep learning CNN-APSO-LSSVM hybrid fusion model for feature optimization and gas-bearing prediction

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Petroleum Science 2024年第4期21卷 2329-2344页

作者： Jiu-Qiang yang nian-Tian Lin Kai Zhang yan Cui Chao Fu Dong Zhang College of Earth Sciences and Engineering Shandong University of Science and Technology Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology Transportation Institute of Inner Mongolia University Key Laboratory of Gas Hydrate Qingdao Institute of Marine Geology Ministry of Natural Resources

Conventional machine learning(CML) methods have been successfully applied for gas reservoir prediction. Their prediction accuracy largely depends on the quality of the sample data; therefore, feature optimization of the input samples is particularly important. Commonly used feature optimization methods increase the interpretability of gas reservoirs; however, their steps are cumbersome, and the selected features cannot sufficiently guide CML models to mine the intrinsic features of sample data efficiently. In contrast to CML methods, deep learning(DL) methods can directly extract the important features of targets from raw data. Therefore, this study proposes a feature optimization and gas-bearing prediction method based on a hybrid fusion model that combines a convolutional neural network(CNN)and an adaptive particle swarm optimization-least squares support vector machine(APSO-LSSVM). This model adopts an end-to-end algorithm structure to directly extract features from sensitive multicomponent seismic attributes, considerably simplifying the feature optimization. A CNN was used for feature optimization to highlight sensitive gas reservoir information. APSO-LSSVM was used to fully learn the relationship between the features extracted by the CNN to obtain the prediction results. The constructed hybrid fusion model improves gas-bearing prediction accuracy through two processes of feature optimization and intelligent prediction, giving full play to the advantages of DL and CML methods. The prediction results obtained are better than those of a single CNN model or APSO-LSSVM model. In the feature optimization process of multicomponent seismic attribute data, CNN has demonstrated better gas reservoir feature extraction capabilities than commonly used attribute optimization methods. In the prediction process, the APSO-LSSVM model can learn the gas reservoir characteristics better than the LSSVM model and has a higher prediction accuracy. The constructed CNN-APSO-LSSVM mode

关键词： Multicomponent seismic data Deep learning Adaptive particle swarm optimization Convolutional neural network Least squares support vector machine Feature optimization Gas-bearing distribution prediction

Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao Ru Wu yan‑yan Gao yang Zhou Jun‑jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors