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Prevalence of and risk factors associated with Cryptosporidium infection in an underdeveloped rural community of southwest china

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Infectious Diseases of Poverty 2017年第1期6卷 9-18页

作者： Ya yang Yi-Biao Zhou Peng-Lei Xiao yan Shi Yue Chen Song {2. wu-Li Yihuo Xiu-Xia Song Qing-wu Jiang School of Public Health Fudan UniversityBuilding 8130 Dong’an RoadXuhui DistrictShanghai 200032China Key Laboratory of Public Health Safety Fudan UniversityMinistry of EducationBuilding 8130 Dong’an RoadXuhui DistrictShanghai 200032China Center for Tropical Disease Research Fudan UniversityBuilding 8130 Dong’an RoadXuhui DistrictShanghai 200032China School of Epidemiology Public Health and Preventive MedicineFaculty of MedicineUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Environmental and Global Health College of Public Health and Health ProfessionsUniversity of Florida2055 Mowry RoadGainesvilleFL 32611USA Emerging Pathogens Institute University of Florida2055 Mowry RoadGainesvilleFL 32611USA Puge Center for Disease Prevention and Control 6 Qingnian RoadPuge CountySichuan 615300China

Background:Cryptosporidium *** an important intestinal protozoan causing diarrhea in humans,livestock,and wild *** infection remains a major public health issue,but its epidemiology in humans is still unclear,particularly in rural *** study was designed to determine the prevalence of and risk factors associated with Cryptosporidium infection in a rural southwestern Chinese ***:A community-based cross-sectional survey was conducted among 687 residents of a small town in a Yi autonomous prefecture of southwest china in *** samples were examined using a broad set of quality-controlled diagnostic methods for hepatitis B virus(HBV)and human immunodeficiency virus(HIV).Stool specimens were processed using the modified acid-fast staining method,and microscopically examined for Cryptosporidium *** and multivariable analyses were performed to determine the risk factors associated with Cryptosporidium ***:The majority of the participants were Yi people with poor living conditions and unsatisfactory hygiene habits,and the study area was of very low socioeconomic *** the 615 individuals included in the analysis,14(2.3%)were HIV positive,51(8.3%)were infected with HBV,and 74(12.0%)had Cryptosporidium *** prevalences of HIV/HBV,HIV/Cryptosporidium,and HBV/Cryptosporidium co-infections were 0.3%,0.3%,and 1.8%,*** prevalence of HBV infection was higher in individuals with Cryptosporidium infection(χ^(2.=5.00,P=0.03).Owning livestock or poultry was an important risk factor for Cryptosporidium infection(aOR=2.2.,95%CI:1.01-5.08,P2.95%CI:1.47-7.92.P china that was investigated,and there was a significant association between HB

关键词： Cryptosporidium Hepatitis B virus Human immunodeficiency virus Prevalence Risk factors Rural areas china

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苯并[a]芘和1-羟基芘诱导人胚胎干细胞分化心肌细胞ROS、CYP基因表达和DNA损伤

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生态毒理学报 2020年第2期15卷 96-103页

作者：吴彬彬晏斌胡梅陈曦梁岩中国科学院深圳先进技术研究院深圳518055 中国科学院大学北京100049 香港大学李嘉诚医学院中国香港山东省食品药品检验研究院济南250101 电子科技大学资源与环境学院成都611731

多环芳烃(PAHs)化合物中的苯并[a]芘和PAHs暴露检测标志物1-羟基芘与心脏功能障碍有关,但其生物学机制尚不清楚。为研究苯并[a]芘和1-羟基芘对心脏的毒性作用,基于人胚胎干细胞分化心肌细胞(hESC-CM)研究了苯并[a]芘和1-羟基芘对心肌细... 详细信息

多环芳烃(PAHs)化合物中的苯并[a]芘和PAHs暴露检测标志物1-羟基芘与心脏功能障碍有关,但其生物学机制尚不清楚。为研究苯并[a]芘和1-羟基芘对心脏的毒性作用,基于人胚胎干细胞分化心肌细胞(hESC-CM)研究了苯并[a]芘和1-羟基芘对心肌细胞活性氧(ROS)生成、CYP基因表达和DNA损伤等的影响。结果表明,苯并[a]芘和1-羟基芘对h ESC-CM活性无影响,但能显著增强细胞ROS水平,诱导DNA损伤。此外,苯并[a]芘还能诱导细胞线粒体促凋亡基因的表达。研究表明,苯并[a]芘和1-羟基芘能通过诱导氧化应激和DNA损伤事件导致h ESC-CM损伤,在一定程度上解释了多环芳烃暴露导致心脏疾病的分子机制。

