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Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups

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Chemical Research in Chinese Universities 2006年第4期22卷 459-464页

作者： ZHAI Xin ZHAO yan-fang WANG jia HONG Wei HUANG Liang GONG Ping School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic（imidazo[ 1,2-b] pyridazine/ imidazo[2,1-b] thiazole） groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by ^1H NMR, IR and MS, and their in vitro antibacterial activities against staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid.

关键词： Oxazolidinone analog Synthesis Antibacterial activity

Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2020年第46期26卷 7325-7337页

作者： Jie yang Ya-han Zhang jia-Wu Li Ying-Yu Shi jia-yan Huang yan Luo Ji-Bin Liu Qiang Lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Combined hepatocellular-cholangiocarcinoma(CHC)is a rare type of primary liver *** to its complex histopathological characteristics,the imaging features of CHC can overlap with those of hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC).AIM To investigate the possibility and efficacy of differentiating CHC from HCC and ICC by using contrast-enhanced ultrasound(CEUS)Liver Imaging Reporting and Data System(LI-RADS)and tumor *** Between January 2016 and December 2019,patients with histologically confirmed CHC,ICC and HCC with chronic liver disease were *** diagnostic formula for CHC was as follows:(1)LR-5 or LR-M with elevated alphafetoprotein(AFP)and carbohydrate antigen 19-9(CA19-9);(2)LR-M with elevated AFP and normal CA19-9;or(3)LR-5 with elevated CA19-9 and normal *** sensitivity,specificity,accuracy and area under the receiver operating characteristic curve were calculated to determine the diagnostic value of the *** After propensity score matching,134 patients(mean age of 51.4±9.4 years,108 men)were enrolled,including 35 CHC,29 ICC and 70 HCC *** on CEUS LI-RADS classification,74.3%(26/35)and 25.7%(9/35)of CHC lesions were assessed as LR-M and LR-5,*** rates of elevated AFP and CA19-9 in CHC patients were 51.4%and 11.4%,respectively,and simultaneous elevations of AFP and CA19-9 were found in 8.6%(3/35)of CHC *** sensitivity,specificity,positive predictive value,negative predictive value,accuracy and area under the receiver operating characteristic curve of the aforementioned diagnostic criteria for discriminating CHC from HCC and ICC were 40.0%,89.9%,58.3%,80.9%,76.9%and 0.649,*** considering the reported prevalence of CHC(0.4%-14.2%),the positive predictive value and NPV were revised to 1.6%-39.6%and 90.1%-99.7%,*** CHCs are more likely to be classified as LR-M than LR-5 by CEUS *** combination of the CEUS LI-R

关键词： Combined hepatocellular-cholangiocarcinoma Contrast-enhanced ultrasound Liver imaging reporting and data system Sensitivity Diagnosis Liver neoplasms

A rare case of gastrointestinal bleeding caused by gastric capillary hemangioma

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Gastroenterology Report 2023年第1期11卷 548-550页

作者： Yu-Zhen Bi Si-jia yan Li-Min Zhou Hong Mou yan Sun Jun Zhang Department of Gastroenterology Chun’an Country First People’s Hospital(Zhejiang Provincial People’s HospitalChun’an Branch)Chun’anZhejiangP.R.China Key Laboratory of Gastroenterology of Zhejiang Province Zhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)HangzhouZhejiangP.R.China

Introduction Gastric hemangioma is a rare neoplasm,accounting for0.05%of gastrointestinal tumors[1].Its submucosal location and dense vascular structure make diagnosis challenging and endoscopic investigations are pivotal in its *** to the risk of bleeding,biopsy may not always be *** most frequently reported symptoms of gastric hemangioma are abdominal pain and upper gastrointestinal bleeding[2].In this report,we present a case of gastric hemangioma in which the initial clinical manifestation was gastrointestinal ***-operative pathological examination revealed a gastric capillary hemangioma.

关键词： gastrointestinal hemangioma bleeding

mgr-mir-9 implicates Meloidogyne graminicola infection in rice by targeting the effector MgPDI

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Journal of Integrative Agriculture 2023年第5期22卷 1445-1454页

作者： TIAN Zhong-ling ZHOU jia-yan ZHENG Jing-wu HAN Shao-jie Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Interdisciplinary Research Academy(IRA)Zhejiang Shuren UniversityHangzhou 310015P.R.China Laboratory of Plant Nematology Institute of BiotechnologyCollege of Agriculture&BiotechnologyZhejiang UniversityHangzhou 310058P.R.China Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insect Pests Zhejiang UniversityHangzhou 310058P.R.China