关键词：多环芳烃胚胎干细胞分化心肌细胞 DNA损伤

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RUP2.facilitates UVR8 redimerization via two interfaces

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Plant Communications 2023年第1期4卷 136-147页

作者： Lixia Wang Yidong Wang Hongfei Chang Hui Ren Xinquan wu Jia Wen Zeyuan Guan Ling Ma liang Qiu Junjie {2. Delin Zhang Xi Huang Ping Yin National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China

The plant UV-B photoreceptor UV RESISTANCE LOCUS 8(UVR8)exists as a homodimer in its inactive ground *** UV-B exposure,UVR8monomerizes and interacts with a downstreamkey regulator,theCONSTITUTIVE PHOTOMORPHOGENIC 1/SUPPRESSOR OF PHYA(COP1/SPA)E3 ubiquitin ligase complex,to initiate UV-B *** WD40 proteins,REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1(RUP1)and RUP2.directly interact with monomeric UVR8 and facilitate UVR8 ground state reversion,completing the UVR8 ***,we reconstituted the RUP-mediated UVR8 redimerization process in vitro and reported the structure of the RUP2.UVR8^(W2.5A) complex(2.0A).RUP2.and UVR8^(W2.5A) formed a heterodimer via two distinct interfaces,designated Interface 1 and *** previously characterized Interface 1 is found between the RUP2.WD40 domain and the UVR8 C2. *** newly identified Interface 2.is formed through interactions between the RUP2.WD40 domain and the UVR8 core *** of Interface 2.impairedUV-B induced photomorphogenic development in Arabidopsis *** biochemical analysis indicated that both interfaces are important for RUP2.UVR8 interactions and RUP2.mediated facilitation of UVR8 *** findings suggest that the two-interface-interaction mode is adopted by both RUP2.and COP1 when they interact with UVR8,marking a step forward in understanding the molecular basis that underpins the interactions between UVR8 and its photocycle regulators.

关键词： photomorphogenesis UV-B photoreceptor UVR8 RUP2 COP1

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Serum Soluble Vascular Endothelial Growth Factor Receptor 1 as a Potential Biomarker of Hepatopulmonary Syndrome

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1150-1160页

作者： Yu-Jie Li Xian-Feng wu Dan-Dan Wang Peng Li Hao liang Xiao-{2. Hu Jia-Qi Gan Yi-Zhu Sun Jun-Hong Li Jun Li Xin Shu Ai-Lin Song Chun-Yong {2.g Zhi-Yong {2.g Wei-Feng Yu Li-Qun {2.g Xiao-Bo Wang Karine Belguise Zheng-Yuan Xia Bin Yi Department of Anesthesiology Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Department of Anesthesiology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduSichuanChina Department of Anesthesiology Renji Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina LBCMCP Centre de Biologie Intégrative(CBI)Universitéde ToulouseCNRSUPSToulouseFrance Department of Anesthesiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Background and Aims:The results of basic research implicate the vascular endothelial growth factor(VEGF)family as a potential target of hepatopulmonary syndrome(HPS).However,the negative results of anti-angiogenetic therapy in clinical studies have highlighted the need for markers for ***,we aimed to determine whether VEGF family members and their receptors can be potential biomarkers for HPS through clinical and experimental ***:Clinically,patients with chronic liver disease from two medical centers were enrolled and examined for *** were divided into HPS,intrapulmonary vascular dilation[positive contrast-enhanced echocardiography(CEE)and normal oxygenation]and CEE-negative *** information and perioperative clinical data were compared between HPS and non-HPS *** levels of VEGF family members and their receptors were *** parallel,HPS rats were established by common bile duct ***,lung and serum samples were collected for the evaluation of pathophysiologic changes,as well as the expression levels of the above ***:In HPS rats,all VEGF family members and their receptors underwent significant changes;however,only soluble VEGFR1(sFlt-1)and the sFlt-1/placental growth factor(PLGF)ratio were changed in almost the same manner as those in HPS ***,through feature selection and internal and external validation,sFlt-1 and the sFlt-1/PLGF ratio were identified as the most important variables to distinguish HPS from non-HPS ***:Our results from animal and human studies indicate that sFlt-1 and the sFlt-1/PLGF ratio in serum are potential markers for HPS.