MicroRNAs (miRNAs),a class of small non-coding RNAs,are crucial endogenous gene regulators in a range of animals,including plant-parasitic *** graminicola is an obligate sedentary endoparasite of rice and causes significant yield losses.A number of studies focused on the roles of *** effectors during the parasitic process;however,how nematode miRNAs regulate its effectors needs *** this research,we analyzed a cluster of *** miRNAs obtained at the second-stage juveniles (J2s) stage that are closely linked to the regulation of *** *** are 49 767 105 total clean reads obtained from three libraries.A total of 233 known miRNAs and 21 novel miRNAs were *** the known miRNAs,mgr-lin-4,mgr-mir-1,mgr-mir-100,mgrmir-86,mgr-mir-279,mgr-mir-87,mgr-mir-71,mgr-mir-9,mgr-mir-50,mgr-mir-72,and mgr-mir-34 are the most abundant11 miRNAs ***,the expression levels of selected miRNAs were validated by real-time quantitative *** hypothesized that these miRNAs might regulate the expression of secreted effectors during the J2s stage to facilitate its *** with this,we found that mgr-mir-9 targets MgPDI,an important *** effector *** addition to that,J2s treated with mgr-mir-9 mimics showed down-regulation of MgPDI expression and reduced reproductive ability,alluding mgr-mir-9 is involved in nematode *** results provide novel insight into the regulatory functions of *** miRNAs during the infection and identify miRNAs and their effector targets as potential key management targets to limit parasite survival during the early stages of infection.

关键词： microRNA function Meloidogyne graminicola deep sequencing Dual-Luciferase Reporter Assay System proteindisulfideisomerase

Numerical investigation on coherent mid-infrared supercontinuum generation in chalcogenide PCFs with near-zero flattened all-normal dispersion profiles

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Chinese Physics B 2019年第10期28卷 338-344页

作者： Jie Han Sheng-Dong Chang yan-jia Lyu Yong Liu State Key Laboratory of Electronic Thin Film and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China School of Environment 3480 University StreetMcGill UniversityMontreal H3A 0E9Canada

We design a novel all-normal flat near-zero dispersion chalcogenide photonic crystal fiber(PCF) for generating midinfrared(MIR) supercontinuum(SC). The proposed PCF with a core made of As2Se3 glass and uniform air holes in the cladding is selectively filled with As2S5 glass. By carefully engineering the PCF with an all-normal flat near-zero dispersion profile, the anomalous-dispersion soliton effect is reduced, thus enabling broadband highly coherent SC to be *** also investigate the influence of the pulse parameters on the SC generation. Broadband SC covering 1.4 μm-10 μm with perfect coherence is achieved by pumping the proposed 3-cm-long PCF with 3-μm 100-fs pulses. The results provide a potential all-fiber realization of the broadband coherent MIR-SC.

关键词： supercontinuum generation photonic crystal fiber nonlinear optics

Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population

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World Journal of Gastroenterology 2015年第14期21卷 4232-4239页

作者： jia-yan Yao Kang Chao Min-Rui Li yan-Qing Wu Bi-Hui Zhong Department of Gastroenterology The First Affiliated Hospital of Sun Yat-Sen University

AIM: To investigate the relationship between inter-leukin-21(IL21) gene polymorphisms and chronic hepatitis B virus(HBV) infection in a Chinese ***: In this case-control study, 366 Chinese HBV-infected patients were recruited and divided into hepatocellular carcinoma(HCC; n = 94) and non-HCC(n = 272) groups at The First Affiliated Hospital of Sun Yat-Sen University, from April 2009 to December *** the non-HCC group, the patients were classified into three clinical subsets, 76 patients had chronic hepatitis B, 101 were HBV carriers and 95 patients had HBV-related *** hundred eight unrelated healthy controls were also *** DNA was extracted from peripheral *** nucleotide polymorphisms(SNPs) rs13143866, rs2221903, and rs907715 were subsequently genotyped using the SNaP shot SNP ***: There were no significant differences in allele and genotype frequencies of SNPs rs13143866, rs2221903, and rs907715 between chronic HBVinfected patients and control ***, no significant differences were found in the frequencies of all alleles and genotypes between the HCC group and the non-HCC ***, in the subgroup analysis, IL21 rs13143866 genotype AA frequency in the HBV carrier group was higher than in controls(OR = 6.280, 95%CI: 1.238-31.854; P = 0.019), and the effect of the recessive model(AA vs GG + GA, OR = 6.505, 95%CI: 1.289-32.828) was observed in the HBV carrier ***21 rs2221903 genotype TC frequency in the HBV carrier group was higher than in controls(OR = 1.809, 95%CI: 1.043-3.139; P = 0.035).In the haplotype analysis, the ATA haplotype(rs13143866, rs2221903, and rs907715) of IL21 was more frequent in the HCC group than in the non-HCC group(0.165 vs 0.104, P = 0.044; OR = 1.700, 95%CI: 1.010-2.863).CONCLUSION: Genotypes rs13143866 AA and rs2221903 TC are risk factors for carrying HBV; ATA haplotype increases the risk of HBV-related HCC onsetin a Chinese population.

关键词： Chinese population Chronic hepatitis B virus infec

Crystalline-State Solvent:Metal-Organic Frameworks as a Platform for Intercepting Aggregation-Caused Quenching

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Chinese Journal of Chemistry 2022年第5期40卷 589-596页

作者： yan-Yuan jia jia-Cheng Yin Na Li Ying-Hui Zhang Rui Feng Zhao-Quan Yao Xian-He Bu School of Materials Science and Engineering Tianjin Key Laboratory of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin300350 China State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071 China

The sequestration of organic luminescent molecules(OLMs)within cage-based metal-organic frameworks(MOFs)as a dispersion platform has been developed to impede aggregation-caused quenching(ACQ).The homogenous encapsulation of distinct luminescent guests of different sizes and emissive behaviors in the cage structure of a MOF resulted in high fluorescent quantum yields of 44.8%for DAPI@NKU-110(DAPI=4',6-diamidino-2-phenylindole),65.4%for TPPA@NKU-110(TPPA=tris(4-(pyridin-4-yl)phenyl)amine),31.3%for R6G@NKU-110(R6G=Rhodamine 6G),and 58.3%for PY@NKU-110(PY=Pyronin Y),attributable to the confinement effect caused by the rigid cages of *** significantly,a positive correlation of the encapsulated quantity of OLMs with their concentration in the in-situ solvothermal reaction was unveiled by spectral analysis and utilized to facilely fabricate a white-light-emitting crystal material TPPA+R6G@*** material features a large crystal size on the millimeter-scale,broadband white emission,ideal CIE coordinates(0.33,0.34),and a high quantum yield(49.1%)when excited at 365 ***,such a strategy can be easily generalized to an abundance of other cage-based MOFs and a plentiful volume of OLMs for the future development of colorful,high performance luminescent materials.

关键词： Metal-organic frameworks Cage compounds Fluorescence Color tunability In-situ encapsulation

Treatment of traumatic globe dislocated completely into the maxillary sinus

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 106-107页

作者： Bei Xu Xue-Liang Xu jia yan Department of Ophthalmology Xiangya HospitalCentral South University Department of Ophthalmology the First People's Hospital

Dear Sir, I am Dr. Bei Xu, from Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. I want to present a rare case of the treatment of traumatic globe dislocated completely into the maxillary sinus. A 46-year-old female was admitted to emergency unit due to traffic accident, presenting disturbance of consciousness for nine hours.

关键词： Treatment of traumatic globe dislocated completely into the maxillary sinus

Layered material GeSe and vertical GeSe/MoS2 p-n heterojunctions

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Nano Research 2018年第1期11卷 420-430页

作者： Wui Chung Yap Zhengfeng yang Mehrshad Mehboudi jia-An yan Salvador Barraza-Lopez Wenjuan Zhu Department of Electrical and Computer Engineering University of Illinois at Urbana-Champaign Urbana IL 6180 I USA Department of Physics University of Arkansas Fayetteville AR 72701 USA Department of Physics Astronomy & Geosciences Towson University Towson MD 21252 USA

GroupqV monochalcogenides are emerging as a new class of layered materials beyond graphene, transition metal dichalcogenides （TMDCs）, and black phosphorus （BP）. In this paper, we report experimental and theoretical investigations of the band structure and transport properties of GeSe and its heterostructures. We find that GeSe exhibits a markedly anisotropic electronic transport, with maximum conductance along the armchair direction. Density functional theory calculations reveal that the effective mass is 2.7 times larger along the zigzag direction than the armchair direction; this mass anisotropy explains the observed anisotropic conductance. The crystallographic orientation of GeSe is confirmed by angle- resolved polarized Raman measurements, which are further supported by calculated Raman tensors for the orthorhombic structure. Novel GeSeflVIoS2 p-n heterojunctions are fabricated, combining the natural p-type doping in GeSe and n-type doping in MoS2. The temperature dependence of the measured junction current reveals that GeSe and MoS2 have a type-II band alignment with a conduction band offset of N 0.234 eV. The anisotropic conductance of GeSe may enable the development of new electronic and optoelectronic devices, such as high-efficiency thermoelectric devices and plasmonic devices with resonance frequency continuously tunable through light polarization direction. The unique GeSe/MoS2 p-n junctions with type-II alignment may become essential building blocks of vertical tunneling field-effect transistors for low-power applications. The novel p-type layered material GeSe can also be combined with n-type TMDCs to form heterogeneous complementary metal oxide semiconductor （CMOS） circuits.

关键词： monochalcogenides germanium selenide anisotropic conductance polarized Raman p-n heterojunction