关键词： Chronic liver disease Hepatopulmonary syndrome Placental growth factor Pathological pulmonary angiogenesis sFlt-1/PLGF ratio

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Electron-ion collider in china

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Frontiers of physics 2021年第6期16卷 1-78页

作者： Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie liang Zuotang liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun wu Xinggang wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi yan Wenbiao yan Wencheng yan Xinhu yan Jiancheng yang Yi-Bo yang Zhi yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China IRFU CEAUniversitéParis-SaclayF-91191 Gif-sur-YvetteFrance Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China university of Chinese Academy of sciences Beijing 100049China Nankai university Tianjin 300071China Xinyang Normal university Xinyang 464000China School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Hunan university Changsha 410082China Nanjing university Nanjing 210093China Huazhong university of Science and Technology Wuhan 430074China European Centre for Theoretical Studies in Nuclear Physics and Related Areas(ECT*)and Fondazione Bruno Kessler Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy School of Physics Peking UniversityBeijing 100871China Hunan Normal university Changsha 410081China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Nanjing Normal university Nanjing 210023China Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Southwest Jiaotong university Chengdu 610000China Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000 ZagrebCroatia Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear ResearchDubna 141980Russia School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Lanzhou university Lanzhou 730000China Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityQingdao 266237China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China School of Physics Southeast UniversityNanjing 211189China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Depa

Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as *** a future high energy nuclear physics project,an Electron-ion collider in china(EicC)has been *** will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron *** proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 2. GeV and the luminosity of(2.3)×1033 cm^(−2.·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the *** main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark *** addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the *** order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge *** document is the result of collective contributions and valuable inputs from experts across the *** EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United *** success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in china.

关键词： electron ion collider nucleon structure nucleon mass exotic hadronic states quantum chromodynamics 3D-tomography helicity transverse momentum dependent parton distribution generalized parton distribution energy recovery linac polarization spin rotator

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严重急性呼吸综合征冠状病毒2.DNA疫苗与重组亚单位疫苗在小鼠中诱导中和抗体的效力分析

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第二军医大学学报 2020年第5期41卷 474-480页

作者：徐铮昊王诚余润芷丁翠玲何燕华江亮亮彭浩然吴俊杰赵平戚中田海军军医大学(第二军医大学)海军医学系生物医学防护教研室上海200433 海军军医大学(第二军医大学)基础医学院学员八队上海200433 海军军医大学(第二军医大学)长海医院呼吸与危重症医学科上海200433

目的探讨以严重急性呼吸综合征冠状病毒2.SARS-CoV-2.受体结合区(RBD)和表面刺突蛋白(S蛋白)S1亚基为疫苗靶抗原诱导中和抗体的效果。方法构建SARS-CoV-2.RBD与小鼠IgG1 Fc段(mFc)融合蛋白表达质粒pVRC-RBD-mFc,转染人胚肾细胞2.3T并进... 详细信息

目的探讨以严重急性呼吸综合征冠状病毒2.SARS-CoV-2.受体结合区(RBD)和表面刺突蛋白(S蛋白)S1亚基为疫苗靶抗原诱导中和抗体的效果。方法构建SARS-CoV-2.RBD与小鼠IgG1 Fc段(mFc)融合蛋白表达质粒pVRC-RBD-mFc,转染人胚肾细胞2.3T并进行培养。用蛋白质印迹法检测细胞培养上清中的RBD-mFc融合蛋白,用微量中和实验检测细胞培养上清中的RBD-mFc及CHO细胞重组表达的SARS-CoV-2.S1与人IgG1 Fc段(S1-hFc)融合蛋白对SARS-CoV-2.染的抑制作用。分别用质粒pVRC-RBD-mFc及S1-hFc融合蛋白通过肌内注射接种BALB/c小鼠,用ELISA检测小鼠血清中的抗-S1 IgG,用微量中和实验检测小鼠血清的病毒中和活性。结果pVRC-RBD-mFc质粒转染2.3T细胞的培养上清中可检测到RBD-mFc融合蛋白,超滤浓缩的细胞培养上清及S1-hFc融合蛋白均呈浓度依赖性抑制SARS-CoV-2.Vero E6细胞的感染;经pVRC-RBD-mFc质粒及S1-hFc融合蛋白免疫的小鼠血清中均可检测出抗-S1 IgG,且能中和SARS-CoV-2.感染;S1-hFc融合蛋白免疫小鼠血清的抗体滴度及病毒中和活性均高于质粒pVRC-RBD-mFc免疫小鼠血清(P均1)。结论SARS-CoV-2.RBD和S1蛋白均可能作为有效的疫苗抗原,重组亚单位疫苗较DNA疫苗能更有效地诱导中和抗体。

关键词：严重急性呼吸综合征冠状病毒2 DNA疫苗亚单位疫苗中和抗体

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昭通市主城区大气挥发性有机物污染特征及健康风险研究

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云南大学学报（自然科学版） 2021年第6期43卷 1156-1165页

作者：任亮史建武韩新宇封银川李帅宁平张朝能闫琨昆明理工大学环境与工程学院云南昆明650500 昆明理工大学建筑工程学院云南昆明650500 云南省生态环境监测中心云南昆明650034

利用苏玛罐采样、大气预浓缩–气相色谱质谱联用分析技术,于2.18—2.19年对昭通市主城区大气挥发性有机物(Volatile Organic Compunds,VOCs)进行采样分析,共检测出48种VOCs.烷烃类总质量浓度最高(51.52.g/m^(3)),其次是芳香烃类的质量... 详细信息

利用苏玛罐采样、大气预浓缩–气相色谱质谱联用分析技术,于2.18—2.19年对昭通市主城区大气挥发性有机物(Volatile Organic Compunds,VOCs)进行采样分析,共检测出48种VOCs.烷烃类总质量浓度最高(51.52.g/m^(3)),其次是芳香烃类的质量浓度(14.2.μg/m^(3)),烯烃类质量浓度最低(4.86μg/m^(3)).其中丙烷质量浓度最高,达到10.69μg/m^(3),其次为3-甲基戊烷、2.甲基戊烷、异丙苯、异戊二烯和甲苯等.通过臭氧生成潜势(Ozone Forination Potential,OFP)计算可知,该地区芳香烃和烯烃对OFP贡献的占比高于烷烃,其中在不同采样点OFP表现为凤禧大饭店>蓝环公司>工业园区.通过主成分分析法得出昭通市主城区大气中VOCs主要来自植物源和油气挥发源(53.3%),其次是机动车尾气源(2..9%)和溶剂/涂料挥发源(17.4%).健康风险研究表明,昭通市主城区大气VOCs对人体非致癌风险和危害指数均小于1,非致癌风险较低;苯作为致癌物质对人体的终身致癌风险高于安全阈值1×10^(−6),存在致癌风险.

关键词：挥发性有机物昭通市主城区臭氧生成潜势主成分分析法健康风险

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基于荧光素眼底血管造影的急性期早产儿视网膜病变治疗分类模型的建立与验证

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眼科新进展 2023年第4期43卷 284-289页

作者：武雷李曼红钱迪严宏祥王亮周子义周毅樊静苟凯丽王雨生张自峰空军军医大学西京医院眼科、全军眼科研究所陕西省西安市710032 海军军医大学卫生勤务学系军队卫生统计学教研室上海市200433

目的探讨急性期早产儿视网膜病变(ROP)患者荧光素眼底血管造影(FFA)检查中与需要治疗相关的指标,建立相应治疗分类模型并加以验证。方法回顾性纳入2.18年4月至2.2.0}月在空军军医大学西京医院眼科行全身麻醉下FFA检查的急性期ROP患儿... 详细信息

目的探讨急性期早产儿视网膜病变(ROP)患者荧光素眼底血管造影(FFA)检查中与需要治疗相关的指标,建立相应治疗分类模型并加以验证。方法回顾性纳入2.18年4月至2.2.0}月在空军军医大学西京医院眼科行全身麻醉下FFA检查的急性期ROP患儿114例2.7眼。患儿按73的比例随机分为训练集(80例160眼)和验证集(34例67眼)。训练集中,38例76眼患儿接受激光治疗(治疗组),42.84眼患儿未治疗发生自然退行(非治疗组);验证集中,15例2.眼患儿接受治疗,19例38眼患儿随诊观察。纳入后极部视网膜血管形态和血管-无血管交界处、血管化区域内改变及黄斑区的FFA特征,借助视盘中央与最靠近后极部的病变边缘之间的距离(DB)和视盘中央与黄斑中心凹距离(DF)的比值(DB/DF)评估病变位置。在训练集中通过单因素和多因素Logistic回归分析ROP需要治疗的独立危险因素,建立治疗分类模型并绘制列线图。在训练集和验证集中应用受试者工作特征曲线下面积(AUC)评估模型的区分度。结果训练集中,治疗组与非治疗组患儿视网膜血管形态、荧光素渗漏分布比较,差异均有统计学意义(均为P2.%)和11眼(16.42.)在血管化区域出现弱荧光区域,差异有统计学意义(P=0.016)。单因素Logistic回归分析结果显示,后极部视网膜血管形态、嵴后血管迂曲扩张、荧光素渗漏、“爆米花”病变、异常血管分支、毛细血管床丢失和颞侧、鼻侧DB/DF值与ROP需要治疗相关(P2.、荧光素渗漏(中度:P=0.117;重度:P2.和0.950(95%CI:0.904~0.996)。结论基于FFA的急性期ROP治疗分类模型具有较好的诊断效能,可为临床决策提供依据。

关键词：荧光素眼底血管造影早产儿视网膜病变治疗分类模型列线图

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Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao wu Lize Xiong Yi {2.g Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji {2.-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA university of Chinese Academy of sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2.identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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优秀运动员两种跳马动作落地的运动学分析

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浙江体育科学 2019年第1期41卷 102-107页

作者：张宇宬郝卫亚李建设顾耀东何卫吴成亮山松俊杰高飞燕宁波大学体育学院浙江宁波315211 国家体育总局体育科学研究所北京100061

落地是跳马动作中非常重要的一个动作,也是运动员最容易出现伤病的一个环节。目的:"前手翻接直体前空翻转体900°和直体笠松转体72.°"在跳马比赛中有着较高的使用频率且难度系数相同。通过对比分析两名高水平运动员分别完成以上两个动... 详细信息

落地是跳马动作中非常重要的一个动作,也是运动员最容易出现伤病的一个环节。目的:"前手翻接直体前空翻转体900°和直体笠松转体72.°"在跳马比赛中有着较高的使用频率且难度系数相同。通过对比分析两名高水平运动员分别完成以上两个动作落地时的运动学特征差异,探究二者的运动学规律,为运动员掌握两种动作和提高落地动作水平提供一定的科学依据和理论指导。方法:对两次全国体操锦标赛和一次全国运动会的男子跳马单项决赛进行三维高速拍摄,使用peak框架进行标定,运用Simi Motion软件进行三维图像解析。结果:两名运动员在完成两种动作时的重心高度变化呈抛物线趋势。在落地阶段,运动员在完成前手翻类的动作的落地缓冲时间、重心高度的变化和下肢髋、膝关节角度变化均大于完成侧手翻类动作,重心最大高度侧手翻类略高于前手翻类,但差别不大。结论:同一名跳马运动员在完成动作"前手翻接直体前空翻转体900°"时的落地缓冲时间要明显高于完成动作"直体笠松转体72.°",与此同时其重心高度变化与下肢关节角度变化和落地缓冲时间存在一定关系,即落地缓冲时间越长,重心高度变化越大,髋关节与膝关节角度变化越大,屈曲程度越大;高水平运动员在落地瞬间对身体控制能力较强,身体左右姿态基本对称,落地更加平稳,致使落地瞬间下肢左右两侧受到的冲击分布较为平均,大大降低了下肢各关节受伤的风险。

关键词：跳马落地运动学分析

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